[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sleepiness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sleepiness":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,59,85,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":34,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100376320","impact-of-positive-airway-pressure-therapy-on-clinical-outcomes-in-older-veterans-with-chronic-obstructive-pulmonary-disease-and-comorbid-obstructive-sleep-apnea-overlap-syndrome-100376320",false,"NCT04179981","Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)","Inclusion Criteria:\n\n* OSA with moderate-to-severe disease, AHI 20 per hour by in-lab polysomnography with concomitant moderate-severe COPD based on pulmonary function tests (PFTS) and with past significant history (\\>10 pack-years) of smoking\n* Male or female gender\n* Age greater than or equal to 60 years\n* Stable treatment regimen for COPD\n\nExclusion Criteria:\n\n* Current or prior treatment with PAP or oral appliance\n* Central sleep apnea defined as central apnea index \\>5 per hour and comprising 50% of AHI\n* Known primary neuromuscular diseases\n* Disorders that may impact cognitive function including:\n\n  * neurodegenerative disorders\n  * traumatic brain injury\n* untreated PTSD and\u002For history of learning disability\n* Medicines that may cause or alter sleepiness: sedative hypnotics, or stimulants as these may alter the results\n* Patient is actively suicidal due to depression, unstable mental health condition\n* Epworth sleepiness score \\>16 (severe sleepiness) or a near-miss or prior automobile accident due to sleepiness within the past 12 months\n* Narcolepsy is the primary sleep disorder, with requirement of stimulant medications\n* Employed as a commercial driver or operating heavy machinery\n* On long-term oxygen therapy prior to start of study, more than 12 hr\u002Fday\n* Patients is unable to use either a nasal or face mask (e.g., facial trauma, claustrophobia)\n* Consumption of \\>3 alcoholic beverages per day or current use of some illicit drugs, as these may contribute to cognitive deficits\n* Patients who cannot give informed consent\n* Patients receiving hospice care\n* Pregnant women due to unknown risks","ALL","60 Years",{"count":18,"type":19},668,"ESTIMATED","INTERVENTIONAL",[22],"NA","Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is highly prevalent in Veterans. Veterans with OVS may be at increased risk for cognitive deficits, poor sleep quality as well as a reduced quality of life (QoL). The overall objective is to study the effects of positive airway pressure therapy on clinical outcomes in patients with OVS.",[25,26,27,28,29,30,31,32,33],"Sleep Apnea Syndrome","Obstructive Sleep Apnea","COPD","Overlap Syndrome","Quality of Life","Neurocognitive Function","Sleepiness","Elderly","Positive Airway Pressure",[35,36,37,38,39,40,41,42,43,44,45],"Apnea","Sleep Apnea Syndromes","Sleep Apnea, Obstructive","Nervous System Diseases","Respiration Disorders","Respiratory Tract Diseases","Signs and Symptoms, Respiratory","positive airway pressure","cognitive function","quality of life","sleepiness","RECRUITING","2026-06-03",{"date":49,"type":50},"2026-06-05","ACTUAL",{"date":52,"type":50},"2020-12-01",{"date":54,"type":19},"2027-12-31",{"name":56,"class":57},"VA Office of Research and Development","FED",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":15,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":20,"phases":71,"briefSummary":72,"conditions":73,"keywords":74,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":80,"leadSponsor":82,"locationsCount":58},"100569789","obstructive-sleep-apnea-therapeutic-intervention-for-residual-sleepiness-100569789","NCT06698809","Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness","Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness (STILL TIRED)","STIL TIRED","Inclusion Criteria:\n\n* Cognitively normal (Telephone Interview for Cognitive Status (TiCS) ≥29))\n* Moderate - severe OSA\n* Currently on therapy for OSA and has received treatment for OSA for at least 3 months.\n* Sustained compliance with continuous positive airway pressure (CPAP), which means using the machine at least 4 hours per night for five nights a week.