[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"social-determinants-of-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:social-determinants-of-health":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,83,117,145,174,204,277],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":45,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100641995","human-observatory-study-100641995",false,"NCT07646782","Human Observatory Study","The Human Observatory: A Prospective Individual and Population-Level Study of Aging, Health, and Longevity","HOS","Inclusion Criteria:\n\n* Enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site; OR completion of online health screener with provision of geographic anchor data and consent.\n\nExclusion Criteria:\n\n* Age under 18 years (current protocol; pediatric amendment planned).",true,"ALL","18 Years",{"count":21,"type":22},1000000,"ESTIMATED","OBSERVATIONAL","The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a continuously-ingested ecological data infrastructure spanning environmental exposures, social determinants, genealogical and family history records, mortality data, and population health databases at geographic resolutions from home address to global scale and beyond. The resulting model generates individual screening recommendations informed by population-level causal estimates, and population-level causal forecasts anchored by present-timepoint individual clinical biology. Thus creating a feedback architecture designed to improve both simultaneously.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44],"Aging","Mortality","All-cause Mortality","Life Expectancy","Cardiovascular Diseases","Neoplasms","Cognitive Dysfunction","Metabolic Syndrome","Frailty","Musculoskeletal Disease","Neurodegenerative Disease","Dementia","Activities of Daily Living","Health Related Quality of Life","Disability Physical","Environmental Exposure","Occupational Diseases","Health Equity","Social Determinants of Health",[46,47,48,49,50,51,52,53,54,55,56,57,58,43,59,60,61,62,63,64,65,66,67,68,69],"longevity","biological aging","causal inference","life expectancy","exposome","Environmental Health","Social Determinants","Genealogy","Family History","Human Family Tree","Population Health","Neighborhood Health","Geographic Health Disparities","Mortality Prediction","Biomarker Validation","Cardiopulmonary Exercise Testing","Body Composition","Preventive Medicine","Healthspan","Functional Decline","Centenarian","Space Medicine","Aerospace Medicine","World Model","RECRUITING","2026-06-09",{"date":73,"type":74},"2026-06-15","ACTUAL",{"date":76,"type":74},"2026-04-25",{"date":78,"type":22},"2099-12-31",{"name":80,"class":81},"Longevity Metrics, Inc.","INDUSTRY",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":82},"100640122","exploration-of-acceptability-of-alcohol-interventions-100640122","NCT07580378","Exploration of Acceptability of Alcohol Interventions","A Mixed-methods Study Exploring the Acceptability of Psychosocial Interventions and Social Determinants of Engagement With an NHS-led Alcohol Care Service.","Inclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, and received training in the delivery of psychosocial interventions using the ITEP Manual, and who are still employed by ELHT in other roles (following de-commissioning of the alcohol care service).\n* Patient data under part 2 of the study, who have not opted to have their data removed, in accordance with the NHS MESH, opt out scheme.\n\nExclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, but who no longer work for the trust, or are retired.\n* Clinical staff who did not receive training in the delivery of psychosocial interventions.\n* Any patient data under part 2 of the study, who have opted to have their data removed for use, under the NHS MESH protocols.","67 Years",{"count":92,"type":22},2000,"This is a mixed-methods study consisting of a qualitative assessment the acceptability of psychosocial interventions, delivered by clinical staff. The study will also investigate the correlation between demographic variables and engagement with a North West England, NHS-led, alcohol care service, amongst the patient population.",[95,96,97,98,99,100,44,101,102,103,104,105],"Alcohol Misuse","Alcohol Use Disorder","Behaviour Change","Health Behaviour","Brief Intervention","Outcome Assessment","Psychosocial Intervention","Socioeconomic Factors","Primary Healthcare","Primary Heath Care","Problem