[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sleep-disturbances\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sleep-disturbances":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,45,71,103,135,166,196,216,260,282,312,343,370,402,427,461],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100581028","effects-of-latin-dancing-on-sleep-quality-in-hispanic-cancer-survivors-100581028",false,"NCT06844981","Effects of Latin Dancing on Sleep Quality in Hispanic Cancer Survivors","Moviendo Las Caderas: Effects of Latin Dancing on Sleep Quality in Hispanic Cancer Survivors","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Self-identify as Hispanic and\u002For Latino(a)\n* Have a confirmed diagnosis of a solid tumor or hematologic malignancy\n* Must have completed primary cancer treatment 3+ months prior to enrollment (e.g., chemotherapy, surgery, and\u002For radiation therapy but may be on hormonal therapy and\u002For immunotherapy or other long-term therapies)\n* Have sleep disturbance (indicated by a response of 3 or more on the MD Anderson Symptom Inventory sleep question by using an 11-point scale anchored by 0 \\[no sleep disturbance\\] and 10 \\[worst possible sleep disturbance\\]\n* Be able to read and understand English and\u002For Spanish\n* Physically Inactive (\\\u003C150 minutes of vigorous exercise\u002Fweek within the past 3 months)\n\nExclusion Criteria:\n\n* Current regular Latin dancing practice within the past year (2-3 times a week over a period of two months that is not interrupted).\n* Inability to speak and read English or Spanish proficiently\n* Inability to understand informed consent\n* Medical conditions that can cause sleep impairment: sleep apnea, restless leg syndrome, shift work\n* Regular use of a walker or wheelchair\n* Healing or unhealed fractures\n* Heart failure\n* Life expectancy \\\u003C12 months\n* Unwilling to be randomized to study arms and\u002For commit to 8 weeks of classes and a follow-up assessment","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objective is to assess the feasibility, acceptability and explore the impact of a culturally appropriate Latin Dance intervention vs. Usual Care on sleep quality for Hispanic cancer survivors.\n\nSecondary objectives are to examine the preliminary efficacy of a culturally appropriate Latin Dance intervention on secondary cancer- and treatment-related side effects (e.g., Quality of Life, distress, insomnia, fatigue).",[26,27],"Cancer Survivorship","Sleep Disturbances",[29,26,27,30,31],"Cancer","Hispanic Cancer Survivors","Latin Dancing","RECRUITING","2026-05-19",{"date":35,"type":36},"2026-05-20","ACTUAL",{"date":38,"type":36},"2026-04-01",{"date":40,"type":20},"2027-03",{"name":42,"class":43},"Rutgers, The State University of New Jersey","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100635612","evaluating-the-impact-of-psychoeducation-and-sleep-informed-workshop-targeting-sleep-concerns-in-women-and-individuals-with-premenstrual-dysphoric-disorder-100635612","NCT07554950","Evaluating the Impact of Psychoeducation and Sleep-informed Workshop Targeting Sleep Concerns in Women and Individuals With Premenstrual Dysphoric Disorder","Evaluating the Subjective and Objective Impact of Psychoeducation and Sleep-informed Workshop Targeting Sleep Difficulties in Individuals With Premenstrual Dysphoric Disorder","PMDD","Inclusion Criteria:\n\n1. Aged 16 and above\n2. positive screening for severe PMS and PMDD as per the Premenstrual Severity Screening Tool (PSST)\n3. experiencing sleep difficulties captured by a score of 12 or greater on the Insomnia Severity Index (ISI)\n4. reported regular menstrual cycle (average length of 25-35 days)\n5. not taking psychoactive medication or oral contraceptives or a) participants must be on a stable in dose and type for at least 8 weeks prior to the start of the study and b) medications remain stable throughout the study\n6. fluent in English, minimal grade 8 reading level to understand written materials\n7. individuals must have access to a smart phone or tablet with stable internet connection in order to complete study daily questionnaires\n\nExclusion Criteria:\n\n1. Severe cognitive disability that could impact the understanding of the clinical questionnaires\n2. a diagnosis of schizophrenia or any other primary psychotic disorder or current alcohol or substance use disorders\n3. presence of any unstable medical conditions","FEMALE","16 Years",{"count":56,"type":20},72,[23],"Premenstrual Dysphoric Disorder (PMDD) is a cyclical mood disorder characterized by emotional, cognitive, physical, and sleep-related symptoms that occur in the days leading up to menstruation and improve shortly after menstruation begins. Although medications are commonly used to treat PMDD, many individuals experience side effects, do not benefit from medication, or prefer non-medication-based approaches. Sleep difficulties are very common in individuals with PMDD and may contribute to mood symptoms, emotional regulation difficulties, and functional impairment. Psychological interventions that focus on sleep, such as sleep psychoeducation and cognitive-behavioural strategies for insomnia, are effective in other mood and anxiety disorders but have not been well studied in PMDD. This study aims to evaluate the feasibility, acceptability, and preliminary effects of a brief, sleep-focused psychoeducation workshop tailored for individuals with PMDD or severe premenstrual symptoms. Information collected in this study may help inform future research