[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skull-base-neoplasms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skull-base-neoplasms":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,76,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100485962","prospective-study-of-sinonasal-and-skull-base-tumours-management-100485962",false,"NCT05607888","Prospective Study of Sinonasal and Skull-base Tumours Management","Prospective Observational Study of Sinonasal and Skull-base Tumours Management in a Tertiary Referral Otorhinolaryngology Service","Sinonasal_Tu","Inclusion Criteria:\n\n* sinonasal and\u002For skull-base cancer\n* sinonasal disease expanding through the skull-base\n* the patient's written informed consent\n\nExclusion Criteria:\n\n* lateral skull-base disease primarily originating in the temporal bone and without central skull-base involvement","ALL",{"count":19,"type":20},120,"ESTIMATED","5 Years","OBSERVATIONAL","This observational prospective clinical study aims to describe the epidemiology, management and outcome of patients with sinonasal and skull-base pathology (tumours and diseases with malignant clinical characteristics) in a tertiary otorhinolaryngology referral centre. The main questions it aims to answer are:\n\n* what is the caseload of patients with the included pathology in our centre\n* what are the results of management of these cases\n* what are the epidemiological characteristics of included patients\n* what is the quality of life of included patients.",[25,26,27,28,29,30],"Nasal Neoplasm","Nasal Neoplasm Benign","Skull Base Neoplasms","Skull Base Osteomyelitis","Sinonasal Disorder","Sinus Disease","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-04-29","ACTUAL",{"date":37,"type":35},"2022-01-01",{"date":39,"type":20},"2027-12-31",{"name":41,"class":42},"University Medical Centre Ljubljana","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100508258","role-of-novel-rada16-hydrogel-in-endoscopic-skull-base-surgery-100508258","NCT05898074","Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery","Novel Application of RADA16 Hydrogel in Reducing Sinonasal Morbidity After Endoscopic Skull Base Surgery","Inclusion Criteria:\n\n* Patient is 18 years of age or older\n* Patient is undergoing endoscopic endonasal approach for the management of a skull base tumor or cerebrospinal fluid leak. Nasoseptal Flap must be harvested.\n* Patient is undergoing surgery via bi-nostril approach requiring bilateral surgical dissection of the nasal cavity in approach to the skull base\n\nExclusion Criteria:\n\n* Patient has evidence of radiographic baseline sinus disease consistent with acute or chronic rhinosinusitis (including nasal polyposis, prior septal perforation) on pre-operative CT sinus\n* Patient has had prior sinonasal surgery or has undergone sinonasal radiation treatment\n* Patient has a known coagulation disorder or immune deficiency.",true,"18 Years",{"count":54,"type":20},30,"INTERVENTIONAL",[57],"NA","The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the nasoseptal flap harvest site during endoscopic skull base surgery and the impact on patient and sinonasal morbidity.",[27,60,61],"Cerebrospinal Fluid Leakage","Nasal; Hypertrophy, Mucous Membrane (Septum)",[63,64,65,66],"Nasoseptal Flap Harvest","Sinonasal Morbidity","Extracellular Matrix","Endoscopic Skull Base Surgery","2026-04-06",{"date":69,"type":35},"2026-04-09",{"date":71,"type":35},"2023-10-09",{"date":73,"type":20},"2026-06-09",{"name":75,"class":42},"Indiana University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":43},"100554640","icg-angiogram-as-a-predictor-of-postoperative-visual-function-after-eea-surgery-100554640","NCT06501716","ICG Angiogram as a Predictor of Postoperative Visual Function After EEA Surgery","I See G: Superior Hypophyseal Artery Intraoperative Indocyanine Green Angiogram as a Predictor of Postoperative Visual Function After Endoscopic Endonasal Surgery","Inclusion Criteria:\n\n* The study will enroll adult (18 y.o. and older) participants undergoing endonasal endoscopic surgery for suprasellar tumors including meningiomas, craniopharyngiomas and pituitary adenomas.