[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"soft-tissue-management-in-subcrestal-dental-implants\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:soft-tissue-management-in-subcrestal-dental-implants":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100632099","peri-implant-tissues-changes-for-different-abutment-shapes-and-heights-100632099",false,"NCT07509281","Peri-implant Tissues Changes for Different Abutment Shapes and Heights","Influence of Supracrestal Soft Tissue on Peri-implant Bone Changes for Different Abutment Shapes and Heights: A Four-Arm Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Posterior edentulism (premolars\u002Fmolars).\n* Good general and oral health, with controlled plaque and bleeding indices.\n* Sufficient bone height and width for implant placement without the need for bone regeneration procedures. Patients who require indirect sinus lift procedure simultaneously with implant placement may be included in the study.\n* Presence of at least 2 mm of keratinized mucosa around the dental implant.\n* Stable occlusion and healthy periodontium.\n* Insertion torque ≥ 35 Ncm at the time of implant placement.\n* Willingness to comply with study protocol and attend scheduled follow-up visits.\n\nExclusion Criteria:\n\n* Presence of medical conditions that contraindicate implant surgery, such as heavy smoking (\\>10 cigarettes per day), severe bruxism, pregnancy or breastfeeding, bisphosphonate therapy, and patients undergoing chemotherapy or radiotherapy in the head and\u002For neck area.\n* Active periodontal disease or peri-implant infection.\n* Uncooperative patients or patients unable to complete follow- up.\n* Implant failures.",true,"ALL","18 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this randomized clinical trial is to investigate the influence of supracrestal soft tissue on abutments of different heights (2-mm vs. 3-mm) and shapes (cylindrical abutment vs. concave abutment) on changes in the marginal bone level (bone loss and bone remodeling) in healthy, partially edentulous volunteer patients undergoing implant-supported rehabilitation.\n\nThe main questions it aims to answer are:\n\n* Is there any difference in marginal bone loss for different abutment shapes and heights?\n* Do the shape and height of the abutment affect implant success?\n\nAll participants will receive bone-level dental implants placed approximately 2-mm below the bone crest, each receiving a different type of abutment and researchers will see whether the shape and height of the abutment influence the success of the implant, periodontal probing depth (PPD), and bleeding on probing (BoP) comparing four groups of patients:\n\n1. 2-mm high abutments with cylindrical shape.\n2. 2-mm high abutments with concave shape.\n3. 3-mm high abutments with cylindrical shape.\n4. 3-mm high abutments with concave shape.\n\nClinical and radiographic assessments will be performed at abutment placement, at definitive prosthesis placement, and at 1, 3, 6, and 12 months after loading to measure marginal bone loss and peri-implant parameters.",[27,28,29],"Dental Implant-Abutment Designs","Marginal Bone Loss in Different Abutment Designs","Soft Tissue Management in Subcrestal Dental Implants",[31,32,33,34,35],"dental implant","implant abutment","marginal bone loss","prostheses abutment width","prostheses abutment height","RECRUITING","2026-06-03",{"date":39,"type":40},"2026-06-05","ACTUAL",{"date":42,"type":40},"2026-06-01",{"date":44,"type":21},"2027-09-30",{"name":46,"class":47},"University of Valencia","OTHER",1,{"id":50,"slug":4,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100634118","NCT07535528","Implant Placement Depth and Peri-Implant Tissue Outcomes","Influence of Implant Placement Depth (-2 mm vs -4 mm Subcrestal) on Peri-implant Tissue Conditions: a Randomized Clinical Trial Protocol","Inclusion Criteria:\n\n* Patients ≥18 years old with partial edentulism.\n* Need for rehabilitation with fixed implant-supported prostheses in posterior regions.\n* Availability of minimum bone height for implants ≥6 mm in length.\n* Minimum bone width without the need for guided bone regeneration.\n* Supracrestal soft tissue thickness ≥2 mm.\n* Non-smokers or smokers of ≤10 cigarettes\u002Fday.\n* Plaque index and bleeding on probing \\\u003C20%.\n* Probing depth ≤3 mm.