and may improve care for individuals with PMDD.",[27,51,60],"PMS","NOT_YET_RECRUITING","2026-04-21",{"date":64,"type":36},"2026-04-28",{"date":66,"type":20},"2026-06",{"date":68,"type":20},"2027-12",{"name":70,"class":43},"St. Joseph's Healthcare Hamilton",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100634330","phase-2-minimizing-delirium-with-nasal-dexmedetomidine-induced-sleep-middies-100634330","NCT07538284","MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)","Minimizing Delirium With Nasal Dexmedetomidine-Induced Sleep in Older Patients Undergoing Major Abdominal Surgery: : a Randomized, Double-blind, Placebo-controlled Trial","MIDDIES","Inclusion Criteria:\n\n* Aged 65-90 years\n* Scheduled for a major abdominal surgery with estimated surgery time ≥ 2 hours\n\nExclusion Criteria:\n\n* Blind, deafness or the inability to speak mandarin\n* Allergy to dexmedetomidine.\n* Renal and liver failure requiring dialysis or Child-Pugh score \\> 5\n* Follow-up difficulties (i.e. active substance abuse, psychotic disorder, homelessness)\n* Previous major abdominal or cardiac surgery within 1 year of surgical procedure\n* Chronic therapy with benzodiazepines and\u002For antipsychotics. Severe deficit due to structural or anoxic brain damage\n* Body weight \\\u003C 35 kg","65 Years","90 Years",{"count":82,"type":20},400,[84,85],"PHASE2","PHASE3","This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.",[88,89,27,90],"Major Abdominal Surgery","Postoperative Delirium (POD)","Intranasal Dexmedetomidine",[92,93],"dexmedetomidine","intranasal administration","2026-04-12",{"date":96,"type":36},"2026-04-20",{"date":98,"type":20},"2026-05-01",{"date":100,"type":20},"2027-06-30",{"name":102,"class":43},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":21,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100632798","sleep-optimization-to-aid-in-recovery-digital-program-100632798","NCT07518368","Sleep Optimization to Aid in Recovery Digital Program","SOARPilot","Inclusion Criteria:\n\n* 18 years or older,\n* Initiating treatment for an eating disorder (e.g., currently on a waitlist for eating disorder treatment, scheduled to start treatment, completed an intake, or started treatment within the past two weeks for an eating disorder),\n* Able to access the internet\n\nExclusion Criteria:\n\n* None",{"count":111,"type":20},154,[23],"The purpose of this pilot study is to evaluate the usability and feasibility of SOAR (Sleep Optimization to Aid Recovery), a brief and self-guided digital program designed to share evidence-based sleep hygiene information with individuals seeking treatment for an eating disorder. The SOAR program delivers well-established recommendations promoted by the National Sleep Foundation and other professional sleep health organizations. The purpose of this study is not to test a new treatment or intervention per se, but rather to examine how effectively this existing information can be delivered through a digital platform to people preparing for or engaged in eating disorder treatment. By providing these evidence-based strategies in a user-friendly and accessible format, SOAR aims to support healthy sleep habits that may enhance overall well-being and facilitate recovery.\n\nThe investigators will compare SOAR against a control condition, which would be no intervention (treatment-as-usual). Participants randomized to the control will receive access to SOAR after the follow-up period has ended, if they wish to use it.",[115,116,117,27],"Sleep Health","Binge Eating","Disordered Eating",[119,120,121,122,123,124,125],"Eating disorders","Disordered eating","Binge eating","Sleep health","Sleep disturbances","waitlist","eating disorder treatment","2026-04-06",{"date":128,"type":36},"2026-04-08",{"date":130,"type":20},"2026-05",{"date":132,"type":20},"2028-03",{"name":134,"class":43},"University of Nevada, Las Vegas",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":21,"phases":144,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":161,"leadSponsor":163,"locationsCount":44},"100574087","decentralized-clinical-trial-of-effectiveness-of-energypoints-app-in-cancer-survivors-100574087","NCT06754722","Decentralized Clinical Trial of Effectiveness of EnergyPoints App in Cancer Survivors","Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors","Inclusion Criteria:\n\n* Have cancer or have been treated for cancer;\n* at least a moderate level of fatigue (greater than 4 on a 0 to 10 Likert-type scale);\n* able to read and speak in English;\n* age 18 years or older; Android 11 or later),\n* adequate hearing, vision, and functional ability to see, hear and use the app and participate in interviews,\n* willing to wear a provided Fitbit 24\u002F7 (except when charging) throughout the study.\n\nExclusion Criteria:\n\n* recent history of easy bruising or bleeding\n* previous use of the EnergyPoints app.\n\nNote: The functional ability questions will exclude anyone who is too sick to participate due to life-limiting disease.",{"count":143,"type":20},180,[23],"The purpose of the study is to evaluate whether EnergyPoints, a mobile phone health app that guides the participant to do self-acupressure, can decrease fatigue and improve sleep. Acupressure consists of applying physical pressure with fingers or a device to small locations on the body called acupoints.