[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"small-bowel-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:small-bowel-disease":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100635718","histomolecular-profiling-in-small-bowel-diseases-100635718",false,"NCT07556328","Histomolecular Profiling in Small-Bowel Diseases","Histological and Molecular Profiling in the Diagnostics and Treatment of Small-Bowel Diseases - A Prospective Cohort Study (The DeepBowel Study)","Deep Bowel","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinically indicated upper gastrointestinal endoscopy (gastroscopy)\n* Written informed consent obtained prior to procedure\n* For Group 1 (Healthy Controls): Negative celiac disease antibodies (anti-transglutaminase and\u002For anti-endomysium); no suspected celiac\n* For Group 2 (Celiac Diagnostics): Referred for primary celiac disease diagnostics requiring duodenal biopsy\n* For Group 3 (Refractory Injury): Confirmed small-bowel mucosal injury not responsive to a gluten-free diet\n\nExclusion Criteria:\n\n* For Group 1 (Healthy Controls): Other small-bowel diseases causing mucosal injury, including Crohn's disease and small-bowel ulcers\n* Inability to provide written informed consent\n* Refusal to participate",true,"ALL","18 Years",{"count":21,"type":22},300,"ESTIMATED","12 Months","OBSERVATIONAL","This prospective cohort study aims to establish reliable histological reference values for normal small-bowel mucosa, improve histological diagnostic quality in celiac disease, and develop an advanced molecular profile for disease diagnosis and treatment response evaluation. The study will collect duodenal biopsies from three groups: healthy controls undergoing clinically indicated gastroscopy, patients referred for primary celiac disease diagnostics, and patients with small-bowel mucosal injury unresponsive to a gluten-free diet. Patients will undergo routine clinical assessment via standard pathology review of diagnostic biopsies. Biopsies will be analyzed using digital morphometry, AI-based image analysis, RNA sequencing (transcriptomics), and intestinal organoid cultures.",[27,28,29],"Celiac Disease","Small Bowel Disease","Refractory Celiac Disease",[31,32,33,34,35,36,37,38,39,40,41,42],"celiac disease","duodenal biopsy","histology","digital morphometry","artificial intelligence","RNA sequencing","transcriptomics","organoids","small bowel","villous atrophy","molecular profiling","machine learning","RECRUITING","2026-04-24",{"date":46,"type":47},"2026-04-29","ACTUAL",{"date":49,"type":47},"2025-11-01",{"date":51,"type":22},"2035-12-31",{"name":53,"class":54},"Tampere University Hospital","OTHER",3,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100582866","anonymous-data-sharing-for-small-bowel-100582866","NCT06868875","Anonymous Data Sharing for Small Bowel","Data Sharing With Collaborative Partners to Develop Computer Aided Detection for the Assessment of the Small Bowel Using MRI","Inclusion Criteria:\n\n* Had a small bowel MRI at UCLH between 2005 and Sept 2010 as part of routine clinical practice who:\n* Have a clinical standard of reference within 6 weeks of the MRI scan\n* Patients with normal small bowel MRI studies and no clinical evidence of bowel pathology on any additional diagnostic investigations\n\nExclusion Criteria:\n\n* Patients \\\u003C16 or not fulfilling either inclusion criteria","16 Years",{"count":65,"type":22},1500,"Crohn's disease is characterised by an abnormal immunological response within the bowel wall leading to abnormal wall thickening, stricturing (narrowing), fistulation (abnormal connections) to adjacent organs and strictures (narrowing), abnormal motility, and local sepsis (infection). Radiological imaging of the small bowel defines diagnosis, disease extent, biological activity and complications and is vital for timely and efficacious clinical management. Small bowel magnetic resonance imaging (MRI) does not impart ionising radiation and is proving to be a safe, well tolerated and robust method of assessing the small bowel and is widely implemented in the NHS and Europe. MRI evaluates multiple disease related features such as bowel wall thickness and motility which are proving increasing reliable for disease identification, staging, therapeutic guidance and assessment of treatment response.\n\nCurrently however radiologists must manually make these measurements which are time consuming and difficult.\n\nThere are no computer tools that can quickly and accurate make relevant measurements on MRI to guide patient management. Radiologists at University College Hospital have formed collaborations with groups within University College London (UCL) and around Europe. The investigators have received grant funding to develop computer software to accurately assess the small bowel using MRI over 3 years. To develop this software, it is necessary to use anonymised datasets from patients with and without Crohn's disease undergoing small bowel MRI. Part of this project will require prospective collection of MRI data which has been granted ethical approval as a major amendment to a currently running project (09\u002FH0714\u002F62). The department of Radiology at UCLH has been running a clinical small bowel MRI service since 2005 and have several hundred datasets on its PACS. This current ethics application seeks permission to datashare with the collaborative partners fully anonymised MRI datasets and relevant clinical data from patients previously undergoing small bowel MRI for clinical indications at UCLH.",[28,68],"Gastrointestinal Diseases",[70],"Observational","2025-03-04",{"date":73,"type":47},"2025-03-11",{"date":75,"type":47},"2011-04-24",{"date":77,"type":22},"2027-08-31",{"name":79,"class":54},"University College, London",1]