[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-health":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,56,82,107,130,159,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100619166","skin-inflammation-in-perimenopause-a-probiotic-intervention-proof-of-concept-trial-100619166",false,"NCT07341087","Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial","Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial (SIPPI)","SIPPI","Inclusion Criteria:\n\n1. Female, aged 40-60 years.\n2. Self-reported or clinician-diagnosed non-infectious, non-autoimmune inflammatory skin condition affecting the face (e.g., rosacea, acne, eczema).\n3. Willing and able to consume a daily oral intervention (2x 65 ml probiotic drinks or skimmed milk) for 8 weeks.\n4. Willing and able to provide sufficient blood, skin and stool samples at baseline and end-of-study (Week 8). Participants unable to provide adequate blood sample volumes will not be able to start the intervention.\n5. Willing and able to provide a photograph of the facial area, with all images anonymised for study purposes.\n6. Able to comply with study procedures, including attending clinic visits at KCL.\n7. Have access to a refrigerator at home and be able to store the study product(s) safely after collection (i.e., travel time allows safe storage).\n8. Capable of providing written informed consent.\n9. Have sufficient proficiency in English to complete study questionnaires and assessments.\n\nExclusion Criteria:\n\n1. Inability or unwillingness to provide informed consent.\n2. Inability or unwillingness to comply with study protocol requirements (e.g., clinic visits, sample provision, daily consumption of study drink)\n3. Unwilling to record dietary intakes using handwritten diet diaries\n4. Not fluent in the English language\n5. Is planning on international travel during the study period\n6. Current participation in another interventional clinical trial or having received an investigational\u002Fpharmaceutical product within the past 3 months.\n7. Known allergy or intolerance to dairy products, skimmed milk, or probiotic drinks containing Lactobacillus species.\n8. Currently pregnant, currently breastfeeding or planning to become pregnant in the next 4 months.\n9. BMI \\\u003C18.5kg\u002Fm2 or \\> 35kg\u002Fm2.\n10. Unintentional weight loss greater than 4 kg in the 3 months prior to enrolment.\n11. History of substance abuse or alcoholism (alcohol intake \\>50 units\u002Fweek) within the last 12 months.\n12. Current smokers, or individuals who quit smoking in the last 6-months.\n13. Fasting glucose \\>7mmol\u002Fl (finger prick test at baseline clinic).\n14. Active skin infection requiring systemic antibiotics, antivirals, or antifungals within the past 4 weeks.\n15. Major gastrointestinal disease (e.g., inflammatory bowel disease, celiac disease, short bowel syndrome) or history of significant gastrointestinal surgery (excluding appendectomy or cholecystectomy).\n16. Known immunodeficiency (e.g., HIV, immunosuppressive therapy, systemic corticosteroids \\>10 mg\u002Fday prednisolone equivalent).\n17. History of malignancy or clinically significant non-malignant skin conditions within the past 5 years (except adequately treated basal cell carcinoma).\n18. Serious medical conditions that, in the opinion of the investigator, would compromise safety or interfere with study outcomes (e.g., uncontrolled diabetes, advanced cardiovascular, hepatic, or renal disease, active cancer, autoimmune conditions).\n19. Women with a history of severe psychiatric illness that would limit adherence to study requirements.\n20. Current use of probiotics, prebiotics, or antibiotics within 4 weeks prior to baseline.\n21. Current use of systemic corticosteroids, or other immunosuppressive\u002Fimmunomodulatory therapies within the past 3 months.\n22. Currently receiving, or having received, phototherapy (e.g., UVB, PUVA, laser\u002Flight-based treatments, including at home treatments) for any skin condition within the past 3 months.\n23. Currently receiving, or having received, systemic dermatology treatments likely to affect skin inflammation or immune response within the past 3 months (e.g., isotretinoin, methotrexate, cyclosporine, biologics such as TNF, IL-17, IL-23 or IL-4\u002FIL-13 inhibitors).\n24. Currently receiving, or having received, topical treatments likely to significantly alter skin inflammation within the past 3 months (e.g., high-potency topical corticosteroids, topical calcineurin inhibitors such as tacrolimus or pimecrolimus, topical retinoids, or photodynamic therapy).