[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"space-maintenance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:space-maintenance":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,76,107,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639363","3d-printed-versus-band-and-loop-versus-denovo-space-maintainers-in-primary-dentition-100639363",false,"NCT07613658","3D-Printed Versus Band-and-Loop Versus Denovo Space Maintainers in Primary Dentition.","3D-Printed Custom Versus Conventional Band-and-Loop Versus Chairside Denovo Space Maintainers in the Primary Dentition: A Randomized Controlled Trial Protocol","Inclusion Criteria:\n\n1. Children aged 5 to 10 years\n2. Premature unilateral loss of at least one primary first or second molar\n3. Radiographically confirmed developing permanent successor at Nolla developmental stage 4 to 7\n4. Parent or legal guardian able and willing to provide written informed consent, and child able to provide age-appropriate assent\n\nExclusion Criteria:\n\n1. Systemic disease affecting bone metabolism or tooth development\n2. Clinically significant mesiodistal space loss at screening, defined as greater than 3 mm\n3. Poor oral hygiene precluding band placement, defined as a full-mouth plaque score greater than 50%\n4. Known allergy or hypersensitivity to stainless steel or resin components\n5. Current participation in another interventional clinical trial",true,"ALL","5 Years","10 Years",{"count":21,"type":22},360,"ESTIMATED","INTERVENTIONAL",[25],"NA","Purpose of the Study When a child loses a \"baby\" molar early due to a cavity or injury, the surrounding teeth can shift into the empty space. This often blocks the permanent adult tooth from growing in correctly. To prevent this, dentists use a small metal device called a space maintainer.\n\nThis study aims to find out which of three different types of space maintainers lasts the longest, is most comfortable for the child, and is most efficient for the dental office to provide.\n\nThe Three Study Groups\n\nChildren in this study are randomly assigned to one of three groups:\n\n1. 3D-Printed Custom Group: The dentist takes a digital picture (scan) of the child's mouth instead of a traditional mold. A custom-fit appliance is then 3D-printed using a specialized, medical-grade clear material.\n2. Conventional Band-and-Loop Group: This is the traditional method. The dentist takes a physical mold of the teeth, which is sent to a laboratory. The child usually has to return for a second appointment a week later to have the metal appliance glued into place.\n3. Denovo Chairside Group: This uses a kit of pre-made metal parts. The dentist selects the best fit and assembles the appliance right at the chairside, allowing it to be placed during a single visit.\n\nWhat is Being Measured?\n\nResearchers are following the children for 12 months to track:\n\nSurvival: Which appliance stays glued in and doesn't break most effectively?\n\nTime: How much time does the dentist spend making and fitting the appliance?\n\nComfort: How much discomfort or pain did the child feel during the process?\n\nHealth: Does the appliance cause any irritation to the gums or surrounding teeth?\n\nWho Can Participate? The study includes children between the ages of 5 and 10 who have lost at least one primary (baby) molar early and need a space maintainer to protect their future adult smile.\n\nImportance of This Research By comparing these three methods, this study helps dentists understand if newer technologies, like 3D printing or pre-made kits, are better or more convenient than the traditional lab-made metal loops used for decades. This information will help families choose the best treatment for their children.",[28,29],"Space Maintenance","Tooth Loss \u002F Rehabilitation",[28,31,32,33],"Band and Loop","3D-Printed Space Maintainer","Denovo Space Maintainer","NOT_YET_RECRUITING","2026-05-21",{"date":37,"type":38},"2026-05-29","ACTUAL",{"date":40,"type":22},"2026-06",{"date":42,"type":22},"2027-07",{"name":44,"class":45},"Murad Alrashidi","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100638031","the-objective-of-this-research-is-to-compare-the-clinical-effectiveness-of-the-conventional-lingual-arch-space-maintainers-with-three-dimensional-printed-space-maintainers-100638031","NCT07591324","the