[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sleep-apnea-syndrome-osas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sleep-apnea-syndrome-osas":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,70,104,128,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639491","splintless-versus-conventional-maxillomandibular-advancement-surgery-for-obstructive-sleep-apnea-100639491",false,"NCT07598461","Splintless Versus Conventional Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea","Splintless Versus Conventional Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea: a Randomized Controlled Trial","SvCMAS","Inclusion Criteria:\n\nFor OSA patients:\n\n* Adults aged 18 years or older;\n* Moderate to severe OSA (apnea hypopnea index (AHI) ≥ 15 events\u002Fhour) as determined by an overnight polysomnography (PSG) preoperatively;\n* Continunous positive airway pressure failure or intolerance;\n* General good health for surgery;\n* MMA surgery indicated for OSA treatment.\n\nFor bedpartners of patients:\n\n• Sharing a bed ⩾2 nights\u002Fweek with patient.\n\nExclusion Criteria:\n\nFor OSA patients:\n\n* Other adjunctive procedures indicated at the time of MMA (e.g., multi-piece Le Fort I osteotomy, temporomandibular joint reconstruction);\n* Previous history of orthognathic surgery;\n* Cleft palate and syndromic patients;\n* Refusal to participate.\n\nFor bedpartners of patients:\n\n• Refusal to participate.","ALL","18 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether using a splintless surgical approach improves the accuracy of maxillomandibular advancement (MMA) surgery for treating obstructive sleep apnea (OSA) in adults. The study will also look at the safety, functional outcomes, and cost-effectiveness of the splintless approach. The main questions it aims to answer are:\n\nDoes the splintless approach lead to more accurate surgical movements of the jaws compared to the conventional splint-based method? What are the safety profile, functional outcomes, and cost-effectiveness of the splintless approach?\n\nResearchers will compare splintless MMA to conventional MMA.\n\nPatients will:\n\nUndergo MMA surgery using either the splintless or splint-based method; Attend regular follow-up visits as part of routine care; Complete questionnaires and undergo assessments at various time points; Receive one additional CT scan (24 months after surgery) and one overnight sleep study (60 months after surgery).\n\nBedpartners of patients will:\n\nComplete questionnaires at various time points.\n\nThis trial will help determine whether the splintless approach is a better, safer, and more effective alternative for treating OSA with MMA surgery.",[27,28,29],"Sleep Apnea Syndrome (OSAS)","Orthognathic Surgical Procedures","Sleep Apnea - Obstructive",[31,32,33,34,35],"OSA","Maxilomandibular advancement surgery","MMA","Patient-specific implants","Splintless orthognathic","NOT_YET_RECRUITING","2026-05-13",{"date":39,"type":40},"2026-05-20","ACTUAL",{"date":42,"type":21},"2026-12-01",{"date":44,"type":21},"2033-02-28",{"name":46,"class":47},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":48},"100637904","natural-history-of-central-and-mixed-sleep-apneas-followed-by-maxillomandibular-advancement-for-obstructive-sleep-apnea-100637904","NCT07596719","Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea","CMAI","Inclusion Criteria:\n\n* Adults aged 18 years or older;\n* Mild to severe OSA as determined by a polysomnography (PSG) preoperatively;\n* Completion of MMA for OSA treatment;\n* Subjects with preoperative and postoperative PSG;\n* Patients who are present with MMA treatment-related central apneas postoperatively\n\nExclusion Criteria:\n\n* Patients who underwent other adjunctive procedures at the time of MMA (e.g., multi-piece Le Fort osteotomy, TMJ reconstruction);\n* Previous history of orthognathic surgery;\n* Cleft palate and syndromic patients.",{"count":57,"type":21},60,"OBSERVATIONAL","The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.\n\nThe main question it aims to answer is:\n\nDo central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?\n\nParticipants will:\n\nUndergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).\n\nBe invited into the study if central\u002Fmixed apneas are detected (CMAI% \\>25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)",[27,61,62,28],"Central Sleep Apnea","Maxillomandibular Advancement Surgery",[31,33,61],{"date":65,"type":40},"2026-05-19",{"date":42,"type":21},{"date":68,"type":21},"2027-12-31",{"name":46,"class":47},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":79,"studyType":58,"phases":4,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100639881","sleep-and-stroke-rehabilitation-study-100639881","NCT07579871","Sleep and Stroke Rehabilitation Study","SnSRehabS","Inclusion Criteria:\n\n* Ischemic stroke.\n* First time stroke.