[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sore-throat\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sore-throat":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,50,79,111,139,169,199,220,247,272,303,323,353],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100639225","observational-study-of-orosedal-in-sore-throat-and-minor-oral-lesions-100639225",false,"NCT07620353","Observational Study of OROSEDAL in Sore Throat and Minor Oral Lesions","Relief of Sore Throat Pain or Minor Mouth Lesions, Including Minor Aphthous Ulcers, in Children and Adults Treated With OROSEDAL: An Observational Study","Inclusion Criteria:\n\n* Age 8 years or older, including adults.\n* Sore throat or minor mouth lesion, including minor aphthous ulcer or histologically confirmed oral lichen planus, evolving for less than 15 days.\n* Global pain intensity over the previous 24 hours, spontaneous and\u002For during chewing or swallowing, \\>40 mm on a 0-100 mm visual analog scale.\n* OROSEDAL prescription decided by the investigator before inclusion.\n* Written informed consent from the patient or from one parent for minors.\n\nExclusion Criteria:\n\n* More than 3 visible oral mucosal lesions.\n* Post-intubation sore throat.\n* Corticosteroid use ongoing or within 3 days before inclusion.\n* NSAID use ongoing or within 3 days before inclusion.\n* Local treatment on the lesion ongoing or within 3 days before inclusion.\n* Non-opioid analgesics, including paracetamol, ongoing or within 3 days before inclusion, unless continued for at least 24 hours at the same daily dose as during the 24 hours before inclusion.\n* Weak or strong opioid analgesics ongoing or within 3 days before inclusion.\n* Signs suggesting a condition requiring additional investigations according to the investigator, except rapid streptococcal throat testing.\n* Signs suggesting a condition requiring corticosteroid prescription according to the investigator.\n* Systemic disease, such as rheumatoid arthritis, lupus, or Behçet disease.\n* Any contraindication listed in OROSEDAL instructions for use.\n* Known allergy to any OROSEDAL component, including glycerol, tamarind extract, mallow extract, benzyl alcohol, orange blossom flavoring, or xylitol.\n* Non-compliance with precautions for use listed in the instructions for use.","ALL","8 Years",{"count":19,"type":20},124,"ESTIMATED","OBSERVATIONAL","This prospective, multicenter, national, observational, non-interventional post-market clinical follow-up study will evaluate the performance and safety of OROSEDAL in children and adults with sore throat or minor oral lesions, including minor aphthous ulcers and histologically confirmed oral lichen planus. OROSEDAL is prescribed in routine practice before inclusion. Patients will be followed for 6 ± 1 days and will complete self-assessments of pain, swallowing discomfort, treatment use, and adverse events.",[24,25,26,27,28],"Sore Throat","Aphthous Ulcer","Oral Lichen Planus","Minor Mouth Lesion","Oral Pain",[30,31,32,33,34,35,36],"sore throat","aphthous ulcer","mouth ulcer","oral lesion","PMCF","real-world evidence","swallowing discomfort","RECRUITING","2026-05-27",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":41},"2026-03-05",{"date":45,"type":20},"2027-07",{"name":47,"class":48},"Laboratoires Elerte","INDUSTRY",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100590475","different-models-of-tracheal-catheters-are-used-for-female-thyroid-glands-100590475","NCT06967896","Different Models of Tracheal Catheters Are Used for Female Thyroid Glands","A Randomized Controlled Trial Comparing Different Models of Tracheal Tube for Thyroid Surgery in Women","Inclusion Criteria:\n\n* Female;\n* Thyroid surgery should be performed under general anesthesia (GA) at an appropriate time;\n* ASA grade I-III;\n* Aged 18-65 years;\n* BMI less than 35Kg\u002Fm2\n* In line with ethics, patients voluntarily accept this experiment and sign informed consent.