[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"soft-tissue-augmentation-at-dental-implants\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:soft-tissue-augmentation-at-dental-implants":157},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,72,108,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641906","evaluation-of-multilayered-prf-in-comparison-with-connective-tissue-graft-by-sohn-ponchos-technique-on-peri-implant-mucosal-enhancement-in-the-esthetic-zone-100641906",false,"NCT07649239","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone. A Randomized Clinical Trial","-Inclusion Criteria: Patients with single bounded missing tooth in the esthetic zone Patients in the age group of 21-65 years Patients having good oral hygiene (mean plaque score of \\\u003C 25%) and with stable periodontal status.\n\n-Exclusion Criteria: Smokers patients Patients with poor maintenance of oral hygiene, as determined by a mean plaque score of ≥ 25% despite efforts by the clinician to improve oral hygiene maintenance.\n\nPatients with medically compromised conditions like uncontrolled diabetes mellitus or any systemic diseases that may result in compromised hard and soft tissue healing.",true,"ALL","20 Years","70 Years",{"count":21,"type":22},26,"ESTIMATED","INTERVENTIONAL",[25],"NA","An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft tissue thickness and increase the width of keratinized tissue around dental implants. The stability of the PRF membrane is maintained by securing it with the healing abutment of the implant. While a few longitudinal studies have assessed the benefits of using PRF membrane with Sohn's Poncho technique in the posterior region, its effectiveness in the anterior region of the mouth remains to be evaluated.",[28,29,30,31,32],"Soft Tissue","Peri-Implant Health","Soft Tissue Augmentation at Dental Implants","Connective Tissue Graft","PRF","RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-16","ACTUAL",{"date":39,"type":37},"2026-01-10",{"date":41,"type":22},"2027-02-01",{"name":43,"class":44},"Gulf Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100638282","volumetric-analysis-of-peri-implant-soft-tissue-changes-between-polyethereketonepeek-anatomic-healing-abutments-and-standard-healing-abutments-in-posterior-single-implant-restorations-100638282","NCT07624331","Volumetric Analysis of Peri-Implant Soft Tissue Changes Between Polyethereketone(PEEK) Anatomic Healing Abutments and Standard Healing Abutments in Posterior Single Implant Restorations","anatomic","Inclusion Criteria:\n\nlegally competent to provide written informed consent form prior to any study related procedures.\n\n* Subjects of either sex or aged 18 above\n* requires replacement of a single missing posterior tooth with adequate mesiodistal dimension (≥8 mm)\n* intact adjacent teeth on both sides with existing opposing tooth condition\n* good oral hygiene, plaque score \\\u003C25% bpe1\n* adequate keratinized mucosa width (kmw) minimum 6 mm at the edentulous site\n* adequate bone volume to accommodate the planned dental implant placement of 5.5 mm diameter and 10 mm in length as verifified by Cone Beam Computed Tomography (CBCT)\n* adequate interoccusal distance (crown height space) of at least 6mm measured from alveolar crest to the occlusal table.\n\nExclusion Criteria:\n\nLocalized or generalized periodontitis\n\n* Presence of active acute infection\n* History of malignancy, radiotherapy or chemotherapy\n* Bone metabolic diseases (e.g.: osteogenesis imperfecta, Paget's disease) or current use of medications affecting bone metabolism\n* Untreated bruxism or parafunctional habits Docusign Envelope ID: FFD7C6C1-66CB-4359-9662-63230F769528 22\n* Severe occlusal discrepancy\n* Any medical condition contraindicating implant placement or alter daily activities to a level consistent with ASA (American Society of Anesthesiologist) III classification (including cardiovascular, hepatic, renal, gastrointestinal, metabolic, neurologic, pulmonary, endocrine, autoimmune or psychiatric disorders)\n* Subjects in need of bone grafting at the site of intended implantation site.