[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"smoking-reduction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:smoking-reduction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,42,78,106,127,148,171,211,232],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053612","phase-4-modifying-progesterone-and-estradiol-levels-to-prevent-postpartum-cigarette-smoking-relapse-and-reduce-secondhand-smoke-exposure-in-infants-and-children-100053612",false,"NCT04783857","Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children","Inclusion Criteria:\n\n* Ability to provide informed consent,\n* Aged 18 to 45 years old\n* Self-reported stable physical and mental health\n\n  1. self-report uncomplicated pregnancy at gestational week 30 or beyond, or\n  2. self-report the birth of a child within the past 6 months\n* History of ≥ 4 cigarettes per month during the six months prior to pregnancy\n* At enrollment, self-report of motivation to become and\u002For remain abstinent after delivery ≥ 6 on a 10 point Likert-type scale\n* Willingness to protect against pregnancy following day 0 to week 12 of the study\n* Participants must live in the continental US and have a device to fully participate in the protocol\n\nExclusion Criteria:\n\n* Current daily use of nicotine replacement therapy or smoking cessation medications, with the exception of e-cigarettes\n* Current major depressive disorder based on the Patient Health Questionnaire-9 (PHQ-9) and the Beck Depression Inventory\n* Contraindication to progesterone treatment (e.g., current use of drugs that may inhibit CYP3A4; current or history of deep vein thrombosis, pulmonary embolus, clotting or bleeding disorder, hypertension, stroke, heart disease, or liver dysfunction or disease; or peanut allergy),\n* Current or within the past 3 months treatment for illicit drug use or alcohol use\n* Any condition or issue that, in the opinion of the clinical team, precludes participation in the trial.","FEMALE","18 Years","45 Years",{"count":19,"type":20},171,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The investigators aim to address the following specific aims:\n\n* Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors.\n* Examine the effects of this maternal smoking intervention on infant health.\n* Examine racial and ethnic differences in intervention outcomes.",[26,27,28],"Smoking","Smoking Cessation","Smoking Reduction","RECRUITING","2026-07-09",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":33},"2022-04-14",{"date":37,"type":20},"2027-06-02",{"name":39,"class":40},"University of Minnesota","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":4,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":41},"100540001","early-life-intervention-in-pediatrics-supported-by-e-health---smoke-100540001","NCT06311162","Early Life Intervention in Pediatrics Supported by E-health - SMOKE","Early Life Intervention in Pediatrics Supported by E-health (ELIPSE II): Coaching Parents to Lower Second-hand Smoke Exposure in Children A Single-blind Randomized Controlled Parallel-group Clinical Trial","ELIPSE-II","Inclusion Criteria:\n\n* Age: younger than 6 years\n* Exposed to second-hand smoke at home (at least one parent smoking)\n* German speaking parent\n* All sex and ethnic backgrounds\n* Signed informed consent form from parent\n* Children live\u002Fgrow-up in the same household as the parental participant\n* Referred by a health care professional (e.g. physician, midwife, nurse, other professions)\n\nExclusion Criteria:\n\n* Participation in another study\u002Ftrial targeting similar outcomes\n* Participation in an active smoking cessation programme",true,"ALL","5 Years",{"count":54,"type":20},160,[56],"NA","Unrestricted parental smoking habits are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of non-communicable diseases (NCDs). Exposure to secondhand tobacco smoke in early life contributes to the development of specific NCDs in children, i.e. asthma. Early preventive measures to improve lifestyle behavior in parents are therefore of utmost importance. The aim of ELIPSE-II is to assess whether an eHealth application intervention for parents is feasible and efficacious in lowering levels of urinary cotinine as a measure of second-hand smoke exposure in their children .",[28,59,60,61,62,63],"Asthma in Children","Wheezing","Non-Communicable Disease","Life Style","Behavior, Smoking",[65,66,67,68],"Secondhand smoke","Children","Prevention","eHealth","2026-04-30",{"date":71,"type":33},"2026-05-06",{"date":73,"type":33},"2024-05-07",{"date":75,"type":20},"2028-12-31",{"name":77,"class":40},"Insel Gruppe AG, University Hospital Bern",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":50,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":41},"100602905","trauma-informed-care-for-smoking-cessation-for-pregnancy-100602905","NCT07129590","Trauma-Informed Care for Smoking Cessation for Pregnancy","TRauma-Informed Care in Smoking cEssation for Pregnancy (RISE Pregnancy)","Inclusion Criteria:\n\nClinician Eligibility Criteria (Aims 1 - 3):\n\nIn Aims 1-3, will be recruiting clinicians working in our clinic sites.