\n\nExclusion Criteria:\n\n* Reflux esophagitis, preoperative sore throat, chronic pharyngitis, preoperative hoarseness, use of anticoagulants or corticosteroids, high risk of reflux or aspiration, dysphagia, previous oral or pharyngeal surgical intervention, bleeding disorder, severe heart, lung, liver and kidney dysfunction\n* Upper respiratory tract infection occurred within 2 weeks before surgery\n* Unable to insert ET (no more than two intubations)\n* Patients with hoarseness or sore throat before surgery\n* Language communication, hearing impairment or brain dysfunction such as stroke, unable to communicate","FEMALE","18 Years","65 Years",{"count":61,"type":20},180,"Objective:Compare whether the use of tracheal catheters of models 6.0 and 6.5 causes less sore throat in women after thyroid surgery compared with the traditional use of model 7.0 tracheal catheters.Methods: Investigators enrolled 180 female patients with American Society of Anesthesiologists (ASA) physical status I and III, aged 18-65 years, and scheduled for elective undergoing thyroid surgery with general anesthesia. The participants were randomly assigned into three groups(n=60 each group):Group A: Tracheal catheter group with an inner diameter of 6.0mm, Group B: Tracheal catheter group with an inner diameter of 6.5mm, Group C: Tracheal catheter group with an inner diameter of 7.0mm.The incidence and severity of postoperative sore throat were recorded in three groups at 1 h, 6 h, 24 h and 48 h after operation.",[24,64,65,66],"Tracheal Tubes With an Inner Diameter of 6.0mm","Tracheal Tubes With an Inner Diameter of 6.5mm","Tracheal Tubes With an Inner Diameter of 7.0mm",[68,30,69],"thyroid surgery","Tracheal tube","2026-05-24",{"date":38,"type":41},{"date":73,"type":41},"2025-05-25",{"date":75,"type":20},"2026-10-01",{"name":77,"class":78},"Anqing Municipal Hospital","OTHER",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":49},"100633781","phase-4-effects-of-flurbiprofen-spray-and-ice-cream-for-pain-and-voice-outcomes-after-thyroidectomy-100633781","NCT07531147","Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy","Comparison of the Effects of Postoperative Oral Flurbiprofen (0.25%) Spray and Ice Cream on Analgesia and Voice Quality in Patients Undergoing Thyroidectomy","Inclusion Criteria:\n\n* No history of neck surgery\n* Age between 18-85 years\n* Undergoing thyroidectomy\n* Agreeing to participate in the study\n* Operation duration between 60-120 minutes\n\nExclusion Criteria:\n\n* History of neck surgery\n* History of radiotherapy to the head and neck region\n* Pre-operative or post-operative vocal cord paralysis\n* Pre-operative phonetic disorder\n* Pre-operative laryngeal pathology\n* Being under 18 years of age\n* Refusal to participate in the study\n* Smoking\n* Flurbiprofen allergy\n* Lactose intolerance","85 Years",{"count":88,"type":20},100,"INTERVENTIONAL",[91],"PHASE4","Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality.\n\nParticipants will:\n\n* Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result\n* Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively\n* Undergo a visual analog scale for analgesia status at 6 hours postoperatively",[94,24,95],"Thyroidectomy","Voice Quality",[97,30,98,99,100],"thyroidectomy","voice quality","flurbiprofen","ice cream","NOT_YET_RECRUITING","2026-04-11",{"date":104,"type":41},"2026-04-15",{"date":106,"type":20},"2026-04",{"date":108,"type":20},"2026-09",{"name":110,"class":78},"Izmir Katip Celebi University",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":89,"phases":119,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":49},"100632764","chewing-gum-and-cold-gargle-on-post-bronchoscopy-symptoms-100632764","NCT07517926","Chewing Gum and Cold Gargle on Post-Bronchoscopy Symptoms","The Effect of Chewing Gum and Gargling With Cold Water on Post-Bronchoscopy Sore Throat, Dysphagia, and Patient Satisfaction: A Randomized Controlled Study","Inclusion Criteria:\n\n* • Being 18 years of age or older\n\n  * Having a scheduled diagnostic bronchoscopy\n  * Having normal speech and swallowing functions\n  * Being conscious and able to communicate\n  * Volunteering to participate in the study\n\nExclusion Criteria:\n\n* • Complications during bronchoscopy\n\n  * Gastroesophageal reflux\n  * Use of non-steroidal anti-inflammatory drugs\n  * Receiving steroid