[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"small-bowel-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:small-bowel-obstruction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,73,99,125,150,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100643229","the-effect-of-nasogastric-tube-placement-on-complications-in-patients-with-small-bowel-obstruction---the-sbo-tube-trial-100643229",false,"NCT07574515","The Effect of Nasogastric Tube Placement on Complications in Patients With Small Bowel Obstruction - the SBO-TUBE Trial","The Effect of Nasogastric Tube Placement on Complications in Patients With Small Bowel Obstruction - the SBO-TUBE Randomized Controlled Trial","SBO-TUBE","Inclusion Criteria:\n\n* Small bowel obstruction diagnosed on Computer Tomography\n\nExclusion Criteria:\n\n* Nasogastric Tube already places\n* Amyotrophic lateral sclerosis\n* Cerebral palsy\n* Dementia\n* Parkinson's disease\n* Multiple Sclerosis\n* Previous stroke with documented persistent dysphagia\n* Planned for urgent surgery\n* Acute Massive Gastric Dilatation\n* Gastric outlet obstruction\n* Fundoplicatio\u002FInability to vomit\n* Signs of pneumonia\u002Fpneumonitis on initial diagnostic CT","ALL","18 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Small bowel obstruction (SBO) is a surgical emergency where the normal continuous bowel movements are hindered and approximately 8000-9000 patients visit the emergency department every year in Sweden due to SBO. A minority of these have evidence of intestinal injury, warranting emergency surgery, while the majority (70-90%) will have an initial plan for non-operative management with a nasogastric tube (NGT), placed to alleviate gastric pressure, reduce pain and prevent complications like aspiration pneumonia. The effectiveness of NGT in patients with SBO to prevent complications is unclear, with current data from observational data indicating increased risk of pneumonia in patients treated with NGT. Objective: To assess whether deferring the placement of a NGT in subjects with small bowel obstruction and planned for non-operative management leads to lower rates of respiratory complication compared to placing an NGT. Methods: This will be a randomized, controlled, open-label, multicenter study of patients with SBO and an initial plan for non-operative management. Patients will be randomized in a 1:1 ratio to not receive an NGT (intervention) or receive an NGT (control) and monitored regularly until the SBO resolves spontaneously or through surgery, whichever comes first. The primary outcome will be a composite of pulmonary complications and treatment in a high dependency unit, analyzed as a superiority study with an intention-to-treat framework with secondary per-protocol and non-inferiority analysis. The trial will recruit 1000 patients. Secondary analysis includes health-economy, qualitative interviews, and long term (1 year) follow up. Discussion: The current management of NGT in SBO is based on clinical and guideline-based recommendations with limited supporting data. Available data, albeit observational with risk for selection bias, indicates increased risk of complications. This equipoise warrants further investigation to understand the true benefit of NGT in SBO. This study will provide high quality evidence of the ability of a NGT to prevent complications in SBO through its randomized, prospective design",[27,28],"Small Bowel Obstruction","Intestinal Obstruction and Ileus",[30,31,32],"ileus","small bowel obstruction","nasogastric tube","RECRUITING","2026-06-08",{"date":36,"type":37},"2026-06-11","ACTUAL",{"date":39,"type":37},"2026-05-27",{"date":41,"type":21},"2028-12-31",{"name":43,"class":44},"University Hospital, Linkoeping","OTHER",3,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100617319","gt-metabolic-magnet-system-in-adults-with-gastrointestinal-disorders-100617319","NCT07317076","GT Metabolic Magnet System in Adults With Gastrointestinal Disorders","Compression Anastomosis Using the GT Metabolic Magnet System in Adults With Gastrointestinal Disorders (GT Metabolic Magnet System Study)","Inclusion Criteria:\n\n* Indicated for gastrointestinal surgery requiring a gastric and\u002For small bowel anastomosis, without need for immediate lumen patency, and meets one of the following criteria:\n\n  1. Superior mesenteric artery syndrome (SMAS); OR\n  2. Gastric outlet obstruction (GOO); OR\n  3. Partial small bowel obstruction.\n* Meets the surgical clearance requirements as governed by the investigator's institution.\n* If a child-bearing female, subject must commit to not becoming pregnant and agree to use contraception for the duration of the study.\n\nExclusion Criteria:\n\n* Other gastrointestinal or abdominal surgeries planned concurrently or within the study follow-up period (e.g., bariatric surgery such as sleeve gastrectomy).