\n* Epworth Sleepiness Score (ESS) greater than or equal to 8 or excess daytime sleepiness as defined by the Functional Outcome Sleep Questionnaire or clinical complaint.\n\nExclusion Criteria:\n\n* Documented diagnosis of chronic insomnia, or sleep onset insomnia based on Insomnia Severity Index (ISI)\n* Documented diagnosis of circadian rhythm disorder\n* Any current use of supplemental oxygen\n* Other sleep-related breathing disorders (central sleep apnea, etc.) based on American Academy of Sleep Medicine (AASM) criteria\n* Current shift work involving night shift (regular work between 12am and 6am or night shift) within the past 6 months\n* Anticipated scheduled bariatric surgery within the next 3 months\n* Chronic regular (\\> 2 nights per week) use of any sedative, stimulant, neuroleptic drugs, or other medications limiting validity of cognitive tests. This includes regular use of alcohol or marijuana for sleep. Melatonin is ok.\n* Diagnosis of uncontrolled psychiatric disease in the last six months, and\u002For history of schizophrenia or bipolar disorder. Controlled conditions will include major depressive disorder, panic disorder, schizoaffective disorder, generalized anxiety disorder, Obsessive-compulsive disorder (OCD), substance use disorders, and alcohol abuse\u002Fdependence. Personality disorders and neurodevelopmental disorders (e.g. autism, ADHD) are allowed if cognition is within normal limits.\n* Taking methylphenidate for ADHD.\n* Presence of other critical comorbid conditions that would lead to inability to complete the study protocol (including follow-up for 2 years), or that would affect cognition (e.g. clinically relevant endocrine or hematological conditions).\n* Chronic regular (\\> 2 nights per week) use of stimulant if unable to complete a washout prior to MRI.\n* Does not have a regular sleeping environment (i.e., sleeps in a different setting \\> 2 nights per week).\n* Currently pregnant or planning to become pregnant.\n* Prior diagnosis of a Central nervous system (CNS) disease, such as multiple sclerosis, stroke, Parkinson's disease, Alzheimer's disease, epilepsy, a loss of consciousness \\> 24 hours, or traumatic brain injury as identified by the Cumulative Illness Rating Scale for Geriatrics (CIRS). Participants who are diagnosed with Mild cognitive impairment (MCI) or Alzheimer's disease based on neuropsychological testing will be excluded. Delirium in the last 12 months.\n* Near-miss or prior automobile accident \"due to sleepiness\" within the past 12 months.\n* Employed as a commercial driver during the study (for example, bus drivers, train engineers, airplane pilots) or construction worker.\n* Past intolerance or hypersensitivity to tPBM.\n* Significant skin conditions (i.e., hemangioma, scleroderma, psoriasis, rash, open wound or tattoo) on the subject's scalp that are found in the area of the procedure sites.\n* Any use of light-activated drugs (photodynamic therapy) within 14 days prior to study enrollment.\n* Any type of implants in the head, whose functioning might be affected by tPBM (e.g., stent, clipped aneurysm, embolized arteriovenous malformation (AVM), implantable shunt - Hakim valve).\n* Failure to meet standard MRI safety requirements (e.g., claustrophobia, non-removable piercings, implanted medical devices, other non-removable metals) as determined by the MRI Safety Checklist.","18 Years","75 Years",{"count":70,"type":19},22,[22],"Obstructive sleep apnea (OSA) is a sleep disorder that is commonly treated using positive airway pressure, yet 50% of patients still experience residual sleepiness after successful therapy. A potential neuromodulation strategy that can decrease residual sleepiness is transcranial photobiomodulation (tPBM). tPBM is a neuromodulatory treatment that uses red and\u002For near infrared light to penetrate the cortex and can alter both cerebral metabolism and blood flow. However, this potential has never been explored before directly in sleep disordered individuals. This project aims to explore the effect of tPBM on sleepiness and understand the potential neural mechanism of tPBM in OSA. The short-term goal of this project is to collect pilot