[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spastic-cerebral-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spastic-cerebral-palsy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,77,108,132,156,181,206],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100561030","3d-microscopic-muscle-architecture-in-cerebral-palsy-100561030",false,"NCT06584851","3D-Microscopic Muscle Architecture in Cerebral Palsy","Evaluation of Microscopic Muscle Properties in Growing Children With Cerebral Palsy and Their Relation to Macroscopic Muscle Properties","3D-MMAP","CHILDREN WITH CP\n\nInclusion criteria\n\n* Children (boys\u002Fgirls) diagnosed with predominantly spastic type of CP\n* Uni- or bilateral involvement\n* Gross Motor Function Classification Scale (GMFCS) Level I-III50\n* 2 to 9 years of age\n* Planned for an orthopedic intervention that requires general anesthesia (botulinum toxin injections, orthopedic surgery, or diagnostic imaging such as Magnetic Resonance Imaging \\[MRI\\], etc.)\n\nExclusion criteria\n\n* Presence of dystonia or ataxia\n* Previous surgery less than 6 months at the investigated muscles\n* Severe co-morbidities (that are likely to prevent proper assessment, such as severe cognitive problems)\n\nTYPICALY DEVELOPING CHILDREN\n\nInclusion criteria\n\n* Children (boys\u002Fgirls)\n* 2 to 9 years of age\n* Planned for a surgical intervention that requires general anesthesia (pure pediatric upper limb orthopedic surgery or trauma surgery, or ophthalmic or ear-nose-throat surgery)\n\nExclusion criteria\n\n* History of neurological problems\n* History of orthopedic problems at the gastrocnemius or semitendinosus\n* Trauma at the level of the lower limbs\n* Involvement in an elite or high-performance sporting program (Children performing sports for \\> 3 5 hours\u002Fweek will be excluded)\n\nADOSESCENTS WITH HSP of 12-18 years old and ADULTS WITH HPS\n\nInclusion criteria\n\n* Adolescents (boys\u002Fgirls) or adults (male\u002Ffemale) diagnosed with HSP, SPG3a or SPG4\n* Gross Motor Function Classification Scale (GMFCS) Level I-III50\n* Adolescents 12 to 18 years or adults 18-40 years of age\n\nExclusion criteria\n\n* Presence of dystonia or ataxia\n* Previous surgery less than 6 months at the investigated muscles\n* Severe co-morbidities (that are likely to prevent proper assessment, such as severe cognitive problems)\n\nTYPICALLY DEVELOPING ADOLESCENTS of 12-18 years old and HEALTHY ADULTS (age- and gender-matched with the recruited HSP patients)\n\nInclusion criteria\n\n* Typically developing adolescents (boys\u002Fgirls) and healthy adults (male\u002Ffemale), who are age and gender matched with the recruited HSP participants\n* Adolescents 12-18 years of age or adults 18-40 years of age\n\nExclusion criteria\n\n* History of neurological problems\n* History of orthopedic or muscular problems at the gastrocnemius\n* Trauma at the level of the lower limbs\n* Involvement in an elite or high-performance sporting program (participants performing sports for \\> 5 hours\u002Fweek will be excluded)\n* Sport session less than 72 hours prior to the biopsy collection",true,"ALL","2 Years","9 Years",{"count":22,"type":23},130,"ESTIMATED","OBSERVATIONAL","The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to muscle macroscopic properties defined by muscle imaging, to neuromuscular symptoms and to treatment.\n\nThis study aims to (1) evaluate intrinsic microscopic muscle properties of young growing children with CP, and (2) to evaluate these muscle properties in relation to macroscopic properties, neuromuscular symptoms and to treatment.\n\nImproved understanding of changes in microscopic muscle properties, and how they relate to macroscopic properties and to the neuromuscular symptoms as well as how they are influenced by treatment, has the potential to delineate CP phenotypes prone to intervention and to optimize treatment protocols or develop new treatments, leading to new avenues for improving function in CP.