treatment within 1 week prior to the procedure\n  * Active infection or disease in the mouth or throat area\n  * History of allergy or intolerance to the procedure\n  * Previous anatomical or functional impediment to chewing gum or gargling",{"count":88,"type":20},[120],"NA","This study aims to evaluate the effects of chewing gum and gargling with cold water on common post-bronchoscopy symptoms, such as sore throat and difficulty swallowing (dysphagia). Bronchoscopy is a procedure that can cause temporary throat discomfort. In this randomized controlled trial, patients will be divided into groups to receive either chewing gum, cold water gargle, or standard care. The researchers will then measure and compare patient satisfaction levels and the severity of throat symptoms to determine if these simple interventions can improve patient comfort after the procedure.",[24,123,124,125],"Dysphagia","Patient Satisfaction","Bronchoscopy",[125,24,123,127,128,129],"Chewing Gum","Cold Water Gargle","Nursing Care","2026-04-07",{"date":132,"type":41},"2026-04-13",{"date":134,"type":41},"2025-11-10",{"date":136,"type":20},"2026-05-11",{"name":138,"class":78},"Ankara University",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":89,"phases":148,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":49},"100615030","endotracheal-tube-suctioning-versus-no-suctioning-during-emergence-from-general-anesthesia-100615030","NCT07287293","Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia","Comparison of Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia With Endotracheal Intubation: A Randomized, Single-Blind Study","Inclusion Criteria:\n\n* Adults aged 18-90 years with American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective surgery under general anesthesia requiring endotracheal intubation.\n* Planned tracheal extubation in the operating room at the end of surgery.\n\nExclusion Criteria:\n\n* Inability to provide informed consent or the presence of a significant language barrier that prevents effective communication with the clinical team.\n* Known diagnosis of obstructive sleep apnea (OSA), active pneumonia, or chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease).\n* Body mass index (BMI) \\>35 kg\u002Fm².\n* Pregnancy or increased aspiration risk (e.g., full stomach).\n* Scheduled for maxillofacial, head and neck, or airway surgery.\n* Anticipated surgical duration \\>3.5 hours.\n* Anticipated difficult airway, defined as the presence of ≥2 predictors of difficult mask ventilation (DMV) based on Langeron et al., or a documented history of difficult intubation.",{"count":147,"type":20},408,[120],"The goal of this study is to determine whether omitting tracheal suctioning immediately prior to extubation is non-inferior to routine tracheal suctioning with respect to early postoperative oxygenation among adult surgical patients (aged 18-90 years, American Society of Anesthesiologists \\[ASA\\] physical status I-III) undergoing elective surgery under general anesthesia with endotracheal intubation.\n\nThe study addresses the following questions:\n\n* Primary outcome (non-inferiority):\n* Is the risk of postoperative desaturation (oxygen saturation \\[SpO₂\\] \\\u003C92% within 60 minutes after extubation) in the no-suction group not worse than in the routine-suction group by more than 10 percentage points?\n* Secondary outcomes (superiority):\n* Does omitting tracheal suctioning reduce postoperative cough severity and sore throat?\n* Does omitting tracheal suctioning avoid increasing extubation-related adverse events?