\n* Subjects that are pregnant","18 Years",{"count":55,"type":22},38,[25],"This prospective randomized clinical trial will evaluate the clinical outcomes of the implant crown fabricated with standard scan body (control) and polyetheretherketone (PEEK) anatomic healing abutment (test).",[29,59,30],"Peri-Implant Tissues",[59,61,62],"volumetric analysis","soft tissue","2026-05-31",{"date":65,"type":37},"2026-06-03",{"date":67,"type":22},"2026-05-23",{"date":69,"type":22},"2028-10-01",{"name":71,"class":44},"DR NUR HAFIZAH KAMAR AFFENDI",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100637934","assessment-of-soft-tissue-thickness-over-zygomatic-implants-in-atrophied-maxilla-covered-with-buccal-fat-pad-vs-palatal-pedicle-flap-100637934","NCT07574606","Assessment of Soft Tissue Thickness Over Zygomatic Implants in Atrophied Maxilla Covered With Buccal Fat Pad vs. Palatal Pedicle Flap","Inclusion Criteria:\n\nPatients ≥18 years with severely atrophic maxilla.\n\n* Acquired maxillary defects resulting from trauma, pathology, or previous surgical resection.\n* Indicated for zygomatic implant-supported fixed prosthesis.\n* Sufficient mouth opening for zygomatic implants placement.\n* Patients willing to sign informed consent and attend follow-ups.\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease affecting healing (e.g., uncontrolled diabetes, etc).\n* Heavy smokers\n* Previous radiotherapy or bisphosphonate therapy.\n* Active sinus or nasal infection.\n* Severe parafunctional habits (e.g., bruxism).\n* Pregnant or lactating women.\n* Patients with psychiatric disorders affecting compliance.",{"count":79,"type":22},4,[25],"Background and Rationale The rehabilitation of the severely atrophied maxilla utilizing zygomatic implants is a highly predictable and effective treatment modality. However, managing the peri-implant soft tissue in these complex cases remains a significant clinical challenge. Because zygomatic implants frequently emerge through thin, non-keratinized, and mobile alveolar mucosa rather than thick, attached gingiva, the peri-implant environment is highly susceptible to complications. Inadequate soft tissue thickness can lead to mucosal recession, exposure of the implant collar, plaque accumulation, and ultimately peri-implantitis, which threatens the long-term success of the prosthesis.\n\nTo mitigate these risks and achieve an optimal permucosal seal, soft tissue augmentation is often required. Vascularized soft tissue grafts are preferred in these compromised anatomical sites due to their robust blood supply and enhanced healing capacity. The Buccal Fat Pad (BFP) flap is a well-documented and frequently utilized technique for this purpose; however, its volume can be unpredictable, and it may be unavailable due to prior surgeries or anatomical deficiencies. Therefore, evaluating robust alternatives, such as the Palatal Pedicle Flap (PPF)-which utilizes the thick, keratinized palatal mucosa-is critical for optimizing surgical outcomes.\n\nStudy Design and Methodology This study is structured as a prospective, randomized controlled clinical trial utilizing a split-mouth design. The split-mouth approach is strategically chosen to eliminate inter-subject biological and immunological variability, allowing each patient to effectively serve as their own control. Patients presenting with a severely resorbed maxilla requiring bilateral zygomatic implant placement will be enrolled.\n\nFollowing successful implant placement, the right and left maxillary quadrants will be randomized. One side will be assigned to receive soft tissue augmentation using the standard Buccal Fat Pad (BFP) flap, while the contralateral side will be assigned to receive the Palatal Pedicle Flap (PPF).\n\nSurgical Intervention Overview All surgical procedures will be performed under appropriate anesthesia following standard sterile protocols.\n\nFor the BFP side: The buccal fat pad will be accessed via a vestibular mucosal incision, carefully bluntly dissected, mobilized, and advanced over the zygomatic implant collar without tension.\n\nFor the PPF side: A palatal pedicle flap will be meticulously outlined, elevated with its vascular supply intact, rotated, and adapted around the contralateral implant collar.\n\nBoth flaps will be secured using appropriate resorbable sutures to ensure tension-free primary closure and optimal tissue adaptation around the implant abutment interface. Post-operative care will adhere to standard institutional guidelines, including the prescription of appropriate analgesics, antibiotics, and antimicrobial mouth rinses.