\n\nThe method to study microscopic muscle properties involves analysis of muscle biopsies (histological \u002F immunohistochemistry analysis, SC and IC culture, gene expression). Biopsies will be collected using the minimally invasive percutaneous needle microbiopsy technique, suitable for collecting repeated samples over time in the same individual while still leading to sufficient tissue of good quality for subsequent analysis1,2. For the children with CP, the local hospital's tradition of applying general anesthesia for delivering BTX injections will be exploited to collect the muscle samples prior to the BTX session and the one-year follow-up, or general anesthesia planned for orthopedic surgery or diagnostic imaging such as MRI, etc. For the collection of the samples 3 months before the BTX session, as well as 3 months and 6 months after BTX injections, the common approach for microbiospy collection will be applied, with local sedation on the skin (Rapydan©) and fascia (Xylocaine©) and local anesthesia by using Kalinox© (nitrous oxide in oxygen) under supervision of the University Hospital PROSA team. Biopsies of TD muscles will be collected in children with no history of neurological disorder, nor musculoskeletal problems at the level of the gastrocnemius or semitendinosus, at the time of upper limb orthopedic or trauma surgery and thus always under general anesthesia. Ultrasound guided percutaneous muscle biopsy has been performed in children (2 months-18 years)3,4 and has proven to be safe and well-tolerated. A pilot study (S61110) was conducted to confirm that the microbiopsy technique is suitable for the analysis of microscopic muscle properties and is well-tolerated in children with CP.\n\nTwo specific research goals are planned, with hypotheses emerging from literature.",[27],"Spastic Cerebral Palsy",[29,30,31,32,33,34,35],"Spastic cerebral palsy","Microscopic muscle properties","Muscle micro-biopsies","3D freehand ultrasound","Histology","Cell culture","CP-phenotypes","RECRUITING","2026-05-04",{"date":39,"type":40},"2026-05-05","ACTUAL",{"date":42,"type":40},"2019-05-02",{"date":44,"type":23},"2028-12",{"name":46,"class":47},"Universitaire Ziekenhuizen KU Leuven","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100519486","feasibility-nutritional-supplements-for-muscle-growth-in-cp-100519486","NCT06044168","Feasibility Nutritional Supplements for Muscle Growth in CP","Feasibility Study: Nutritional Supplements to Support Muscle Growth in Children With Cerebral Palsy","Nut-CP","Inclusion Criteria:\n\nSpastic Cerebral Palsy (diagnosed by a neuro-pediatrician from the CP Reference Centre of the University Hospital Leuven)\n\n* Uni- of bilateral involvement\n* Level II or III on the Gross Motor Function Classification System (GMFCS)\n* Muscle volume for the medial gastrocnemius (target muscle) of at least 20% compared to the expected muscle volume in age-matched typically developing children\n\nExclusion Criteria:\n\n* Presence of dyskinesia or ataxia\n* Severe co-morbidities\n* Botulinum toxin treatment ten months prior to assessment\n* Previous orthopedic or neurosurgery\n* Severe ankle deformities preventing fitting in test positions\n* Ankle range of motion (ROM) \\\u003C30% of normal values","4 Years","10 Years",{"count":60,"type":23},5,"INTERVENTIONAL",[63],"NA","The purpose of this study is to investigate the feasibility of a 10-week plan with a nutritional supplement (leucine) and to perform pilot analyses on the effect of leucine on macroscopic muscle morphology in children with cerebral palsy.",[27],[27,32,67,68,69,70],"Muscle morphology","Nutritional supplements","Leucine","Feasibility",{"date":39,"type":40},{"date":73,"type":40},"2023-07-31",{"date":75,"type":23},"2027-12",{"name":46,"class":47},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":61,"phases":86,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":48},"100587210","effect-of-task-specific-electrical-stimulation-on-upper-limb-gross-motor-skills-in-children-with-spastic-quadriplegia-100587210","NCT06925425","Effect of Task Specific Electrical Stimulation on Upper Limb Gross Motor Skills in Children With Spastic Quadriplegia","Inclusion Criteria:\n\n1. Their age will be ranged from 2 to 6 years. Their grade of spasticity will be from 1+ to 2 according to Modified Ashworth scale (Baunsgaard etal., 2016). (APPENDIX II).\n2. They will be on Level III and IV according to Gross Motor Functional Classification System (GMFCS) (Palisano et al., 2008).