\n\nParticipants will be randomly assigned (1:1) to one of two groups:\n\n* Routine suctioning (SUC): Endotracheal suctioning plus oropharyngeal suctioning immediately before extubation\n* No suctioning (NON-SUC): Oropharyngeal suctioning only, without endotracheal suctioning\n\nAll participants will receive standard anesthetic care and postoperative monitoring in the post-anesthesia care unit (PACU) for 60 minutes. Follow-up for airway symptoms and patient satisfaction will be conducted at 24 hours after surgery.",[151,152,24,153],"Hypoxia","Airway Obstruction, Postoperative","Cough, Postoperative",[155,156,157,151,158,159],"Airway Management","Suctioning","Emergence from Anesthesia","Endotracheal Intubation","Postoperative Complications","2026-01-09",{"date":162,"type":41},"2026-01-12",{"date":164,"type":41},"2026-01-05",{"date":166,"type":20},"2027-03-31",{"name":168,"class":78},"Mahidol University",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":89,"phases":179,"briefSummary":180,"conditions":181,"keywords":184,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":49},"100603559","comparison-of-gastric-volume-in-i-gel-and-proseal-laryngeal-mask-airways-100603559","NCT07138092","Comparison of Gastric Volume in I-gel and ProSeal Laryngeal Mask Airways","Comparison of Gastric Insufflation Volume by Ultrasound Using I-gel and ProSeal Laryngeal Mask Airways in Patients Undergoing Urological Surgery","Inclusion Criteria:\n\n* Patients with an ASA (American Society of Anesthesiologists) physical status score of 1 to 3\n* undergoing urological surgeries performed with I-gel or ProSeal LMA\n\nExclusion Criteria:\n\n* Difficult airway\n* Clinically significant upper respiratory tract infection\n* Pre-existing airway disease\n* Pre-existing airway disease\n* History of head and neck surgery\n* Pregnant patients\n* Patients with upper gastrointestinal tract disease","79 Years",{"count":178,"type":20},50,[120],"This study was planned to compare the gastric insufflation volume between i jel and ProSeal laryngeal mask airway (LMA) and its relationship with the oropharyngeal sealing pressure and the incidence of postoperative complications in patients undergoing urological surgery.",[182,183],"Nausea and Vomiting, Postoperative","Sore-throat",[185,186,187,188],"Gastric insufflation","Ultrasound","Supraglottic airway devices","Oropharyngeal leak pressure","2025-08-15",{"date":191,"type":41},"2025-08-22",{"date":193,"type":20},"2025-08-18",{"date":195,"type":20},"2025-10-10",{"name":197,"class":198},"Diskapi Yildirim Beyazit Education and Research Hospital","OTHER_GOV",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":89,"phases":208,"briefSummary":209,"conditions":210,"keywords":211,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":218,"leadSponsor":219,"locationsCount":49},"100603558","air-q-in-totally-edentulous-and-dentate-geriatric-patients-100603558","NCT07138079","Air-Q in Totally Edentulous and Dentate Geriatric Patients","The Comparison of the Effectiveness of the Self-Pressurizing Air-Q Intubating Laryngeal Airway in Totally Edentulous and Dentate Geriatric Patients","Inclusion Criteria:\n\n* 65-90 year-old patients\n* Edentulous and gentate patients\n* American Society of Anesthesiologist Physical Status classification I-III,\n* Undergoing an elective operation under general anesthesia in our hospital\n\nExclusion Criteria:\n\n* Predicted difficult airway (Mallampati class 4, mouth opening \\\u003C 3 cm, or thyromental distance \\\u003C 6 cm)\n* Body mass index (BMI) \\> 40 kg\u002Fm2\n* Patients with a high risk of aspiration (e.g., history of gastrectomy, -gastroesophageal reflux disease, or hiatal hernia),\n* Unstable vital signs\n* Cervical spine problems, Respiratory complications (e.g. recent pneumonia).","90 Years",{"count":178,"type":20},[120],"In this study, we aim to investigate the clinical performance, efficacy, and associated complications of the Air-Q Intubating Laryngeal Airway in totally edentulous and dentate geriatric patients.",[159,183],[212,188,213,214,215],"Air-Q Laryngeal İntubating Airway","supraglottic airways","Edentulous patients","Geriatric patients",{"date":191,"type":41},{"date":193,"type":20},{"date":195,"type":20},{"name":197,"class":198},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":227,"sex":16,"minAge":58,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":89,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":245,"locationsCount":4},"100602454","effect-of-nebulized-magnesium-sulfate-on-post-intubation-stress-response-in-patients-undergoing-laparoscopic-cholecystectomy-100602454","NCT07123714","Effect of Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy","Effect of Preoperative Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* American society of anesthesiologists (ASA) physical status I-II.