[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"smoke-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:smoke-exposure":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100580792","phase-4-woodsmoke-exposure-influenza-infection-and-nasal-immunity-100580792",false,"NCT06841913","Woodsmoke Exposure, Influenza Infection, and Nasal Immunity","The Effects of Woodsmoke Exposure on Nasal Immune Responses to Influenza Infection in Normal Human Volunteers","SmokeyFlu","Inclusion Criteria:\n\n* Normal lung function,\n* oxygen saturation of \\>94%,\n* normal blood pressure,\n* no respiratory symptoms on history, no abnormalities on exam, normal pulmonary function testing,\n* 18-49 Years of age.\n\nExclusion Criteria:\n\n* A history of significant chronic illnesses (to include diabetes, autoimmune diseases, immunodeficiency state, known ischemic heart disease, chronic respiratory diseases such as chronic obstructive pulmonary disease or asthma, hypertension)\n* Positive pregnancy test within 48 hours of the time of challenge\n* Use of any inhaled substance (for medical or recreational purposes).\n* Nonsmokers must have been abstinent from smoking for the prior 12 months, having not smoked more than 1 pack over the course of the previous year.\n* History of allergy to eggs\n* Acute, non-chronic, medical conditions, including (but not limited to) pneumonia or bronchitis requiring antibiotics, febrile illnesses, flu-like symptoms must be totally resolved symptomatically for 3 weeks\n* Unspecified illnesses, which in the judgment of the investigator increase the risk associated with the experimental LAIV infection, will be a basis for exclusion.\n* Expected exposure of subject to immunocompromised individuals (who can be infected by LAIV) for the 3 weeks following LAIV inoculation.\n* Use of immunosuppressive drugs within the past 6 months.\n* Previous Woodsmoke exposure \\\u003C3 weeks, which is considered to an appropriate washout period",true,"ALL","18 Years","49 Years",{"count":22,"type":23},112,"ESTIMATED","INTERVENTIONAL",[26],"PHASE4","This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modifies biomarkers of nasal mucosal immune function, increases in Live Attenuated Influenza Virus (LAIV) -induced nasal symptoms, and reduces mucosal antibody production.",[29,30],"Smoke Exposure","Influenza",[32,33,30,34,35,36],"LAIV","Flumist","Wood Smoke","Smoke","Fire","RECRUITING","2026-04-24",{"date":40,"type":41},"2026-04-30","ACTUAL",{"date":43,"type":41},"2025-09-26",{"date":45,"type":23},"2028-12-31",{"name":47,"class":48},"University of North Carolina, Chapel Hill","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100620997","platelet-derived-growth-factors-to-enhance-healing-and-reduce-post-extraction-complications-in-smokers-100620997","NCT07364890","Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers","Inclusion Criteria:\n\n* Smokers\n* Aged 18 years or older\n* Actively smoking at least 10 cigarettes per day\n* Requiring bilateral extractions.\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Diabetes mellitus\n* Hypertension\n* Bleeding disorders\n* Pregnant or lactating women\n* Individuals who used tobacco products other than conventional cigarettes (such as e-cigarettes or waterpipes) were excluded.",{"count":57,"type":23},12,[59],"NA","This study is a randomized controlled clinical trial with a split-mouth design to evaluate the effect of Advanced Platelet-Rich Fibrin (A-PRF) application on socket healing following dental extractions in smokers. In the split-mouth design, each participant serves as their own control, minimizing inter-subject variability and controlling for potential confounders such as smoking habits, oral hygiene, and systemic health conditions.\n\nBilateral tooth extractions will be performed for each participant, with one extraction site randomly assigned to receive socket preservation using an A-PRF plug, while the contralateral site will be left to heal naturally without intervention.\n\nThe study will be conducted at the Faculty of Dentistry and the University Dental Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. Recruitment began in December 2025 and will continue until the targeted sample size is achieved.",[29],[63,64,65,66],"Smokers","A- PRF","Extraction","Socket","NOT_YET_RECRUITING","2026-01-18",{"date":70,"type":41},"2026-01-23",{"date":72,"type":23},"2026-01-31",{"date":74,"type":23},"2026-06-30",{"name":76,"class":48},"King Abdulaziz University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":17,"sex":18,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100571685","effect-of-passive-smoking-on-functional-capacity-cognition-and-academic-performance-in-primary-school-children-100571685","NCT06723470","Effect of Passive Smoking on Functional Capacity, Cognition and Academic Performance in Primary School Children","Inclusion Criteria:\n\n1. Children aged 6-11 years, enrolled in primary school.\n2. Both genders (male and female).\n3. Healthy children with no musculoskeletal, visual, auditory, or cognitive impairments.\n4. Children whose parents have been smoking for at least 6 years, with moderate to high smoking levels (based on the smoking index).\n5. Children residing in a moderate socioeconomic status.\n6. Children living in Cairo, Egypt.\n7. Children who are able to follow simple commands and participate in assessments.\n\nExclusion Criteria:\n\n1. Children with musculoskeletal problems, congenital deformities, visual or auditory defects, learning disabilities, or autism.\n2. Children who are currently taking medications that affect alertness or cognitive function.\n3. Children who are not exposed to secondhand smoke (non-smokers) but have parents who smoke at very low levels or do not meet the inclusion criteria for passive smoking exposure.\n4. Children who are unable to cooperate or participate in the assessments.","6 Years","11 Years",{"count":86,"type":23},90,"OBSERVATIONAL","This is an observational study that aims to understand the effects of passive smoking (secondhand smoke exposure) on children's health and development. The main question the study seeks to answer is:\n\nHow does exposure to secondhand smoke affect the physical fitness, cognitive abilities, and academic performance of primary school children?\n\nThe study will compare two groups of children aged 6-11 years: one group exposed to secondhand smoke at home (due to parents or caregivers who smoke) and another group not exposed to secondhand smoke. The children's physical capacity, cognitive skills, and school performance will be assessed through various tests.\n\nThe goal of the study is to provide valuable insights into how secondhand smoke may negatively impact children, helping families, schools, and healthcare providers understand the risks and promote healthier, smoke-free environments for children.",[29,90],"Smokeless Tobacco",[92,93,94,95,96,97,98],"Passive Smoking","Functional Capacity","Cognitive Abilities","Academic Performance","Children","Primary School","Physical Fitness","2024-12-15",{"date":101,"type":41},"2024-12-18",{"date":99,"type":23},{"date":104,"type":23},"2025-12-15",{"name":106,"class":48},"Egyptian Chinese University"]