(APPENDIX III).\n3. Parents\u002Flegals representatives consenting to their child's participation 5 - Diagnosed with Spastic Quadriplegic cerebral palsy\n\nExclusion Criteria:\n\n1. Previous neurological or orthopedic surgery in the upperextremities.\n2. Fixed deformity in the joints of upper limb. 3- Severe hearing and visual defect.\n\n4-Irregular attendance at assessments or therapy sessions","6 Years",{"count":85,"type":23},30,[63],"Cerebral palsy is a non-progressive lesion of the brain occurring before 2 years of age resulting in disorders of posture and movement.( Ostensjo S, 2004)( Keles MN, 2018). Although non- progressive, motor impairments develop as the child grows leading to activity and participation restriction.\n\nFor children with CP, body function and structure impairments include changes in muscle tone and strength that affect the ability to control movement, specifically in regard to postural responses, selective control, regulation of activity, ability to learn unique movements, and inappropriate sequencing.(Ross SA,2007)( Ostensjo S, 2004) .\n\nLack of proper loading and maladaptive muscle pulls over time causes the skeletal system to adapt to positions of malalignment, malformation, and overall bone weakness (Beckung E, 2007) (Elbasan B, 2018).\n\nThese changes lead to delays in the natural progression of gross motor skills. As the child falls behind in motor function, they also fall behind in cognitive stimulation and development.( Akaya KU, 2018) . Understanding the anatomical and physiological implications that CP has on the developing child is necessary for physical therapists to treat this population, especially when utilizing electrical stimulation.\n\nSpastic quadriplegia Is a type of cerebral palsy that affects all four limbs and typically involves significant motor impairment. It results from brain damage that occurs before, during, or shortly after birth, affecting the areas of the brain responsible for movement and coordination.\n\nElectrical stimulation is a mode of physical therapy that can be utilized in the treatment of various nerve and muscle injuries, in addition to patients with acute and chronic pain. It involves an electrical pulse applied to a muscle or nerve that activates excitable tissue utilizing internal or external electrodes to build muscle strength, reduce pain, as well as create or support limb movement (Kerr C, 2007).\n\nTask-specific electrical stimulation (TASES) is a therapeutic technique used primarily in rehabilitation settings to enhance motor function. The primary aim of TASES is to facilitate movement and improve motor learning by applying electrical stimulation to specific muscles during targeted tasks.",[89,27,90,91,92],"Cerebral Palsy (CP)","Quadriplegic Cerebral Palsy","Upper Limb Function","Gross Motor Delay",[94,95,96,97,98],"TASES","Cerebral palsy","Gross motor skills","Upper limb","Task specific electrical stimulation","2026-03-27",{"date":101,"type":40},"2026-04-01",{"date":103,"type":40},"2025-05-01",{"date":105,"type":23},"2026-03-29",{"name":107,"class":47},"Kafrelsheikh University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":83,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":48},"100557043","the-effect-of-afos-on-the-emg-of-children-with-cp-100557043","NCT06532981","The Effect of AFOs on the EMG of Children With CP","The Effect of the Ankle-foot Orthosis on Muscle Activity in the Lower Limbs in Children With Cerebral Palsy","Inclusion criteria:\n\n* Gross Motor Function Classification System (GMFCS) level I - III\n* CP (bilateral \\& unilateral)\n* Age: 6 - 17 years\n* Prescribed AFO by the medical team (as part of the standard care)\n\nExclusion criteria:\n\n* Severe contractures or spasticity, which makes it impossible to wear a conventional AFO\n* Cognitive or visual impairment that hinder them to understand instructions\n* Previous surgery on bones and\u002For muscles of the legs in the last 12 months prior to assessment\n* Presence of ataxia or dystonia","17 Years",{"count":85,"type":23},"Children with cerebral palsy (CP) have altered gait patterns as a result of primary and secondary symptoms. Ankle-foot orthoses (AFOs) are frequently used to improve their gait. Despite evidence of AFO-effects on gait kinetics and -kinematics, the effects on muscle activity remain unclear.