\n* Elective fit laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* • Patient refusal.\n\n  * Patients with history of hypersensitivity to magnesium sulphate.\n  * Patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure on beta blockers or calcium channel blockers expected difficult intubation (Mallampati 4).\n  * Body mass index (BMI) \\> 40 kg\u002Fm2.",true,"70 Years",{"count":230,"type":20},140,[120],"This randomized controlled double blinded study will be carried out on 140 patients underwent elective fit laparoscopic cholecystectomy at El-Rajhi Assiut University Hospital.\n\nInclusion criteria:\n\n* 20-50 years old.\n* Both sexes.\n* American society of anesthesiologists (ASA) physical status I-II.\n* Elective fit laparoscopic cholecystectomy\n\nExclusion criteria:\n\n* Patient refusal.\n* Patients with history of hypersensitivity to magnesium sulfate.\n* Patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure on beta blockers or calcium channel blockers expected difficult intubation (Mallampati 4).\n* Body mass index (BMI) \\> 40 kg\u002Fm2.\n\nAn online randomization program (http:\u002F\u002Fwww.randomizer.org) will be used to generate a random list and each patients' code will be kept in an opaque sealed envelope. Patients will be randomly allocated with 1:1 allocation ratio into two equal groups in a parallel manner:\n\n* Group A: (N=70) Patients will receive nebulized magnesium sulfate in 5 ml (250 mg) over 15 min.\n* Group B: (N=70) Patients received nebulized normal saline in 5 ml over 15 min, ending 5 min before the induction of anesthesia.\n\nA. Preoperative assessment:\n\nAll patients will be subjected to the followings:\n\n1. Demographic data collection (age, weight, height, BMI, and ASA).\n2. Complete clinical examination.\n3. Routine Laboratory investigations:\n\n   * Random blood sugar.\n   * Blood sample withdrawal for cortisol level at baseline 2ml intravenously. The sample will be sent to be centrifugated within 30 minutes and the serum will be separated and stored in -20°C till time of cortisol level by ELIZA technique.",[24],[235,236,237,238],"Magnesium sulfate nebulization","postoperative sore throat","Post-intubation sore throat","Post-intubation stress response","2025-08-08",{"date":241,"type":41},"2025-08-14",{"date":243,"type":20},"2025-08-20",{"date":134,"type":20},{"name":246,"class":78},"Assiut University",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":254,"targetDuration":4,"studyType":89,"phases":256,"briefSummary":257,"conditions":258,"keywords":261,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":4},"100589276","intravenous-lidocaine-plus-intratracheal-dexmedetomidine-on-postoperative-sore-throat-100589276","NCT06952309","Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat","Effect of Intravenous Lidocaine Combined With Intratracheal Dexmedetomidine on Postoperative Throat Pain in Patients Undergoing Thyroid Cancer Surgery","Inclusion Criteria:\n\n* Thyroid cancer surgery with ASA grades I-II\n* Aged 18-65 years\n* The patient's communication is normal and they have a certain learning ability\n\nExclusion Criteria:\n\n* Severe respiratory and circulatory system diseases\n* There was bradycardia (HR \\\u003C 60 beats\u002Fminute) or atrioventricular block before the operation\n* Nervous system disease\n* Mental and psychological disorders\n* Abnormal liver and kidney functions\n* Pregnant and lactating women",{"count":255,"type":20},144,[120],"Objective: The present study was to investigate the effect of intravenous lidocaine combined with intratracheal dexmedetomidine on postoperative sore throat in patients undergoing thyroid cancer surgery.