[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"socket-preservation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:socket-preservation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,47,79,109,137,157,189,213,239,262,283,307],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100638907","injectable-alloplastic-bone-graft-for-socket-preservation-clinical-radiographic-and-histological-evaluation-100638907",false,"NCT07595445","Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation","Clinical, Radiographic, and Histological Evaluation of Injectable Alloplastic Bone Graft in Extraction Socket Preservation","Inclusion Criteria:\n\n* Patient aged between 40 and 60 years.\n* General good health.\n* Presence of a hopeless mandibular posterior tooth that requires extraction.\n* Volunteer subjects have to voluntarily sign an informed consent.\n* Patient Indicated for implant.\n\nExclusion Criteria:\n\n* Patient with systemic disease affection bone metabolism.\n* Large periapical radiographic changes related to the tooth to be Extracted, in the form of abscess, granuloma, or cyst.\n* Teeth need trans-alveolar extraction.\n* Patients with contraindication to surgical treatment.\n* Patients suffering from a psychological disorder.\n* Patients with uncontrolled medical conditions.","ALL","40 Years","60 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.",[27,28],"Tooth Extraction","Socket Preservation",[30,28,31,32,33,34],"Injectable Alloplastic Bone Graft","Bone Regeneration","Clinical Evaluation","Radiographic Evaluation","Histological Evaluation","NOT_YET_RECRUITING","2026-05-14",{"date":38,"type":39},"2026-05-19","ACTUAL",{"date":41,"type":21},"2026-08",{"date":43,"type":21},"2026-11",{"name":45,"class":46},"Suez Canal University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100619392","comparative-analysis-of-2-bone-graft-materials-in-socket-preservation-100619392","NCT07344025","Comparative Analysis of 2 Bone Graft Materials in Socket Preservation","Comparative Analysis of Healing Outcomes Between Two Bone Graft Materials in Socket Preservation Procedure","Inclusion Criteria:\n\n* • Systemically healthy individuals\n\n  * Non-smokers\n  * Age between 21 and 50 years\n  * Indicated for tooth extraction and socket preservation\n  * Good oral hygiene (full-mouth plaque score \\\u003C20%)\n  * Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* • Stage III or IV periodontitis\n\n  * Active periodontal or periapical infection\n  * Severely resorbed sockets (buccal bone height \\\u003C5 mm)\n  * Smoking more than 10 cigarettes per day\n  * Pregnancy\n  * Systemic conditions or medications affecting bone metabolism",true,"21 Years","50 Years",{"count":58,"type":21},18,[24],"Socket preservation procedures after tooth extraction have been designed and implemented to maintain the volume of the bone and gingival tissues, which can decrease following the extraction of the teeth. In this clinical trial we will compare clinically and histologically the effectiveness of two distinct bovine bone graft materials; an allograft and a xenograft, in alveolar ridge preservation procedures following tooth extraction .",[28,62,63],"Alveolar Ridge Augmentation","Dental Implants",[65,66,67],"Alveolar ridge preservation","Allograft","Bovine xenograft","RECRUITING","2026-01-15",{"date":71,"type":39},"2026-01-20",{"date":73,"type":21},"2026-01",{"date":75,"type":21},"2026-04",{"name":77,"class":46},"Pharos University in Alexandria",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":78},"100559832","evaluation-of-dentin-graft-and-i-prf-with-and-without-vitamin-c-for-post-extraction-socket-preservation-100559832","NCT06569264","Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation","Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation. A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nInclusion criteria:\n\n* ≥ 18 years of age.\n* Single extraction of non-molar teeth with periodontally healthy adjacent teeth.\n* Non-contributory medial history.\n* Non- restorable teeth indicated for extraction.\n* Requiring alveolar preservation after tooth extraction prior to placement of dental implant.\n* Participants that are eligible for immediate implantation, yet having factors that are hindering these patients from immediate placement of an implant at the time of extraction (ex: Financial related factors - psychological psychological factors - time related factors).\n* Cooperative patients who are willing to commit for 3 months follow up.\n\nExclusion Criteria:\n\n* Pregnant female.\n* Acute infection at extraction site.\n* Systemic conditions affecting healing (e.g., diabetes, medications as bisphosphonates...)\n* A participant who had radiotherapy or chemotherapy.