Behavior","NOT_YET_RECRUITING","2026-05-05",{"date":109,"type":74},"2026-05-12",{"date":111,"type":22},"2026-05-01",{"date":113,"type":22},"2026-06-10",{"name":115,"class":116},"East Lancashire Hospitals NHS Trust","OTHER",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":17,"sex":18,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":128,"phases":129,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":82},"100551440","health-equity-and-rural-education-here-clinical-trial-100551440","NCT06460116","Health Equity and Rural Education (HERE!) Clinical Trial","Health Equity and Rural Education (HERE!) Clinical Trial: A Healthcare-Community Partnership Leveraging School-Based Community Health Workers to Improve Student Attendance","HERE","Phase I Stakeholder Interviews (nonintervention):\n\nInclusion Criteria:\n\n* A member of the program's Community Advisory Board, including community health workers;\n* Caregiver of a child ages 12-18 from the Southeast Kansas region; or\n* Student at least 12 years in age.\n\nPhase II Feasibility Pilot- SB-CHW Intervention and Enhanced Usual Care Conditions\n\nInclusion Criteria:\n\n* Children ages 12-18 and their parents\u002Fguardians from the Southeast Kansas region\n* Student with or at risk for chronic poor attendance (missing 10% or more of the days that school has been in session at any point in the school year)\n\nExclusion Criteria:\n\n* Parents\u002Fguardians or youth with profound intellectual\u002Fcognitive disability will be excluded.","12 Years",{"count":127,"type":22},126,"INTERVENTIONAL",[130],"NA","The goal of this community-engaged research is two-fold. The first goal is to gather stakeholder feedback to inform a school-based community health worker intervention with youth with poor school attendance and an enhanced usual care condition. The second goal is to evaluate the feasibility of implementing the school-based community health worker intervention and enhanced usual care approach within rural schools.\n\nThe main question it aims to answer is whether it is feasibile to recruit children with poor school attendance and their families to the intervention, to complete the trauma-informed intervention, and to complete the associated study measures of meeting social determinants of health\u002Fmental health needs, school-based health center utilization, and behavioral helath symptoms. At least 38 rural students in grades 6-12 with poor school attendance and their parents\u002Fguardians will meet with the school-based community health worker for support around social determinants of health needs that may be barriers to attendance. Researchers will also assess the feasibility of recruiting at least 10 rural students and their parents\u002Fguardians to complete the study measures in an enhanced usual care condition in which the school-based health center without a school-based community health worker is reminded of the availability of an online social services directory.",[133,134,44,135],"Behavioral Symptoms","Community Health Workers","Educational Problems","2026-04-17",{"date":138,"type":74},"2026-04-20",{"date":140,"type":22},"2026-05-15",{"date":142,"type":22},"2026-12-31",{"name":144,"class":116},"University of Kansas Medical Center",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":128,"phases":156,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":82},"100634028","intensive-case-management-between-va-and-community-care-for-suicide-prevention-100634028","NCT07534358","Intensive Case Management Between VA and Community Care for Suicide Prevention","Improving Access to VA Mental Health and Suicide Prevention Services: A Randomized Clinical Trial of Intensive Case Management Between VA and Community Care (SUPERCEDE RCT)","SUPERCEDERCT","Inclusion Criteria: Veterans must be:\n\n* enrolled in the VA Eastern Colorado Health Care System (ECHCS)\n* able to complete an online questionnaire\n* age 18-80 years\n* able to comprehend and provide virtual informed consent\n* receiving both VA care and VA authorized community care, through the MISSION Act, which is related to any physical or mental health disorder\n* Veteran's non-VA care is authorized (i.e., non-VA care\u002Ftreatment approved in advance by the VA)\n* at risk for suicide, which is defined as any 1 of the following circumstances: a) prior lifetime suicide attempt; b) suicidal ideation in the past month; c) current mental health symptoms, defined as PHQ-9 \\>10, or PCL-5 \\>31\n* psychosocial challenges reported on the ACORN or Assessment of Needs measure\n* issues with VA community care coordination (i.e., Veteran reported challenges, consults canceled in medical record, appointments canceled or rescheduled in medical record, etc.)