\n25. Currently using, or have used, probiotic skincare (e.g., topical creams and serums) within the past 3 months.\n26. Currently receiving, have undergone, or plan to undergo cosmetic skin procedures (e.g., chemical peels, laser therapy, dermal fillers, microneedling) within the 3 months prior to, or within 3 months after the first (baseline) visit.\n27. Currently using, or have used, hormonal contraceptives or treatments known to exacerbate skin conditions, including Mirena (levonorgestrel-releasing intrauterine system), oral progesterone-only contraceptives (e.g., mini-pill), and synthetic progestogens (e.g., norethisterone) within the past 3 months.","FEMALE","40 Years","60 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will explore whether a daily probiotic drink containing Lactobacillus casei Shirota (LcS) can help improve immune function and reduce inflammation in women going through the menopausal transition. Hormonal changes during this stage of life can affect the immune system, gut health, and skin, sometimes leading to increased inflammation or conditions such as eczema, acne or rosacea.\n\nParticipants will consume either a low-sugar LcS probiotic drink or a skimmed milk control drink every day for eight weeks. The study will assess markers of immune ageing, inflammation, skin health, wellbeing, and hormone levels. The results will help determine whether a safe, non-hormonal probiotic approach may support immune and skin health during the menopausal transition.",[28,29,30,31,32,33,34,35],"Skin Inflammation","Immunosenescence","Inflammation","Skin Health","Eczema","Rosacea","Acne","Menopause",[37,38,39,40,41,42],"Probiotics","Lactobacillus casei Shirota","Immune ageing","Gut-skin axis","Skin health","Menopausal transition","RECRUITING","2026-05-05",{"date":46,"type":47},"2026-05-08","ACTUAL",{"date":49,"type":47},"2026-04-28",{"date":51,"type":22},"2027-11-01",{"name":53,"class":54},"King's College London","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":55},"100634626","the-effects-of-hyaluronic-acid-on-skin-health-100634626","NCT07542132","The Effects of Hyaluronic Acid on Skin Health","HYDROHEALTH","Inclusion criteria:\n\n* Informed Consent signed by the subject\n* Healthy adult volunteers aged 18 to 50 years at the time of inclusion\n* Ability and willingness to comply with all study procedures and visits as required by the protocol.\n\nExclusion criteria:\n\n* Pregnant or breastfeeding women, or women unwilling to use an effective method of contraception, as the use of the investigational medical device is contraindicated according to the Instructions for Use (IFU)\n* Known hypersensitivity to any of the product ingredients, as well as fructose intolerance.\n* Any skin disease or systemic disease that, in the opinion of the investigator, may affect the treatment area or interfere with study assessments.\n* Presence of any skin alteration at the test sites, including but not limited to scars, tattoos, or other visible skin lesions.\n* History of hypertrophic scars or keloid formation or a similar abnormal wound healing.\n* Presence of terminal hairs at the designated test sites.\n* Current use of any medication or treatment that, in the judgment of the investigator, may interfere with the interpretation of study results or pose a safety concern.\n* Body Mass Index (BMI) \\> 36 kg\u002Fm².\n* Any medical, psychological, psychiatric, or cognitive condition, including drug or alcohol abuse, language barriers, or other circumstances that, in the opinion of the investigator, may impair the subject's ability to understand the study information, comply with the investigation procedures, or complete the investigation.\n* Participation in another clinical investigation involving an investigational medicinal product or medical device within the 30 days prior to enrolment.\n* Previous enrolment in the current investigation.\n* Enrolment of the principal investigator, sub-investigators, their family members, employees, or other dependent persons.",true,"ALL","18 Years","50 Years",{"count":68,"type":22},20,[25],"As people age, skin health gradually changes. The structure and function of the skin are modified, its ability to regenerate decreases, and certain biological changes may accumulate over time. These processes can make the skin more fragile and more sensitive to certain diseases, including skin cancer.