\n\n1. Nurse practitioner, physician assistant, nurse-midwife, medical doctor, registered nurse, clinical pharmacist, behavioral health professional, social worker, or any other healthcare professional caring for pregnant patient-participants.\n2. Age ≥ 18 years old.\n\nPatient-participant Eligibility Criteria (Aim 1):\n\nIn Aim 1, will be recruiting pregnant women (ages 18+) who:\n\n1. Currently smoking or report having smoked during a previous pregnancy\n2. Age ≥18 years old.\n3. Currently Pregnant.\n4. Identifies as a cisgender woman, or female at birth.\n5. Reports having experienced trauma aligned with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definition for traumatic exposure.\n6. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 2):\n\nPatient-participants will be recruited to give feedback on our intervention using Evidence-Based Quality Improvement (EBQI) meetings.\n\nInclusion criteria:\n\n1. Current or former patient in the participating clinical sites.\n2. Age ≥18 years old.\n3. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 3): In Aim 3, will be recruiting pregnant women who are actively smoking and have histories of trauma (ages 18+).\n\nInclusion criteria:\n\n1. Currently smoking (ever smoked 100 cigarettes in their lifetime, smoked in the past 7 days and at least 1 cigarette per day, verified by CO≥6ppm)\n2. ≥18 years old\n3. Currently Pregnant\n4. Identifies as a cisgender women, or female at birth\n5. Meets DSM-5 Criterion A for trauma exposure on the Brief Trauma Questionnaire (BTQ)\n6. English or Spanish Proficient\n\nExclusion Criteria:\n\nClinician- and Patient-participant Exclusion criteria (Aims 1 - 3):\n\n1\\. Any condition, including active mental health crises or cognitive impairment, that would interfere with the ability to provide informed consent or safely complete the study.",{"count":86,"type":20},20,[56],"Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma, (3) Responding by embedding knowledge of trauma into practices and policies and (4) Resisting re-traumatization (the 4Rs). In close partnership with Breathe California and a public safety-net clinic in San Francisco that serves primarily racial and ethnic minoritized (REM) pregnant women, the 4Rs along with the Ask, Advise, Assess, Assist and Arrange (the 5As) evidence-based intervention for tobacco cessation that is delivered by health care professionals and is a US Public Health Services clinical practice guideline for treating tobacco will be used to create and implement a smoking cessation intervention for pregnant women with experiences of trauma.",[27,90,91,28,92,93,94],"Tobacco Smoking","Tobacco Use Cessation","Smoking, Cigarette","Trauma, Psychological","Trauma and Stressor Related Disorders",[96],"Pregnancy","2026-04-20",{"date":99,"type":33},"2026-04-23",{"date":101,"type":33},"2025-11-19",{"date":103,"type":20},"2026-07-31",{"name":105,"class":40},"University of California, San Francisco",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":50,"sex":51,"minAge":16,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":41},"100490007","leveraging-community-pharmacists-to-optimize-smoking-cessation-services-for-rural-smokers-in-appalachia-100490007","NCT05660525","Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia","Study participants will be rural cigarette smokers from Virginia, Tennessee, Kentucky and North Carolina who visit one of the participating study pharmacies. Pharmacies will be located in rural geographic areas of the Central and South Central subregions of Appalachia that include Virginia, Tennessee, Kentucky and North Carolina, as defined by the USDA Rural-Urban Continuum Codes (RUCC) 4-9, Rural-Urban Commuting Area (RUCA) codes 4-10, or Frontier and Remote (FAR) areas level 4. No exclusionary criteria are based on race, gender, or age.\n\nInclusion Criteria include:\n\n* must be 18 years of age and older\n* must be able to read, speak, and understand English\n* must report smoking at least 5 cigarettes per day for the past 6 months (regardless of non-cigarette tobacco product use)\n* must be willing to set a quit date within the next 30 days\n* must own a cell phone\n* must be willing and able to use NRT in the form of patch or lozenge\n* Not be pregnant or planning to be pregnant in the next 6 months.\n\nExclusion Criteria include:\n\n* are pregnant women (self-reported), breastfeeding, planning to become pregnant during the next 6 months\n* have a medical contraindication to NRT (e.g., past 30 days, heart attack or stroke; past 6 months, serious or worsening angina, very rapid or irregular heartbeat requiring medication)",{"count":113,"type":20},768,[56],"The goal of this clinical trial is to evaluate the effectiveness and implementation of a pharmacist-delivered MTM (medication therapy management) approach, called QuitAid, to quitting cigarette smoking in rural Appalachia.