[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"small-intestine-bacterial-overgrowth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:small-intestine-bacterial-overgrowth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100627633","phase-2-comparative-efficacy-of-antibiotics-for-small-intestine-bacterial-overgrowth-in-bangladeshi-children-100627633",false,"NCT07451171","Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children","A Phase II Trial to Prevent Linear Growth Stunting and Malnutrition in Impoverished Children From a Low-Income Country by Treating Small Intestine Bacterial Overgrowth","Inclusion Criteria:\n\n* Positive glucose hydrogen breath test (GHBT)\n* Weight-for-age Z score \\> -1\n* Length-for-age Z score \\> -1\n\nExclusion Criteria:\n\n* Presence of known chronic or congenital illness, including developmental delay\n* Presence of acute gastrointestinal illness in the preceding 14 days\n* Antibiotic use in the preceding 14 days\n* Previous adverse reaction to any of the three study medications or other drugs in the same antibiotic classes\n* Sibling previously enrolled in this study","ALL","1 Year","2 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.",[27],"Small Intestine Bacterial Overgrowth",[29],"environmental enteric dysfunction","RECRUITING","2026-05-01",{"date":33,"type":34},"2026-05-06","ACTUAL",{"date":36,"type":34},"2026-04-18",{"date":38,"type":21},"2026-09-01",{"name":40,"class":41},"University of Virginia","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100555958","phase-1-study-of-clinical-features-and-efficacy-of-small-intestinal-bacterial-overgrowth-in-patients-with-abdominal-distension-100555958","NCT06518850","Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension","A Multicentre Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Abdominal Distension Patients","Inclusion criteria:\n\nPart 1 Clinical characteristics of small intestinal bacterial overgrowth in patients with abdominal distension of different etiologies\n\n1. Age 18-60 years old and gender;\n2. The chief complaint is abdominal distension and\u002For abdominal distension, abdominal distension and\u002For abdominal distension more prominent than other symptoms.\n\nPart 2 Efficacy observation of functional abdominal distention combined with small intestine bacterial overgrowth\n\n1. Patients with functional abdominal distension and small intestinal bacterial overgrowth were selected in Part 1;\n2. No drug contraindications.\n\nExclusion criteria:\n\nPart 1 Clinical characteristics of small intestinal bacterial overgrowth in patients with abdominal distension of different etiologies\n\n1. Preparation for pregnancy, pregnancy, breastfeeding women, or overall poor compliance, or other conditions that the investigator believes need to be excluded;\n2. History of malignant tumors, history of abdominal surgeries;\n3. Food intolerance, confirmed or suspected lactose intolerance;\n4. Diagnosis of urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's disease, etc.), mental system (depression, etc.) and other diseases outside the digestive system;\n5. Antibiotics and microecological preparations should be used within two weeks. Use motility enhancers, secretagogues, antifoaming agents, spasmolytics, opioids, antidepressants and other medications within a week.\n\nPart 2 Efficacy observation of functional abdominal distention combined with small intestine bacterial overgrowth\n\n1. Antibiotics and microecological preparations should be used within two weeks;\n2. Use motility enhancers, secretagogues, antifoaming agents, spasmolytics, opioids, antidepressants and other medications within a week.","18 Years","60 Years",{"count":53,"type":21},30,[55,24],"PHASE1","Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and\u002For oral cecum transit time abnormalities are more urgent to explore. On this basis, patients with functional abdominal distension complicated with small intestine bacterial overgrowth were divided according to whether there was abnormal oral cecum transit time, and given the same treatment plan. The relief effect of abdominal distension, small intestine bacterial overgrowth turning negative and oral cecum transit time recovery were observed, so as to further clarify the cause of abdominal distension patients.",[27],[59,60,61],"small intestine bacterial overgrowth","oral cecum transit time","abdominal distention","NOT_YET_RECRUITING","2024-07-18",{"date":65,"type":34},"2024-07-24",{"date":67,"type":21},"2024-08-01",{"date":69,"type":21},"2025-12-31",{"name":71,"class":41},"Peking Union Medical College Hospital"]