\n* receiving no or infrequent mental health services at the VA (e.g., seen less than once a month by a mental health provider).\n\nExclusion Criteria: Veterans must be:\n\n* not at imminent risk of suicide or homicide warranting crisis intervention (will be able to participate once stabilized)\n* unable or unwilling to participate in the intervention (e.g., unwilling to provide VA community care information, etc.)\n* without access to a device capable of telephone calls or video calls\n* presenting with any situation which the principal investigator deems this type of care is inappropriate for the Veteran.","80 Years",{"count":155,"type":22},100,[130],"The goal of this randomized clinical trial is to build the evidence base for SUPERCEDE, a suicide prevention focused intensive case management intervention to increase access, improve care coordination, provide suicide prevention monitoring, and procure a timely response of VA mental health and suicide prevention services among VA-enrolled veterans receiving VA authorized community care. This phase is a hybrid effectiveness Type 1 randomized control trial, which will include 2 arms: the treatment intervention, SUPERCEDE, and the control intervention, present centered therapy. The main questions it aims to answer are:• This RCT will continue to build the evidence base for effectiveness and determine feasibility and acceptability for the previously piloted SUPERCEDE. • This RCT will improve the understanding of implementation of this intervention, both in VA and VA authorized community care organizations in preparation for broader implementation. Researchers will compare SUPERCEDE and present centered therapy to see if SUPERCEDE results in improved functioning and a decrease in suicidal ideation. Participants will be randomized to either SUPERCEDE or present centered therapy (PCT) plus a safety plan if warranted. SUPERCEDE is a suicide prevention case management intervention that combines BCBT-SP, a Crisis Response Plan (CRP), intensive case management to alleviate suicide risk factors, and VA authorized community care coordination. PCT is an active control condition often used in clinical trials of posttraumatic stress disorder. The intervention focuses on the present moment and encouraging the client to find solutions to their problems. In this trial, investigators will mirror the sessions of PCT to SUPERCEDE. Thus, the control group will receive 3 sessions, with an optional 3 additional sessions.\n\nDetailed Description For hypothesis 3a: Overall, 100 participants will be randomized to either SUPERCEDE or present centered therapy (PCT) plus a safety plan if warranted. SUPERCEDE is a suicide prevention case management intervention that combines BCBT-SP, a Crisis Response Plan, intensive case management to alleviate suicide risk factors, and VA authorized community care coordination. PCT is an active control condition often used in clinical trials of posttraumatic stress disorder. The intervention focuses on the present moment and encouraging the client to find solutions to their problems. In this trial, investigators will mirror the sessions of PCT to SUPERCEDE. Thus, the control group will receive 3 sessions, with an optional 3 additional sessions. The study therapist is trained in both SUPERCEDE and PCT. Recruitment. Eligible participants will be identified through the VA Rocky Mountain Regional (RMR) Medical Center the VA Corporate Data Warehouse (CDW), flyers and advertisements, or through clinician or community referral. A recruitment letter will be sent to participants identified in the CDW. Investigators will attempt to contact potential participants with a warm call by telephone (up to 3 times) after the letter is sent.",[159,160,44],"Suicidal Ideation","Mental Health Issue",[162,163],"suicide prevention","Veteran","2026-04-09",{"date":166,"type":74},"2026-04-16",{"date":168,"type":74},"2024-08-01",{"date":170,"type":22},"2027-06",{"name":172,"class":173},"VA Eastern Colorado Health Care System","FED",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":128,"phases":185,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":82},"100546668","sdoh-homecare-intervention-focus-team-shift-trial-to-improve-stroke-outcomes-100546668","NCT06397937","SDOH-Homecare Intervention Focus Team (SHIFT) Trial to Improve