\n\nThis study will investigate the effect of AFOs on the amplitude and timing, as well as the co-activation of lower limb muscle activity in children with spastic CP.",[27],[120,121,122,123],"Cerebral Palsy","Rehabilitation","Gait analysis","Variability","2026-02-09",{"date":126,"type":40},"2026-02-12",{"date":128,"type":40},"2023-01-06",{"date":130,"type":23},"2026-12-31",{"name":46,"class":47},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":15,"eligibilityCriteria":138,"healthyVolunteers":17,"sex":18,"minAge":139,"maxAge":20,"enrollmentInfo":140,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":48},"100454455","evaluation-of-macroscopic-muscle-growth-in-infants-and-young-children-with-spastic-cerebral-palsy-100454455","NCT05197764","Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy","The Integration of Macroscopic and Microscopic Muscle Properties With Cell Modelling to Feature Altered Neuromuscular Behavior in Cerebral Palsy: 3D-Macroscopic Muscle Architecture in Cerebral Palsy","Inclusion Criteria:\n\n* Confirmed diagnosis of spastic cerebral palsy or patients at high-risk for spastic cerebral palsy\n* Suspected GMFCS levels I-III (GMFCS = Gross Motor Function Classification Scale, expressing the overall functional level of impairment)\n\nExclusion Criteria:\n\n* Non-ambulatory\n* Botulinum neurotoxin type-A injections six months prior to enrollment\n* Lower limb surgery two years prior to enrollment\n* Muscle surgery at the muscles in the lower limb\n* Selective dorsal rhizotomy as treatment history\n* Presence of ataxia or dystonia\n* Severe co-morbidities (severe epilepsy, severe behavior problems that impede the cooperation)","6 Months",{"count":141,"type":23},229,"A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP). Therefore, this project aims to (1) describe the macroscopic morphological muscle changes with increasing age and (2) evaluate the onset and development of muscle alterations in relation to the brain lesion (e.g., timing, extent and location), to the neuromuscular impairments and to treatment. Overall, this project will evaluate the macroscopic muscle properties by means of 3D freehand ultrasound (3DfUS).",[27,144],"Acquired Brain Injury",[27,144,146,32,67,147,148,149],"Brain imaging","Range of motion","Stiffness","Spasticity",{"date":126,"type":40},{"date":152,"type":40},"2019-02-11",{"date":154,"type":23},"2026-12",{"name":46,"class":47},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":18,"minAge":164,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":61,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":178,"locationsCount":180},"100521487","radiosurgery-treatment-for-spasticity-associated-with-stroke-sci--cerebral-palsy-100521487","NCT06070233","Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy","A Randomized, Sham Controlled Trial of Dorsal Root Rhizotomy Stereotactic Radiosurgery Versus Standard of Care for Spasticity Associated With Stroke, Spinal Cord Injury & Cerebral Palsy","SPASM","Inclusion Criteria:\n\n* Chronic spasticity refractory to medical management or in a patient who cannot receive appropriate medical management mediated by one or more spinal nerve roots\n* Age \\> 16 (if under 18, patients parents must sign consent).\n\nExclusion Criteria:\n\n* Inability to lie supine for simulation \\& treatment\n* Inability to visualize the target nerve on either CT or MRI imaging\n* Patients with confirmed pregnancy (all women of child-bearing age with intact uterus \\& ovaries will be required to undergo a pregnancy test prior to simulation)","16 Years",{"count":166,"type":23},22,[63],"A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called \"stereotactic radiosurgery dorsal rhizotomy.\" It uses very accurate beams of radiation to target certain nerves in the back to help loosen up the muscles. In this study, people are put into two groups by chance: one group gets the real treatment, and the other group gets a \"fake\" treatment that doesn't do anything. This fake treatment is called a \"sham.