\n\n* The investigators will conduct this clinical trial remotely, allowing participants to use the app wherever they are. Participation will involve using the app daily while wearing a fitness tracker (a Fitbit) on the wrist, answering questions on the app and online, as well as completing a questionnaire and participating in an online interview at the end of the study. Participants will be assigned by chance to one of two groups. In both groups, participants will have a 1 week baseline week (Week 0) to get used to the Fitbit. Participants in the Immediate Group will start the 6 week trial of EnergyPoints immediately (Week 1). Participants in the Wait-List Group will be on a wait-list for 6 weeks during which time they will wear the Fitbit and answer online questions daily and weekly. At the end of the waiting period (week 7), these participants will begin the 6 week trial of EnergyPoints.\n* The risks to participating are minimal. There is a small risk of bruising or getting sore at a point where participants apply pressure. As with any mobile app, there is the possibility that electronic information could be viewed by third parties not involved in the study. The investigators cannot promise any benefits from participating in the study. However, it is possible that using acupressure might improve fatigue or sleep. Participants may use any other approaches to improve fatigue and sleep while in the study.\n\nA pilot study will be conducted first with 8 participants and 1 week periods (1 week baseline, 1 week waitlist, and 1 week intervention followed by an End of Study Questionnaire and Exit Interview",[147,148,27,149],"Cancer-related Problem\u002FCondition","Fatigue in Cancer Survivors","Health-related Quality of Life",[151,152,153,154,155,156],"fatigue","sleep disturbances","acupressure","mobile health app","cancer survivors","cancer symptoms","2026-04-05",{"date":159,"type":36},"2026-04-07",{"date":38,"type":36},{"date":162,"type":20},"2027-12-31",{"name":164,"class":165},"5 Point App, Inc.","INDUSTRY",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":21,"phases":177,"briefSummary":178,"conditions":179,"keywords":182,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100621522","home-based-auricular-transcutaneous-vagus-nerve-stimulation-tvns-for-sleep-quality-and-psycho-academic-outcomes-in-health-sciences-students-100621522","NCT07371715","Home-Based Auricular Transcutaneous Vagus Nerve Stimulation (tVNS) for Sleep Quality and Psycho-Academic Outcomes in Health Sciences Students","Efficacy, Safety, and Feasibility of a Home-Based Auricular Transcutaneous Electrical Stimulation Intervention Using a Low-Frequency TENS-Like Device to Improve Sleep Quality and Psycho-Academic Outcomes in Health Sciences Students: A Randomized Controlled Pilot Study","NEUROSLEEP","Inclusion Criteria:\n\n* Aged 18 to 35 years.\n* Undergraduate student enrolled in a Health Sciences degree program.\n* Poor sleep quality defined as PSQI \\> 7.\n* Meets diagnostic criteria for primary insomnia according to ICSD-3.\n* Ability to understand study procedures and provide written informed consent.\n* Willing and able to self-administer the intervention at home and complete study questionnaires.\n\nExclusion Criteria:\n\n* Current severe psychiatric disorder or ongoing psychotherapy treatment.\n* Neurological disorders (e.g., epilepsy).\n* Cardiac arrhythmias or implanted cardiac devices (e.g., pacemaker).\n* Current use of medications that significantly affect sleep (e.g., hypnotics or anxiolytics), unless stable and approved by the investigator.\n* Pregnancy.\n* Ear infection, skin lesions, or dermatologic condition preventing electrode placement.\n* Hypersensitivity or intolerance to electrical stimulation.\n* Participation in another clinical trial within the last 30 days.","35 Years",{"count":176,"type":20},60,[23],"This study aims to evaluate the efficacy, safety, and feasibility of a home-based auricular transcutaneous vagus nerve stimulation (tVNS) program in Health Sciences university students with poor sleep quality. Participants will be randomly assigned (1:1) to receive either active auricular stimulation (cymba conchae\u002Ftragus) or a control stimulation applied to the earlobe. The intervention will be self-administered at home using a low-frequency TENS-like device for 60 minutes per session, 5 sessions per week for 3 weeks. Sleep quality will be primarily assessed using the Pittsburgh Sleep Quality Index (PSQI) before and after the intervention. Secondary outcomes include insomnia severity, daytime sleepiness, perceived stress, anxiety, quality of life, and psycho-academic outcomes.",[27,180,181],"Insomnia","Stress",[183,184,185,186],"Transcutaneous Vagus Nerve Stimulation","sleep quality","Auricular Stimulation","university students","2026-01-23",{"date":189,"type":36},"2026-01-28",{"date":191,"type":20},"2026-03-01",{"date":193,"type":20},"2026-06-01",{"name":195,"class":43},"University of Malaga",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":53,"minAge":202,"maxAge":79,"enrollmentInfo":203,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":214,"locationsCount":44},"100610185","the-effect-of-non-invasive-stellate-ganglion-disrupting-on-sleep-disturbances-on-postmenopausal-female-100610185","NCT07224295","The Effect of Non Invasive Stellate Ganglion Disrupting on Sleep Disturbances on Postmenopausal Female","Inclusion Criteria:\n\n1. postmenopausal women who are firstly have sleep disturbances.\n2. Their ages will range from 50- 65 years old.\n3. All patients will be medically stable when attending the study.\n4. BMI≥30.\n\nExclusion Criteria:\n\n\\-\n\nWomen will be excluded from study if:\n\n1. Women with Impaired consciousness.