\n* Psychiatric patient, or with a learning disability, or unable to give consent.","18 Years","65 Years",{"count":89,"type":21},26,[24],"The aim of the study is to evaluate radiographic ridge width change following autogenous demineralized dentin graft (ADDG) and i-PRF addition with and without vitamin C (AA) for post extraction socket preservation.\n\nThe main question is:\n\nIn patient with non-restorable teeth, does adding vitamin C to dentin graft and i-PRF affect the radiographic ridge width of post extraction sockets?\n\nIntervention group:\n\nAlveolar ridge preservation using vitamin C (AA) with autogenous demineralized dentin graft combined with i-PRF.\n\nAdding vitamin C to dentin graft and i-PRF might aid in reducing the dimensional changes, since it increases osteoblast proliferation and viability during socket preservation. Layers of osteoblast cell morphology can be seen at day 11 with the presence of 25mM of vitamin C. By adding vitamin C to i-PRF we can add the advantages of improving soft tissue quality as well.\n\nControl group:\n\nAlveolar ridge preservation using autogenous demineralized denting graft combined with i-PRF.\n\nDentin particle can be used as an excellent autogenous graft material to replace other autogenous graft materials, it can be used in socket preservation. as it enhances bone formation, and has shown an ability to maintain the alveolar ridge dimensions because of its osteo-conductive properties. Moreover, dentin graft is used as a cost-effective grafting material during socket preservation.\n\nThe initial therapy consists of periodontal treatment (phase I therapy) including supragingival scaling, subgingival debridement if needed, adjustment of faulty restoration and polishing. The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques. Flapless and atraumatic tooth extraction will be initiated, Then the sockets will be carefully packed with the allocated graft material that are shaped to match the individual size and contours of each socket. Once the grafts are properly adapted to the sockets, they will be covered with the corresponding graft material, and an absorbable gelatin sponge (gelfoam) will be used for socket and graft material coverage and secured using an internal crisscross knot using 5-0 monofilament polypropylene suture material.",[28],[94,95,96,97,98,99],"Socket preservation","Ridge preservation","Demineralized autogenous dentin graft","i-PRF","vitamin C","ascorbic acid","2025-11-23",{"date":102,"type":39},"2025-12-01",{"date":104,"type":39},"2025-11-04",{"date":106,"type":21},"2026-02-28",{"name":108,"class":46},"Cairo University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":78},"100611331","demineralized-dentin-matrix-versus-mineralized-plasmatic-matrix-on-alveolar-ridge-preservation-in-molar-extraction-sites-100611331","NCT07239193","Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites","Effect of Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites; A Randomized Clinical Trial.","Inclusion Criteria:\n\n\\- Non-restorable tooth indicated for extraction Multi-rooted teeth Age group of 18 to 55 years Patients free from any systemic disease that may affect bone healing.\n\nExclusion Criteria:\n\n\\- Pregnant females Active infection at extraction site Smokers Systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...) Poor oral hygiene. Patient with systemic disease that may affect bone healing. o Uncooperative patient.","55 Years",{"count":118,"type":21},24,[24],"When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction:\n\nDemineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins.\n\nMineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.",[28,122],"Alveolar Ridge Preservation",[124,125,126,127,128,129],"socket preservation","alveolar ridge preservation","DDM","demineralized dentin matrix","MPM","mineralized plasmatic matrix","2025-11-16",{"date":132,"type":39},"2025-11-20",{"date":102,"type":21},{"date":135,"type":21},"2026-11-01",{"name":108,"class":46},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":54,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100566483","socket-preservation-using-socket-plug-technique-with-alloplastic-putty-bone-versus-ice-cream-cone-technique-in-extraction-socket-with-buccal-dehiscence-100566483","NCT06655766","Socket Preservation Using Socket-plug Technique With Alloplastic Putty Bone Versus Ice Cream Cone Technique in Extraction Socket With Buccal Dehiscence.","Socket Preservation Using Socket-plug Technique With Alloplastic Putty Bone Versus Ice Cream Cone Technique in Extraction Socket With Buccal Dehiscence: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Single or double rooted teeth indicated for extraction.\n* Systemically free patient\n* Presence of small buccal dehiscence not exceeding 1\u002F3 of the root.\n* Maxillary and Mandibular Arches\n* Non-smoker\n* Adults or above the age of 21.