\" Doing this helps make sure the study is fair and the results are true. After the people in the study get their treatment, the researchers will watch and see how they do. They will check if their muscles are less stiff and if they have any side effects. By looking at the results from both groups, the researchers can find out if the special treatment really helps people with spasticity. Patients who got the \"fake\" treatment will be eligible to receive the \"real\" treatment after 6 months.",[170,27,171],"Spasticity as Sequela of Stroke","Spasticity, Muscle","2025-12-18",{"date":174,"type":40},"2025-12-19",{"date":176,"type":40},"2023-10-12",{"date":130,"type":23},{"name":179,"class":47},"Ohio State University",2,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":61,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":204,"locationsCount":48},"100585423","effect-of-diving-and-aquatic-exercises-on-muscle-spasticity-and-motor-function-in-children-with-spastic-cerebral-palsy-100585423","NCT06902168","Effect of Diving and Aquatic Exercises on Muscle Spasticity and Motor Function in Children With Spastic Cerebral Palsy","Inclusion Criteria:\n\n* Age from 2 to 5 years.\n* Both sexes.\n* Children diagnosed with spastic cerebral palsy, categorized according to the Gross motor function classification system (GMFCS) levels IV, V.\n\nExclusion Criteria:\n\n* Botulinum toxin treatment or surgery in the preceding three months.\n* Botox injections before or during the application of the program.\n* Dorsal rhizotomy.","5 Years",{"count":189,"type":23},37,[63],"This study aims to evaluate the effect of diving and aquatic exercises on muscle spasticity and motor function in children with spastic cerebral palsy.",[193,194,195,196,197,27],"Diving","Aquatic","Muscle Spasticity","Motor Function","Children","2025-03-29",{"date":200,"type":40},"2025-04-01",{"date":198,"type":40},{"date":203,"type":23},"2025-08-01",{"name":205,"class":47},"Benha University",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":17,"sex":18,"minAge":213,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":61,"phases":216,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":48},"100483130","operant-conditioning-of-the-soleus-stretch-reflex-in-adults-with-cerebral-palsy-100483130","NCT05571033","Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy","SRC-CP","Inclusion Criteria:\n\n1. Age 18 and above\n2. Diagnosis of spastic Cerebral Palsy\n3. Gross Motor Function Classification System level I-III\n4. Stable medical background\n5. Current medication will remain unchanged for 3 months\n6. Provides informed consent\n7. can walk at least 10 meters with or without assistive device\n8. meets minimum study procedure requirements (elicitation of H-reflex).\n\nExclusion Criteria:\n\n1. Pregnancy\n2. uncontrolled diabetes\n3. weak dorsiflexion\n4. History of cardiac conditions\n5. cognitive deficits that interfere with study procedure and steps for completion\n6. Botox within 2 months of the study\n7. H\u002FO ankle surgeries in affected leg (Dorsal root rhizotomy etc.)\n8. regular use of electrical stimulation to lower extremity muscles\n9. Cochlear or metal implantations on body\n10. No history of seizure after age 2 years\n11. Current use of antiseizure medicines\n12. Any metal or magnetic components in the head (surgical clips, metal work etc.)\n13. Implanted device or cardiac pacemakers (applicable for DS8R too)\n14. Skin disorders\n15. Damaged skin (wounds, broken skin, or recent scar tissue)\n16. Allergy to latex (tape)","18 Years",{"count":215,"type":23},12,[63],"12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times\u002Fweek. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and follow ups after 2 weeks, 1 month and 3 months. The soleus H reflex (electric analogue of the stretch reflex) will be elicited in all sessions. In each session, participants will complete 20 baseline trials and 225 down conditioning trials to decrease the magnitude of the H-Reflex.",[120,27],[220,221],"Hoffman Reflex","Spinal Reflex Conditioning","2023-09-25",{"date":224,"type":40},"2023-09-26",{"date":226,"type":40},"2022-09-30",{"date":130,"type":23},{"name":229,"class":47},"Burke Medical Research Institute"]