\n2. Inability to communicate with the paramedic because of insufficient language skills.\n3. receiving any medication for sleep disturbances.\n4. Patients who already have sleep disturbances due to another pathological reason or taking any medications which directly affect sleep.\n5. Patients with psychological diseases.\n6. Women who have any cancer diseases.\n7. Diabetic and patient with cardiovascular disease.","50 Years",{"count":204,"type":20},32,[23],"The goal of this clinical trial is to asses the effect of non invasive stellate ganglion disrupting on sleep distyrbances on postmenopausal female .\n\nThe primary hypothesis:\n\nThere is no effect of noninvasive stellate ganglion disrupting on sleep disturbance parameters of postmenopausal women.\n\nThere is no effect of noninvasive stellate ganglion disrupting on quality of female's life\n\nNon invasive stellate ganglion disrupting with physical modality TENS will be applied on participants of study group. The participants will be screened for estradiol level and assed for the quality of sleep by specialized questionnaire.",[27],"2025-11-22",{"date":210,"type":36},"2025-11-25",{"date":212,"type":20},"2025-12-01",{"date":191,"type":20},{"name":215,"class":43},"Kafrelsheikh University",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":224,"sex":16,"minAge":17,"maxAge":174,"enrollmentInfo":225,"targetDuration":4,"studyType":21,"phases":227,"briefSummary":228,"conditions":229,"keywords":236,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":258,"locationsCount":44},"100610994","resistance-exercise-and-sleep-quality-by-chronotype-100610994","NCT07234812","Resistance Exercise and Sleep Quality by Chronotype","The Effects of Tailored Resistance Exercise on Sleep Quality in Relation to Chronotype","TRE-SLEEP","Inclusion Criteria:\n\n* Age between 18 and 35 years\n* Generally healthy, with mild to moderate sleep disturbance as categorized by the Pittsburgh Sleep Quality Index (PSQI)\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²\n* No physical or organic limitations or diseases that would prevent participation in physical activity\n* Non-smoker and non-alcoholic\n* Caffeine consumption ≤ 2 cups per day (including coffee and energy drinks)\n* Have not participated in more than 60 minutes\u002Fweek of usual moderate-to-vigorous physical activity in the past 6 months, categorized as \"moderate\" on the International Physical Activity Questionnaire-Short Form (IPAQ-SF)\n* No clinically diagnosed sleep apnea or other medical\u002Fpsychiatric disorders responsible for sleep complaints\n* Regular sleep schedule (no night shifts or transmeridian travel) in the 30 days prior to study enrollment\n* Able to speak and write English\n\nExclusion Criteria:\n\n* Current use of medications or psychotherapeutic drugs for insomnia or other psychiatric disorders\n* Use of melatonin or other sleep aids in the past month\n* Currently performing any aerobic or mind-body exercise classes (e.g., yoga, Pilates)\n* Habitual daytime napping\n* History of epilepsy or other convulsive disorders\n* Pregnant individuals\n* Habitual or recent use (within the past 30 days) of illegal drugs, psychotropic drugs, hypnotics, stimulants, or analgesics",true,{"count":226,"type":20},64,[23],"This study examines whether doing moderate resistance exercises in the morning can improve sleep quality and well-being in young adults. Participants with different daily activity patterns (morning or evening types) will take part in an 8-week online exercise program. The study will compare how exercise affects sleep, mood, and daily rhythm across these groups.",[230,231,27,232,233,234,235],"Physical Therapy","Resistance Exercise","Sleep Quality","Chronotype","Circadian Rhythm","Health Behavior \u002F Well-Being",[237,238,233,239,240,241,242,243,244,230,245,246,247,248,249,250,251],"sleep disturbance","Sleep quality","Morningness-eveningness","Circadian rhythm","Resistance exercise","Home-based exercise","Sleep and exercise","Physical activity and sleep","Exercise","Telerehabilitation","Munich Chronotype Questionnaire (MCTQ)","Pittsburgh Sleep Quality Index (PSQI)","Mood (BRUMS, DASS-21)","Randomized controlled trial","Physical therapy and rehabilitation","2025-11-18",{"date":254,"type":36},"2025-11-20",{"date":256,"type":20},"2025-12",{"date":130,"type":20},{"name":259,"class":43},"Medipol University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":268,"phases":4,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":4},"100608201","sleep-disturbances-and-their-association-with-serum-magnesium-level-in-patients-with-major-depressive-disorder-100608201","NCT07198477","Sleep Disturbances and Their Association With Serum Magnesium Level in Patients With Major Depressive Disorder","Inclusion Criteria:\n\n* Confirmed diagnosis of major depressive disorder\n\nage 18 years and older\n\nAbility to complete questionnaires (BDI-II and PSQI; validated Arabic versions)\n\nWilling to participate and provide informed consent\n\nExclusion Criteria:\n\n* hronic renal failure or metabolic disorders affecting magnesium balance\n\nCurrent use of medications known to significantly interfere with serum magnesium (e.g., long-term diuretics, proton pump inhibitors) unless stable and documented\n\nPresence of other comorbid psychiatric disorders\n\nCognitive impairment or language difficulties preventing questionnaire completion",{"count":267,"type":20},90,"OBSERVATIONAL","This cross-sectional study investigates the relationship between serum magnesium levels and the presence of sleep