\n\nThe main questions it aims to answer are:\n\n* Is QuitAid, alone or combined with other quitting tobacco treatments, effective?\n* What makes QuitAid easy or hard to carry out? Is it cost effective? Is it easy to maintain?\n\nTreatment:\n\nAll participants will be given at least 4 weeks of the nicotine patch.\n\nSome participants will be randomized (like the flip of a coin) to receive additional treatments (listed below).\n\nThese groups will be compared to each other to see which combination works best to help them quit smoking.\n\n* Smokefree TXT - a texting program that helps people quit smoking\n* Tobacco quitline - 4 phone sessions to help people quit smoking\n* 8 weeks of NRT (nicotine replacement therapy in the form of nicotine patches or nicotine patches and lozenge) medication instead of 4 weeks\n* QuitAid - An MTM program given by the patient's pharmacist. This is a quitting smoking coaching program\n* Nicotine patch AND nicotine lozenge instead of just nicotine patches",[27,92,28,26,117,118],"Smoking, Tobacco","Quitting Smoking","2026-04-16",{"date":97,"type":33},{"date":122,"type":33},"2024-03-06",{"date":124,"type":20},"2028-03-01",{"name":126,"class":40},"University of Virginia",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":50,"sex":51,"minAge":133,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":41},"100481903","the-impact-of-menthol-flavoring-on-switching-in-adult-menthol-smokers-100481903","NCT05555069","The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers","Inclusion Criteria:\n\n* ≥ 21 years of age\n* Smoke ≥ 5 cigarettes per day (CPD)\n* Smoke menthol cigarettes for ≥ 6 months\n* Verified smoker (CO \\>5ppm)\n* Functioning telephone\n* Interested in switching to E-cigarettes\n\nExclusion Criteria:\n\n* Interested in quitting smoking\n* Use of other tobacco products in past 30 days (i.e. cigarillos, cigars, hookah, smokeless tobacco, pipes)\n* E-cigarette use on ≥ 4 of the past 30 days\n* Uncontrolled hypertension: BP ≥ 180(systolic) or ≥ 105 (diastolic)\n* Use of smoking cessation pharmacotherapy in the month prior to enrollment\n* Pregnant, contemplating getting pregnant, or breastfeeding\n* Plans to move from Kansas City during the treatment and follow-up phase\n* Another household member enrolled in the study","21 Years",{"count":135,"type":20},800,[56],"This study will compare the efficacy of menthol-flavored versus tobacco-flavored 4th generation nicotine salt-based pod-system e-cigarettes in facilitating a switch from combustible cigarettes to e-cigarettes in adult menthol smokers.",[28],"2026-01-21",{"date":141,"type":33},"2026-01-23",{"date":143,"type":33},"2022-11-08",{"date":145,"type":20},"2027-03-31",{"name":147,"class":40},"Nikki Nollen, PhD, MA",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":50,"sex":51,"minAge":133,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":21,"phases":157,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":170},"100493324","phase-3-switching-to-e-cigarettes-in-smokers-not-interested-in-quitting-100493324","NCT05703672","Switching to E-cigarettes in Smokers Not Interested in Quitting","4th Generation E-cigarettes: Reducing Harm and Quitting Combustible Cigarettes in Dual Users","Inclusion Criteria:\n\n* ≥ 21 years of age\n* Smoke \\>5 cigarettes per day\n* Smoked cigarettes for \\> 6 months\n* Verified smoker (CO \\> 5 ppm)\n* Functioning telephone\n* Interested in switching to EC\n* Willing to take varenicline and complete all study visits\n\nExclusion Criteria:\n\n* Interested in quitting smoking\n* Use of smoking cessation pharmacotherapy in the month prior to enrollment\n* Use of other tobacco products in past 30 days (i.e., cigarillos, cigars, hookah, smokeless tobacco, pipes)\n* EC use on \\> 4 of the past 30 days\n* Uncontrolled hypertension: BP \\> 180 (systolic) or \\> 105 (diastolic)\n* Heart-related event in the past 30 days\n* Medical contraindications to VAR: unstable cardiac condition (e.g., unstable angina or AMI) cardiac event, or stroke in the past 4 weeks; renal impairment; history of clinically significant allergic reactions; history of epilepsy or seizure disorder; hospitalized for psychiatric issue in past 30 days; active suicidal ideation\n* Pregnant, contemplating getting pregnant, or breastfeeding\n* Plans to move from Kansas City metro area during the treatment and follow-up phase\n* Another household member enrolled in the study",{"count":156,"type":20},500,[158],"PHASE3","The objectives of this application are to 1) compare short- and long-term harm reduction and abuse liability potential of a nicotine salt pod-based electronic