[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-transplantation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-transplantation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,83,110,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100633236","the-application-of-infrared-thermography-in-the-prediction-of-skin-healing-in-surgery-100633236",false,"NCT07524062","The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery","The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery THERMS: THermography for Evaluation of Recovery and Monitoring of Surgical Wounds","THERMS","Inclusion Criteria:\n\n1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures\n2. Adult subjects (\\>18 years of age) at time of enrolment\n3. Patients undergoing a surgical excision under local anesthesia\n4. Indications of the excisions were skin lesions suspected to be malignant, skin lesions confirmed to be malignant via prior biopsy\n\nExclusion Criteria:\n\n1. Patient has history of pre-existing diabetes type I and II\n2. Patients with pre-existing chronic wound problems\n3. Patients with renal dysfunction,\n4. Patients with venous insufficiency confirmed via radiographic imaging\n5. Patients who received radiotherapy in the affected area in the past\n6. Patients with chronic steroid use in the past (\\> 3 months) or a immunosuppressant medication history\n7. Female who is pregnant","ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates whether infrared thermography, a harmless and non-invasive thermal camera technique, can help monitor how surgical wounds heal after skin surgery. The goal is to detect wound problems earlier, such as infection or delayed healing, and to support doctors in making timely clinical decisions.",[27,28,29,30,31],"Wound Healing","Surgical Wound Infection","Postoperative Complications","Skin Neoplasms","Skin Transplantation",[33,34,35,36,37],"Infrared thermography","Surgical wound healing","Dermatosurgery","Thermal imaging","Wound complications","RECRUITING","2026-06-16",{"date":41,"type":42},"2026-06-18","ACTUAL",{"date":44,"type":42},"2026-06-15",{"date":46,"type":21},"2028-10",{"name":48,"class":49},"Universitaire Ziekenhuizen KU Leuven","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":72,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":50},"100596071","negative-pressure-wound-therapy-for-split-thickness-skin-grafting-to-the-lower-leg-after-excision-of-skin-tumour-a-multicentre-randomised-study-100596071","NCT07040683","Negative Pressure Wound Therapy for Split Thickness Skin Grafting to the Lower Leg After Excision of Skin Tumour: A Multicentre Randomised Study","Negative Pressure Wound Therapy for Split Thickness Skin Grafting to the Lower Leg After Excision of Skin Tumour: The Legs Trial - A Multicentre Randomised Study","LEGS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Undergoing excision of a skin tumour on the lower leg with planned coverage using split-thickness skin grafting (STSG)\n* Eligible procedures include primary excision, secondary excision, or extended excision performed at the same site as a previous tumour surgery\n* Ability to provide written informed consent\n* Ability to comply with postoperative instructions and follow-up visits\n\nExclusion Criteria:\n\n* Inability to follow postoperative instructions due to cognitive impairment, dementia, or significant language barriers\n* Inability to provide informed consent\n* Severe systemic illness, including:\n* Ongoing sepsis\n* Advanced heart failure\n* End-stage renal or liver disease\n* Active chemotherapy within the previous three months\n* Ongoing treatment with immunosuppressive medications, including:\n* Systemic corticosteroids (e.g., prednisone \\>20 mg\u002Fday or equivalent)\n* Calcineurin inhibitors (e.g., cyclosporine, tacrolimus)\n* Antimetabolites (e.g., methotrexate, azathioprine, mycophenolate mofetil)\n* mTOR inhibitors (e.g., sirolimus, everolimus)\n* Biologic therapies (e.g., rituximab, TNF inhibitors, IL-6 inhibitors, IL-1, IL-17, IL-23 inhibitors)\n* Targeted molecular therapies (e.g., JAK inhibitors such as tofacitinib, baricitinib)\n* Other immunosuppressive drugs\n* Previous radiation therapy to the surgical site\n* Presence of severe skin disease affecting the planned graft recipient site (e.g., advanced psoriasis)",{"count":60,"type":21},242,[24],"The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting (STSG) to the lower leg following excision of a skin tumour. The main questions it aims to answer are:\n\nDoes NPWT reduce the incidence of transplant infection within three months after STSG?\n\nDoes NPWT improve secondary outcomes such as graft take, reduce reoperations, complications, and resource use?\n\nResearchers will compare patients treated with NPWT to patients treated with traditional dressings to see if NPWT results in lower infection rates and better clinical outcomes.\n\nParticipants will:\n\nUndergo excision of a skin tumour on the lower leg followed by STSG.\n\nBe randomized to receive either NPWT or traditional dressings applied over the graft.\n\nFollow a structured postoperative care and mobilisation schedule.\n\nAttend follow-up visits at day 5 and day 14 postoperatively and be monitored through medical record review up to three months after surgery.",[31,64,65,66,29,28,67,68,69,27,70,71],"Skin Grafting","Split Thickness Skin Graft","Negative-Pressure Wound Therapy","Lower Extremity","Skin Cancer","Skin Tumour","Bandages","Leg",[31,64,73,66,29,28,67,27,70,71,30,68],"Split Thickness","2026-05-27",{"date":76,"type":42},"2026-05-28",{"date":78,"type":42},"2025-11-01",{"date":80,"type":21},"2030-03-31",{"name":82,"class":49},"Region Skane",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100624895","the-use-of-cultured-dermal-epithelial-autografts-in-severely-burned-patients-100624895","NCT07415577","The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients","Multicenter Cohort Study for the Use of Cultured Epithelial Autografts (CEA) or Cultured Dermal Epidermal Autografts (CDEA) in Severely Burned Patients","Swisskera","Inclusion Criteria:\n\n* Patients who have undergone treatment at the three Swiss burn centres and received grafts utilizing CEA since the introduction of the CEA technique in Switzerland (from 1985 to 2023) will be invited to participate in this study.