[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"smell-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:smell-loss":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,73,102,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645278","cognitive-and-immunologic-profiles-of-patients-with-olfactory-dysfunction-after-smell-training-100645278",false,"NCT07681973","Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training","CIPOD","Inclusion Criteria:\n\n* Age less than 18 years-old\n* Present to rhinology clinic with CRS with nasal polyps\n* Sense of smell loss for any reason (other than trauma or tumor)\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years of age\n* Individuals with unilateral nasal polyps\n* Autoimmune diseases\n* Ciliary disorders\n* Cystic fibrosis\n* Smell loss due to tumors or trauma",true,"ALL","18 Years",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated.\n\nThe primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.",[27,28],"Smell Loss","Chronic Rhinosinusitis (CRS)",[27,30,31,32],"Chronic Rhinosinusitis","Nasal Polyps","CRSwNP","RECRUITING","2026-06-26",{"date":36,"type":37},"2026-07-02","ACTUAL",{"date":39,"type":37},"2025-12-09",{"date":41,"type":21},"2027-03-31",{"name":43,"class":44},"The Cleveland Clinic","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100594560","olfactory-biopsies-100594560","NCT07021040","Olfactory Biopsies","Analysis of Human Olfactory Biopsies","Group 1: Alzheimer's study\n\nInclusion Criteria:\n\n* Between the ages of 18 and 80\n* Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);\n* Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)\n\nExclusion Criteria:\n\n* Advanced Alzheimer's\u002Fdementia\n* Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)\n* Active Rhinosinusitis symptoms\n* Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)\n* Parkinson's disease\n* Unable or willing to complete the nasal endoscopy procedure.\n* Unable to read or speak English\n* Unable to provide legally effective consent\n\nGroup 2: Act-seq study or Non-AD controls\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Patients being seen for rhinology or olfactory disorders\n* Patients having unrelated endoscopic nasal surgery\n\nExclusion Criteria:\n\n* Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)\n* Unable or willing to complete the nasal endoscopy procedure\n* Unable to read or speak English\n* Unable to provide legally effective consent",{"count":54,"type":21},125,[24],"This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell.\n\nThe purpose of this study is to collect tissue from the nasal cavity.",[58,27,59],"Alzheimer Disease","Smell Dysfunction",[61,62,63],"act-seq","nasal biopsy","RNA-seq","2026-06-11",{"date":66,"type":37},"2026-06-12",{"date":68,"type":37},"2025-01-06",{"date":70,"type":21},"2029-07-31",{"name":72,"class":44},"Duke University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":100,"locationsCount":45},"100572466","scents-of-progress-leveraging-a-novel-device-for-olfactory-training-in-older-adults-100572466","NCT06733636","Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults","SPLENDOR-OA; Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults","SPLENDOR-OA","Inclusion Criteria:\n\n* Adults 60 years of age or older.\n* English-speaking patients.\n* Patients with a diminished or lost sense of smell.\n* Patients who have not done smell training before\n\nExclusion Criteria:\n\n* Patients who are sensitive to any of the scents used in the study.\n* Patients with a diagnosis of congenital anosmia.","60 Years",{"count":83,"type":21},60,[24],"The goal of this clinical trial is to learn if ScentCare, a novel olfactory training device and accompanying companion web-based application, will lead to improved olfactory and well-being outcomes in elderly patients with Olfactory Dysfunction (OD). The main question it aims to answer is:\n\n\\- What effect does the olfactory training device (ScentCare) and accompanying companion web-based application have on olfaction?\n\nResearchers will compare ScentCare to solving Sudoku puzzles to see the effects of olfactory training using this novel device on olfaction. Previous studies have used Sudoku puzzles when studying the effect of smell training. Since smell training is thought to work by stimulating and engaging higher order cognition, Sudoku is a suitable activity for participants in the control group since it serves as a correlate with similar degree of stimulation.\n\nParticipants will:\n\n* Use ScentCare (intervention) or solve Sudoku puzzles (control) twice daily for 3 months.\n* Visit the clinic twice, once upon enrollment and once three months later.\n* Complete a formal smell test using Sniffin' Sticks smell test at the beginning of the study and again at the end of the study (3 months) during the initial and follow up visit.\n* Complete questionnaires at the beginning of the study and again at the end of the study (3 months) during the initial and follow up visit.",[87,27,88,89],"Olfactory Dysfunction","Anosmia","Hyposmia",[87,91,92,93,27,88,89],"Olfactory Training","Smell Training","Smell Training Device","2026-04-10",{"date":96,"type":37},"2026-04-13",{"date":98,"type":37},"2025-04-15",{"date":41,"type":21},{"name":101,"class":44},"Johns Hopkins University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":45},"100467236","olfactory-training-on-smell-dysfunction-patients-in-hk-100467236","NCT05364125","Olfactory Training on Smell Dysfunction Patients in HK","Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population","Inclusion Criteria:\n\n* Olfactory dysfunction \\> 6 months and \\\u003C 5 years\n\nExclusion Criteria:\n\n* History of significant head injury (fracture, ICH)\n* History of brain surgery\n* History of nasal surgery\n* Active nasal disease\n* Active neurological disease\n* Poor premorbid status\u002F non-communicable patients\n* Mentally incompetent patients\n* \\\u003C18 years' old\n* Pregnancy\n* Hypersensitivity to the aromatic substance.","70 Years",{"count":111,"type":21},80,[24],"* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes.\n* Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery\n* Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases.\n* Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries.\n* Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study.\n* However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.",[115,116,88,89,117,27,59],"Olfaction Disorders","Smell Disorders","Olfactory Impairment","2025-05-28",{"date":120,"type":37},"2025-06-03",{"date":122,"type":37},"2022-07-01",{"date":124,"type":21},"2027-06-30",{"name":126,"class":44},"Pamela Youde Nethersole Eastern Hospital",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":137,"phases":4,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":45},"100584696","olfactory-cleft-obstruction-and-electrophysiological-field-potentials-predict-olfactory-restoration-by-dupilumab-in-crswnp-patients-100584696","NCT06892704","Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.","Olfactory Cleft Obstruction and Electrophysiological Olfactory Bulb Generated Beta Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.","* Well documented history of CRSwNP\n* BSIT age\u002Fsex classified as \"abnormal\" score\n* Self-reported stable olfactory deficit of moderate to severe quality \\> 3 months\n* Prior endoscopic sinus surgery \\>3 months, \\\u003C10 years prior","65 Years",{"count":136,"type":21},30,"OBSERVATIONAL","The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab. The main questions it aims to answer are:\n\n1. Does obstruction of the olfactory cleft predict return of the sense of smell?\n2. Do electrophysiological signals generated by breathing and sniffing behavior predict return of the sense of smell?\n\nParticipants starting dupilumab will undergo assessment for their degree of olfactory cleft obstruction, and an electrophysiologic assessment of their olfactory cleft and be followed over 6 months of treatment with dupilumab.",[140,27],"Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)",[142,143,27,144],"Dupilumab","Chronic Rhinosinusitis with Nasal Polyps","Electrophysiology","2025-05-12",{"date":147,"type":37},"2025-05-14",{"date":149,"type":37},"2025-05-01",{"date":151,"type":21},"2027-12-31",{"name":153,"class":44},"Northwestern University"]