Stroke Outcomes","The SDOH-Homecare Intervention Focus Team (SHIFT) Trial to Mitigate Social Determinants of Stroke Outcomes and Build Community Capacity (The SHIFT Trial)","SHIFT","Inclusion Criteria:\n\n* Ischemic stroke (arterial subtypes) or primary intracerebral hemorrhage (excluding diagnosis of probable cerebral amyloid angiopathy by Boston Criteria)\n* African American\u002FBlack or Hispanic race-ethnicity\n* Age 18-75 years old\n* Have at least 3 SDOH barriers from within the 5 SDOH domains (Social and Community, Education, Economic, neighborhood\u002Fenvironment, Health Care)\n* Have a discharge plan to 1) home with or without home services, or 2) acute rehabilitation with plan to return home after\n* Pre-stroke Modified Rankin Scale score of ≤3\n* Residence in New York City.\n* English or Spanish speaking.\n* Can provide informed consent and engage in the initial assessment prior to stroke discharge\n* Lives in a household with a telephone, and has a caregiver (family member or Home Health Aide) if not fully independent on discharge. If the patient requires a family member to assist with activities of daily living or decision-making, the family member must state a willingness to be present at home visits where their assistance is needed.\n\nExclusion Criteria:\n\n* Discharge disposition to a long-term care facility.\n* Diagnosis of dementia or other neurological diagnosis that affects cognition\n* Diagnosis of active major depression\n* Aphasia severe enough to preclude initial examination\n* Impaired level of consciousness at initial cognitive assessment\n* Subarachnoid hemorrhage\n* Diagnosis of probable cerebral amyloid angiopathy by Boston criteria\n* Life expectancy less than 1 year","75 Years",{"count":184,"type":22},275,[130],"Primary Goal:\n\nTo test the hypothesis that among stroke patients 18-75 years with ≥3 SDOH risk factors, SHIFT will improve: (1) functional outcomes as measured by the SIS (Primary Outcome), (2) physiological outcomes as measured by changes in blood pressure and cognition, (secondary outcomes) and (3) epigenetic allostatic load biomarkers (exploratory outcome) such as DNA methylation (DNAm) and telomere length, at 6 months and 1-year post-stroke, compared with usual care (UC).",[188,44],"Stroke",[190,191,192,193,194],"stroke","social determinants of health","health disparities","community health workers","home visits","2026-04-03",{"date":197,"type":74},"2026-04-08",{"date":199,"type":74},"2024-09-15",{"date":201,"type":22},"2030-01-31",{"name":203,"class":116},"Columbia University",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":17,"sex":18,"minAge":212,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":215,"conditions":216,"keywords":239,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":82},"100469557","generation-victoria-cohort-2020s-a-statewide-longitudinal-cohort-study-of-victorian-children-and-their-parents-100469557","NCT05394363","Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents","Generation Victoria Cohort 2020s. A Statewide Longitudinal Cohort of Victorian Children and Their Parents","GenV","Inclusion Criteria (Children):\n\n* Birth date between 4th October 2021 and 3rd October 2023\n* Live at the time of recruitment\n* Residing in Victoria at the time of recruitment\n* Has a legally acceptable representative capable of understanding the informed consent document and providing consent on the child's behalf, who provides a signed and dated informed consent form (e.g. a parent\u002Fguardian)\n\nInclusion Criteria (Adults):\n\n* Be a parent or guardian of a child who meets the eligibility criteria above\n* Provide a signed and dated informed consent form or have a legally acceptable representative capable of understanding the informed consent document and providing consent on the participant's behalf.\n\nExclusion criteria:\n\n* Children who are deceased at the time of recruitment (i.e. still born or died after birth) and their parents\u002Fguardians\n* Families unable to provide informed consent in any of the languages available","1 Day",{"count":214,"type":22},150000,"Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes. GenV blends study-collected, study-enhanced and linked data. It will be multi-purpose, supporting observational, interventional, health services and policy research within the same cohort. It is designed to address physical, mental and social issues experienced during childhood, as well as the antecedents of a wide range of diseases of ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of children and adults.