[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"social-cognition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:social-cognition":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,84,112,139,166,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100498716","evaluation-of-social-cognition-in-patient-with-type-1-or-type-2-narcolepsy-versus-patients-with-idiopathic-hypersomnia-100498716",false,"NCT05773872","Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic Hypersomnia","COGNAR","Inclusion Criteria:\n\n* adult patients (\\>\u002F= 18years old)\n* diagnosis of type 1 or type 2 narcolepsy or idiopathic hypersomnia\n* non opposition\n\nExclusion Criteria:\n\n* comorbid psychiatric or neurologic disease\n* patient under 18 years old\n* patient under guardianship, curators or deprived of liberty, refusal of the patient","ALL","18 Years",{"count":19,"type":20},75,"ESTIMATED","INTERVENTIONAL",[23],"NA","Narcolepsy is a chronic disabling neurologic disorder mainly characterised by excessive daytime sleepiness. Type 1 narcolepsy is associated with a deficit of hypocretin in the cerebrospinal fluid responsible for the cataplexy symptom while type 2 shows a normal hypocretin level and no cataplexy. While the development of narcolepsy is independent of parental social level, narcolepsy has a significant influence on educational level, grading, social outcome, and welfare consequences. Several studies assessed global cognition efficiency, mood, and attention in narcoleptic patients but only a few specifically measured social cognition and mostly without a control group.\n\nIn a population of narcoleptics children, a severe impairment in social cognition is described for 20% of the group, contrary to 2 % for the control group. The literature also depicts some impairments in decision making, somatic and cognitive emotions responses but the emotion recognition seems to be preserved.\n\nA better understanding of the social and cognitive aspects of narcolepsy could lead to a better treatment of the disease in its entirety, including if relevant specific cognitive behavioural therapy.\n\nThe protocol consists in a psychometric evaluation including several questionnaires in order to assess social cognition. It will be proposed to patients with type 1 or type 2 narcolepsy and patients with idiopathic hypersomnia.",[26,27],"Narcolepsy","Social Cognition",[26,29],"social cognition","RECRUITING","2026-05-28",{"date":33,"type":34},"2026-06-01","ACTUAL",{"date":36,"type":34},"2022-11-18",{"date":38,"type":20},"2027-05",{"name":40,"class":41},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":42},"100637560","using-illusions-to-boost-social-cognition-100637560","NCT07602712","Using Illusions to Boost Social Cognition","Socio-cognitive Benefits of Exposure to Visual Illusions in Patients With Psychotic Disorders","SOLLUSIONS","Inclusion Criteria:\n\n* Aged 18 to 40 years\n* Fluent French speaker\n* Has provided written informed consent\n* For individuals under guardianship (curatorship): inclusion is permitted if the curator is available to assist or advise when needed.\n* Established diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or brief psychotic disorder according to theDiagnostic and statistical manual of mental disorders (DSM-5-TR) criteria\n* Presence of social cognition impairment, defined by:subjective complaint reported by the participant or identified by care teams regarding difficulties in social interaction and clinical confirmation of observable difficulties (e.g., social withdrawal, misinterpretation of others' intentions, inappropriate social behaviour)\n* Membership or entitlement to a social security plan\n\nExclusion Criteria:\n\n* Clinical state incompatible with participation in group-based activities (e.g., severe psychomotor agitation, severe behavioural disturbance)\n* Concurrent participation in another social cognition remediation program\n* Diagnosis of intellectual disability\n* Insufficient comprehension of French for verbal interaction and test completion\n* Significant change in psychotropic medication within the past month\n* Uncorrectable visual impairment preventing participation\n* Pregnant women\n* Individuals under full guardianship (tutorship)","40 Years",{"count":53,"type":20},60,[23],"This study aims to explore whether the observation of complex visual objects can help improve social cognition in people living with psychotic disorders. Social cognition refers to the ability to understand what others think, feel, or intend, and plays a key role in social relationships and daily interactions.