\n* Availability of clinical data, including at minimum demographic information and the date and time of CEA\u002FCDEA transplantation.\n* Signed informed consent from the patient or his\u002Fher legal representative\u002Frelatives.\n\nExclusion Criteria:\n\n* Refusal of participation in the study by the patient or his\u002Fher legal representative\u002Frelatives.\n* Patients, who are, of any reason, unable to attend a study visit at one of the study sites or in their home",{"count":92,"type":21},236,"OBSERVATIONAL","The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA) and, where applicable, cultured dermal-epidermal autograft (CDEA). Patients who received CEA\u002FCDEA between 1985 and 2023 will be invited for a study visit , using available clinical records and standardized long-term scar and skin assessments.\n\nLong-term skin quality will be evaluated by comparing the previously transplanted area with a matched healthy skin reference site using non-invasive measurements (e.g., thickness, transepidermal water loss, hydration, elasticity, and color). Optional small punch biopsies may be obtained from transplanted areas (under local anesthesia or during clinically indicated anesthesia) for histological and immunohistochemical characterization of scar tissue remodeling, including collagen and elastin architecture, vascularization, nerve fiber ingrowth, inflammatory cell patterns, and melanocyte distribution.",[96,97,31,98],"Burn Degree Second","Burn Degree Third","Full Thickness Skin Defects","NOT_YET_RECRUITING","2026-05-20",{"date":102,"type":42},"2026-05-26",{"date":104,"type":21},"2026-12-01",{"date":106,"type":21},"2030-12-31",{"name":108,"class":49},"University Children's Hospital, Zurich",3,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},"100535758","clinical-and-histological-study-of-a-novel-dermal-substitute-100535758","NCT06255990","Clinical and Histological Study of a Novel Dermal Substitute","Clinical and Histological Study of a Novel Dermal Substitute, NovoSorb® BTM, Used in the Treatment of Full-thickness Skin Defects","Inclusion Criteria:\n\n* Age: 1 to 75 years\n* Full-thickness skin defect qualifying for coverage with the dermal substitute NovoSorb® BTM before transplantation with a STSG:\n\n  * Acute cases: burn injury, soft tissue injury, skin necrosis after purpura fulminans or similar condition\n  * Reconstructive cases (elective surgery): e.g. scar formation after burn injury, giant congenital nevus, defect after removal of skin tumor, skin defect due to other surgical procedures\n* Documented medical treatment decision of covering the full-thickness skin defects with either the two-step BTM\u002FSTSG procedure or with STSG alone or by using both techniques on different wound areas\n* Informed consent by patients\u002Fparents or other legal representative\n\nExclusion Criteria:\n\n* Infected wounds needing surgical procedure other than a dermal template\n* Patients with known underlying or concomitant medical conditions that may interfere with normal wound healing (e.g. immune deficiency, systemic skin disease, any kind of congenital defect of metabolism including diabetes)\n* Previous enrolment of the patient into the current study\n* Adolescent\u002FAdult patients or in case of children their parents\u002Flegal representatives unable to comply with the study protocol\n* Pregnant or breast feeding females","1 Year","75 Years",{"count":120,"type":21},42,"The goal of this observational study is to compare a novel dermal substitute to a the current standard procedure in the treatment of full thickness skin defects.\n\nThe main questions aim to answer are:\n\n• Is the skin elasticity treated with the novel dermal substitute better than the skin elasticity treated with the current standard procedure Participants skin elasticity will be measured by Cutometer® MPA-580 assessment.",[31],"2026-03-30",{"date":125,"type":42},"2026-04-03",{"date":127,"type":42},"2024-01-15",{"date":129,"type":21},"2027-06",{"name":108,"class":49},4,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":50},"100597366","aloe-vera-vs-paraffin-tulle-dressings-for-pain-management-in-split-thickness-skin-graft-donor-sites-100597366","NCT07057557","Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites","Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site","AloePaTu","Inclusion Criteria:\n\n* • Patients aged 18-60 years of age of either gender needing Split thickness skin graft\n\nExclusion Criteria:\n\n* • Patients known to have exaggerated\u002Fdiminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.)\n\n  * Patients allergic to either dressings","60 Years",{"count":142,"type":21},72,[24],"The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60. The main questions it aims to answer are:\n\nDoes Aloe Vera gel dressing reduce postoperative pain more effectively than paraffin-based tulle dressing on the 7th day after surgery?\n\nIs there a difference in the need for additional pain medication between the two groups?\n\nResearchers will compare Aloe Vera gel dressing to paraffin-based tulle dressing to see if Aloe Vera leads to better pain control.\n\nParticipants will:\n\nUndergo split-thickness skin graft surgery\n\nReceive either Aloe Vera gel dressing or paraffin-based tulle dressing at the donor site\n\nHave pain measured using a visual analogue scale (VAS) on the 7th day after surgery\n\nBe given pain medication if their pain score is 4 or higher, and the amount used will be recorded",[146,147,148,31],"Skin Graft Wounds","Donor Site Complication","Pain, Postoperative","2025-09-21",{"date":151,"type":42},"2025-09-25",{"date":153,"type":42},"2025-08-05",{"date":155,"type":21},"2026-04-14",{"name":157,"class":49},"King Edward Medical University"]