\n* Prior surgery, trauma, prostheses, disease or genetic expression which prevent or contraindicate the anastomosis or study procedure, including scarring and abnormal anatomy at the anastomosis sites.\n* Any anomaly precluding gastrointestinal access by gastroscope \u002F endoscope, catheters, and associated manipulation techniques for device placement.\n* Any condition or disease that precludes laparoscopic surgery.\n* Implantable pacemaker, defibrillator, other active and\u002For metallic implant that may interfere with or be adversely impacted by a temporary magnetic implant (Magnet System) and associated procedures.\n* Unhealed ulcers, bleeding lesions, tumor, diseased tissue or any other lesion at or distal to the target Magnet deployment sites.\n* Any need for immediate lumen patency while the anastomosis is formed.\n* History of prior or current malignancy.\n* Expected need for Magnetic Resonance Imaging (MRI) within the first 3 months post-procedure (or before if Magnet expulsion is confirmed radiologically).\n* Known allergies to the device components (including the biofragmentable material PGLA or similar compounds) or contrast media.\n* Pregnant, lactating, or planning pregnancy during the clinical investigation and follow up period.\n* Currently participating in an investigational drug, biologic, or medical device or other interventional clinical study.\n* Presence of other anatomic or comorbid conditions, or medical, social or psychological conditions that, in the investigator's opinion, could limit the participant's ability to participate in the clinical investigation or to comply with follow-up requirements.",{"count":54,"type":21},35,[24],"Evaluate the performance and safety of the GT Metabolic Magnet System for the creation of side-to-side compression anastomosis in the stomach and\u002For small bowel in conditions requiring an anastomosis as part of the underlying clinical treatment.",[58,27,59],"Gastric Outlet Obstruction","Superior Mesenteric Artery Syndrome",[61,62],"Magnet System","GT Metabolic Solutions, Inc.","2026-05-18",{"date":65,"type":37},"2026-05-19",{"date":67,"type":37},"2025-12-09",{"date":69,"type":21},"2026-11",{"name":62,"class":71},"INDUSTRY",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100577848","contribution-of-point-of-care-ultrasound-by-the-emergency-physician-to-rule-out-the-small-bowel-obstruction-a-diagnostic-multicenter-study-100577848","NCT06803628","Contribution of Point of Care Ultrasound by the Emergency Physician to Rule Out the Small Bowel Obstruction: a Diagnostic, Multicenter Study","OCCLUS-POCUS","Inclusion Criteria:\n\n1. Major patient (age \\> 18 years old), no upper limit\n2. Patient admitted to the ED with suspected SBO (abdominal pain, vomiting, cessation of gas and feces...)\n3. Low or moderate pretest Gestalt clinical probability\n4. Patient able to understand protocol and express agreement\n5. Oral non-opposition given\n\nExclusion Criteria:\n\n1. Patient under legal guardianship\n2. Pregnant women\n3. Nursing mothers\n4. Patient who does not speak or understand French\n5. Patient without a health insurance plan\n6. Patient who already had imaging confirming the diagnosis\n7. Patient who participates simultaneously in any interventional study focused on abdominal pain before POCUS and CT realization",{"count":81,"type":21},667,"OBSERVATIONAL","Small Bowel Obstruction (SBO) is a frequent pathology in the emergency department (ED). Diagnosis is currently based on abdominal CT scan (CT). Moreover, CT is warranted to determine the therapeutic strategy in patients with SBO which could include medical treatment; surgical intervention or both. However, CT is associated with drawbacks such as radiation exposure, increased cost and ED length-of-stay.\n\nIn a prospective observational study, a SBO was excluded by CT in 45% \\[95%CI: 37-53\\] of patients. There is, thus, a need for improving the appropriateness of CT-scan for suspected SBO.\n\nA recent meta-analysis showed that Point of care ultrasound (POCUS) had a good diagnostic accuracy (sensitivity 83% \\[95%CI 71.7%-90.4%\\]), specificity 93% \\[95%CI 55.3%-99.3%\\]). Another meta-analysis found rather similar results (sensitivity 83% \\[(95% CI 89.0% to 94.7%\\], specificity 96,6% \\[95% CI 88.4% to 99.1%\\]).\n\nIn order to improve the negative predictive value of POCUS for its implementation as a rule-out strategy, CHU of Nantes emergency unit studied the combination of POCUS with Gestalt pre-test probability of SBO determined by the emergency physician. This SBO probability classified the patients as low, moderate or high risk of SBO. In patients with low or moderate Gestalt probability, CHU of Nantes emergency unit found that this combined strategy had a sensitivity of 100% \\[95% CI: 88-100\\] and NPV 100% \\[92-100%\\].