disturbances among patients with major depressive disorder (MDD).",[271,27],"Depressive Disorder",[152],"2025-09-29",{"date":275,"type":36},"2025-09-30",{"date":277,"type":20},"2026-08-30",{"date":279,"type":20},"2027-12-30",{"name":281,"class":43},"Assiut University",{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":224,"sex":16,"minAge":289,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":21,"phases":293,"briefSummary":294,"conditions":295,"keywords":299,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":4},"100606664","sleep-hygiene-plus-physiotherapy-for-sleep-and-disability-in-chronic-neck-pain-100606664","NCT07178496","Sleep Hygiene Plus Physiotherapy for Sleep and Disability in Chronic Neck Pain","Effect of Integrating Sleep Hygiene Techniques With Physiotherapy Exercise in Improving Sleep Quality and Disability in Patients With Chronic Neck Pain","Inclusion Criteria\n\nParticipants will be eligible for the study if they meet the following conditions:\n\n1. Adults aged 20-55 years.\n2. Clinical diagnosis of chronic neck pain, defined as symptoms persisting for more than 3 months.\n3. Poor sleep quality, indicated by a Pittsburgh Sleep Quality Index (PSQI) score \\>5.\n4. Willingness to participate and comply with both the physiotherapy and sleep hygiene intervention program.\n5. Ability to provide informed consent.\n\nExclusion Criteria\n\nParticipants will be excluded if any of the following conditions are present:\n\n1. History of cervical spine trauma, surgery, or fracture within the past 6 months.\n2. Severe depression or anxiety, defined by scores above the severe threshold on the Hospital Anxiety and Depression Scale (HADS).\n3. Neurological disorders affecting neck function (e.g., cervical radiculopathy, myelopathy).\n4. Other musculoskeletal disorders causing significant neck or shoulder pain.\n5. Sleep disorders unrelated to neck pain (e.g., obstructive sleep apnea, restless legs syndrome, narcolepsy), whether diagnosed or suspected.\n6. Ongoing pharmacological treatments that may significantly affect sleep (e.g., sedatives, hypnotics), unless the patient has been on a stable dose for \\>3 months.\n\n6 Uncontrolled systemic illnesses such as diabetes, cardiovascular disease, or cancer.\n\n7 Pregnancy.\n\n8 Participation in any recent physiotherapy program targeting neck pain within the last 3 months.","25 Years","55 Years",{"count":292,"type":20},120,[23],"This study investigates the effectiveness of a combined intervention that integrates sleep hygiene education with physiotherapy exercises in patients suffering from chronic neck pain. Chronic neck pain is often associated with both musculoskeletal dysfunction and secondary sleep disturbances, which in turn may exacerbate pain perception, fatigue, and disability. Traditional physiotherapy exercise programs focus primarily on improving cervical mobility, muscle strength, and postural control, but they do not typically address sleep-related problems that can hinder recovery.\n\nThe intervention in this study consists of two main components:\n\nPhysiotherapy Exercise Program - A structured regimen targeting cervical spine mobility, deep cervical flexor strengthening, scapular stabilization, and postural correction. These exercises aim to reduce pain, restore function, and improve overall physical performance.\n\nSleep Hygiene Education - A structured educational module covering principles of healthy sleep habits, including maintaining consistent sleep-wake schedules, creating an optimal sleep environment, limiting stimulants before bedtime, and adopting relaxation strategies to promote better sleep initiation and maintenance.\n\nBy combining these approaches, the intervention addresses not only the physical impairments associated with chronic neck pain but also the psychosocial and behavioral factors contributing to poor sleep quality.\n\nOutcome Measures:\n\nPrimary Outcomes: Sleep quality, assessed using validated tools such as the Pittsburgh Sleep Quality Index (PSQI).\n\nSecondary Outcomes: Disability and functional limitations, measured by the Neck Disability Index (NDI), along with pain intensity assessed using a Visual Analog Scale (VAS).\n\nFatigue will be assessed by fatigue inventory index\n\nStudy Hypothesis: The combined intervention of sleep hygiene education and physiotherapy exercise will lead to greater improvements in sleep quality and reductions in disability and fatigue compared to physiotherapy exercise alone.\n\nClinical Significance: If effective, this integrative approach may provide a cost-effective, non-pharmacological management strategy for patients with chronic neck pain, targeting both physical and behavioral contributors to their condition.",[296,297,27,298],"Neck Pain","Neck Pain Musculoskeletal","Fatigue, Mental",[300,301,302],"sleep quaity","sleep hygiene","neck pain","2025-09-16",{"date":305,"type":36},"2025-09-17",{"date":307,"type":20},"2025-10-15",{"date":309,"type":20},"2026-05-02",{"name":311,"class":43},"Al-Azhar University",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":224,"sex":16,"minAge":319,"maxAge":80,"enrollmentInfo":320,"targetDuration":4,"studyType":21,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":44},"100606716","neurobiological-investigations-of-mindfulness-depression-and-sleep-disturbances-in-medical-staffs-and-community-elders-100606716","NCT07179172","Neurobiological Investigations of Mindfulness, Depression and Sleep Disturbances in Medical Staffs and Community Elders","NIMDS","Inclusion Criteria:\n\n1. Hospital staff aged 20-65 years, or elderly individuals aged 55-90 years.