\n\nClinical Significance By systematically comparing the healing trajectories, tissue stability, and functional outcomes of the BFP and PPF techniques over a 6-month period, this trial aims to provide definitive, evidence-based guidance for soft tissue management in zygomatic implantology. Furthermore, it seeks to validate the PPF as a reliable and predictable reconstructive alternative in clinical scenarios where the buccal fat pad is deemed insufficient or inaccessible.",[83,84,85,30,86,87,88,89],"Atrophic Edentulous Maxilla","Zygomatic Implants","Dental Implant","Soft Tissue Coverage","Buccal Fat Pad","Palatal Pedicle Flap","Zygomatic Implant Recession",[91,92,93,94,95,96,97,98],"atophic edentulous maxilla","zygomatic implants","dental implants","soft tissue augmentation at dental implant site","soft tissue coverage","buccal fat pad","palatal pedicle flap","zygomatic implant recession","2026-05-18",{"date":101,"type":37},"2026-05-20",{"date":103,"type":37},"2025-11-03",{"date":105,"type":22},"2026-08",{"name":107,"class":44},"Future University in Egypt",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":45},"100636180","assessment-of-soft-tissue-thickness-following-utilization-of-buccal-pad-of-fat-versus-platelet-rich-fibrin-for-covering-zygomatic-implants-a-randomized-clinical-trial-100636180","NCT07562334","Assessment of Soft Tissue Thickness Following Utilization of Buccal Pad of Fat Versus Platelet-rich Fibrin for Covering Zygomatic Implants: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Patients with severely atrophic edentulous upper arch (Cawood class IV, V, VI) that could not be restored by other type of treatment\n2. Patients who had at least 8-12 mm vertical bone height in anterior maxilla to allow installation of 2 conventional implants.\n3. Lacking posterior maxillary bone support due to significant sinus pneumatization\n4. Good systemic health (ASA score I-II)\n5. Highly motivated patients\n\nExclusion Criteria:\n\n1. Patient not willing to give his\u002Fher informed consent.\n2. Patients with systemic disease that did not permit the surgical procedure (including general anesthesia).\n3. Patients with uncontrolled diabetes or under bisphosphonate therapy.\n4. Heavy smoker. (\\> 20 cigarettes daily)\n5. Patient with psychiatric problems, severe bruxism or other parafunctional habits.\n6. Acute sinusitis.\n7. Malignancy or pathology in Maxilla or Zygoma.",{"count":115,"type":22},24,[25],"Would buccal pad of fat be comparable to platelet rich fibrin for Zygomatic implant coverage as a step for reconstruction of atrophic posterior maxilla, in terms of peri-implant soft tissue thickness and avoiding complicated postoperative sequalae?",[30],[120],"evaluation of soft tissue thickness around zygomatic implants","2026-04-25",{"date":123,"type":37},"2026-05-01",{"date":125,"type":37},"2025-12-01",{"date":127,"type":22},"2027-05-01",{"name":129,"class":44},"Cairo University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":45},"100629185","adjunctive-keratinized-mucosa-augmentation-in-peri-implantitis-100629185","NCT07471386","Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis","Impact of Keratinized Mucosa Augmentation as an Adjunct to Non-Surgical Therapy in the Management of Peri-Implantitis","Inclusion Criteria:\n\n* Non-smoker\n* Systemically healthy\n* Keratinized mucosa witdh \\\u003C 2 mm\n\nExclusion Criteria:\n\n* İntake of medications that impede periodontal tissue health and healing\n* Pregnancy or lactation","75 Years",{"count":139,"type":22},30,[25],"This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive approach to non-surgical peri-implantitis therapy. The procedure is indicated for patients diagnosed with peri-implantitis who present with an inadequate KM (midbuccal KM height \\\u003C 2 mm). One month after non-surgical therapy, patients in the test group will undergo keratinized mucosa augmentation using an FGG, while patients in the control group will continue with supportive periodontal therapy and regular follow-up visits. The primary outcome measure of the study is the change in probing depth (PD) at 12 months following peri-implantitis treatment.",[143,30],"Peri-implantitis",[143,145,146,147],"Free gingival graft","Inflamation","Soft tissue deficiency","2026-03-10",{"date":150,"type":37},"2026-03-13",{"date":152,"type":37},"2026-03-01",{"date":154,"type":22},"2027-06-01",{"name":156,"class":44},"Gazi University","Soft Tissue Augmentation At Dental Implants"]