\n\nExclusion Criteria:\n\n* Underage patients (younger than 18 y.o).",{"count":84,"type":20},40,"Endonasal endoscopic approaches are an established treatment for suprasellar lesions compromising the optic nerves (ON). Surgery often involves dissecting tumors from the optic nerves and its blood supply, which can result in nerve damage and visual loss after surgery. To date, there are no reliable methods to monitor the optic nerve function during surgery and thus, post-surgical visual outcomes is unknown until the patients are fully awake after surgery for a visual exam. This delay in diagnosis prevents early therapeutic measures and can result in further harm to the ON. We have recently recognized that when ICG is routinely injected during these cases to check for patency of the big arteries the sub millimetric superior hypophyseal arteries supplying (SHA) the ON are also visible and that lack of visualization of these vessels is associated with worse visual deficits after surgery. Thus, ICG may be a tool to intraoperative predict visual outcomes after endonasal approach for suprasellar lesions and fill the nondiagnostic gap. This study will assess whether endoscopic ICG angiography before and after resection of suprasellar lesions can predict post-operative visual deficits. Successful completion will provide surgeons a novel tool to assess visual function during surgery. The ICG endoscopic angiograms suggested in this study are noninvasive and currently routinely performed at the end of surgery to check for patency of big brain arteries.",[87,27],"Indocyanine Green","NOT_YET_RECRUITING","2024-07-18",{"date":91,"type":35},"2024-07-22",{"date":93,"type":20},"2024-07",{"date":95,"type":20},"2025-12",{"name":97,"class":42},"University of California, San Francisco",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":55,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":43},"100554168","optic-nerve-stimulation-to-prevent-visual-deficits-after-endoscopic-cranial-approaches-100554168","NCT06495580","Optic Nerve Stimulation To Prevent Visual Deficits After Endoscopic Cranial Approaches","Optimizing Visual Outcomes: Use of Optic Nerve Stimulation in Endoscopic Cranial Approaches","Inclusion Criteria:\n\n* Patients diagnosed with suprasellar tumors including meningiomas, craniopharyngiomas and pituitary adenomas.\n* Must not present with any permanent or temporal visual deficit.\n* Must receive an open or endoscopic endonasal procedure as part of their care.\n\nExclusion Criteria:\n\n* Preexisting visual impairments unrelated to the tumor.\n* History of prior cranial surgeries or radiation therapy.\n* Significant cognitive impairment or inability to provide informed consent\n* Contraindications to microstimulation procedures such as uncontrolled coagulopathy or active infection.\n* Patients with tumors located outside the sellar region or those requiring emergent or urgent surgery due to life-threatening complications.\n* Additionally, individuals with systemic conditions or comorbidities that may significantly impact visual function or surgical outcomes, such as uncontrolled diabetes mellitus or severe cardiovascular disease.",{"count":106,"type":20},20,[57],"Assessing the function of the optic nerve is paramount during various neurosurgical procedures. Effective optic nerve monitoring has remained elusive as Visual Evoked Potentials (the current existing tool) provides only diffuse and delayed assessment of nerve function. Here, the investigators propose a prospective study involving adult patients (aged 18 years and older) undergoing endonasal or open cranial approaches around the optic nerves, who will receive pre- and post-operative visual evaluations. During surgery, the optic nerve and chiasm will be stimulated, and the response will be recorded in both eyes and the occipital cortex via skin electrodes. The investigators aim to utilize anterograde optic nerve microstimulation to assess the nerve's integrity during open and endoscopic cranial approaches. Electrophysiological readings will be acquired, as is routine in the operating room, by our team of experts, and intraoperative findings will be correlated with post- surgical clinical outcomes. Our objective is to utilize existing technology in the operating room to safely and effectively monitor optic nerve function during surgery.",[110,111,27],"Optic Nerve Injuries","Sellar Tumor","2024-07-10",{"date":114,"type":35},"2024-07-12",{"date":116,"type":20},"2024-08",{"date":118,"type":20},"2026-12",{"name":97,"class":42}]