\n\nBy (i) focusing on patients with a low or moderate Gestalt clinical probability and (ii) increasing the number of patients included, CHU of Nantes emergency unit intends to demonstrate that POCUS is able to exclude SBO in this population. This would avoid unnecessary CT and thus lower costs, ED length-of-stay and hospital radiologists workload.\n\nA POCUS will be performed followed by a CT (gold standard). The main objective will be the ability of POCUS to rule-out SBO in patients with low or moderate Gestalt clinical probability.",[27],[86,87,88],"Small bowel obstruction","Point of care ultrasound","Emergency Medicine","2026-05-11",{"date":91,"type":37},"2026-05-12",{"date":93,"type":37},"2025-03-10",{"date":95,"type":21},"2027-03-10",{"name":97,"class":44},"Nantes University Hospital",18,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100600577","water-soluble-contrast-induced-intestinal-stimulation-for-the-treatment-of-small-bowel-obstruction-a-feasibility-study-100600577","NCT07099300","Water-Soluble Contrast Induced Intestinal Stimulation for the Treatment of Small Bowel Obstruction: A Feasibility Study","The Use of Nasogastric Tubes and Water-Soluble Contrast With or Without Radiographic Imaging in The Management of Adhesive Small Bowel Obstruction: A Feasibility Study","Inclusion Criteria:\n\n1. Documentation of aSBO as evidenced by one or more clinical features meeting the following criteria:\n\n   * Nausea\n   * Emesis\n   * Abdominal pain\n   * Distended abdomen\n   * CT evidence of aSBO\n   * Known abdominal surgical history.\n2. Written informed consent obtained from subject.\n\nExclusion Criteria:\n\n1. Unable to provide consent for the study.\n2. Pregnant or breastfeeding.\n3. Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data.\n4. Unstable angina or recent myocardial infarction or stroke within 6 months\n5. Patients with peritonitis or who require immediate surgery.\n6. Non-adhesive SBO, including.\n\n   * Paralytic Ileus\n   * Incarcerated hernia\n   * Fecal impaction\n   * Intra-abdominal malignancy\n   * Early aSBO within 4 weeks of a prior abdominal operation","80 Years",{"count":108,"type":21},60,[24],"Small bowel obstruction (SBO) is common yet, how to best manage it remains unknown. One approach is to administer water soluble oral contrast (WSC) and the obtain x-rays to determine how well the bowel is functioning. WSC may help resolve SBO by stimulating the bowel by itself. The intent of this study is to determine if the x-ray component of this therapeutic approach is necessary.",[27],[113,114],"water soluble contrast","radiology","NOT_YET_RECRUITING","2025-08-01",{"date":118,"type":37},"2025-08-07",{"date":120,"type":21},"2025-08-15",{"date":122,"type":21},"2030-08-15",{"name":124,"class":44},"University of California, Los Angeles",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":138,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":72},"100355230","a-procalcitonin-based-algorithm-in-adhesion-related-small-bowel-obstruction-100355230","NCT03905239","A Procalcitonin-based Algorithm in Adhesion-related Small Bowel Obstruction","Impact of a Procalcitonin-based Algorithm on Quality of Management in Patients With Uncomplicated Adhesion-related Small Bowel Obstruction Assessed by Textbook Outcome: a Multicenter Cluster-randomized Open-label Controlled Trial. (ALPROC)","ALPROC","Inclusion Criteria:\n\n* Uncomplicated acute adhesion-related small bowel obstruction (ASBO)\n* Adults\n* Patients able to express consent\n* Signed written informed consent form\n* Covered by national health insurance\n\nExclusion Criteria:\n\n* Disease-related criteria:\n* Large bowel obstruction\n* No previous abdominal surgery\n* Signs of peritonitis or strangulation requiring emergency surgery)\n* Obstruction within 4 weeks following previous surgery\n* Ongoing or history of bowel cancer\n* Ongoing or in history of inflammatory bowel disease\n* History of abdominal radiotherapy\n* Active infection\n* Contraindication to contrast-enhanced CT scan\n* Minors\n* Patient deprived of liberty by administrative or judicial decision or placed under judicial protection (guardianship or supervision)\n* Pregnancy or breastfeeding",{"count":134,"type":21},488,[24],"Adhesion-related small bowel obstruction is a common digestive emergency that can be managed either conservatively or surgically. However, the choice between these two approaches can be difficult due to the absence of specific signs. The objective of this study is to evaluate the clinical impact of a procalcitonin-based algorithm.",[27],[139,140,31],"algorithm","procalcitonin","2025-06-05",{"date":143,"type":37},"2025-06-08",{"date":145,"type":37},"2019-04-01",{"date":147,"type":21},"2026-08-01",{"name":149,"class":44},"Centre Hospitalier Universitaire, Amiens",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":168,"locationsCount":72},"100491353","study-about-contrast-media-100491353","NCT05678023","Study