Objective of This Research is to Compare the Clinical Effectiveness of the Conventional Lingual Arch Space Maintainers With Three-dimensional Printed Space Maintainers.","Comparative Evaluation of the Conventional and Three-Dimensional Printed Lower Lingual Arch Space Maintainers A Randomized Clinical Trial","Inclusion Criteria:\n\n* Apparently, healthy cooperative children have recently prematurely loss of more than one mandibular primary molar in any of the quadrants, full erupted mandibular first permanent molars in both sides, and whose lower permanent incisors have erupted\n* The permanent successors of the lost primary molars were not expected to erupt within 6 months\n* Angle's class 1 occlusion with normal primary molar relation\n* Caries-free and periodontally healthy abutment teeth\n* Absence of parafunctional habits or abnormal occlusion conditions such as crossbite, open bite, or deep bite.\n* Children's age ranges from 7 to 9 years-old\n* Radiographically, presence of permanent successors, more than one millimeter of bone covering the successor tooth germ, and\u002For only about one-third of the root of the permanent tooth has been formed.\n* Parents and children were accepting the new treatment modality.\n\nExclusion Criteria:\n\n* children exhibited poor oral hygiene, para-functional oral habits, severe crowding, space loss, and abnormal occlusion\n* Extraction of primary molars exceeding three months.\n* Radiographically, absence of permanent successor.\n* uncooperative children","7 Years","9 Years",{"count":57,"type":22},44,[25],"the objective of this research is to compare the clinical effectiveness of the conventional lingual arch space maintainers with three-dimensional printed space maintainers.",[61,28,62],"Gingival Health","Pain and Anxiety",[64,65],"lingual arch spacemaintainer","3D printed spacemaintainer","RECRUITING","2026-05-12",{"date":69,"type":38},"2026-05-15",{"date":71,"type":38},"2025-01-22",{"date":73,"type":22},"2026-09-01",{"name":75,"class":45},"Suez Canal University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":46},"100590312","space-changes-after-premature-loss-of-lower-first-primary-molars-in-children-using-digital-scanning-100590312","NCT06965777","Space Changes After Premature Loss of Lower First Primary Molars in Children Using Digital Scanning","The Space Changes Following Premature Loss of Lower First Primary Molars in the Primary Dentition Stage Using Digital Scanning A Prospective Split-mouth Clinical Study","Inclusion Criteria:\n\n* Children aged 3 to 5.5 years\n* Mandibular first primary molar indicated for extraction due to extensive decay or hopeless prognosis\n* Contralateral mandibular first primary molar must be intact and free of proximal caries\n* No eruption of mandibular permanent first molar at the time of enrollment\n* Presence of primary canines and second primary molars\n* No space maintainers placed\n* Parents\u002Fcaregivers unable or unwilling to fabricate a space maintainer\n\nExclusion Criteria:\n\n* Bilateral premature loss of mandibular first primary molars\n* Contralateral mandibular molar has proximal caries or poor prognosis\n* Children with good prognosis first primary molars (i.e., not needing extraction)\n* Eruption of the mandibular permanent first molar\n* Children who already have space maintainers\n* Uncooperative behavior preventing study participation","3 Years","66 Months",{"count":86,"type":22},11,"OBSERVATIONAL","This prospective split-mouth clinical study aims to evaluate space changes in the mandibular dental arch following premature extraction of the lower first primary molar in children aged 3 to 5.5 years. Using digital 3D models, changes in the D space and mandibular arch perimeter will be measured at baseline and 6 months post-extraction. The goal is to determine whether space maintainers are necessary in the primary dentition stage.",[90,28,91,92],"Premature Loss of Primary Molars","Dental Arch Development","Pediatric Tooth Extraction",[94,95,96,97],"Tooth Loss","Dental Arch","Pediatric Dentistry","Primary Dentition","2025-05-10",{"date":100,"type":38},"2025-05-14",{"date":102,"type":22},"2025-08-01",{"date":104,"type":22},"2026-03-01",{"name":106,"class":45},"Cairo