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Systemic diseases contraindicating implant surgery.\n* Treatment with intravenous bisphosphonates.\n* Head and neck radiotherapy.\n* Uncontrolled diabetes.\n* Pregnancy or breastfeeding.\n* Alcohol or drug use.\n* Psychiatric disorders.\n* Need for bone regeneration procedures.\n* Inability to complete follow-up.\n* Implant failure during the study period.",{"count":56,"type":21},80,[24],"The primary aim of this randomized clinical trial is to evaluate the influence of subcrestal implant placement depth (-2 mm vs -4 mm) on peri-implant marginal bone level changes, including marginal bone loss and bone remodeling. Secondary outcomes include implant success, peri-implant probing depth (PPD), and bleeding on probing (BoP).\n\nPartially edentulous patients requiring fixed implant-supported prosthetic rehabilitation with two implants in posterior maxillary or mandibular regions will be included. Implants will be placed subcrestally at either -2 mm or -4 mm from the bone crest, following a submerged healing protocol. Allocation to insertion depth will be randomized. Marginal bone level changes will be assessed using standardized periapical radiographs at second-stage surgery, prosthesis placement, and at 1, 3, 6, and 12 months after functional loading. PPD and BoP will be recorded at the same time points.",[60,29,61],"Dental Implant Placement","Marginal Bone Loss",[63,64,65,66],"Dental implant","Subcrestal placement","Marginal bone loss","Insertion depth","NOT_YET_RECRUITING","2026-04-14",{"date":70,"type":40},"2026-04-17",{"date":72,"type":21},"2026-05-15",{"date":74,"type":21},"2027-07-20",{"name":46,"class":47},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100624888","immediate-implants-in-front-teeth-with-bone-loss-regeneration-and-temporary-crown-in-a-randomized-clinical-study-100624888","NCT07415486","Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study","Immediate Implant Placement in Buccal Dehiscence Aesthetic Sites With Simultaneous Regeneration and Immediate Provisionalization: a Controlled Randomized Clinical.","GBR \u002F RCT","Inclusion Criteria:\n\n* • Adult patients with ⩾ 25 years of age.\n\n  * Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.\n  * Periodontal health in an intact or reduced periodontium (2017 World Workshop in Periodontal and Peri-implant Diseases and Conditions) (G. Caton et al., 2018).\n  * Good level of oral hygiene (Plaque Index \\\u003C 20%) (Löe, 1967).\n  * Failing tooth in the anterior area of the maxillary arch (incisors, canines and premolars).\n  * Bone availability for a prosthetically driven single-unit immediate implant.\n  * A peri-implant BBD with a minimum vertical dimension height (VDH) of 3mm, detected by means of a CT imaging.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Keratinized mucosa of at least 2mm on the buccal aspect of the tooth to be extracted.\n\nExclusion Criteria:\n\n* Smokers ⩾ 10 cigarettes per day.\n\n  * Pregnant women or lactating females.\n  * Acute periapical infection.\n  * Presence of buccal\u002Fpalatal and\u002For interproximal gingival recession in the target tooth.\n  * Any systemic disease or medication that contraindicates implant treatment or could influence the outcome of the therapy (i.e., non-controlled diabetes mellitus, osteoporosis, radiotherapy, bisphosphonate medication, ...).\n  * Long-term non-steroidal anti-inflammatory drug therapy (⩾ 3 months).\n  * Lack of primary manual stability of the implant during installation.","25 Years",{"count":86,"type":21},24,[24],"This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence. Traditionally, these defects are treated with a bone graft and covered using a collagen membrane; however, there is ongoing debate about whether the membrane is necessary for optimal regeneration. This study proposes the use of a connective tissue graft instead of a collagen membrane, aiming to improve soft tissue volume and aesthetics without compromising bone healing.\n\nThe objective of the study is to evaluate whether the use of an autogenous connective tissue graft in combination with a deproteinized bovine bone mineral with collagen (DBBM-C) achieves results that are not inferior to the conventional protocol that uses DBBM-C and a collagen membrane. The main outcome variable is the vertical buccal bone gain measured after twelve months of healing.