\n\nIn dermatological and aesthetic practice, injectable formulations based on hyaluronic acid are widely used to improve skin quality. Although these products are generally well tolerated, their deeper biological effects are most often assessed through subjective clinical observations. Quantitative scientific data are therefore needed to better understand how these products affect the skin.\n\nThe aim of this study is to determine whether a hyaluronic acid-based formulation induces measurable changes in biological markers associated with skin health and fibroblast activity, which are important for skin regeneration. The study also examines whether these biological changes are accompanied by internal changes in skin structure.\n\nFor each participant, three skin areas located on the lower abdomen will be studied. One area will receive an injection of the medical device, a second area will undergo needle insertion without injection, and a third area will receive no intervention. The assignment of the interventions to the skin areas will be done by chance, similar to a coin toss. The participant will know which interventions are performed and on which areas, while the evaluators will not.\n\nThe study includes three visits over a period of approximately six weeks. Non-invasive examinations as well as three small skin biopsies will be performed. There is no direct benefit expected for participants. The risks are mainly local and temporary. The overall results of the study will be shared after its completion in the form of a summary written in language understandable to the general public.",[31],"NOT_YET_RECRUITING","2026-04-21",{"date":75,"type":47},"2026-04-27",{"date":77,"type":22},"2026-06",{"date":79,"type":22},"2026-12",{"name":81,"class":54},"Hans Laubach",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":55},"100622465","the-impact-of-12-week-retention-of-nutrients-on-skin-and-the-perception-of-physical-health-status-100622465","NCT07383974","The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status","Inclusion Criteria:\n\n1. Chinese adults of Asian descent aged 18 and above;\n2. Daily fruit and vegetable intake \\\u003C 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);\n3. S3 measurement index \\\u003C 30000;\n4. Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;\n5. Voluntary participation in the test and signing of the informed consent form;\n6. Willingness to comply with all evaluation requirements.\n\nExclusion Criteria:\n\n1. Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;\n2. Skin lesions, scars, or significant pigmentation on the hand measurement area;\n3. Symptoms of skin disease on the face or hand measurement areas;\n4. Having undergone medical aesthetic procedures within the last 6 months;\n5. Participation in other clinical trials involving product use within the last 3 months;\n6. Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month;\n7. Currently planning for pregnancy, pregnant, or lactating;\n8. Presence of any disease under current treatment;\n9. Any other health issues or chronic diseases that affect behavioral or cognitive abilities;\n10. Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results.\n\nThe S3 instrument refers to a Raman spectroscopy-based biophotonic scanner. The threshold for the S3 screening value is based on previously published literature, which indicated that participants with a daily fruit and vegetable intake of less than 240g had an average Raman spectroscopy biophotonic scanner score below 25,000. However, considering practical recruitment challenges, the inclusion criterion was set at \\\u003C 30,000. The S3 device measures the Skin Carotenoid Index, a non-invasive biomarker reflecting skin carotenoid levels.",{"count":89,"type":22},120,[25],"This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status.\n\nThe study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Participants will be randomly assigned to one of two groups: one group will take a combination of Nu Skin's Vitamin C \\& Green Tea Capsules and Multivitamin \\& Mineral Capsules, while the other group will take a matching placebo.\n\nThe primary goal is to assess if the supplement combination improves skin health after 12 weeks, measured through specialized facial imaging (assessing spots, redness, evenness) and probe measurements (assessing elasticity, moisture, gloss). Secondary goals include evaluating changes in participants' self-perceived health status (via quality of life, fatigue, and digestive health questionnaires), psychological resilience, memory, and exploring a new method for measuring skin carotenoid levels.