\n\nThe GenV Cohort 2020s is open to all children born over a two-year period, and their parents, residing in the state of Victoria Australia. The GenV Cohort 2020s is preceded by an Advance Cohort of children born between 5 Dec 2020 and 3 October 2021, and their parents. This comprises all families recruited at GenV's Vanguard hospital (Joan Kirner Women's and Children's) and at birthing hospitals throughout Victoria as GenV scaled up to commence recruiting for the GenV Cohort 2020s. The Advance Cohort have ongoing and full participation in GenV for their lifetime unless they withdraw but may have less complete data and biosamples.",[217,218,219,220,221,222,43,223,44,41,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238],"Mental Health","Child Wellbeing","Infant Health","Child Health","Reproductive Health","Healthy Aging","Quality of Life","Genetics","Cognition","Learning","Child Development","Congenital Abnormalities","Disability","Injuries","Communicable Diseases","Noncommunicable Diseases","Physical Fitness","Diet","Obesity","Allergy and Immunology","Inflammation","Intergenerational Relations",[240,210,241,242,243,220,244,245,246,247,248,249,250,251,56,252,253,254,255,256,257,258,43,259,260,261,262,263,264,265,44,266,267],"Generation Victoria","Cohort Studies","Data Collection","Data Linkage","Midlife Health","Children","Infants","Family","Parents","Mothers","Fathers","Life course perspective","Longitudinal Studies","Genetics, population","Demography","Epidemiology","Health Disparity","Minority Health","Vulnerable Populations","Clinical Trial","Randomized Controlled Trial","Pragmatic Clinical Trial","Health Services Research","Economic Models","Value of Life","Geographic Information Systems","Climate Change","Built Environment","2025-07-30",{"date":270,"type":74},"2025-08-03",{"date":272,"type":74},"2021-10-04",{"date":274,"type":22},"2033-10",{"name":276,"class":116},"Murdoch Childrens Research Institute",{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":17,"sex":284,"minAge":285,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":128,"phases":289,"briefSummary":290,"conditions":291,"keywords":295,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":312},"100504101","teen-mom-study-feasibility-trial-100504101","NCT05843903","Teen Mom Study Feasibility Trial","Teen Mom Study Feasibility Trial: A Multicomponent Digital Health Intervention to Improve Cardiometabolic Health in Pregnant Black Adolescents","Inclusion criteria:\n\n* 15- to 19-years\n* Black or African American\n* \\\u003C20 weeks' gestation\n* Enrolled in WIC\n* Residing in 1 of 8 Mississippi Delta Counties\n* English speaking\n* Own or have personal use of a mobile smart phone\n* Singleton pregnancy\n* Plan to carry the fetus to term and keep the infant after birth\n* No history of chronic medical conditions in the past year that could influence weight loss or gain\n\nExclusion Criteria:\n\n* Restrictions on physical activity or exercise","FEMALE","15 Years","19 Years",{"count":288,"type":22},20,[130],"The proposed multicomponent digital health intervention has the potential to significantly impact the trajectory of maternal health in a rural, pregnant, Black adolescent population with the highest risks for cardiometabolic diseases worldwide. The proposed implementation strategy leverages mobile technologies which are ubiquitous across the socioeconomic gradient and proposes to train young adult WIC moms to deliver peer health coaching in a telehealth setting to address social barriers and support behavior change in pregnant, Black adolescent WIC clients in the Mississippi Delta - a rural region where the population is more than two-thirds percent Black and the teen birth rate is the highest in the United States. This is a scalable and sustainable approach to enhance WIC services and improve WIC's impact on population health and cardiometabolic health disparities in Black women.",[292,293,294,44],"Physical Activity","Sedentary Behavior","Gestational Weight Gain",[296,297,298,299,300,301,302],"implementation science","pragmatic clinical trial","telemedicine","health disparity, minority and vulnerable populations","behavior and behavior mechanisms","adolescent pregnancy","black maternal health","2025-05-13",{"date":305,"type":74},"2025-05-15",{"date":307,"type":74},"2025-04-07",{"date":309,"type":22},"2026-06-01",{"name":311,"class":116},"University of Mississippi Medical Center",2]