\n* Able to tolerate surgical periodontal procedures.\n* Full mouth plaque and bleeding scores less than 15%.\n* Compliance with the maintenance program.\n* Provide informed consent\n\nExclusion Criteria:\n\n* Systemic conditions\u002Fdisease that contraindicate surgical procedure.\n* Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy.\n* Extraction socket with intact walls with no buccal dehiscence\n* Patients with large distinct pre-apical pathology\n* Heavy Smokers more than 10 cigarettes a day\n* Patients without availability to attend follow-up visits or patients rejecting to sign the informed consent.\n* Patients with parafunctional habits that produce overload on implant, such as bruxism and clenching.",{"count":145,"type":21},30,[24],"Socket Preservation Using Socket-plug Technique with Alloplastic Putty Bone Versus Ice Cream Cone Technique in Extraction Socket with Buccal Dehiscence: A Randomized Controlled Clinical Trial.",[28],"2025-09-20",{"date":151,"type":39},"2025-09-23",{"date":153,"type":21},"2025-10-30",{"date":155,"type":21},"2026-02-01",{"name":108,"class":46},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":165,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":174,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":188},"100600619","hyaluronic-acid-and-polynucleotides-in-ridge-preservation-100600619","NCT07099846","Hyaluronic Acid and Polynucleotides in Ridge Preservation","The Use of Hyaluronic Acid and Polynucleotides in Ridge Preservation Sites Rehabilitated With a Complete Full Digital Workflow","P-005","Inclusion Criteria:\n\n* ≥25-year-old males and females;\n* good systemic health (self-assessment);\n* presence of an unrestorable\u002Fhopeless tooth with periodontal attachment and buccal bone preserved at least for 2\u002F3rd of the root and not associated with acute periapical pathology;\n* full mouth bleeding and plaque scores ≤ 25%\n\nExclusion Criteria:\n\n* uncontrolled or untreated periodontal disease;\n* history of local (head and neck) radiation therapy in the past 5 years;\n* acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible);\n* medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteoporosis) or transmittable diseases (e.g. HIV-related disease);\n* history of alcohol or drug abuse;\n* smokers of ≥10 cigarettes a day;\n* self-reported pregnancy or lactation.","25 Years",{"count":167,"type":21},40,[24],"The aim of this study is to test the use of a bovine-derived bone graft combined with a polynucleotides-rich hyaluronic acid (PNHA) gel for the preservation of the bone after a tooth extraction (alveolar ridge preservation) and to test the performance of a fully-digital workflow to rehabilitate the site with a dental implant. 40 patients in need for a single tooth extraction will be recruited at Centro di Odontoiatria, Università di Parma and they will be randomly assigned to 2 groups: extraction and spontaneous healing or extraction and regeneration of the site with a bovine-derived bone graft combined with a PNHA gel. At 4 months after extraction an implant will be placed in the extraction site, which will be rehabilitated with a fully-digital workflow and patients will be followed up at up to 12 months post rehabilitation. Two 3D x-rays with a small field of view will be performed immediately after extraction and at 4 months post extraction to plan implant placement. These images will also be used to assess changes in the dimension of the post extraction bone (primary outcome). As part of the study different questionnaires will be administered to assess quality of life and perception of the therapy and the wound exudate in the area of the extraction will be collected non invasively with a collagen sponge to assess the expression of different proteins during the early healing days. On the day of implant placement a sample of bone tissue will also be collected as part of the bone drilling and histologically analysed.",[28,171,172,173],"Implant-supported Single Crowns","Hyaluronic Acid","CAD-CAM",[125,175,176,177,173,178],"hyaluronic acid","polynucleotides","digital workflow","Implant rehabilitation","2025-09-01",{"date":181,"type":39},"2025-09-08",{"date":183,"type":39},"2025-06-09",{"date":185,"type":21},"2028-05",{"name":187,"class":46},"University of Parma",2,{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":4},"100595395","the-effectiveness-of-hyaluronic-acid-in-bone-regeneration-100595395","NCT07031895","The Effectiveness of Hyaluronic Acid in Bone Regeneration","Evaluation of the Efficacy of Xenograft Containing Hyaluronic Acid in Socket Preservation Procedure Radiologically and Histologically: A Prospective Randomized Controlled Clinical Study","socket healing","Inclusion Criteria:\n\n* Socket type: Sockets with less than 