\n\nThis study is not intended to verify the approved health functions of the products but to explore the potential combined effects of antioxidant and nutritional supplementation on skin and general well-being.",[93,94,31,95,96],"Healthy Volunteers","Dietary Supplementation","Health Status","Antioxidants","2026-01-26",{"date":99,"type":47},"2026-02-03",{"date":101,"type":47},"2025-11-03",{"date":103,"type":22},"2026-02-02",{"name":105,"class":106},"ChinaNorm","INDUSTRY",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":19,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":55},"100609523","effects-of-ksm-66-ashwagandha-300-mg-on-skin-and-hair-health-in-healthy-men-and-women-100609523","NCT07215689","Effects of KSM-66 Ashwagandha® (300 mg) on Skin and Hair Health in Healthy Men and Women\"","A Prospective, Randomized, Double-Blind, Placebo Controlled Clinical Study to Evaluate the Effects of KSM- 66 Ashwagandha® Capsule (300 mg) on Skin and Hair Health in Healthy Men and Women","Inclusion Criteria:\n\n1. Healthy adult men and women participants ≥ 18 years and ≤60 years of age.\n2. Willingness to follow the protocol requirements as evidenced by written informed consent.\n3. Participants who were on consistent dietary, hair, and skin product 3 months prior to start of the study and are willing to follow the same during the study.\n4. Participants who agree not to use any medication (prescription and over the counter), including vitamins and minerals, during or before the course of this study.\n5. Participants with mild to moderate hair loss classified as the Norwood-Hamilton type II, III, IV and V in males and Ludwig type I and II in females.\n6. Willing to come for all follow-up visits.\n7. Participants who agree not to cut hair for the entire duration of the study.\n8. Participants willing to undergo Trichoscan evaluation and not to wash their hair 48 hours before the visit.\n9. Participants or LAR can and willing to give meaningful, written informed consent prior to participation in the trial, in accordance with regulatory requirements.\n10. Participants who agree to take investigational product (i.e., Till Day 90 ± 4 ± 4).\n\nExclusion Criteria:\n\n1. Participants having any clinically significant medical history, medical finding including rosacea, eczema, psoriasis, and atopic dermatitis or an on-going medical or psychiatric condition exists which in the opinion of the Investigator could jeopardize the safety of the subject, impact validity of the study results or interfere with the completion of study according to the protocol.\n2. Participants on any medication or supplement for hair loss, including finasteride, any other 5 α-reductase inhibitor, minoxidil, steroids, or hormonal products, during the 3 months prior to study commencement.\n3. Participants having a history of hypersensitivity reactions (i.e., allergic or oversensitivity to study medication).\n4. Participants who have undergone or plan to undergo hair transplantation surgery during the study period.\n5. Participants with facial skin cancer.\n6. Participants with sunburn, moderate to pronounced suntan, uneven skin tones, tattoos, scars or other disfiguration, dilated vessels or other conditions on the test area that might influence the test results.\n7. Participants with severe seborrheic dermatitis, alopecic disease, except for androgenic alopecia, and scalp disorders, such as scalp psoriasis and infection.\n8. Participants who have participated in a clinical study during the preceding 180 days.\n9. Participants having eating disorders (i.e., bulimia, psychogenic eating disorders, etc.).\n10. Pregnant and lactating females\n11. Participants with alcohol addiction or persistent abuse of drugs of dependence.",{"count":115,"type":22},50,[25],"Hair and skin play major roles in protecting the body, and maintaining their health is essential. Poor hair and skin health have become increasingly common due to the stress associated with modern lifestyles. Effective and time-efficient treatments for hair and skin health remain limited. Although hair loss, baldness, and skin issues are not life-threatening, managing these conditions is important because of the psychological and social complications-such as anxiety and depression-they can cause. There is an unmet need for therapies that provide safe and long-term improvements in hair and skin health.