[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-microbiome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-microbiome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100627891","examine-impact-of-topical-application-of-active-versus-placebo-on-the-skin-microbiome-in-sensitive-skin-100627891",false,"NCT07454525","Examine Impact of Topical Application of Active Versus Placebo on the Skin Microbiome in Sensitive Skin.","SkinBiome","Inclusion Criteria:\n\n* Women aged 40-60 among all ethnicities and Fitzpatrick scale.\n* With self-assessed sensitive skin (SS10 \\> 13) and self-reported mild to moderate fine lines and wrinkles.\n* Must spend minimum 1 hour outside from 10am-4pm at least 5 times per week.\n* Residing within the same country on the mid to west coast (California, Nevada, Utah, Arizona, Colorado, New Mexico, Kansas, Oklahoma, Texas, Illinois, Kansas, Idaho, Nebraska, Montana).\n* Consider themselves to be in good health.\n* Willing to continue to use their current cosmetic products (foundation, blush, eyeshadow, sunscreen, etc.) and with the same routine\u002Ffrequency if they do not contain anti-aging ingredients.\n* Willing to refrain from using AHA, other peeling acids (PHA, BHA), prescription products such as retinoids or hydroquinone etc. during the study.\n* Willing to take skin swabs to support measures of the skin microbiome.\n* Must understand their role in the study, provide written informed consent, and fully participate over the 14-week period.\n* Willing to use the products provided within the study as instructed. Willing to change their current skincare routine and replace it with the given regimen for 14 weeks.\n* Willing to maintain diet and lifestyle (including physical exercise) during study period.\n\nExclusion Criteria:\n\n* Used any of the products to be tested in the claim study in the past 3 months. - Participation in a similar skin study within the past 30 days.\n* Have active skin disorders such as psoriasis, eczema, allergies, wounds, scars, or severe acne on their forehead.\n* Regular use of probiotic supplements\n* Consumption of fermented foods (including kefir, probiotic containing yoghurt, kombucha or other) for more than 5 times a week\n* Are orally or topically using or have used in the past 6 months: antibiotics, NSAIDS, antihistamines, immuno-suppressants, corticosteroids, prescription products such as retinoids, hydroquinone, or strong AHA treatments.\n* Have started hormonal treatment (e.g., contraceptives, fertility treatments, or HRT for menopause) within the past 3 months or in case they are on a treatment for more than 3 months they are unwilling to maintain a stable regimen for the duration of the study.\n* Pregnant or breastfeeding.\n* Any history of significant disease or medical condition to alter skin appearances such as type 2 diabetes, cancer, renal disorders or hepatic dysfunction.\n* Individuals who have had medical procedures in their face such as laser resurfacing (or any type of laser treatment ex. photo depilation), plastic surgery (including Botox) within the last 12 months or history of UV radiation (tanning and facial lamps) within the last 3 months.\n* Active Vitiligo or any other chronic skin conditions.\n* Individuals with any history that, in the investigator's opinion, indicates potential harm to the subject or could jeopardize the validity of the study.\n* History of poor cooperation, non-compliance, unreliability, or unwillingness to follow the research protocol and timeline.",true,"FEMALE","40 Years","60 Years",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to build insights to understand how the placebo and active impacts the skin microbiome in women with high skin sensitivity (SS10 \\> 13) and sun exposure. Microbiome samples will be taken at baseline after 2 weeks of using the placebo (base without active) as a run-in period followed by the usage of placebo for an additional 4 weeks. The participants will then start the usage of active formula for an additional 8 weeks with microbiome samples collected at the 10-week and 14-week. This will allow us to observe how the microbiome changes over time after the product usage of both placebo and active formulations relative to the pre-regimen condition. In addition, headshot photos will be taken using the Haut AI application at each time point concurrent to the microbiome sample collection to examine changes in skin appearances after the regimen.",[28,29,30,31],"Skin","Skin Microbiome","Skin Microbiota","Skin Ageing",[33,28,34,35,36,37,38],"Microbiome","Skin ageing","Fine lines","Face Skin","Sun exposure","Skin appearance","NOT_YET_RECRUITING","2026-03-04",{"date":42,"type":43},"2026-03-06","ACTUAL",{"date":45,"type":22},"2026-02",{"date":47,"type":22},"2026-06",{"name":49,"class":50},"AB Biotics, SA","INDUSTRY",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":75,"locationsCount":78},"100598037","phase-3-modulating-the-skin-microbiome-to-prevent-radiation-dermatitis-in-breast-cancer-100598037","NCT07066280","Modulating