\n2. Individuals willing to participate in the entire mindfulness course and comply with study enrollment procedures.-\n\nExclusion Criteria:\n\n1. History of major neurological disorders (e.g., epilepsy, Parkinson's disease, stroke).\n2. History of major psychiatric disorders (e.g., schizophrenia, bipolar disorder).\n3. Use of medications that may affect sleep, other than illegal substances or sleeping pills.\n4. Individuals with metal implants.\n5. Individuals with claustrophobia.\n6. Pregnant women.\n7. History of alcohol or substance addiction.","20 Years",{"count":19,"type":20},[23],"The research team proposes a multi-year study with the first year focusing on the developmental phase. In this initial phase, we aim to recruit 40 participants (including healthcare staff and older adults) from Shuang-Ho Hospital and the surrounding community to undergo two mindfulness intervention sessions, each lasting four months. We anticipate that these interventions will prevent and alleviate stress and depressive symptoms while enhancing self-awareness and psychological health.",[27,324],"Depression",[326,327,328,329,330,331,332,333,334],"Medical personnel","sleep","depression","mental health","preventive medicine","mindfulness","aging","functional magnetic resonance imaging (fMRI)","wearable device","2025-09-10",{"date":305,"type":36},{"date":338,"type":36},"2025-06-14",{"date":340,"type":20},"2025-11-08",{"name":342,"class":43},"Taipei Medical University Shuang Ho Hospital",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":224,"sex":16,"minAge":350,"maxAge":17,"enrollmentInfo":351,"targetDuration":353,"studyType":268,"phases":4,"briefSummary":354,"conditions":355,"keywords":358,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":44},"100602393","cross-sectional-study-of-sleep-disturbance-in-hong-kong-children-with-cancer-comparing-with-healthy-counterparts-and-children-with-other-chronic-diseases-100602393","NCT07122921","Cross-sectional Study of Sleep Disturbance in Hong Kong Children With Cancer Comparing With Healthy Counterparts and Children With Other Chronic Diseases","Sleep Disturbance in Hong Kong Children With Cancer: A Cross-Sectional Study Comparing Healthy Counterparts and Children With Other Chronic Diseases","Inclusion Criteria:\n\n1. Children with Cancer (n=50) Participants in this group will be children with a confirmed cancer diagnosis, such as leukemia, lymphoma, or solid tumors, who are currently hospitalized for treatment at the inpatient oncology wards of Hong Kong Children's Hospital. Eligible participants must be actively receiving cancer-directed therapy (e.g., chemotherapy, radiation) during their hospital stay. Inclusion criteria require that participants, or their parents or legal guardians as proxies, can provide accurate reports about sleep patterns, either through self-assessment or observation, ensuring reliable data collection. This group will capture the acute impact of cancer treatment and hospitalization on sleep, a critical focus of the study.\n2. Children with Other Chronic Illnesses (n=50) This group will comprise children diagnosed with chronic conditions other than cancer, such as asthma, type 1 diabetes, or chronic kidney disease, recruited from the cardiac, nephrology, and mixed wards of Hong Kong Children's Hospital. These illnesses are selected for their known potential to disrupt sleep-e.g., nocturnal asthma symptoms or glucose instability-while differing in pathophysiology from cancer. Participants must be under active management for their condition and currently hospitalized, but must not have a history of primary sleep disorders (e.g., narcolepsy, obstructive sleep apnea) unrelated to their chronic illness. This criterion ensures that observed sleep disturbances are attributable to the chronic condition rather than pre-existing sleep pathology.\n3. Healthy Children (n=50) The healthy control group will be of adequate sample size. These include siblings of pediatric patients (both oncology and non-oncology wards), and children of hospital staff (e.g., nurses, administrative personnel). Inclusion criteria require no history of chronic illness, psychiatric disorders, or known sleep conditions. Parental consent and child assent will be obtained for all participants.\n\nExclusion Criteria:\n\nAcross all three groups, children will be excluded if they are not Chinese and are in intensive care units. Children who exhibit severe cognitive impairments that preclude accurate reporting of sleep experiences, either by themselves or their parents or legal guardians, will be excluded. Additionally, participants with neurological conditions known to independently affect sleep, such as epilepsy or cerebral palsy, will be excluded to avoid confounding the primary relationship between chronic illness and sleep disturbances. The use of sedative medications unrelated to the participant's primary condition (e.g., for behavioral management rather than cancer treatment) will also disqualify participants, as these could artificially alter sleep patterns and obscure study outcomes. These exclusion criteria ensure that sleep disturbances observed are primarily linked to the participants' health status rather than extraneous factors.","6 Years",{"count":352,"type":20},150,"1 Week","Sleep disturbances are prevalent among children with chronic illnesses, yet the specific impact of cancer on sleep remains underexplored. This prospective and cross-sectional study aims to evaluate the prevalence, severity, and characteristics of sleep disturbances in Chinese children with cancer compared to healthy peers and children with other chronic diseases. By leveraging validated sleep assessment tools and parental reports, the goal is to identify unique challenges faced by children with cancer. Results might influence the design of personalized interventions aimed at enhancing the overall well-being of children with cancer.