\n\nMany individuals seek Complementary and Alternative Medicine (CAM) to identify natural and effective options for these conditions. Adaptogens such as Ashwagandha (Withania somnifera) have long been studied for their potential to reduce stress and modulate cortisol levels in the body. Reducing stress may help prevent inflammation, a common contributor to hair shedding and loss. Ashwagandha also contains antioxidants and amino acids that may strengthen the hair and minimize breakage. Traditionally, Ashwagandha has been recognized for its multiple health benefits, including support for hair and skin wellness. However, there remains limited scientific evidence to substantiate these traditional claims, underscoring the need for controlled clinical evaluation.",[31,119],"Hair Health","2025-10-10",{"date":122,"type":47},"2025-10-15",{"date":124,"type":47},"2025-07-11",{"date":126,"type":22},"2025-12-10",{"name":128,"class":129},"SF Research Institute, Inc.","NETWORK",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":63,"sex":64,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":55},"100603204","a-study-to-evaluate-the-effect-of-fish-oil-concentrate-on-skin-function-100603204","NCT07133477","A Study to Evaluate the Effect of Fish Oil Concentrate on Skin Function","A Randomised, Placebo-Controlled Study to Evaluate the Effect of Fish Oil Concentrate on Skin Function","NEMO","Inclusion Criteria:\n\n* Volunteers who are able to provide signed informed consent\n* Healthy male or female volunteers between the ages of 35 and 65 years\n* Volunteers with a self-perceived history of atopic skin, prone to redness and\u002For dryness\n\nExclusion Criteria:\n\n* Females who are pregnant, breast feeding, or have given birth within the previous 6 weeks or are planning to be pregnant during the study\n* Volunteers with previous experience of intolerance or allergic reactions to fish or fish products\n* Volunteers with an active skin disorder or a significant history of skin disorders (e.g. psoriasis, eczema, vitiligo, pityriasis versicolor, acne) which in the opinion of a trained assessor or dermatologist may affect the test results\n* Volunteers currently taking or who have recently taken antihistamines, antibiotics, systemic anti-inflammatory drugs during the previous week\n* Volunteers currently taking or who have recently taken retinoids, immunosuppressive drugs, anti-cancer drugs during the six previous months\n* Volunteers who have started, stopped or changed hormonal treatment (including contraceptive pills) in the five previous weeks\n* Volunteers whose skin has been exposed to excessive levels of sun or UV rays during the previous month\n* Volunteers who are suffering from chronic asthma, a malfunction of the lymphatic system, or an auto immune deficiency disease (e.g. lupus, thyroiditis)\n* Volunteers with a history of skin tumours or malignant disease\n* Volunteers who have participated in any clinical study involving the test sites within the previous month\n* Volunteers taking fish oil supplements or other lipid-based supplements regularly during the last 4 weeks","35 Years","65 Years",{"count":141,"type":22},90,[25],"The primary objective of the study is to determine the benefits of the food product EPAX Omega 3-9-11 on skin function.\n\nBenefits (if any) will be determined by evaluating biophysical measurements of the face and inner forearm. Moreover, the study will determine the dosage effect of Omega-3-9-11 on these measurements.",[31],[146,147,148,149],"skin","mono-unsaturated fatty acids","LCMUFA","omega-3","2025-08-18",{"date":152,"type":47},"2025-08-21",{"date":154,"type":47},"2025-04-30",{"date":156,"type":22},"2025-12-01",{"name":158,"class":106},"Epax Norway AS",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":63,"sex":17,"minAge":138,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":171,"conditions":172,"keywords":175,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":4},"100590715","phase-4-impact-of-supplementation-with-low-molecular-weight-hydrolyzed-collagen-and-verisol-on-the-expression-of-lines-skin-quality-and-levels-of-klotho-vegf-and-tgf-beta-in-the-eye-region-100590715","NCT06971029","IMPACT OF SUPPLEMENTATION WITH LOW MOLECULAR WEIGHT HYDROLYZED COLLAGEN AND VERISOL ON THE EXPRESSION OF LINES, SKIN QUALITY, AND LEVELS OF KLOTHO, VEGF, AND TGF-BETA IN THE EYE REGION","Effects Of Supplementation With New Technology for Obtaining Low Molecular Weight Hydrolyzed Collagen Vs. Verisol Collagen on Expression Lines, Skin Quality in the Orbicularis Oculi Region, And Serum Levels of Klotho, VEGF, and TGF-Beta","Inclusion Criteria:\n\n* \"Inclusion criteria require that volunteers be between 35 and 58 years old, have been sedentary for at least one year, and, after reading and understanding all stages of the study, agree to and sign the informed consent form (ICF).