[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"soft-tissue-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:soft-tissue-injuries":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,82,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100615522","iastm-effects-on-pain-functionality-and-proprioception-in-subacromial-impingement-100615522",false,"NCT07293702","IASTM Effects on Pain, Functionality, and Proprioception in Subacromial Impingement","**Effect of Instrument-Assisted Soft Tissue Mobilization on Pain, Functionality, and Proprioception in Individuals With Subacromial Impingement Syndrome**","Inclusion Criteria:\n\n* Individuals diagnosed with SIS by MRI\n* Men and women between 40 and 60 years of age\n* Individuals with symptoms persisting for at least one month\n* Individuals with a minimum of 60° of shoulder flexion and abduction range of motion\n\nExclusion Criteria:\n\n* Individuals with a history of surgery on the affected arm\n* Individuals with an open wound on the arm\n* Individuals with an active infection\n* Individuals with inflammatory joint disease\n* Individuals with malignant or benign tumors were excluded from the study.",true,"ALL","40 Years","60 Years",{"count":21,"type":22},38,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study will be to investigate the effects of Instrument-Assisted Soft Tissue Mobilization (IASTM), applied in addition to a conventional exercise program, on pain, range of motion, proprioception, functionality, and quality of life in individuals with Subacromial Impingement Syndrome (SIS).",[28,29,30,31],"Subacromial Impingement Syndrome","Massage","Instrument-Assisted Soft Tissue Mobilization","Soft Tissue Injuries",[33,34,35],"Subakromial Impingement Syndrome","IASTM","Shoulder","RECRUITING","2026-03-24",{"date":39,"type":40},"2026-03-25","ACTUAL",{"date":42,"type":40},"2026-01-25",{"date":44,"type":22},"2026-05-20",{"name":46,"class":47},"Istanbul Medipol University Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100627789","resurfacing-of-foot-and-distal-leg-soft-tissue-defects-using-reversed-pedicled-peroneal-artery-flaps-augmented-by-superficial-sural-artery-100627789","NCT07453199","Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery","Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery: A Prospective Clinical Trial","Inclusion Criteria:\n\n* Patients with soft tissue defects of the distal third of the leg, ankle, heel, or foot requiring flap coverage.\n* Defect size greater than \\[Specify size, e.g., 5x5 cm\\] or involving exposed bone, tendon, or joint.\n* Palpable pulse in at least one of the major vessels Anterior Tibial Artery (ATA) or Posterior Tibial Artery (PTA)) at the ankle level.\n* Informed consent obtained from the patient or legal guardian\n\nExclusion Criteria:\n\n* Patients with peripheral vascular disease (PVD) or diabetes mellitus (DM) or smokers\n* Comminuted fractures of the tibia \\& fibula\n* Patients requiring free flap coverage for massive defects or location beyond the RPAF's reach as the planter aspect of the foot","18 Years",{"count":58,"type":22},30,[25],"Wounds involving the skin and soft tissue of the lower leg, ankle, heel, and foot can be difficult to treat because there is very little skin and tissue available in that area to cover the wound. When the wound is large or involves exposed bone or tendon, a flap, which is a piece of skin and tissue moved from a nearby area, is needed to close it.\n\nThis study evaluates a surgical technique called the Reversed Peroneal Artery Flap (RPAF). In this procedure, a flap of skin and tissue from the outer side of the lower leg is lifted and rotated to cover the wound. The blood supply to the flap comes from the peroneal artery, which runs along the fibula bone, and is augmented by the superficial sural artery to improve flap survival. The study will include 30 adult patients who have soft tissue defects of the distal leg, ankle, heel, or foot. All patients will undergo the RPAF procedure at Assiut University Hospitals, Egypt. The main goal is to measure how well the flap survives after surgery. Secondary goals include assessing complications, functional recovery, and the condition of the donor site.",[31,62,63,64],"Leg Injuries","Foot Injuries","Ankle Injuries",[66,67,68,69,70,71],"Reverse Peroneal Artery Flap","Soft Tissue Reconstruction","Distal Leg Defect","Superficial Sural Artery","Pedicled Flap","Reconstructive Surgery","NOT_YET_RECRUITING","2026-02-27",{"date":75,"type":40},"2026-03-05",{"date":77,"type":22},"2026-04",{"date":79,"type":22},"2027-05",{"name":81,"class":47},"Assiut University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":48},"100473739","phase-3-effectiveness-of-phentolamine-mesylate-as-a-reversing-agent-for-local-anesthesia-in-children-100473739","NCT05448807","Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children","A Randomized Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Decreasing Self- Inflicted Soft Tissue Trauma Following Local Anaesthesia Injection for Dental Procedure in Children: Randomized Clinical Trial","Inclusion Criteria:\n\nChildren aged 5-7 years.\n\n* Patients in need of dental procedures requiring local anaesthesia.\n* Healthy Children without any systemic or mental disorders.\n* Normal lip sensation before administration of LA.\n* Normal paediatric functional assessment battery (pFAB) for smiling, speaking and drinking and absence of drooling.\n\nExclusion Criteria:\n\n* Children seeking dental treatment that does not necessitate local anaesthesia.\n* Children who didn't achieve profound numbness requiring additional anaesthesia.\n* Children who lack the ability to distinct the anaesthetised numb side from the non-anaesthetised one.\n* Children who are not willing to participate in the study.","5 Years","7 Years",{"count":92,"type":22},100,[94],"PHASE3","Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures. The effect of Local anaesthesia can last from 3 to 5 hours due to the presence of vasoconstrictor. The U.S Food and Drug Administration (FDA approved the use of phentolamine mesylate (Oraverse) in May 2008 to be used as a drug in reversing the numbing effect of Local anaesthesia by decreasing the time needed to restore the normal functions of the mouth",[31],[98],"lip biting hematoma","2025-07-06",{"date":101,"type":40},"2025-07-10",{"date":103,"type":40},"2025-07-05",{"date":105,"type":22},"2026-06",{"name":107,"class":47},"Cairo University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":123,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":48},"100491450","a-cross-sectional-observational-study-on-retained-drug-needle-fragments-in-people-who-use-intravenous-drugs-100491450","NCT05679284","A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs","The Prevalence and Predisposing Factors to Retained Drug Needle Fragments in People Who Inject Drugs: a Protocol for a Cross-sectional Observational Study","Inclusion Criteria:\n\n* History of intravenous drug use\n* Current treatment of the drug abuse problem at a local low-threshold drug abuse service unit or primary health care centre.\n* Adherence to fill in the questionnaire\n* Participation to X-ray imaging of injection sites\n\nExclusion Criteria:\n\n* No history of intravenous drug use\n* Does not adhere to fill in the questionnaire or refuses X-ray imaging\n* Pregnancy\n* Underage (18 years old)",{"count":92,"type":22},"OBSERVATIONAL","In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions. Drug needle fragments in subcutaneous tissue may cause local symptoms (usually pain and infections), but they have also been identified as causing emboli to organs. The literature has described numerous case reports of people who inject drugs (PWIDs) and have retained needle fragments. The prevalence of the condition is not known, and the researchers therefore aim to perform the first cross-sectional study of PWIDs to estimate how common needle fragment retentions are and what their risk factors are in this population.",[119,120,121,31,122],"Drug Abuse, Intravenous","Substance Dependence","Needle Injury","Foreign Bodies",[124,125,126],"Intravenous drug use","needle retention","needle fragment","2023-05-30",{"date":129,"type":40},"2023-06-01",{"date":131,"type":40},"2023-05-25",{"date":133,"type":22},"2028-11-15",{"name":135,"class":47},"Tampere University Hospital"]