the Skin Microbiome to Prevent Radiation Dermatitis in Breast Cancer","Skin Repairing Cream for the Prevention of Radiation Dermatitis and Regulation of Skin Microbial Environment in Breast Cancer: A Multicenter, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* Age ≥18 and \\\u003C70 years, with pathologically confirmed breast cancer;\n\n  * TNM stage T1-3N1-3M0 or T3-4N0M0;\n\n    * Underwent mastectomy with or without implant reconstruction; ④ Medically fit for adjuvant radiotherapy (i.e., in good general condition to tolerate expected side effects such as fatigue, nausea, or vomiting); ⑤ No concurrent use of other skincare products throughout the study period;\n\n      * Voluntary participation with signed informed consent, agreeing to comply with investigator-directed use of the trial product.\n\nExclusion Criteria:\n\n* Prior history of radiotherapy;\n\n  * Severe systemic diseases (e.g., significant cardiac, hepatic, or renal dysfunction; immunocompromising conditions such as lymphoma, acquired immunodeficiency syndrome \\[AIDS\\], or Wiskott-Aldrich syndrome) or history of other malignancies; ③ Skin reactions due to systemic therapies (e.g., chemotherapy, immunotherapy) or active dermatologic conditions in the treatment area;\n\n    * Known hypersensitivity to the natural weak-acid macromolecular\u002Fsmall molecular repair cream or any of its components; ⑤ Current participation in other clinical trials or participation within the past 3 months, or judged by investigators to have poor compliance that would prevent completion of the study.","18 Years","70 Years",{"count":61,"type":22},326,[63],"PHASE3","Acute radiation dermatitis (ARD) is the most common treatment-related adverse reaction following radiotherapy after modified radical mastectomy and\u002For prosthetic breast reconstruction in breast cancer patients. Moderate-to-severe ARD may compromise cosmetic outcomes and quality of life, and even impair radiotherapy efficacy. Current pharmacological prophylactic measures clinically employed - including topical corticosteroids, superoxide dismutase, and trolamine cream - demonstrate suboptimal efficacy and lack high-level evidence-based medical support. Emerging research indicates an association between cutaneous microbial homeostasis and ARD development, suggesting that maintaining skin surface acidity and modulating microecological balance may represent more effective preventive strategies.\n\nThis study evaluates the efficacy and safety of a natural weak-acid macromolecular\u002Fsmall molecular repair cream in preventing ARD among post-operative breast cancer patients receiving radiotherapy through skin microbiome modulation. We enrolled 326 high-risk early-stage breast cancer patients scheduled for post-operative radiotherapy and randomized them to compare the superiority of the natural weak-acid repair cream versus conventional care with moisturizer. Concurrent skin microbiome sampling was performed to assess microecological changes and their impact on ARD development. The findings will provide high-level clinical evidence and theoretical basis for the safer and more effective application of this natural weak-acid repair cream in preventing post-radiotherapy ARD in breast cancer patients.",[29,66,67],"Breast Cancer","Radiation Dermatitis","RECRUITING","2025-07-04",{"date":71,"type":43},"2025-07-15",{"date":73,"type":43},"2025-04-10",{"date":47,"type":22},{"name":76,"class":77},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","OTHER",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":78},"100441776","the-association-between-radiation-dermatitis-and-skin-microbiome-in-breast-cancer-patients-100441776","NCT05032768","The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients","The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients Receiving Radiation After Mastectomy and Reconstructive Surgery","Inclusion Criteria:\n\n1. Female patients\n2. Invasive breast cancer confirmed by pathology\n3. Underwent mastectomy and breast reconstruction\n4. Radiotherapy after breast reconstruction\n5. ECOG score 0-1\n6. Signed informed consent\n\nExclusion Criteria:\n\n1. Previous breast or chest radiotherapy\n2. Other serious skin diseases (systemic lupus erythematosus, skin sclerosis, et al) and cannot receive radiotherapy\n3. Pregnant women\n4. Patients who are unwilling or unable to receive regular follow-up.",{"count":87,"type":22},100,"OBSERVATIONAL","The breast cancer patients who received radiotherapy after mastectomy and breast reconstruction will be enrolled. The skin microbiome before radiotherapy and its changes after radiotherapy will be analyzed systematically to find out whether the skin microbiome is associated with the severity of radiation dermatitis.",[67,29,66,91],"Reconstructive Surgery","2021-09-01",{"date":94,"type":43},"2021-09-02",{"date":96,"type":43},"2021-01-01",{"date":98,"type":22},"2026-12-31",{"name":100,"class":77},"Fudan University"]