50% bone resorption in the buccal and palatal\u002Flingual walls according to the Kim JJ classification (Type I-IVa)\n\nAge range: 18-65 years\n\nAbsence of active periodontal disease\n\nNo systemic diseases\n\nPatients who will attend regular follow-up visits\n\nExclusion Criteria:\n\n* Smoking\n\nUncontrolled systemic disease\n\nPresence of infection in the area\n\nUse of medications affecting bone metabolism\n\nPregnancy or lactation",{"count":198,"type":21},60,[24],"Bone loss due to resorption is commonly observed in the alveolar socket following tooth extraction. This situation makes it difficult to preserve sufficient bone volume that would allow for ideal implant placement in cases requiring dental implants. Alveolar ridge preservation is a procedure aimed at minimizing bone resorption and preserving the volume and morphology of the alveolar ridge after tooth extraction.\n\nThe aim of this study is to evaluate the clinical effectiveness of socket preservation using a xenograft enriched with hyaluronic acid in patients with defective extraction sockets.\n\nThis study is designed as a randomized, controlled clinical trial including three parallel groups:\n\nStudy group - Patients whose alveolar bone was evaluated using cone-beam computed tomography (CBCT) will undergo tooth extraction, followed by the application of a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid into the socket. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas where the graft was applied. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.\n\nComparison group - Patients whose alveolar bone was evaluated using CBCT will undergo tooth extraction, followed by the application of a standard bovine-derived graft\u002Fxenograft into the socket. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas where the graft was applied. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.\n\nControl group - Patients whose alveolar bone was evaluated using CBCT will undergo tooth extraction, and the socket will be left to heal naturally without the application of any graft material. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.",[28],[28,175,203],"bone formation","2025-08-15",{"date":206,"type":39},"2025-08-20",{"date":208,"type":21},"2025-09-02",{"date":210,"type":21},"2026-09-01",{"name":212,"class":46},"TC Erciyes University",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":78},"100599620","alveolar-ridge-preservation-using-autogenous-whole-tooth-graft-with-1-metformin-a-randomized-controlled-clinical-trial-100599620","NCT07086859","Alveolar Ridge Preservation Using Autogenous Whole Tooth Graft With 1 %Metformin :A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* 18 years or older\n* patients requiring single extraction of non-molar tooth\n* extraction sockets having more than 50% buccal alveolar bone loss\n\nExclusion Criteria:\n\n* Pregnancy\n* smokers\n* patients not maintaing good oral hygiene\n* presernce of acute endodontic infection in the tooth to be ectracted\n* medical conditions hindering implant placement\n* uncontrolled diabetes\n* Immune suppression\n* bisphosphanates",{"count":118,"type":21},[24],"This study describes a technique used to preserve the bone dimensions after the tooth extraction inorder to facilitate later on the dental implant placement",[223,224,28],"Dimensional Changes After Tooth Extraction","Tooth Extraaction",[65,124,226,227,228,229,230],"Autogenous Whole tooth Graft","AWTG","Tooth grafting","tooth extraction","bone graft","2025-07-18",{"date":233,"type":39},"2025-07-25",{"date":235,"type":21},"2025-07-30",{"date":237,"type":21},"2026-03-30",{"name":108,"class":46},{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":4},"100591637","sticky-bone-vs-xenograft-with-cross-linked-hyaluronic-acid-in-socket-preservation-100591637","NCT06983015","Sticky Bone vs Xenograft With Cross-linked Hyaluronic Acid in Socket Preservation","The Effect of Sticky Bone vs Cross-linked Hyaluronic Acid With Xenograft in Socket Preservation: Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\>18 years old.\n* Patient with hopeless maxillary anteriors and premolar with cl ii socket that needs extraction and delayed implant placement.\n\nExclusion Criteria:\n\n* Acute abscesses or active infections localized in the proximity of the surgical field.\n* Presence of heavy metallic artefacts that can distort CBCT scans\n* Bad oral hygiene and non-compliance.\n* Systemic diseases interfering with bone healing.