\n\nThe study design is a randomized controlled clinical trial including twenty-four patients divided equally into two groups. Each participant will attend eight follow-up visits over twelve months. After atraumatic tooth extraction, immediate implants (BLC, Straumann) will be placed using a prosthetically guided protocol. Buccal dehiscence will be measured intraoperatively, and a partial-thickness tunnel flap will be prepared to allow soft tissue adaptation and graft placement.\n\nIn the control group, the defect will be filled with DBBM-C and covered with a collagen membrane stabilized with horizontal mattress sutures. In the test group, the defect will receive DBBM-C covered by a connective tissue graft harvested from the palate and fixed in a similar manner. When primary stability is equal to or greater than 35 N\u002Fcm, an immediate screw-retained provisional crown will be delivered; if stability is lower, a customized healing abutment or Maryland-type provisional will be used instead.\n\nAfter three months, digital impressions will be taken to fabricate the definitive zirconia restoration. All restorative steps will be performed by experienced clinicians using a standardized digital workflow. Patients will follow routine postoperative care instructions, including soft diet and restricted brushing in the surgical area for one week.\n\nThe main benefits of this study include advancing the understanding of regeneration strategies for buccal bone dehiscence and improving clinical decision-making in immediate implant protocols. Participants are also expected to benefit from implant-supported rehabilitation, functional restoration, and aesthetic improvement. The potential risks are minimal and limited to typical surgical complications such as discomfort, swelling, or minor infection, which will be managed following established clinical protocols.\n\nIf a patient declines participation, conventional implant treatment will be offered, or alternative prosthetic options such as fixed or removable restorations will be provided. Any intra- or postoperative complications during the study will be treated promptly and documented according to institutional standards.\n\nThe biomaterials used include BLC Straumann implants, Bio-Oss Collagen (DBBM-C), Bio-Gide collagen membranes, and appropriate suture materials. Procedures will employ standard periodontal and tunneling instruments, as well as a digital intraoral scanner for accurate prosthetic fabrication.\n\nStatistical analysis will involve descriptive and inferential methods. The Kolmogorov-Smirnov test will assess normality, and mixed ANOVA models will evaluate differences between groups and across time points. Covariate adjustment will be performed using ANCOVA when necessary, and intra- and inter-examiner reliability will be tested with the intraclass correlation coefficient. The level of statistical significance will be set at 0.05.\n\nThe expected outcome is that the use of an autogenous connective tissue graft will demonstrate bone regeneration results equivalent to those obtained with a collagen membrane, while potentially improving soft tissue thickness and aesthetic integration. This finding would support the clinical use of soft tissue grafts as an alternative to collagen membranes in immediate implant placement within aesthetic regions showing buccal dehiscence.\n\nAll study procedures follow the principles of the Declaration of Helsinki and ethical standards for human clinical research. Participants will receive detailed information about the study protocol and will sign informed consent before inclusion.\n\nIn summary, this study aims to determine whether a connective tissue graft can safely replace a collagen membrane in the management of buccal dehiscence during immediate implant placement, offering comparable regenerative outcomes with possible superior soft tissue aesthetics.",[90,91,92,29],"Immediate Dental Implant Placement","Connective Tissue Graft","Connective Tissue Graft Harvesting",[94,95,96,97,98],"Connective tissue graft","volumen changes in vestibular plate","immediate implant placement","emergence profile","immediate aesthetic crown","2026-02-12",{"date":101,"type":40},"2026-02-17",{"date":103,"type":21},"2026-04-01",{"date":105,"type":21},"2029-07-01",{"name":107,"class":47},"Universitat Internacional de Catalunya"]