cigarettes (EC) in adult (AA) exclusive EC, dual cig-EC, and exclusive cig users, 2) characterize factors that predict who switches fully, partially, or not at all, and 3) examine if harm reduction can be further enhanced by treating dual users with varenicline (VAR) to eliminate cigarette smoking.",[28],"2025-12-24",{"date":163,"type":33},"2025-12-29",{"date":165,"type":33},"2023-07-17",{"date":167,"type":20},"2027-02-28",{"name":169,"class":40},"University of Kansas Medical Center",2,{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":50,"sex":51,"minAge":16,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":21,"phases":180,"briefSummary":181,"conditions":182,"keywords":187,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":210},"100569396","a-study-evaluating-the-use-of-an-indoor-air-quality-monitor-to-promote-a-smoke-free-home-100569396","NCT06693700","A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home","Freedom to Breathe: Pilot Study Towards Achieving Environmental Justice for Cancer Patients and Their Families","Inclusion Criteria:\n\n* Adult (aged \\>18 years) MSK patients as per the EHR\n* Has been referred and enrolled in the MSK TTP and completed the initial counseling session as per the TTP clinical database\n* Reports current (within the past 30 days) tobacco use (i.e., cigarettes and\u002For any other tobacco products) as per the TTP Intake form\n* Must be English-speaking in the EHR\n* Must be reachable by phone as per self-report\n* Must have Wi-Fi available at home as per self-report\n\nExclusion Criteria:\n\n* Patient reports that no smoking is allowed, by them or anyone else, in the home as per the TTP intake form and\u002For per self-report",{"count":179,"type":20},10,[56],"The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.",[26,27,28,183,184,117,92,185,186,90],"Smoking Habit","Smoking Behaviors","Smoking (Tobacco) Addiction","Tobacco Use",[188,189,190,191,192,193,194,195,196,197,198,199,200,201],"smoking","smoking cessation","smoking reduction","smoking habit","smoking behaviors","smoking, tobacco","smoking, cigarette","smoking (tobacco) addiction","tobacco use","tobacco smoking","air quality","indoor air quality monitoring devices","24-260","Memorial Sloan Kettering Cancer Center","2025-10-21",{"date":204,"type":33},"2025-10-22",{"date":206,"type":33},"2024-11-14",{"date":208,"type":20},"2027-11-14",{"name":201,"class":40},8,{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":51,"minAge":16,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":21,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":41},"100533624","rtms-concurrent-behavioral-priming-for-reducing-smoking-cravings-100533624","NCT06228235","rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings","Optimizing the rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings","Inclusion Criteria:\n\n* Able to provide written informed consent, and to follow study procedures\n* Active cigarette smoker consuming at least 8 cigarettes a day for at least 6 months.\n* Dual use of cigarettes and e-cigarettes is permitted.\n\nExclusion Criteria:\n\n* History of epilepsy or seizure disorder\n* History of cerebral vascular accident or cortical stroke\n* History of brain lesions (such as multiple sclerosis, tumor)\n* History of moderate or severe traumatic brain injury\n* Possible DSM-5 Axis-I disorders as suggested by scores on the DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure (41) exceeding any domain thresholds set by ratings of 2 or higher on individual item, with two exceptions. 1) For depression and anxiety, item scores of 3 or higher will be exclusionary. 2) For substance use (except nicotine\u002F tobacco and alcohol), item scores of 1 or higher will be exclusionary. For alcohol, the item score of 2 or higher will be the exclusionary.\n* Active suicidal ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)\n* Pregnancy\n* Positive urine toxicology for recreational drugs of abuse\n* Shoulder-to-shoulder width of \\> 60cm (24'') to ensure fit in the MRI scanner\n* Positive responses to the TMS Screening Form or the MRI checklist that preclude participation at the discretion of the investigator\n* Intracranial metallic objects (excluding dental fillings)\n* Prior rTMS treatment\n* Current treatment with varenicline or nicotine replacement therapy (NRT)\n* A score of \\> 6 on the Readiness to Quit Ladder (42) for smoking\n* Intake of one or a combination of the following drugs presenting a 'Strong Potential Hazard' for application of rTMS due to their significant seizure threshold lowering potential:\n\n  * Imipramine, Amitriptyline, Doxepine, Nortriptyline, Maprotiline, Chlorpromazine, Clozapine, Foscarnet, Ganciclovir, Ritonavir, Amphetamines, Cocaine (MDMA, ecstasy), Phencyclidine (PCP, angel's dust), Ketamine, Gamma-hydroxybutyrate (GHB), Alcohol, Theophylline.