[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skull-base-chordoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skull-base-chordoma":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":5},"100507490","multi-parametric-imaging-in-personalized-radiotherapy-100507490",false,"NCT05888064","Multi-parametric Imaging in Personalized Radiotherapy","A Technical Framework for Combining Multi-parametric Imaging With Advanced Modelling in Personalized Radiotherapy","Inclusion Criteria:\n\n* Patients with histologically confirmed diagnosis of chordoma of the skull base\n* Particle therapy with curative intent\n* Karnofsky Performance status greater than or equal to 60\n* Patients with macroscopic disease detectable at pre-radiotherapy imaging\n* Patients undergoing PT with standardized treatment procedures\n* Patients who have signed the written informed consent for research\n\nExclusion Criteria:\n\n* Metastatic disease\n* Palliative treatment\n* Other malignancies with disease-free interval \\\u003C 5 years (excepting pre- cancerous lesions)\n* Pregnancy\n* Simultaneous CHT or Immunotherapy\n* Extensive metal instrumentation\u002Fimplants\n* Patients with autoimmune diseases (ADs) -including collagen-vascular (CVD) and inflammatory bowel (IBD)","ALL","18 Years",{"count":19,"type":20},35,"ESTIMATED","OBSERVATIONAL","The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.",[24],"Skull Base Chordoma","RECRUITING","2024-08-20",{"date":28,"type":29},"2024-08-21","ACTUAL",{"date":31,"type":29},"2022-04-19",{"date":33,"type":20},"2025-08-18",{"name":35,"class":36},"CNAO National Center of Oncological Hadrontherapy","OTHER"]