data, which is the first of its kind, and suggest tPBM as a potential modulator of sleepiness in OSA.",[26,31],[75],"Transcranial Photobiomodulation","2026-01-12",{"date":78,"type":50},"2026-01-14",{"date":76,"type":50},{"date":81,"type":19},"2026-10-03",{"name":83,"class":84},"NYU Langone Health","OTHER",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":15,"minAge":67,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":20,"phases":95,"briefSummary":96,"conditions":97,"keywords":103,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":58},"100607732","shift-hours-impact-on-fatigue-and-tracking-of-eye-dynamics-100607732","NCT07192380","Shift Hours' Impact on Fatigue and Tracking of Eye Dynamics","SHIFTED","Inclusion Criteria:\n\nAssociate radiologists at IMADIS Group\n\n* In their current position for at least one year\n* Working at one of the IMADIS Group on-call centers\n* Performing night shifts during the study period\n* Able to wear an actimeter watch during the study period (it may be removed during certain procedures, but must be put back on afterwards)\n* Having given their free and informed consent to participate in the study\n\nNon- inclusion criteria:\n\n* Leave during the study period\n* Pregnant women, women in labor, or breastfeeding women\n* Subjects wearing glasses or contact lenses\n\nExclusion Criteria:\n\n\\- Having slept more than 6 hours during the night shift",true,{"count":94,"type":19},40,[22],"The goal of this clinical trial is to learn how night shift-induced sleep debt affects oculomotor patterns, attentional state, and diagnostic performance in emergency radiologists.\n\nThe main questions it aims to answer are:\n\n* Does sleep debt from a night shift alter oculomotor parameters, as eyes movements (speed and amplitude), fixation duration, pupil size?\n* Does a night shift impact radiologists' diagnostic accuracy, attentional state, and perceived fatigue? Researchers will compare radiologists after a night shift (sleep-deprived) with the same radiologists after a night of rest (control) to see if fatigue-related changes affect both visual exploration strategies and diagnostic performance.\n\nParticipants will:\n\n* Perform a guided saccade task assessed by eye tracking (primary endpoint),\n* Read thoracic CT scans (with and without pulmonary embolism cases) to assess diagnostic performance and visual exploration patterns,\n* Undergo EEG recording to measure attentional state,\n* Complete self-report questionnaires on sleepiness and fatigue.",[98,31,99,100,101,102],"Sleep Deprivation","Eye-Tracking Technology","Radiologists","Tomography","Electroencephalography",[104,105,106,107,108,109],"Night-Shift","Radiology","performance","Eye-tracking","Fatigue","Eye strain","NOT_YET_RECRUITING","2025-09-17",{"date":113,"type":50},"2025-09-25",{"date":115,"type":19},"2025-09-15",{"date":117,"type":19},"2026-05-15",{"name":119,"class":120},"IMADIS Technologies et Services","INDUSTRY",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":92,"sex":15,"minAge":16,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":20,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100597891","vr-based-multi-dimensional-intervention-on-cognitive-function-with-ai-agents-100597891","NCT07064382","VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agents","VR-based Multi-dimensional Intervention on Cognitive Function and Well-beings","Inclusion Criteria:\n\n* older adults\n\nExclusion Criteria:\n\n* cannot attend physical activity like pedalling rehabilitation bike\n* other health issues (assessed by health professionals)","120 Years",{"count":130,"type":19},60,[22],"Virtual Reality-based multi-dimensional intervention for cognition and well-being will be provided to older adults, with AI-agents. The digital health intervention include physical activity, gamification, cognitive trainings. Cognition, like memory, spatial function, sleepiness and mental health will be studied as outcomes.",[134,31,135,136],"Dementia","Mental Health","Alzheimer Disease","2025-07-03",{"date":139,"type":50},"2025-07-14",{"date":141,"type":19},"2025-07-15",{"date":143,"type":19},"2028-06-15",{"name":145,"class":84},"Hong Kong University of Science and Technology"]