\n  * The urine toxicology panel will verify the presence of some of these drugs prior to each rTMS session\n* Recent withdrawal from one of the following drugs representing a 'Strong Relative Hazard' for application of rTMS due to the resulting significant seizure threshold lowering potential:\n\n  * Alcohol, Barbiturates, Benzodiazepines, Meprobamate, Chloral hydrate","60 Years",{"count":86,"type":20},[56],"The objective of this pilot clinical trial is to test the effects of different types of thinking strategies at the time of repetitive Transcranial Magnetic Stimulation (rTMS), applied to the left Dorsolateral Prefrontal Cortex (DLPFC), on smoking craving and brain activity. Participants will be individuals with moderate to high smoking dependence (smoking at least 8 cigarettes a day) who have no intention of quitting in the next 3 months and are eligible to have rTMS and functional magnetic resonance imaging (fMRI). The main objectives of the trial are:\n\n1. To compare the craving-reducing effects of \"upregulation\" and \"downregulation\" of craving while looking at pictures related to cigarette smoking during rTMS versus no regulation of craving while looking at neutral pictures unrelated to smoking. 'Upregulation\" is thinking about the immediate positive experience of smoking. \"Downregulation\" is thinking about the long-term negative consequences of smoking.\n2. To examine changes in brain activity that accompany craving reductions produced by rTMS paired with upregulation and downregulation of craving while looking at pictures related to cigarette smoking versus no regulation of craving while looking at neutral pictures unrelated to smoking.\n\nFollowing screening for eligibility, participants will be trained on how to do upregulation and downregulation of craving. The participants will then participate in 3 testing sessions. In each session, the participants will receive rTMS at 20Hz in 50 trains (2000 pulses total), followed immediately by fMRI. Sessions will take place 1-2 weeks apart and will differ in the type of thinking strategy participants will use while looking at pictures during the rTMS:\n\n* upregulation of craving while viewing smoking-related images\n* downregulation of craving while viewing smoking-related images\n* no regulation of craving while viewing neutral smoking-unrelated images\n\nThe order of sessions will be randomized across participants.",[28,184],"2025-04-05",{"date":225,"type":33},"2025-04-09",{"date":227,"type":33},"2024-04-16",{"date":229,"type":20},"2026-05",{"name":231,"class":40},"West Virginia University",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":51,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":21,"phases":242,"briefSummary":243,"conditions":244,"keywords":247,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":41},"100568001","detour-a-smartphone-game-to-help-youth-quit-smoking-100568001","NCT06675526","Detour: a Smartphone Game to Help Youth Quit Smoking","Inclusion Criteria:\n\n1. aged 16 to 25 years\n2. smokes at least weekly\n3. motivated to quit smoking (participants should answer \"misschien\", \"waarschijnlijk\" or \"heel erg\" to the question are you motivated to quit smoking at this specific moment?).\n4. installed Detour application; only applicable for participants assigned to the game intervention group.\n\nExclusion Criteria:\n\n1. younger than 16 or older than 25\n2. smoke less than once a week\n3. not motivated to quit smoking are not eligible for this study i.e. participants who answered \"helemaal niet\"\u002F\"not at all\") or \"onwaarschijnlijk\"\u002F\"unlikely\" to the question are you motivated to quit smoking at this specific moment?).","16 Years","25 Years",{"count":241,"type":20},604,[56],"The researchers are testing a mobile game (named Detour) to support smoking cessation in adolescents and young adults (16-25 years). The game will be tested in a randomized-controlled trial (RCT) where Detour is tested against a digital self-help brochure (\"Jouw eigen plan om te stoppen met roken\" \\[in English: Your personal plan to quit smoking\\]) as the active control group. The researchers will recruit 604 participants (aged 16-25) and randomly assign them to receive the game or brochure intervention. The duration between pre-test and post-test for both groups is 5 weeks during which participants can access (parts of) their respective intervention. All participants quit smoking at the end of week 1 of the intervention period. Data is collected on smoking behaviour, intervention usage, and emotional well-being.",[27,28,245,246],"Adolescent Behavior","Social Behavior",[248,249,250,251,252],"Behaviour change","Game intervention","Peer influence","Smoking cessation","Youth","2024-11-07",{"date":255,"type":33},"2024-11-08",{"date":257,"type":33},"2024-07-05",{"date":259,"type":20},"2026-08-31",{"name":261,"class":40},"Behavioural Science Institute"]