\n* Active and progressive periodontal disease\n* Smoking, alcoholism and drug abuse\n* Pregnant and lactating women",{"count":167,"type":21},[24],"The present study aimed to evaluate clinical and radiographic outcomes of sticky bone in comparison to crosslinked hyaluronic acid mixed with xenograft in alveolar ridge preservation.",[28],[251,252],"sticky bone","xenograft with cross-linked hyaluronic acid","2025-05-23",{"date":255,"type":39},"2025-05-29",{"date":257,"type":21},"2025-06",{"date":259,"type":21},"2026-07",{"name":261,"class":46},"Fayoum University",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":22,"phases":271,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":78},"100570489","phase-4-the-local-effect-of-vitamin-k2-on-bone-remodeling-in-socket-preservation-100570489","NCT06707909","The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation","The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation of Mandibular Single Rooted Teeth Randomized Clinical Trail","Inclusion Criteria:• Age \\> 18 years without other age or gender restrictions.\n\n* Patients requiring extraction of mandibular single-rooted teeth.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism.\n\n  * Allergies or sensitivities to hydroxyapatite or Vitamin K2\n  * Untreated or residual periodontal disease;\n  * Uncontrolled diabetes (HbA1c \\> 7.5%);\n  * Head and\u002For neck radiotherapy\n  * Immunosuppressive therapy\n  * Pregnant or nursing\n  * Substance abuse\n  * Treated or under treatment with intravenous amino-bisphosphonates\n  * Patients participating in other studies, if the present protocol could not be properly followed.","80 Years",{"count":20,"type":21},[272],"PHASE4","This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups:\n\nStudy Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability.\n\nControl Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it.\n\nOutcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.",[28],"2025-02-02",{"date":277,"type":39},"2025-02-05",{"date":279,"type":21},"2025-02-15",{"date":281,"type":21},"2025-11-24",{"name":108,"class":46},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":78},"100558567","post-extraction-alterations-following-ridge-preservation-in-the-esthetic-zone-using-partially-demineralized-autogenous-dentine-graft-versus-xenograft-100558567","NCT06552793","Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft","Evaluation of Post Extraction Hard Tissue Alteration Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Patients with non-restorable teeth and Type II extraction socket in the esthetic zone indicated for extraction for periodontal, carious or traumatic reasons.\n* Healthy patients with adequate oral hygiene (bleeding on probing ≤20%; Plaque index ≤20%).\n* Adult patients above 18 years old.\n* Patients accept 6-months follow-up period and provide an informed consent.\n\nExclusion Criteria:\n\n* Heavy smokers (more than 10 cigarettes per day or an electronic cigarette dose of \\>6 mg\u002Fml of nicotine).\n* Patients reporting systemic conditions that may compromise healing or bone metabolism (eg: diabetes).\n* Patients with poor oral hygiene (bleeding on probing \\>20%; Plaque index \\>20%)\n* The presence of acute periapical infection.\n* The presence of severe periodontal destruction.",{"count":291,"type":21},23,[24],"the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Partially Demineralized Dentin graft versus Xenograft in the esthetic zone. as a clinical application in alveolar bone regeneration procedures related to implant dentistry, including socket preservation, alveolar ridge augmentation, after tooth extraction in the esthetic zone. After extraction of non-restorable teeth in the esthetic zone, will ridge preservation with application of partially demineralized autogenous dentin graft produce less hard tissue changes compared to xenograft?\n\nThe initial therapy consists of periodontal treatment (phase I therapy) including supragingival scaling, subgingival debridement if needed, adjustment of faulty restoration and polishing. The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques. Flapless and atraumatic tooth extraction will be initiated, Then the sockets will be carefully packed with the allocated graft material that are shaped to match the individual size and contours of each socket. Once the grafts are properly adapted to the sockets, they will be covered with collagen membrane. The membrane will be shaped to extend 2-3 mm beyond the margins of the extraction socket and positioned just beneath the marginal mucosa. To ensure its stability, a cross-suture will be performed, securing the membrane in place.\n\nIntervention group: The socket will be filled with partially demineralized autogenous dentin graft Control group: The socket will be filled with xenograft . For both groups, All the subjects will be evaluated at pre-surgical, baseline and 6 months post surgical months for clinical parameters and baseline( immediate post-surgical and 6 months post-surgical . Outcomes: Change in radiographic horizontal ridge width at 1mm below the most coronal aspect of the crest , Change in radiographic horizontal ridge width at 3 and 5mm below the most coronal aspect of the crest,Change in radiographic buccal ridge height , Change in radiographic buccal ridge height ,Change in radiographic Palatal ridge height,Percentage of new vital bone formation,Percentage of residual bone graft,Implant Primary Stability.