\n\nThis study will enroll Chinese children aged 6 to 18 years, divided into three distinct groups based on their health status: children with cancer, children with other chronic illnesses, and healthy children. A total sample size of 150 participants (50 per group) will be targeted to ensure adequate statistical power for comparative analyses. Recruitment will occur at Hong Kong Children's Hospital or the cancer and chronic illness groups, and healthy children will be recruited from healthy siblings of participants or the healthy children of hospital staff with specific inclusion and exclusion criteria applied to each group to maintain homogeneity and minimize confounding variables.",[356,357,27],"Sleep","Sleep Disturbances in Children",[327,237,359,360],"children","paediatrics","2025-08-13",{"date":363,"type":36},"2025-08-17",{"date":365,"type":36},"2025-07-02",{"date":367,"type":20},"2026-06-30",{"name":369,"class":43},"Chinese University of Hong Kong",{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":11,"sex":16,"minAge":377,"maxAge":378,"enrollmentInfo":379,"targetDuration":4,"studyType":21,"phases":381,"briefSummary":382,"conditions":383,"keywords":386,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":400,"locationsCount":401},"100575778","low-intensity-tus-for-sleep-disturbances-in-patients-with-chronic-tinnitus-100575778","NCT06776705","Low-intensity TUS for Sleep Disturbances in Patients With Chronic Tinnitus","A Pilot Randomized Controlled Trial of MRI-guided Focused Low-intensity Transcranial Ultrasound Stimulation (TUS) for Sleep Disturbances in Patients With Chronic Tinnitus","Inclusion Criteria:\n\n* Chinese, right-handed, aged from 60 to 80 years.\n* Chronic tinnitus is defined as tinnitus with a duration of at least 3 months. Depending on the justification, different time course definitions of chronic tinnitus are possible.\n* Sleep disturbances are defined as a Pittsburgh Sleep Quality Index (PSQI) total score above 5.\n* No interference with independence in everyday activities.\n\nExclusion Criteria:\n\n* Diseases of ear canal and tympanic membrane checked by otoscopic examination.\n* Previous diagnosis of Meniere's disease and acoustic neuromas.\n* Past history of neurological or mental disorders.\n* Physically frail affecting attendance to treatment sessions.\n* Already attending regular treatments, such as cognitive behavioral therapy or music therapy.\n* Taking a psychotropic or other medication known to affect hearing functions.\n* Significant communicative impairments.","60 Years","85 Years",{"count":380,"type":20},14,[23],"Background: Tinnitus, as a common symptom, can jeopardize the sleep quality and brain function and even lead to hearing loss and cognitive decline in elderly patients. The co-occurring tinnitus and sleep disturbances can significantly affect the cognitive functions and quality of life, and even be implicated as a key contributing factor in the development of prodromal dementia. At present, very few non-pharmacological therapies are developed for managing these comorbidities in elderly patients. Focused low-intensity transcranial ultrasound stimulation (TUS) enables to stimulation the deep brain structures, such as hippocampus, with optimized focality and specific frequency.\n\nObjectives: We aim to 1) investigate the safety, feasibility and efficacy of a 2-week focused low-intensity TUS on the severity of tinnitus and sleep disturbances in elderly patients; 2) determine the sample size of a full-scale randomized clinical trial of low-intensity TUS in patients with tinnitus; 3) evaluate the effects of low-intensity TUS on the severity of tinnitus, sleep quality and cognitive functions at 2, 4 and 6 weeks after the treatments.\n\nDesign: A 2-week randomized, double-blind, controlled clinical trial. Methods: Chinese right-handed tinnitus patients with sleep disturbances (aged from 60 to 90 years) will be randomly assigned to a 2-week intervention of either low intensity TUS or sham TUS, with 7 participants per arm. Before intervention, T1-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) data is used to construct individual realistic head model. Comprehensive assessments, including sleep quality, cognitive performance and quality of life will be conducted at baseline, 2nd week, 4th week and 6th week. Program adherence and adverse effects will be monitored throughout intervention.",[384,27,385],"Tinnitus","Cognition",[384,387,388,389,390,391,392,393],"Cognitive Dysfunction","Sleep distubances","Transcranial ultrasound stimulation","Hippocampus","Complex attention","Simulation","Central Nervous System Diseases","2025-07-17",{"date":396,"type":36},"2025-07-18",{"date":398,"type":36},"2025-01-15",{"date":367,"type":20},{"name":369,"class":43},2,{"id":403,"slug":404,"hasResults":11,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":409,"targetDuration":4,"studyType":21,"phases":410,"briefSummary":411,"conditions":412,"keywords":414,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":4},"100595122","exploring-substance-use-sleep-disturbances-and-reward-sensitivity-100595122","NCT07028346","Exploring Substance Use, Sleep Disturbances and Reward Sensitivity","An Exploratory Study of the Relationship Between Substance Use, Sleep Disturbances and Reward Sensitivity - A Randomized Control Trial of Cognitive Behavioral Therapy for Insomnia","Inclusion Criteria:\n\n1. Individuals who receive treatment services at Substance Abuse Assessment Clinic and other psychiatric out-patient clinics of Kwai Chung Hospital;\n2. Individuals who have problematic substance or alcohol use in the past 3 months, confirmed by scores higher than or equal to 1 in both part 1 and part 2 of Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS);\n3. Individuals who have sleep disturbances, confirmed by a score higher than or equal to 8 on the Insomnia Severity Index (ISI).