\n\nExclusion Criteria:\n\n* \"Exclusion criteria include undergoing facial aesthetic procedures involving hyaluronic acid or botulinum toxin, being an active or passive smoker within the past 3 years, using protein- or amino acid-based supplements within the past 6 months, or using cosmetics with skin-repairing properties in the orbicularis oculi region.","58 Years",{"count":168,"type":22},150,[170],"PHASE4","Skin is the largest organ of the human body and performs various vital functions, including protection against external agents, regulation of body temperature, and sensory perception. As we age, our skin undergoes a series of changes that can be noticeable both visually and physically. One of the most evident changes is the appearance of wrinkles and fine lines, resulting from decreased skin elasticity and reduced production of collagen and elastin. Nutrition plays a key role in skin health, influencing its structure, function, and ability to defend against damage and diseases. However, it is unknown to what extent supplementation with different types of collagens can attenuate these effects in middle-aged women. Therefore, the present study aims to recruit 150 middle-aged women (35-58 years old) who will be randomized into three groups, Verisol Collagen 2.5 g\u002Fday, Peptech Collagen 2.5 g\u002Fday, and Peptech Collagen 10 g\u002Fday, 7 days a week, for 3 months. Skin hydration, oiliness, and flexibility, as well as the number and depth of expression lines, will be evaluated, along with plasma levels of Klotho, VEGF, and TGF-beta. Data will be analyzed, and graphs constructed using GraphPad Prism 5.0 software (California, USA). The normality distribution of the data will be assessed by the Kolmogorov-Smirnov test. Data with parametric distribution will be subjected to paired Student's t-test for intragroup comparison, and unpaired t-test will be used for comparison between groups. Significance levels will be considered statistically different for p\\\u003C0.05.",[31,173,174],"Collagen Supplementation","Growth Factors",[41,176,177],"collagen supplementation","growth factors","2025-05-13",{"date":180,"type":47},"2025-05-14",{"date":182,"type":22},"2025-06-09",{"date":184,"type":22},"2025-12",{"name":186,"class":54},"Federal University of São Paulo",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":63,"sex":64,"minAge":194,"maxAge":19,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":55},"100589326","the-effects-of-cosmetic-acupuncture-100589326","NCT06952959","The Effects of Cosmetic Acupuncture","Using Professional Intelligent Skin Analyzers to Analyze the Effects of Cosmetic Acupuncture on Skin Health and Aging: A Randomized Controlled Trial","Inclusion Criteria:\n\n* both female and male\n* 30 to 60 years old\n* never had acupuncture beauty treatment, or the last time they had acupuncture beauty treatment has been more than six months.\n\nExclusion Criteria:\n\n* medical cosmetic fillers on their face\n* cosmetic surgery\n* needle sickness\n* afraid of acupuncture\n* wounds on the facial skin\n* poor wound healing\n* abnormal coagulation function\n* severe diabetes\n* keloids\n* dialysis\n* cancer patients undergoing chemotherapy or radiotherapy\n* pregnant","30 Years",{"count":196,"type":22},40,[25],"The study recruited 40 subjects and divided them into an intervention group and a waiting list group in a 1:1 ratio using a randomized controlled trial. The changes in skin health and aging-related indicators before and after TCM cosmetic acupuncture treatment were analyzed. The subjects are of all genders and aged between 30 and 60 years old. The TCM cosmetic acupuncture treatment is arranged twice a week for a three-week course. The study will conduct a skin test before and after the TCM cosmetic acupuncture, and use the Antera 3D smart skin detector to comprehensively evaluate the subjects' skin condition. Antera 3D Skin Detector can detect multiple skin indicators, including wrinkle depth, skin tone uniformity and subtle changes in the skin surface, melanin, red pigment, etc. After the treatment, the subjects' acceptance and satisfaction with TCM cosmetic acupuncture were collected.",[200,31],"Aging","2025-04-29",{"date":203,"type":47},"2025-05-01",{"date":205,"type":47},"2025-04-10",{"date":207,"type":22},"2026-03-31",{"name":209,"class":54},"China Medical University Hospital"]