\n\nMethods: Investigators enrolled 144 patients with American Society of Anesthesiologists (ASA) physical status I and II, aged 18-65 years, and scheduled for elective undergoing thyroid cancer surgery with general anesthesia. The participants were randomly assigned into four groups(n=36 each group): Group L received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia. Group D received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group LD received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group C received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia.The incidence and severity of postoperative sore throat were recorded in four groups at 1 h, 2 h, 6 h, 24 h and 48 h after operation.",[259,260,24],"Dexmedetomidine","Lidocaine",[262,263,68,30],"dexmedetomidine","lidocaine","2025-04-28",{"date":266,"type":41},"2025-04-30",{"date":268,"type":20},"2025-04-25",{"date":270,"type":20},"2025-09-25",{"name":77,"class":78},{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":57,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":89,"phases":284,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":49},"100568094","early-phase-1-benzydamine-hydrochloride-and-post-operative-sore-throat-100568094","NCT06676748","Benzydamine Hydrochloride and Post-operative Sore Throat","The Effect of Benzydamine Hydrochloride Spray on Post-operative Sore Throat: a Randomized Controlled Study","DIFFLAM","Inclusion Criteria:\n\n1. American Society of Anaesthesiologists (ASA) physical status 1-2\n2. Female patients having laryngeal mask airway (LMA) for airway management for surgery in KKH;\n3. BMI \\\u003C 40 kg\u002Fm2.\n\nExclusion Criteria:\n\n1. Pregnant;\n2. Pre-existing sore throat, or history of upper respiratory tract infection\u002F abnormalities, hypertension, chronic pain or anti-inflammatory drugs and antihypertensive treatment;\n3. Allergies to benzydamine hydrochloride;\n4. Symptomatic hiatus hernia;\n5. Severe gastroesophageal reflux disease;\n6. Contraindications to the use of LMA.","21 Years","80 Years",{"count":283,"type":20},106,[285],"EARLY_PHASE1","Postoperative sore throat (POST) after laryngeal mask airway (LMA) insertion is prevalent and unappealing. A significant cause of POST is mechanical injury to the airway mucosa during airway instrumentation, leading to mucosal injury and inflammation. The Difflam Forte Anti-Inflammatory Throat Spray (Difflam) contains benzydamine hydrochloride, a non-steroidal anti-inflammatory agent with topical analgesic properties. This study will randomize 106 women undergoing gynaecological surgery under general anaesthesia with LMA use at KK Women's and Children's Hospital (KKH) in 1:1 allocation ratio of study (Difflam spray) and control (usual practice; no intervention) groups. Demographic and intraoperative airway data collection will be conducted in perioperative period. Those allocated to study group will receive Difflam spray when awake in the post-anaesthesia care unit (PACU). The primary aim to determine if patients undergoing general anaesthesia with LMA use with the Difflam spray in PACU will have a lower incidence of POST in the immediate and 4 hours postoperative recovery period, as compared with those in the control group. Other outcome measures include the severity of pain of sore throat as measured by the visual analog scale, and incidence of side effects associated with the Difflam spray. This proposal will determine whether the use of Difflam spray is suitable to be implemented in local clinical setting and improve perioperative care.",[24,288],"Postoperative Care",[290,291,292,293],"Sore throat","Posoperative care","benzydamine hydrochloride","laryngeal mask airway","2025-04-15",{"date":296,"type":41},"2025-04-17",{"date":298,"type":20},"2025-04",{"date":300,"type":20},"2026-12",{"name":302,"class":198},"KK Women's and Children's Hospital",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":281,"enrollmentInfo":309,"targetDuration":4,"studyType":89,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":49},"100574974","the-effects-of-gma-tulip-i-gel-and-blockbuster-laryngeal-mask-in-laparoscopic-surgeries-with-trendelenburg-position-under-general-anesthesia-100574974","NCT06766253","The Effects of GMA-TULIP, I-gel, and BlockBuster Laryngeal Mask in Laparoscopic Surgeries With Trendelenburg Position Under General Anesthesia","Inclusion Criteria:\n\n1. Patients received laparoscopic surgeries with trendelenburg position and an estimated surgery duration of less than 3 hours.\n2. Ages between 18 to 80, and body mass index less than 28 kg\u002Fm².