About Contrast Media","Multicentre Randomized Trial on the Timing and Effect of Contrast Media on Patients with Adhesive Small Bowel Obstruction","Inclusion Criteria:\n\n* Patients 18 years or older\n* Adhesive small bowel obstruction diagnosed (clinical, laboratory and radiologic evaluation\n* No peritonitis present, no need for an emergent surgery\n* Patients sign an informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 yeas\n* Patients with mechanical small bowel obstruction caused by incarcerated hernias\n* Patients with mechanical small bowel obstruction caused by carcinomatosis\n* Patients with paralytic small bowel obstruction\n* Patients who have undergone surgery within 6 weeks\n* Patients who do not want to be enrolled in the study",{"count":158,"type":21},120,[24],"Patients hospitalized with adhesive small bowel obstruction (SBO) are randomized to 2 study groups at admission after signing an informed consent form. Water-soluble contrast media (CM) will be administered after 4 or after 24 hours of nasogastric- tube decompression.",[27],"2025-03-25",{"date":164,"type":37},"2025-03-30",{"date":166,"type":37},"2023-09-01",{"date":116,"type":21},{"name":169,"class":44},"University of Tartu",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":193},"100521096","early-surgery-versus-3-days-non-surgical-management-in-acute-small-bowel-obstruction-surgi-bow-100521096","NCT06065150","Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction (SURGI-BOW)","SURGI-BOW - Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction: a Randomized Open-label Controlled Study","SURGI-BOW","Inclusion Criteria:\n\n* Admission for acute intestinal obstruction of the small intestine on adhesion or bridle\n* Confirmation of the aSBO by a scanner\n* Adult patient\n* Beneficiary of a social security scheme\n* Having signed an informed consent\n\nExclusion Criteria:\n\n* Indication for urgent surgery (small intestine ischemia, intestinal pain, defence, hemodynamic shock, etc.)\n* Pregnancy or breastfeeding\n* Poor understanding of the French language\n* Person deprived of liberty by judicial or administrative decision\n* Person undergoing psychiatric treatment under duress\n* Person subject to a legal protection measure\n* Person unable to express consent",{"count":179,"type":21},630,[24],"For uncomplicated acute small bowel obstruction (aSBO), the \"Bologna guidelines\" recommend non-surgical management of 72 hours before considering surgery. This treatment is based on the placement of a nasogastric tube and the correction of hydro-electrolyte disorders. Non-surgical management is only effective in 60 to 70% and surgery is therefore necessary in 30 to 40% of cases after medical treatment for at least 3 days. This therefore leads to an increase in the length of hospital stay. Some authors also point out that postponing surgery for 3 days would aggravate the morbidity and mortality of surgery. Indeed, aSBO surgery has a complication rate of 10-40% and a mortality of up to 4%.\n\nThere is a lack of studies evaluating what is the best management strategy for aSBO, especially with regard to the duration of medical treatment. Many recent studies plead in favor of early surgical treatment (\\\u003C24 hours) which would reduce the morbidity and mortality rate of surgery but also the overall cost of treatment by reducing the length of stay.\n\nThis paradigm shift is linked to the improvement of anesthetic and intensive care management over the last few years, but also to the advent of laparoscopy in emergency surgery. Indeed, laparoscopy could reduce the duration of hospitalization but also the operative morbidity and mortality. However, this surgical approach is not feasible in all situations and the conversion rate is reported in 30 to 76% of cases. One of the factors favoring the feasibility of the laparoscopic approach is the performance of early surgery.\n\nAnother parameter favoring the feasibility of the laparoscopic approach is the aSBO mechanism: an aSBO on flange (SBA) is more likely to be treated effectively by laparoscopic than an aSBO on multiple adhesions (MA).\n\nIn the literature, there is little to differentiate SBAs from MAs. Advances in CT scans have made it possible to describe the signs associated with the SBA mechanism and then to propose a score making it possible to predict the SBA mechanism with good performance (sensitivity 67.6%, specificity 84.6%). This score not only has the advantage of predicting the mechanism of the occlusion but it also makes it possible to predict the failure of non-surgical treatment if the score is ≥5.",[27],"2024-06-12",{"date":185,"type":37},"2024-06-13",{"date":187,"type":37},"2024-01-30",{"date":189,"type":21},"2028-01-29",{"name":191,"class":192},"University Hospital, Angers","OTHER_GOV",14]