[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"social-isolation-in-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:social-isolation-in-older-adults":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,75,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100585012","increasing-physical-activity-through-social-support-and-stress-resilience-100585012",false,"NCT06896825","Increasing Physical Activity Through Social Support and Stress Resilience","Increasing Physical Activity Through Social Support and Stress Resilience (I-PASS) Among Older Adults Living Alone With SCD to Lower ADRD Risk","I-PASS","Inclusion Criteria:\n\n* Aged 60 years or older\n* Living alone and community dwelling\n* Engaging in 60 minutes or less per week of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported decline in cognitive functioning\n* Self-reported ownership of\u002Fwillingness to use a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a wearable activity monitor).\n* Able to read and speak in English. We hope to offer the intervention in Spanish in the future; however, currently, the study materials are only available in English, and participation will require ability to read and respond to study materials.\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 6 months\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Telephone-Montreal Cognitive Assessment (T-MoCA) at the Baseline Session. A score \\\u003C 18 is an exclusion criterion.\n* Individuals with neurodegenerative (e.g., dementia), developmental (e.g., autism), neurologic (e.g., Parkinson's, epilepsy), or major psychiatric (e.g., bipolar, schizophrenia) diagnoses\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 9 or higher on the 15-item Geriatric Depression Scale (GDS) at the Baseline Session \\[scores of 9 and higher are indicative of moderate to severe depression\\]\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)",true,"ALL","60 Years",{"count":21,"type":22},86,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which include social support and stress resilience.\n\nThe primary questions are to determine whether\n\n* the tech-enhanced condition lead to greater physical activity over time?\n* the tech-enhanced condition lead to social support and stress resilience over time?\n* social support and stress resilience mediate the relationship between the study condition and physical activity?\n\nAll participants will engage in self-monitoring of physical activity, will receive weekly text reminders of their physical activity goals for the week, and will receive basic education about the importance of physical activity, social support, and stress resilience for cognitive, physical, and psychological health. Participants in the tech-enhanced condition will also receive access to a study-specific website and virtual coaching to reinforce the information presented. Researchers will then compare the tech-enhanced condition to the basic education condition to determine the benefits of technology to deliver the intervention materials in order to increase physical activity, social support, and stress resilience.\n\nParticipants will:\n\n* Use a Garmin wearable device to monitor their physical activity\n* Be randomly assigned to a basic education condition or tech-enhanced condition\n* Set achievable goals for weekly physical activity, with incremental increases to achieve 7000 average daily steps by the end of the study\n* Respond to surveys to monitor their social support, stress resilience, quality of life, and depression.\n\nThe sample has several risk factors for Alzheimer's disease and related dementias: low physical activity, social isolation risk via living alone, and subjective cognitive impairment. Therefore, a long-term goal includes the determination of the intervention's effectiveness at increasing physical activity, social support, and stress resilience to reduce risk for developing dementia.",[28,29,30,31],"Healthy","Subjective Cognitive Decline (SCD)","Sedentary Behavior","Social Isolation in Older Adults","RECRUITING","2026-06-25",{"date":35,"type":36},"2026-06-29","ACTUAL",{"date":38,"type":36},"2025-06-23",{"date":40,"type":22},"2027-04",{"name":42,"class":43},"Arizona State University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100617518","community-based-social-connection-intervention-program-to-improve-cardiovascular-and-brain-health-100617518","NCT07319663","Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health","Quasi-experimental Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health in Older Adults Living in Rural Ecuador","Inclusion Criteria:\n\nAge 60 years or older Permanent resident of the community for at least one year Able to provide written informed consent Able to participate in community activities and home-based assessments No plans to relocate during the 12-month follow-up\n\nExclusion Criteria:\n\nSevere disability that prevents participation in study activities Diagnosed dementia, major psychiatric illness, or severe cognitive impairment History of stroke with significant functional limitation Terminal illness or medical condition that precludes follow-up\n\n\\-",{"count":53,"type":22},500,[25],"This study evaluates the effectiveness of a community-based social connection intervention program (SCIP) designed to reduce social isolation and loneliness and improve cardiovascular and brain health among older adults living in rural Ecuador. Loneliness and social isolation are recognized risk factors for poor cardiovascular outcomes, cognitive decline, depression, and reduced quality of life. However, evidence from low- and middle-income countries, particularly in rural Latin American settings, remains limited. This protocol describes a quasi-experimental, longitudinal study conducted in three rural villages that have been part of a long-standing population-based cohort.\n\nThe intervention will be implemented in one community and compared with two similar communities that will continue receiving usual community activities. SCIP consists of three components: (1) monthly community activities and educational talks designed to promote social participation; (2) monthly peer-support group sessions facilitated by trained personnel; and (3) individualized home-based coaching delivered twice per month, incorporating principles of Social Cognitive Theory and Cognitive Behavioral Therapy. The program aims to strengthen social networks, enhance coping skills, and promote healthier behaviors.