\n3. American Society of Anesthesiologists (ASA) Grades I-III.\n4. Patients are willing to participate and be able to understand and sign an informed consent form.\n\nExclusion Criteria:\n\n1. Patients with a mouth opening less than 2 cm.\n2. Patients with risk factors for regurgitation and aspiration of gastric contents.\n3. Patients with laryngopharyngeal diseases.\n4. Patients with potentially difficult airways.\n5. Patients with hearing, intellectual, communication, and cognitive impairments.\n6. Any reason that patients could not cooperate with the study or that the researcher deems inappropriate for inclusion in this trial.",{"count":310,"type":20},195,[120],"This project aims to compare the application effects of traditional inflatable BlockBuster laryngeal mask, i-gel non-inflatable laryngeal mask and GMA-TULIP non-inflatable laryngeal mask in laparoscopic surgeries with trendelenburg position under general anesthesia, in order to explore which laryngeal mask is best for reducing postoperative throat pain of patients and improving patient comfort and satisfaction.",[183],"2025-01-05",{"date":316,"type":41},"2025-01-09",{"date":318,"type":41},"2024-08-21",{"date":320,"type":20},"2026-06-01",{"name":322,"class":78},"The Second Affiliated Hospital of Chongqing Medical University",{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":11,"sex":16,"minAge":331,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":89,"phases":334,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":352},"100368907","phase-4-sore-throat-in-primary-care---a-comparison-of-phenoxymethylpenicillin-and-no-antibiotic-treatment-100368907","NCT04083417","Sore Throat in Primary Care - a Comparison of Phenoxymethylpenicillin and No Antibiotic Treatment","A Randomized Controlled Clinical Trial of Streptococcus Group A-negative Acute Tonsillitis in Primary Health Care - a Comparison of Phenoxymethylpenicillin and No Antibiotic Treatment","SANT","Inclusion Criteria:\n\n' Centor score 3-4: absence of cough, anamnestic fever (temperature \\>38.5°C), tender cervical lymphadenitis, and tonsillar exudates (one or both tonsils)\n\n* Duration of symptoms \\\u003C 8 days\n* Rapid antigen detection test for GAS taken and negative\n* Willing and able to give informed consent. Subjects under 18 years of age must in addition have the consent from both parents\u002Fcaretakers\n\nExclusion Criteria:\n\n* Ongoing antibiotic treatment\n* Known or suspected allergies to phenoxymethylpenicillin\n* Suspicion of peritonsillar abscess or indication for admittance.","15 Years",{"count":333,"type":20},260,[91],"Sore throat is the second most common cause of antibiotic prescribing in primary care in Sweden. Guidelines for sore throat focus on identifying people with sore throat where there are 3 and 4 specified criteria and where near patient tests identify group A streptococci (GAS). In these cases, phenoxymethylpenicillin is recommended.\n\nStudies that have identified microorganisms in sore throat show that there are other bacteria and viruses than GAS, that give similar symptoms and that sometimes no microorganism is trapped despite pronounced symptoms. In recent years, a bacterium F. necrophorum has been identified, which is found in increased incidence of sore throat, but it is also found in healthy individuals. In clinical practice, many patients are treated with penicillin even if GAS is not captured. This may be because the doctor perceives the patient as sick or because other bacteria are not caught with a near patient test which causes the doctor to treat anyway.\n\nThe specific aims are to in patients with GAS-negative sore throat and 3 and 4 criteria, aged 15 years and older in primary care, study whether phenoxymethylpenicillin treatment shortens the duration of the disease, reduces the symptom intensity and sickness absence, and investigates the importance of other microorganisms than GAS in sore throat.\n\nThe study is a randomized controlled trial in which patients with sore throat are randomized to phenoxymethylpenicillin 3 times daily for 10 days or to no antibiotic therapy. There will also be and a reference group with severe (Centor score 3-4), GAS-positive acute tonsillitis.