[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-rejuvenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-rejuvenation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100628923","comparative-effectiveness-of-long-pulsed-1064-nm-ndyag-and-fractional-co-laser-in-skin-rejuvenation-100628923",false,"NCT07467954","Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation","A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores","Inclusion Criteria:\n\n* Male and female patients with skin aging classified as Glogau scale II-III\n* Age 30-59 years.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* Active smokers.\n* Individuals with high levels of sun exposure.\n* History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months.\n* Use of oral isotretinoin within the past six months.\n* Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks.\n* Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month.\n* Presence of active facial skin inflammation.\n* History of keloid formation.\n* History of allergy to topical lidocaine anesthesia.",true,"ALL","30 Years","59 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.",[28,29],"Skin Rejuvenation","Laser","RECRUITING","2026-03-08",{"date":33,"type":34},"2026-03-12","ACTUAL",{"date":36,"type":34},"2025-10-14",{"date":38,"type":22},"2026-04-16",{"name":40,"class":41},"Universitas Padjadjaran","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":42},"100606635","bridging-technique-validation-for-nasolabial-folds-jn-bridge-1-100606635","NCT07178119","Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1","A Prospective Clinical Evaluation of the Bridging Technique Using AILEENE Vol. 2 Dermal Filler for the Treatment of Nasolabial Folds","BRIDGING","Inclusion Criteria\n\nAdults aged 30 to 65 years, inclusive, at the time of screening.\n\nMale or female, able and willing to comply with study procedures.\n\nPresence of visible bilateral nasolabial folds (NLF), each with a score of 2 or higher on the Nasolabial Fold Severity Scale (NLFSS), as assessed by the Principal Investigator.\n\nWilling to undergo facial dermal filler treatment using the Bridging Technique with AILEENE Vol. 2.\n\nIn generally good health, without uncontrolled chronic illness or active skin disease that could interfere with treatment or healing.\n\nAble to provide written informed consent and understand the nature and purpose of the study.\n\nWilling to refrain from undergoing any other facial cosmetic procedures (e.g., dermal fillers, botulinum toxin, laser, surgery, or radiofrequency) during the six-month study period.\n\nAgree to photographic documentation of the treatment area and follow-up assessments, and willing to allow use of anonymized photographs for blinded evaluation and publication.\n\nFor women of childbearing potential: negative urine pregnancy test at baseline.\n\nFemale participants of childbearing potential will undergo a urine pregnancy test on the day of treatment as a safety precaution, since there is insufficient evidence on filler safety during pregnancy.\n\nExclusion Criteria Presence of NLF graded less than 2 on the NLFSS on either side of the face.\n\nKnown allergy or hypersensitivity to hyaluronic acid (HA), lidocaine, or any component of AILEENE Vol. 2.\n\nHistory of severe allergic reactions, anaphylaxis, or allergy to local anesthetics.\n\nPrior use of dermal fillers, permanent implants, or other cosmetic procedures in the NLF area or lower face within the past 12 months.\n\nUse of botulinum toxin, chemical peels, laser, radiofrequency, or cryotherapy in the mid- or lower face within the last six months.\n\nActive skin infection, inflammation, herpes simplex (cold sore), acne, or other dermatologic condition in the treatment area.\n\nUse of topical medications such as retinoids or corticosteroids on the face within 30 days prior to treatment.\n\nCurrent or recent use (within 14 days) of anticoagulant, antiplatelet, or non-steroidal anti-inflammatory drugs (NSAIDs) that may increase the risk of bruising or bleeding.\n\nHistory of bleeding disorders.","65 Years",{"count":53,"type":22},60,[25],"The goal of this clinical study is to learn whether the Bridging Technique can safely and effectively treat nasolabial folds (NLF, also known as smile lines) in adults. The main questions are:\n\nDoes the Bridging Technique, which places very small amounts of filler in thin horizontal threads (less than 0.05 milliliters \\[ml\\] per retrograde placement), improve the appearance of nasolabial folds?\n\nIs the treatment safe, and are participants satisfied with the results?\n\nThe Bridging Technique is a new method of filler injection where very small amounts of hyaluronic acid (HA) filler are placed in thin horizontal lines under the fold using a blunt cannula. These small \"bridges\" of filler act like internal support, helping to lift and soften the fold without overfilling or distorting the natural shape of the face.\n\nParticipants will:\n\nReceive an HA dermal filler (AILEENE Vol. 2) injected with the Bridging Technique to both nasolabial folds.\n\nAttend follow-up visits at Week 2 (virtual safety check), Week 4, Month 3, and Month 6.\n\nHave photographs taken at baseline, Week 4, Month 3, and Month 6, which will be reviewed by independent observers who are blinded to the visit sequence.\n\nComplete short questionnaires about their satisfaction and experience.\n\nThe study includes 60 adults aged 30 to 65 years. Each participant may receive up to 1.0 ml of filler in total across both folds. An optional top-up treatment may be offered at Week 2 or Week 4 if clinically indicated, using only the remaining balance of the total 1.0 ml allowance. Any top-up will be performed with a new, sterile syringe, not with filler physically left over from the first visit. There is no cost to participants, and participation is voluntary.",[57,58,28,59],"Nasolabial Fold Correction","Facial Aging","Wrinkles Such as Nasolabial Folds",[61,62,63,64,65,66,67,68,69],"Hyaluronic Acid Filler","Dermal Filler","AILEENE Vol. 2","Bridging Technique","Minimally Invasive Aesthetics","Non-Surgical Facial Rejuvenation","Wrinkle Correction","Global Aesthetic Improvement Scale (GAIS)","Nasolabial Fold Severity Scale (NLFSS)","2025-12-03",{"date":72,"type":34},"2025-12-04",{"date":74,"type":34},"2025-11-22",{"date":76,"type":22},"2026-11",{"name":78,"class":41},"Dr. Joseph M Novoa Libermann"]