\n\nExclusion Criteria:\n\n* Short expected survival.\n* Unable to carry HSAT equipment (e.g., gel nails; the patient is wearing other medical devices; motor or cognitive impairment without the possibility of assistance from healthcare staff or relatives).\n* Reduced understanding of the project due to insufficient Swedish, which cannot be bridged with an interpreter.",{"count":78,"type":21},226,"9 Months","The study aims to map sleep disorders and their impact on the ability to engage in an active daily life among people who have had a stroke, with particular focus on how sleep apnea can be identified.\n\nThe study has the following objectives:\n\n1. To examine the occurrence of sleep apnea, insomnia, excessive daytime sleepiness, and restless legs syndrome\u002Fperiodic limb movements in patients with ischemic stroke three months after onset.\n2. To investigate associations between these sleep disorders and physical and mental health, fatigue, quality of life, cognitive and physical function, and daily physical behavior including physical activity levels.\n3. To identify which clinical factors and patient reported data, including patient reported data from commercial wearable health technology, predict a diagnosis of sleep apnea.\n4. To examine how sleep disorders affect changes in physical and mental health, fatigue, quality of life, cognitive and physical function, and daily physical behavior including physical activity levels one year after stroke.",[82,27,83,84],"Stroke","Insomnia","Excessive Daytime Sleepiness",[86,87,88,89,90,91,92,93],"actigraphy","HSAT","Quality of life","rehabilitation","recovery","smartwatch","sleep","stroke","RECRUITING","2026-05-06",{"date":97,"type":40},"2026-05-12",{"date":99,"type":40},"2026-03-18",{"date":101,"type":21},"2028-10-30",{"name":103,"class":47},"Malin Eleonora av Kák Gustafsson, MD, PhD",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":48},"100635625","night-to-night-variability-of-novel-physiological-parameters-in-home-sleep-apnea-testing-100635625","NCT07555119","Night-to-Night Variability of Novel Physiological Parameters in Home Sleep Apnea Testing","N2N-OSA","Inclusion Criteria:\n\n* Patients with suspected or diagnosed sleep-disordered breathing, irrespective of disease severity, as defined by the indications for home sleep apnea testing in the German guidelines \\[15\\]\n* No active treatment during sleep recordings or within preceding two weeks (e.g., mandibular advancement devices, positive airway pressure therapy)\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Known or suspected neurological sleep disorder (e.g., narcolepsy, parasomnia)\n* Known or suspected psychiatric sleep disorder\n* Known or suspected central and complex sleep apnea\n* Participants who are unable to perform sleep measurements reliably\n* Insufficient knowledge of the project language (German)\n* Inability to give consent\n* Shift workers (with shift work \\\u003C2 weeks before testing)",{"count":112,"type":21},192,"Obstructive sleep apnea (OSA) is usually diagnosed from a single night of home sleep apnea testing using the apnea-hypopnea index (AHI). However, the AHI varies substantially from night to night, undermining diagnostic accuracy, and shows only modest correlation with symptoms. This variability further limits its usefulness for predicting cardiovascular and other complications. Besides the traditional AHI, more robust physiological markers are needed.\n\nSeveral emerging physiological metrics - hypoxic burden, ventilatory burden, heart rate variability, autonomic arousals, and the pulse wave amplitude drop index - capture the physiological impact of OSA more comprehensively and demonstrate stronger associations with cardiovascular risk. Despite this promise, their night-to-night variability has not been studied.\n\nA systematic evaluation of both established and novel OSA metrics across nights is essential to identify reliable, stable parameters suitable for clinical routine. This improves diagnostic precision beyond what traditional metrics can provide, enhances patient selection, reduces costs and patient harm, and may improve treatment outcomes.",[115,116,27],"Obstructive Apnea","Diagnostic",[118],"Home Sleep Apnea Testing","2026-04-28",{"date":121,"type":40},"2026-05-05",{"date":123,"type":21},"2026-05-01",{"date":125,"type":21},"2027-06-30",{"name":127,"class":47},"Insel Gruppe AG, University Hospital Bern",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100623680","phase-2-botulinum-toxin-in-the-palatopharyngeal-muscle-for-the-treatment-of-obstructive-sleep-apnea-100623680","NCT07399782","Botulinum Toxin in the Palatopharyngeal Muscle for the Treatment of Obstructive Sleep Apnea","EVALUATION OF BOTULINUM TOXIN IN THE PALATOPHARYNGEAL MUSCLE FOR THE TREATMENT OF OBSTRUCTIVE SLEEP APNEA","ARAP1","Inclusion Criteria:\n\n* Diagnosis of moderate to severe OSA, confirmed by home or laboratory polysomnography.