\n\nExclusion Criteria:\n\n1. Individuals who cannot understand Cantonese, or cannot read Traditional Chinese\n2. Individuals who cannot provide informed consent due to, for example, intoxication or abnormal mental state\n3. Individuals who report abnormal or unstable mental states, such as active psychotic symptoms or acute intoxication, at any point of the study\n4. Individuals who work overnight or have rotating shifts\n5. Individuals who report pregnancy or medical conditions (including sleep apnea) that may have a severe impact on sleep\n6. Individuals who use hypnotics regularly",{"count":111,"type":20},[23],"According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve medical treatment and overall care for substance misuse in the future. Participants will be randomized into CBTi and sleep education groups, and their substance\u002F alcohol use, sleep parameters and reward sensitivity will be measured at multiple time points.",[413,27],"Substance Abuse",[415,416,152,417],"Substance abuse","substance misuse","sleep problem","2025-06-18",{"date":420,"type":36},"2025-06-24",{"date":422,"type":20},"2025-06-16",{"date":424,"type":20},"2026-08-31",{"name":426,"class":43},"Kwai Chung Hospital",{"id":428,"slug":429,"hasResults":11,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":433,"eligibilityCriteria":434,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":435,"enrollmentInfo":436,"targetDuration":4,"studyType":21,"phases":437,"briefSummary":438,"conditions":439,"keywords":450,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":401},"100457248","better-lifestyle-counseling-for-african-american-women-during-pregnancy-100457248","NCT05234125","Better Lifestyle Counseling for African American Women During Pregnancy","A Randomized Control Trial to Improve Metabolic Outcomes in African American Pregnant Women","BETTER","Inclusion Criteria:\n\n* African American pregnant woman.\n* Women between 16 and 22 GWs.\n* Overweight or obese - pregravid Body Mass Index \\>25.0 kg\u002Fm2.\n* Singleton gestation.\n* Established prenatal care at The University of Illinois Hospital \\& Health Sciences.\n* System Obstetric (UIHHSS' OB) clinics. Able to understand, speak and write in English.\n\nExclusion Criteria:\n\n* Multiple gestations.\n* Night-shift work.\n* Diagnosed sleep disorders.\n* Known fetal chromosomal or anatomical abnormalities.\n* Diagnosed mood disorders.\n* Gestational diabetes in early pregnancy.\n* Glycated Hemoglobin (HbA1c) ≥ 6.5%.\n* Hypoglycemic medications.\n* Stimulant medication or taking a sleeping aid.\n* Active drug abuse\u002Fexcessive alcohol intake.","40 Years",{"count":352,"type":20},[23],"The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.",[440,441,27,442,443,444,445,446,245,447,448,449],"Overweight or Obesity","Pregnancy Related","Sleep Hygiene","Pregnancy Complications","Diversity","Stress, Psychological","Fitness Trackers","African Americans","Disparities in Pregnancy Complications","Sleep Disparities",[451],"Sleep, Pregnancy, Intervention, glucose metabolism,","2025-04-01",{"date":454,"type":36},"2025-04-04",{"date":456,"type":36},"2022-08-16",{"date":458,"type":20},"2027-04-30",{"name":460,"class":43},"University of Illinois at Chicago",{"id":462,"slug":463,"hasResults":11,"nctId":464,"briefTitle":465,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":11,"sex":16,"minAge":350,"maxAge":467,"enrollmentInfo":468,"targetDuration":4,"studyType":21,"phases":470,"briefSummary":471,"conditions":472,"keywords":475,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":488,"locationsCount":44},"100578217","intervention-with-weighted-blankets-for-children-with-adhd-and-sleep-problems-implementation-and-effectiveness-100578217","NCT06808425","Intervention With Weighted Blankets for Children With ADHD and Sleep Problems: Implementation and Effectiveness","Inclusion Criteria:\n\n* Children diagnosed with ADHD (DSM-5) and sleep problems (defined by screening instrument).\n* Being a patient at child and adolescent mental health service (CAMHS) in Region Halland, Sweden.","14 Years",{"count":469,"type":20},200,[23],"The aim is to study a sleep intervention with weighted blankets in children with ADHD and sleep problems regarding 1) short- and long-term effects on sleep and health-related outcomes in comparison with standard treatment (melatonin), 2) barriers and facilitators to implementation in routine clinical practice, and 3) health-economic outcomes.",[473,27,356,474],"ADHD","Sleep Problems",[476,477,478,479,480],"implementation","sleep intervention","weighted blankets","children with ADHD","sleep problems","2025-03-12",{"date":483,"type":36},"2025-03-14",{"date":485,"type":36},"2025-02-03",{"date":487,"type":20},"2034-02",{"name":489,"class":43},"Halmstad University"]