\n\nMain questions this study aims to answer:\n\n* Does dyadic exposure to complex visual objects improve mental state attribution, as measured by the Faux Pas Test?\n* Does the intervention enhance related domains of social cognition, including implicit intention inference (Hinting Task), interpretation of complex interactions (Movie for the Assessment of Social Cognition, MASC), and reduction of hostile attribution biases (Ambiguous Intentions Hostility Questionnaire, AIHQ)?\n* Are improvements maintained after one month, and do patients who receive the intervention later (waitlist group) show the same benefits once exposed?",[57,27],"Schizophrenia Spectrum Disorders",[59,60,27,61,62,63,64,65,66,67,68,69,70,71,72,73],"Schizophrenia","Psychosis","Mentalizing","Theory of Mind","Cognitive Remediation","Metacognition","Perspective-Taking","Visual Illusions","Viewpoint Illusions","Bottom-Up Intervention","Sensorimotor Rehabilitation","Faux Pas Test","Hinting Task","Social Interaction","Rehabilitation in Psychosis","NOT_YET_RECRUITING","2026-05-19",{"date":77,"type":34},"2026-05-22",{"date":79,"type":20},"2026-07",{"date":81,"type":20},"2029-02",{"name":83,"class":41},"Hôpital le Vinatier",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":16,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":21,"phases":97,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":42},"100621946","social-cognition-screening-100621946","NCT07377227","Social COgnition Screening","Evaluation of Social Cognition: A New Screening Approach for Autism","ECoS-A","Inclusion Criteria:\n\n* ASD Group:\n* Boys or girls diagnosed with Autism Spectrum Disorder (based on clinical tools and observations)\n* Aged between 4 and 10 years old\n* Affiliation with a social security scheme\n* Informed consent of those with parental authority\n* DT Group:\n* Boys or girls\n* Aged between 4 and 10\n* Attending school in the Hauts-de-France region\n* Affiliation with a social security scheme\n* Consent of those with parental authority\n\nExclusion Criteria:\n\n* For ASD: Uncorrected visual or auditory impairments.\n* For DT: Intellectual disability, neurological or genetic disorders, autistic traits reported by teachers. The discrepancy between actual age and abilities calculated on the basis of standardised test scores",true,"4 Years","10 Years",{"count":96,"type":20},128,[23],"Social cognition refers to the mental processes involved in social interactions, including social perception, motivation, communication, emotion recognition, and theory of mind. Face perception plays a key role in children's social development, but children with Autism Spectrum Disorder (ASD) tend to look less at social stimuli, especially faces, than typically developing (TD) peers. Eye-tracking studies highlight these visual exploration differences, linked to difficulties in joint attention, emotion recognition, and theory of mind, as well as in executive and memory functions. Standard diagnostic tests often require active participation and sufficient language, which makes assessment challenging for children with ASD and additional cognitive or language impairments.\n\nThis research project investigates how visual activity supports social cognition depending on cognitive and language levels, hypothesizing that eye-tracking can provide useful indicators for ASD screening and diagnosis.",[100,101,27,102],"Eye-tracking","Autism Spectrum Disorder","Diagnosis",[100,101,27,102],"2026-02-04",{"date":106,"type":34},"2026-02-06",{"date":108,"type":20},"2026-02",{"date":110,"type":20},"2028-12",{"name":40,"class":41},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":42},"100564110","early-phase-1-losartan-and-social-processing-100564110","NCT06624904","Losartan and Social Processing","The Effects of Single-dose Losartan on Social Processing in Healthy Adults: a Randomized Controlled Study","Inclusion Criteria:\n\n* Willing and able to provide informed consent\n* Aged 18-50 years\n* Sufficient written and spoken English skills to understand what the study involves, and to complete the questionnaires\n* Non- or light-smoker (5 cigarettes a day, if vaping: less than 50 puffs)\n* BMI between 18 - 30\n\nExclusion Criteria:\n\n* Current DSM-5 axis-I diagnosis (based on SCID results at screening) or history of a severe psychological disorder such as psychotic disorder, bipolar disorder, alcohol or substance abuse, or post-traumatic stress disorder\n* First-degree family member with severe psychiatric illness (including psychosis, bipolar disorder, unipolar psychotic depression).