\n\nBlood samples for inflammatory and immunological response to infections are taken. Throat samples for culture of F. necrophorum and streptococcal groups C and G, as well as polymerase chain reaction (PCR) analysis for bacteria and viruses are also taken at inclusion and at follow-up.\n\nThe outcome will be followed in a patient diary for 10 days and at a return visit after 18-24 days where the clinical outcome is asked for and where the blood- and throat samples are repeated.\n\nFollow-up will also takes place via e-mail after 1 and 3 months.",[24,337],"Tonsillitis",[30,339,340,341,342],"tonsillitis","randomized controlled trial","primary care","phenoxymethylpenicillin","2024-12-01",{"date":345,"type":41},"2024-12-04",{"date":347,"type":41},"2019-09-09",{"date":349,"type":20},"2026-06",{"name":351,"class":198},"Katarina Hedin",6,{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":227,"sex":16,"minAge":58,"maxAge":361,"enrollmentInfo":362,"targetDuration":364,"studyType":21,"phases":4,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":49},"100498046","safe-brain-initiative-operationalizing-precision-anaesthesia-100498046","NCT05765162","Safe Brain Initiative, Operationalizing Precision Anaesthesia","Safe Brain Initiative - Dedicated to Advancing Anaesthesia and Perioperative Personalised Care Towards Precision Anaesthesia Care. A Continuous Quality Improvement Initiative.","SBI","Inclusion Criteria:\n\n• All patients from age ≥18\n\nExclusion Criteria:\n\n• All patients from age \\\u003C18","100 Years",{"count":363,"type":20},15000,"5 Years","Perioperatively, patients experience an unnecessarily high level of side effects associated with their treatment. These side effects include nausea, severe pain, anxiety, and stress. Moreover, many patients develop postoperative delirium (POD) and neurocognitive dysfunctions, often resulting in long-term cognitive impairment, decreased quality of life, and increased mortality. However, physicians, nurses and their institutions do not receive structured feedback regarding these aspects of each patient's well-being. They may therefore be unable to engage in the essential cause-and-effect learning necessary to evaluate and consecutively reduce such side effects.\n\nEffective guidelines conform prevention is the proven key to shielding our patients from adverse Outcomes. The Safe Brain Initiative's high-quality routine data-for-action is a sword and accelerator for moving towards patient-centred, precision care. Thus, establishing a foundation for value-based and patient-centred healthcare development.\n\nHowever, a turnkey real-world solution is challenging to develop and implement and requires substantial resources. As a result, such solutions are usually beyond the scope of a single institution. The SBI platform provides high-quality, real-world data to bridge this gap. It allows monitoring and in-depth analysis of cause and effect in the day-to-day routine of individuals, departments, and institutions.\n\nThe SBI's approach is continuously improved and updated. An organization called the SBI Global Society oversees the quality and precision of science through experts in the field. At SBI Hospitals and Flagship centres, Masterclasses are conducted and can be attended alongside clinical immersions.\n\nSBI Solutions manages, develops, and provides technical and service support for the Safe Brain Initiative. Its service guarantees the professional and GDPR conform management of data handling and storage as well as the user-friendly functionality of the SBI-Dashboard solutions.",[367,368,369,370,371,372,373,374,375,376,377,378,379,380,381,183,382],"Neurocognitive Disorders","Post Operative Delirium","Pain","Nausea","Vomiting","Wellbeing","Shivering","Anxiety","Stress","Agitation,Psychomotor","Sedation Complication","Thirst","Satisfaction, Patient","Temperature Change, Body","Fasting","Hearing and Vision Loss","2024-06-05",{"date":385,"type":41},"2024-06-07",{"date":387,"type":41},"2021-12-01",{"date":389,"type":20},"2026-01-01",{"name":391,"class":78},"University of Southern Denmark"]