\n\nDetailed Description: This study aims to evaluate clinical, radiographic and histomorphometrica",[28],[124,296,297,298],"ridge preservation","autogenoues partially demineralized dentin graft","xenograft","2024-08-10",{"date":301,"type":39},"2024-08-14",{"date":303,"type":39},"2024-05-01",{"date":305,"type":21},"2025-02-01",{"name":108,"class":46},{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":18,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":317,"conditions":318,"keywords":319,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":78},"100552807","post-extraction-changes-following-ridge-preservation-using-allogenis-dentin-vs-autogenous-partially-demineralized-dentin-100552807","NCT06477887","Post Extraction Changes Following Ridge Preservation Using Allogenis Dentin Vs Autogenous Partially Demineralized Dentin","Evaluation Of Post Extraction Hard Tissue Alteration Following Ridge Preservation in The Esthetic Zone Using Allogeneic Dentin Matrix Versus Autogenous Partially Demineralized Dentine Matrix: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with good health status (ASA-1, ASA-2).\n* Adult patients over 18 years old.\n* Patients with non-restorable teeth in the aesthetic zone for periodontal, carious, or traumatic reasons.\n* Extraction socket with no more than 50% buccal bone loss.\n* Patients accept a 6-month follow-up period (cooperative patients).\n* Patients provide informed consent.\n\nExclusion Criteria:\n\n* Patients reporting systemic conditions that may compromise healing (e.g., uncontrolled diabetes).\n* Patients with poor maintenance of oral hygiene.\n* Pregnancy.\n* Smokers.\n* Patients taking any medications that could compromise healing.",{"count":315,"type":21},32,[24],"Research question:\n\nIn patients with unrestorable anterior teeth, will the use of allogenic dentin matrix be more effective than autogenous partially demineralized dentine matrix (APDDM) in reducing hard tissue changes after post-extraction ridge preservation in the aesthetic zone? After enrolment, periodontal and radiographic examinations will be conducted, and patients with badly unrestorable teeth in the aesthetic zone will be identified. These patients will undergo measurements of mesio-distal distance between adjacent teeth, corono-apical height of bone, the presence of a labial undercut, dehiscence, or fenestration, and the relationship to adjacent teeth using the transgival probing technique and a preapical radiograph, or CBCT.\n\nIn both groups, the desired tooth will be atraumatically extracted under local anaesthesia using peritomies and surgical forceps.\n\nIn the intervention group: preparation of the allogenic dentin matrix.\n\nSteps of Allogenic Dentin Processing:\n\nWashing with distilled water for 30-120 minutes Ultrasonic cleaning cycles: 1st with distilled water for 5-10 minutes, 2nd with 5-7% hydrogen peroxide 10-30 minutes, then 3 minutes with distilled water for 5-10 minutes at 60-80 Defatting with Chloroform Methanol Solution 1:0.5 for 3-12 hours. Demineralization with 0.5% HCL for 10-60 min Dehydration with Neutral Ethyl Alcohol for 30 minutes, then defatting with Chloroform Methanol Solution 1:0.5 for 3-12 hours Washing with normal saline and freeze-drying, then sterilisation using ethylene oxide gas.\n\nAfter the recovery period of 6 months\", a biopsy is taken for cases from the site of the operation for histological evaluation during implant placement.\n\n• In the control group, the teeth will be cleaned and dried, and then the dentin will be ground to obtain particles of a certain size, which will be partially demineralized by using a tooth transformer machine. In both groups, the dentin graft will be placed inside the socket, and then a 5\u002F0 proline suture will be used to fix the collagen membranes to cover the graft. After the recovery period of 6 months\", a biopsy is taken for cases from the site of the operation for histological evaluation during implant placement.\n\nOutcome:\n\nRadiographic bucco-lingual ridge width loss. Radiographic palatal vertical bone changes. Radiographic buccal vertical bone changes. Percentage of new vital bone formation. Percentage of residual bone graft. Implant Primary Stability.",[28],[28,320,321],"Allogenic Dentin Matrix","Autogenous Partially Demineralized Dentine Matrix","2024-08-05",{"date":324,"type":39},"2024-08-06",{"date":326,"type":39},"2024-06-03",{"date":328,"type":21},"2024-12",{"name":108,"class":46}]