\n* CNS-medication last 6 weeks (including as part of another study)\n* Current blood pressure or other heart medication, including aliskiren and beta blockers)\n* Diagnosis of intravascular fluid depletion or dehydration\n* History of angioedema\n* Impaired kidney function (based on self-report)\n* Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below 90\u002F50 mmHg (in accordance with established standard definitions)\n* Lifetime history of epilepsy or other neurological disorder, as established by a professional diagnosis (e.g. autism, ADHD)\n* Lifetime history of systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study\n* Significant loss of hearing that is not corrected with a hearing device\n* Women: pregnancy (as determined by a urine test, if the participant's pregnancy status is unknown during the in-person visit), breast-feeding","50 Years",{"count":121,"type":20},68,[123],"EARLY_PHASE1","This study explores the effects of single-dose losartan (50mg) versus placebo on social processing in healthy volunteers.",[27],[127,128,129],"Social Processing","Losartan","Renin Angiotensin System","2025-07-23",{"date":132,"type":34},"2025-07-28",{"date":134,"type":34},"2024-08-19",{"date":136,"type":20},"2025-10-01",{"name":138,"class":41},"University of Oxford",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":92,"sex":16,"minAge":94,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":155,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":42},"100454185","mri-eye-tracking-pairing-a-tool-for-assessing-social-cognition-in-children-with-asd-100454185","NCT05194254","MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD","IRM-ET","Inclusion Criteria:\n\nFor the group of people with Autism Spectrum Disorders (experimental group):\n\n* Age between 10 to 20 years old\n* Diagnosis of ASD (CARS) ≥ 30 performed at inclusion\n* IQ test evaluation (regardless of the result) performed by a trained psychologist\n* Obtaining informed oral and written consent after appropriate information\n* Obtaining informed oral and written consent from the legal guardian after information\n* Be affiliated with social security\n* No contraindication to magnetic resonance imaging\n\nFor the TD (Typical Development) group of people (control group):\n\n* Age between 10 to 20 years old\n* Diagnosis of ASD (CARS) \\\u003C30 performed at inclusion\n* IQ test evaluation (regardless of the result) performed by a trained psychologist\n* Obtaining informed oral and written consent after appropriate information\n* Obtaining informed oral and written consent from the legal guardian after information\n* Be affiliated with social security\n* No contraindication to magnetic resonance imaging\n\nExclusion Criteria:\n\nFor all groups:\n\n* Age outside the range 10 to 20 years\n* Person with a contraindication to MRI (including claustrophobia, pace maker, neurosurgical clips, vascular clips, heart valves, ventriculoperitoneal valves, cochlear implant, neurostimulator, intraocular metal shards, joint prosthesis, etc.)\n* Person suffering from major obesity (\\> 140 kg) not allowing him to enter the tunnel of the MRI machine (diameter \\\u003C70cm)\n* Pregnant or breastfeeding woman\n* Person under guardianship or guardianship or deprived of liberty by a judicial or administrative decision\n\nFor TD people (control group):\n\n* Person with psychiatric disorders such as attention disorder with or without hyperactivity, depression, bipolar disorder and schizophrenia.\n* Person with a neurological history such as epilepsy and \u002F or neurovascular accident.","20 Years",{"count":121,"type":20},[23],"Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an essential step in achieving joint attention. The originality of this study is to improve the design of visual percepts (in the form of video) in order to mimic an ecological environment as much as possible by using MRI-ET coupling. The second originality of this study is the longitudinal exploration of the neurodevelopment of social cognition in autistic children. Studies by the Redcay and Oberwelland teams observe different activations at different ages. The hypothesis is that the perception of joint attention varies over time in people with ASD. To date, there are no studies to determine the influence of childhood