University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100579513","clinical-evaluation-of-3-d-printed-partial-denture-space-maintainer-100579513","NCT06825273","Clinical Evaluation of 3-D Printed Partial Denture Space Maintainer","Clinical Evaluation of 3-D Printed Partial Denture Space Maintainer and Its Impact on Children's Oral Health Status: A Randomized Controlled Clinical Crossover Study","Inclusion Criteria:\n\n* apparently, healthy cooperative children having recent premature loss of lower primary molars\n* the permanent successors of the lost primary molars were not expected to erupt within 6 months\n* Angle's class 1 occlusion with normal primary molar relation\n* Presence of teeth on the mesial and distal side of the edentulous area\n* Absence of para-functional habits or abnormal occlusion conditions such as crossbite, open bite, or deep bite.\n* Radiographically, presence of permanent successors.\n* parents and children were accepting the new treatment modality.\n\nExclusion Criteria:\n\n* children exhibited poor oral hygiene, para-functional oral habits, severe crowding, space loss, and abnormal occlusion\n* Extraction of primary molars exceeding three months.\n* Radiographically, absence of permanent successor.\n* uncooperative children",{"count":115,"type":22},40,[25],"Primary dentition is the most suitable space maintainer for permanent teeth. However, as infants often lose their primary teeth too soon, using a space maintainer is the most efficient, long-lasting, and economical way to prevent malocclusions and function impairment in the future. Regarding personalized appliances, space maintainers in digital pediatric dentistry have made significant progress. Digital technology decreases the manual manufacturing stages that take a long time and increases the reliability and durability of digital fabrication procedures.",[28,61],[120,121,122,123],"partial denture space maintainer","3-D printing","plaque index","gingival index","2025-04-15",{"date":126,"type":38},"2025-04-17",{"date":128,"type":38},"2025-03-01",{"date":130,"type":22},"2025-10",{"name":132,"class":45},"Tanta University",2,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":83,"studyType":87,"phases":4,"briefSummary":145,"conditions":146,"keywords":155,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":46},"100544681","tornado-omics-techniques-and-neural-networks-for-the-development-of-predictive-risk-models-100544681","NCT06372054","TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models","Integration of Omics-based Technologies and Artificial Intelligence to Identify Predictive Risk Models in a Air Force's Pilot Cohort for the Maintenance of Safety, Well-being, Health, and Performance to be Translated to Civil Population","Inclusion Criteria:\n\n* Being part of the Italian Air Force, as in active flight service or ground staff\n* Age between 26 and 38 years\n* Consent to collect biological samples and use the wearable device to monitor exposure parameters\n\nExclusion Criteria:\n\n* Age \\\u003C 25 years and \\> 39 years\n* no signature on informed consent","26 Years","38 Years",{"count":144,"type":22},200,"The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots. This peculiar cohort conducts dynamic activities in an extreme environment, compared to a population of military people not involved in flight activity. The study integrates the analyses of biological samples (urine, blood, and saliva), clinical records, and occupational data collected at different time points and analyzed by omic-based approaches supported by Artificial Intelligence. Data resulting from the study will clarify many etiopathological mechanisms of diseases, allowing the creation of a model of analyses that can be extended to the civilian population and patient cohorts for the potentiation of precision and preventive medicine.",[147,148,149,150,28,151,152,153,154],"Oxidative Injury","Stress Physiological","Discogenic Pain","Cardiovascular Risk Factor","Epigenetic Changes","LONGEVITY 1","Neuroplasticity","NGS",[156,157,158,159],"pilots","air force","epigenetic change","environmental exposure","2024-04-16",{"date":162,"type":38},"2024-04-17",{"date":164,"type":38},"2024-02-05",{"date":166,"type":22},"2027-02-05",{"name":168,"class":45},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico"]