[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"socioeconomic-adversity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:socioeconomic-adversity":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100581395","early-assessment-and-initiation-of-guideline-directed-evidence-based-management-hf-100581395",false,"NCT06849752","Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF","EAGLE-HF is Part of a Multinational Group of Studies Titled; Screening for Early Heart Failure Diagnosis and Management in Primary Care or at Home Using Natriuretic Peptides and Echocardiography","EAGLE-HF","Inclusion Criteria are patients enrolled in SYMPHONY as described below:\n\n* ≥40 years old at enrollment\n* Willing to sign informed consent\n* Specific Activity Scale results that match a NYHA-FC score II-IV\n* Has a minimum of 2 documented risk factors for heart failure:\n* Established cardiovascular disease (e.g. persistent or permanent atrial fibrillation, myocardial infarction\u002F coronary artery disease \\[coronary artery bypass grafting, percutaneous coronary intervention or documented stenosis or an epicardial coronary artery (50% LMS, \\>70% LAD\u002FCx\u002FRCA\\], or valvular heart disease)\n* An established diagnosis of diabetes (type I or II)\n* Persistent or permanent atrial fibrillation (NOT paroxysmal atrial fibrillation)\n* Previous ischemic or embolic stroke\n* Peripheral arterial disease (previous surgical or percutaneous revascularisation or a documented stenosis \\> 50% of a major peripheral arterial vessel).\n* Chronic kidney disease (defined as an estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73m2 or eGFR 60-90 mL\u002Fmin\u002F1.73m2 and UACR \\> 300 mg\u002Fg)\n* Loop diuretic use for \\> 30 days (reported at any time in the 12 months prior to consent)\n* Chronic obstructive pulmonary disease (COPD; evidenced by one of the following; PFTs showing airway obstruction, diagnosis by respiratory physician, CT scan reporting presence of emphysema or treatment with national guideline advocated COPD therapy).\n\nExclusion Criteria:\n\n* Inability to give informed consent; e.g., due to significant cognitive impairment, low English proficiency, inability to read, and\u002For inability to understand consent content or explanations provided by investigators\n* Previous diagnosis of HF (with any ejection fraction and due to any cause)\n* Receiving renal replacement therapy\n* Inability to travel to Cleveland Clinic for biomarker or handheld point-of-care echo with AI (receiving hospice or skilled nursing facility care).\n* Anyone who, in the investigators' opinion, is not suitable to participate in the trial for other reasons e.g. a diagnosis which may compromise survival over the study period; female with a history of left breast mastectomy and breast reconstruction (inability to use AI echocardiogram) or history of only 1 visit to Cleveland Clinic for medical care in any service or with any provider (reflects a lack of using Cleveland Clinic for routine medical care)","ALL","40 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","EAGLE-HF (Early Assessment and initiation of GuideLine-directed Evidence-based management-HF) is a prospective single site study of a multinational, unblinded, randomized-controlled, longitudinal trial called SYMPHONY. Primary, secondary and exploratory outcomes that are part of SYMPHONY are not described herein as they replicate SYMPHONY outcomes. Data associated with SYMPHONY outcomes will be sent to the SYMPHONY coordinating center. In EAGLE-HF, site investigators will examine if a new-onset heart failure (HF) diagnosis are asscoiated with social determinants of health (6 factors), social vulnerability index and distressed community indices. In addition, for patients diagnosed with HFrEF, prescribing patterns (use of and dose of) core HF medications will be assessed for association with physician practice type and medical provider type. Finally, (among participants in the SYMPHONY Active arm, an optimal NTproBNP cut-point will be assessed for diagnosis of HF based on social determinants of health, social vulnerability index, distressed community index, HF risk factors and medical comorbidities.",[25,26],"Heart Failure","Socioeconomic Adversity",[28,29,30,31],"medication prescribing","NTproBNP","Provider type","Social determinants of health","RECRUITING","2026-05-05",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2025-03-11",{"date":40,"type":21},"2031-12",{"name":42,"class":43},"The Cleveland Clinic","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":72,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":44},"100592937","enhanced-mentor-mother-strategy-for-pregnant-and-postpartum-women-living-with-hiv-100592937","NCT06999928","Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV","Pilot Implementation-Effectiveness Study of an Enhanced Mentor Mother Strategy","PIE-eMMs","Inclusion Criteria:\n\n* Pregnant and postpartum women living with HIV (and their infants born during the study)\n* ≥18 years of age\n* Enrolled in PMTCT services at BFSDH\n* Able to understand and provide informed consent in English or Kiswahili\n\nExclusion Criteria:\n\n* Women who are not pregnant or postpartum\n* \\\u003C18 years of age\n* Not enrolled in PMTCT services at BFSDH\n* Unable to understand and provide informed consent in English or Kiswahili\n* Cognitive impairment that would interfere with ability to participate in the study",true,"FEMALE","18 Years",{"count":57,"type":21},200,"INTERVENTIONAL",[60],"NA","Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya. Differentiated service delivery (DSD) is a care model that tailors services based on clients' needs, helping to improve both the quality and efficiency of care.\n\nThis hybrid implementation-effectiveness study will test whether an enhanced MM strategy that uses DSD can be successfully carried out and improve health outcomes for mothers and infants. The study will take place at Burnt Forest Sub-District Hospital (BFSDH) in Kenya.\n\nResearchers will ask:\n\n* Can the enhanced MM strategy be delivered as planned and accepted by patients and staff?\n* Does the strategy improve clinical outcomes like keeping mothers in PMTCT care, achieving HIV viral suppression, completing infant HIV testing, and preventing HIV transmission to infants? Researchers will compare health outcomes before and after the strategy is introduced at BFSDH, and also compare outcomes at other similar clinics that continue with standard MM services.\n\nWomen who choose to participate will meet with a MM during their routine antenatal and postnatal clinic visits. They will be offered the enhanced MM support, but can choose to receive standard care if they prefer.",[63,64,65,66,67,26,68,69,70,71],"Hiv","Transmission Vertical","Viremia","Adherence, Treatment","Stigmatization","Health Care Utilization","Health Care Acceptability","Peer Group","Mothers",[73,74,75,76,77,78,79],"prevention of mother-to-child transmission","retention","implementation","mentor mothers","differentiated service delivery","maternal-child health","Kenya","2025-07-14",{"date":82,"type":36},"2025-07-15",{"date":84,"type":36},"2025-07-10",{"date":86,"type":21},"2026-10-12",{"name":88,"class":43},"Indiana University"]