neurodevelopment in autistic people on the perception of joint attention. It would be unprecedented to use the MRI-ET pairing as a tool for assessing social cognition as a function of the development of children with ASD.",[151,152,153,27,154],"ASD","Functional Magnetic Resonance Imaging","Eye Tracking","Joint Attention",[151,156,153,29,157],"Functional magnetic resonance imaging","joint attention","2025-05-22",{"date":160,"type":34},"2025-05-28",{"date":162,"type":34},"2022-01-04",{"date":164,"type":20},"2025-06",{"name":40,"class":41},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":92,"sex":173,"minAge":93,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100583272","social-cognition-in-dystrophinopathies-and-neurodevelopmental-disorders-100583272","NCT06874166","Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders","Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders. Behavioural and Psychophisiological Measures","Inclusion Criteria:\n\n* Patients diagnosed with Duchenne and Becker muscular dystrophy (genetic and histological diagnosis and clinical diagnosis) (ambulant and non-ambulant).\n* Patients diagnosed with osteogenesis imperfecta.\n* Control group: participants without any neurological or psychiatric disorder\n\nExclusion Criteria:\n\n* presence of comorbid diagnoses,\n* sensory deficit\n* specific condition that could prevent the application of the tests and tasks under study, such as: a) the need for PEG; b) the need for tracheostomy; c) the need for assisted ventilation.\n* cognitive level lower than 60.","MALE",{"count":175,"type":20},45,"OBSERVATIONAL","The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients affected by Becker (BMD) and Duchenne (DMD) muscular dystrophy, compared with a sample of patients affected by osteogenesis imperfecta (OI), and both compared with a control sample with typical development.\n\nThe secondary aim is to study cortical activity at rest, by means of electroencephalography (EEG), to explore frequencies and time course of EEG responses. Moreover, the relationship between EEG activity and neuropsychological, dispositional and subjective measures will be explored through correlational analyses.",[179,180,27],"Duchenne \u002F Becker Muscular Dystrophy","Osteogenesis Imperfecta (OI)",[27,182,180,183,184,185],"Duchenne \u002F Becker muscular dystrophy","EEG","Interpersonal distance","Interoception","2025-03-11",{"date":188,"type":34},"2025-03-13",{"date":190,"type":20},"2025-09",{"date":192,"type":20},"2027-12",{"name":194,"class":41},"IRCCS Eugenio Medea",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":202,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":207,"conditions":208,"keywords":213,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":225},"100348141","neuropsychological-assessment-of-children-and-adolescents-with-turner-syndrome-100348141","NCT03812913","Neuropsychological Assessment of Children and Adolescents With Turner Syndrome","ENEAST","INCLUSION CRITERIA\n\nTurner syndrome group :\n\n* girls with diagnosed Turner syndrome.\n\nIsolated GHD group :\n\n* girls with diagnosed isolated growth hormone deficiency\n\nAll participants :\n\n* age between 7 years to 16 years and 11 months.\n* informed consent signed by the participant and her parents (or her legal representatives)\n* being registered in the national social security system\n\nEXCLUSION CRITERIA :\n\nTurner syndrome group :\n\n* patients with chronic pathology other than Turner syndrome.\n* karyotype : part of a Y chromosome and r(X) cases.\n* medical treatment other than those usually prescribed in patients with Turner syndrome.\n\nIsolated GHD group :\n\n* patients with chronic pathology other than isolated growth hormone deficiency.\n* medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency.\n\nAll participants :\n\n* diagnosed intellectual disability (IQ\\\u003C70) or intellectual giftedness\n* history of acquired brain injury\n* sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks.\n* insufficient French language proficiency","FEMALE","7 Years","16 Years",{"count":206,"type":20},70,"Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.",[209,210,211,27,212],"Turner Syndrome","Isolated Growth Hormone Deficiency","Cognitive Functions","Pediatrics",[214,211,27,212],"Turner syndrome","2024-12-26",{"date":217,"type":34},"2024-12-30",{"date":219,"type":34},"2019-09-05",{"date":221,"type":20},"2025-12-05",{"name":223,"class":224},"University Hospital, Angers","OTHER_GOV",3]