[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-pigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-pigmentation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100429718","phase-4-prospective-evaluation-of-topical-almond-oil-vs-hydroquinone-100429718",false,"NCT04875715","Prospective Evaluation of Topical Almond Oil vs Hydroquinone","Prospective Evaluation of Topical Almond Oil vs Hydroquinone on the Appearance of Facial Pigmentation and the Stability of the Microbiome","Inclusion Criteria:\n\n* Premenopausal women of Fitzpatrick skin types 3 to 6\n\nExclusion Criteria:\n\n* Those with a nut allergy\n* Smoking is an independent risk factor and serves as a confounder for the development of facial aging \\[18\\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded.\n* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging.\n* Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based hormonal replacement therapy.\n* Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment will also not be eligible.\n* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention.\n* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study.\n* Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that contain:\n\n  * Retinoids such as tretinoin, adapalene, retinol.\n  * Antioxidant ingredients such as vitamin C or vitamin E.\n  * Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study.\n  * Topicals that contain a nut oil or nut extract as part of their ingredient list.\n* Furthermore, subjects will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.","FEMALE","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.",[26],"Skin Pigmentation","RECRUITING","2025-09-10",{"date":30,"type":31},"2025-09-12","ACTUAL",{"date":33,"type":31},"2021-07-01",{"date":35,"type":20},"2026-08-01",{"name":37,"class":38},"University of California, Davis","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":39},"100526997","pulse-oximeter-accuracy-in-healthy-humans-during-hypoxia-100526997","NCT06142019","Pulse Oximeter Accuracy in Healthy Humans During Hypoxia","Inclusion Criteria:\n\n1. The subject is male or female, aged ≥18 and \\\u003C50.\n2. The subject is in good general health with no evidence of any medical problems.\n3. The subject is fluent in both written and spoken English.\n4. The subject has provided informed consent and is willing to comply with the study procedures.\n\nExclusion Criteria:\n\n1. The subject is obese (BMI\\>35).\n2. The subject has a known history of heart disease, lung disease, kidney or liver disease.\n3. Diagnosis of asthma, sleep apnea, or use of CPAP.\n4. Subject has diabetes.\n5. Subject has a clotting disorder.\n6. The subject a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.\n7. The subject has any other serious systemic illness.\n8. The subject is a current smoker.\n9. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.\n10. The subject has a history of fainting or vasovagal response.\n11. The subject has a history of sensitivity to local anesthesia.\n12. The subject has a diagnosis of Raynaud's disease.\n13. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).\n14. The subject is pregnant, lactating or trying to get pregnant.\n15. The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.\n16. The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.",true,"ALL","50 Years",{"count":50,"type":20},10000,"OBSERVATIONAL","The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.",[54,26],"Hypoxia","2025-08-29",{"date":57,"type":31},"2025-09-02",{"date":59,"type":31},"2021-11-29",{"date":61,"type":20},"2028-09-01",{"name":63,"class":38},"University of California, San Francisco",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":47,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":74,"briefSummary":77,"conditions":78,"keywords":86,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":99},"100582895","phase-1-autologous-adipose-cells-therapy-100582895","NCT06869252","Autologous Adipose Cells Therapy","Inclusion Criteria:\n\n1. Outpatients who express interest in skin rejuvenation, and\u002For who are experiencing skin conditions, such as winkles, fine lines, loss of skin elasticity, skin pigmentation, scarring.\n2. Outpatients who are experiencing hair loss or hair thinning\n3. Provision of signed and dated informed consent form\n4. Clearly stated willingness to comply with all the procedures of the study and availability of the study\n5. Female and Male aged between 21 to 80 years old 6 Medical clearance by family doctor\n\nExclusion Criteria:\n\n1. Pregnancy or lactation\n2. Known allergic reaction to components of cell culture media\n3. Chronic disease , e.g. cardiovascular disease, diabetes, chronic kidney disease, seizures\n4. Chronic infections, e.g. skin fungi infection, psoriasis\n5. Chronic wound healing\n6. Currently taking hormone therapy\n7. History of cancers and active cancers\n8. Viral infection, e.g. HIV, hepatitis B, influenza, coronaviruses.","21 Years","80 Years",{"count":73,"type":20},40,[75,76],"PHASE1","PHASE2","Autologous Adipose Cell Therapy is a series of process designated to address the demerits of the traditional autologous fat grafting and dermal fillers, while enhancing the versatility and aesthetic outcomes. In this study, the goal is to evaluate the safety and efficacy of Autologous Adipose cell Therapy for skin rejuvenation and hair improvement in human application.",[79,80,81,82,83,84,26,85],"Hair Loss\u002FBaldness","Wrinkle Appearance","Volume","Fine Lines","Skin Elasticity","Hair Thinning","Skin Texture",[87,88],"Adipose Cells","Adipocytes","2025-05-30",{"date":91,"type":31},"2025-05-31",{"date":93,"type":20},"2025-08-01",{"date":95,"type":20},"2026-02-01",{"name":97,"class":98},"CERM INC.","INDUSTRY",2]