\n* Age between 18 and 50 years.\n* BMI in the range of 18.5-30.\n* Neck circumference ≤ 44 cm (men) and ≤ 42 cm (women).\n* Absence of signs of upper obstruction\n\nExclusion Criteria:\n\n* Skeletal or craniofacial disorders:\n* Tonsillar hypertrophy 3-4\n* Obesity (BMI \\> 30 kg\u002Fm²)\n* Elderly (age \\> 50 years)\n* Neuromuscular diseases (e.g., dystrophies, myasthenia gravis)\n* Chronic use of medications that alter muscle tone.\n* Excessive alcohol consumption (\\> 14 drinks\u002Fweek)\n* Chronic obstructive pulmonary disease (COPD)\n* Congestive heart failure (NYHA III-IV) or decompensated heart disease.\n* Concomitant sleep disorders: narcolepsy, restless legs syndrome, sleep behavior disorder (REM).\n* Predominant central or mixed sleep apnea on polysomnography (≥ 50% central events).\n* Previous airway surgery (uvulopalatopharyngoplasty, recent tonsillectomy).\n* Pregnancy or postpartum (\\\u003C 6 months).\n* Neurological conditions: Previous stroke, Parkinson's disease, dementia.","50 Years",{"count":138,"type":21},20,[140],"PHASE2","Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder characterized by recurrent collapse of the upper airway during sleep, in which the palatopharyngeal muscle plays a key role in pathophysiology. Although continuous positive airway pressure (CPAP) remains the standard treatment, adherence is often suboptimal. Botulinum toxin type A (BoNT-A), a peripheral neuromodulator, has been proposed as a potential therapeutic alternative by inducing chemodenervation and muscle volume reduction, thereby potentially increasing upper airway patency. This study aims to evaluate the efficacy and safety of BoNT-A injection into the palatopharyngeal muscle in patients with moderate to severe OSA. This is a prospective, single-arm, interventional clinical trial with pre- and post-intervention assessment. We hypothesize that the intervention will result in a significant reduction in the Apnea-Hypopnea Index (AHI), along with improvements in secondary outcomes such as excessive daytime sleepiness and oxygenation parameters.",[143,27,144,29],"Sleep Apnea Syndrome, Obstructive","Sleep Apnea\u002FHypopnea Syndrome","2026-02-05",{"date":147,"type":40},"2026-02-10",{"date":149,"type":21},"2026-04-05",{"date":151,"type":21},"2026-09-01",{"name":153,"class":47},"Hospital Felicio Rocho",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":162,"targetDuration":164,"studyType":58,"phases":4,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":184},"100561139","the-snore-trial-analysis-of-alterations-in-sleep-stages-following-anesthesia-and-their-relation-to-the-severity-of-obstructive-sleep-apnea-in-the-first-3-nights-after-surgery-100561139","NCT06586268","The SNORE-trial: Analysis of Alterations in Sleep Stages Following Anesthesia and Their Relation to the Severity of Obstructive Sleep Apnea in the First 3 Nights After Surgery","The SNORE-trial: Postoperative REM-Sleep Disturbance iN Obstructive Sleep-apnea Patients and the Relation With AH-index","SNORE","Inclusion Criteria:\n\n* Patients scheduled for elective surgery at the operating theatres of the AUMC with a diagnosis of OSA with or without treatment with an expected admittance of a minimum of 3 days\n* Patients with continuous positive airway pressure (CPAP) or mandibular advancement device (MAD) are considered patients with treatment for OSA\n* Patients ≥ 18 years\n* Dutch or English speaking\n* Willing and able to sign consent for re-use of care data\n\nExclusion Criteria:\n\n* Patients \\< 18 years\n* Not speaking Dutch or English\n* Patients who do not sign consent for re-use of care data\n* Surgery scheduled in day case or with an expected discharge before the third night after surgery",{"count":163,"type":21},35,"3 Days","The goal of this observational study is to learn about the relationship between sleep alterations following anesthesia and their relationship to a potential increase of obstructive sleep apnea (OSA) severity.\n\nOur main question is: Is there an increased severity of OSA on the third post-operative night compared to the first post-operative night and does this have a relation with REM sleep?\n\nParticipants enrolled in this research are all diagnosed with OSA, with or without treament. All participants will be asked to wear a watchlike device called WATCHPAT to identify sleep paterns and register apneic (no breathing) and hypopneic (insufficient breathing) incidents. We ask our participants to wear this device for 8-10 hours a night when they are a sleep.",[143,27],[168,31,169,170,171,172,173,174,175],"OSAS","obstructive sleep apnea","Post-surgical","post-anesthesia","REM sleep","PACU","AHI","Desaturations","2025-01-28",{"date":178,"type":40},"2025-01-29",{"date":180,"type":40},"2024-10-01",{"date":182,"type":21},"2025-08",{"name":46,"class":47},2]