\n\nParticipants aged 60 years and older will be enrolled and followed for 12 months. Assessments will occur at baseline, 6 months, and 12 months. Primary outcomes include changes in social isolation (Lubben Social Network Scale-6) and loneliness (De Jong Gierveld Scale). Secondary outcomes include cardiovascular health (Life's Essential 8), sleep quality (Pittsburgh Sleep Quality Index), cognitive performance (Montreal Cognitive Assessment), depressive symptoms (DASS-21), and quality of life (SF-36). Exploratory outcomes include incident stroke, cardiovascular events, and mortality, monitored through ongoing community surveillance.\n\nThis study will generate evidence on the feasibility and impact of a culturally adapted, community-based intervention to promote social connection and healthy aging in a resource-limited rural setting. Findings may inform scalable public health strategies for older adults in similar contexts.",[31,57,58,59],"Loneliness","Stroke","Cognitive Decline",[61,57,62,63,64,65],"Social isolation","Social support","Community Health Services","Rural population","Aged","2026-06-09",{"date":68,"type":36},"2026-06-11",{"date":70,"type":36},"2026-06-01",{"date":72,"type":22},"2027-06-01",{"name":74,"class":43},"Universidad de Especialidades Espiritu Santo",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100602422","capable-care--connect-100602422","NCT07123298","CAPABLE Care + Connect","CAPABLE Care + Connect: Pilot Feasibility of Implementing CAPABLE Into Homebased Primary Care","Inclusion Criteria:\n\n* Any patient currently in JHOME\n* At risk for or experiencing social isolation as defined by the Lubben Social Network Scale 6 item score less than or equal 12 points or loneliness as defined by the UCLA Loneliness Scale 3 item score of 6 to 9 points\n* Cognitive inclusion criteria Montreal Cognitive Assessment (MOCA) \\>23 as determined by referring JHOME study team member provider\n* English speaking (measures are standardized in English)\n* Ability to participate in an approximately 45-60 min virtual or in person meeting\n* Eligible for CAPABLE\n* 50 years or older\n* Not hospitalized over night more than 4 times in the last 12 months\n* Have some difficulty with any ADL\n* Cognitively intact\n* Live in Baltimore County or Baltimore City\n* Not receiving active cancer treatment\n* Interested in participating in CAPABLE Care partners will be included if the care partners provide \\> 10 hours of care\u002Fweek\n\nExclusion Criteria:\n\n* Terminally ill\n* live in long term care setting\n* receiving active cancer treatment\n\nStandard of Care\u002FComparison group Inclusion Criteria:\n\n• Any patient currently in JHOME who did not receive the CAPABLE intervention","50 Years",{"count":84,"type":22},450,[25],"In this evaluation scale-up research project, the investigators seek to test an implementation of CAPABLE on the infrastructure of home-based primary care for individuals who may experience social isolation and\u002For loneliness. These two home-based care programs may improve each other and provide opportunity to further improve quality of life for people living with disabilities and the caregivers. The purpose of this mixed methods study is to adapt and test CAPABLE, an existing evidence-based program, to a new target population with the scalable infrastructure of home-based primary care.",[31,88,89,90,91,92],"Social Isolation or Loneliness","Social Isolation","Quality of Life","Disability Physical","Homebound Persons",{"date":94,"type":36},"2026-06-02",{"date":96,"type":36},"2025-08-14",{"date":98,"type":22},"2027-05",{"name":100,"class":43},"Johns Hopkins University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":119,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":44},"100605296","tech-based-respite-care-for-caregivers-and-homebound-older-adults-100605296","NCT07160673","Tech-based Respite Care for Caregivers and Homebound Older Adults","Tech-based Respite Care for Caregivers and Homebound Older Adults: A Randomized Controlled Trial","TechRespiteRCT","Caregivers (CGs)\n\nInclusion Criteria:\n\n* Aged 18 or above\n* Provide care to at least one homebound older adult (aged 60 or above)\n* Provide no less than 6 hours of caregiving per week\n* Able to communicate in either Cantonese, Mandarin or English\n* Willing to participate for the entire duration\n* Able to tolerate VR headset for at least 5 minutes (no severe motion sickness\u002Fepilepsy)\n\nExclusion Criteria:\n\n* History of severe psychiatric disorders (e.g., schizophrenia, bipolar)\n* Severe cognitive impairment (MMSE \\\u003C10)\n* Major neurological diseases (e.g., recent stroke, severe Parkinson's)\n* Uncorrectable visual\u002Fhearing impairments affecting VR\u002Fvideo\n* Unable to tolerate VR due to motion sickness or discomfort\n* Care recipient receiving long-term care service that conflicts with study\n\nCare Recipients (CRs)\n\nInclusion Criteria:\n\n* Aged 60 or above\n* Homebound (unable to leave home without assistance)\n* Stable medical condition\n* Willing to participate for the entire duration\n* Able to tolerate VR headset for at least 5 minutes (no VR contraindications)\n* Able to understand and provide informed consent Exclusion Criteria: Same as CGs, plus MMSE \\\u003C10","18 Years",{"count":111,"type":22},180,[25],"The goal of this study is to examine the effectiveness of VR-based respite in improving cognitive function, mental health, and quality of life in caregivers and homebound older adults compared to a control group using videos and a usual care group. Participants are randomly assigned to one of three groups: VR intervention, video control, or usual care.\n\nThe VR group receives immersive VR sessions using the SilVR Adventures platform. The video group receives non-immersive video sessions with similar content. The usual care group receives no additional intervention.\n\nAssessments are conducted at baseline, immediate post-intervention, and 3 months post-intervention to measure changes in depression, anxiety, loneliness, quality of life, and other outcomes. The intervention dosage will be 4 weeks (1 sessions\u002Fweek; 30 min\u002Fsession).\n\nSecondarily, the study explores differences in effectiveness between caregivers and homebound older adults, and potential moderators or mediators such as baseline health status, technological literacy, and social support.",[115,31,116,117,118],"Caregiver Stress","Cognitive Decline in Older Adults","Depression in Older Adults","Anxiety in Older Adults",[120,121,122,123,124,125,126,127],"Virtual Reality","Respite Care","Caregivers","Older Adults","Randomized Controlled Trial","Mental Health","Cognitive Function","uality of Life","NOT_YET_RECRUITING","2025-09-06",{"date":131,"type":36},"2025-09-12",{"date":133,"type":22},"2025-09-01",{"date":135,"type":22},"2027-02-28",{"name":137,"class":43},"Hong Kong University"]