[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spastic-diplegia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spastic-diplegia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,49,74,93,123,152,177,196,218],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100054132","effects-of-proprioceptive-neuromuscular-facilitation-and-task-oriented-training-on-upper-extremity-function-in-children-with-spastic-diplegic-cerebral-palsy-100054132",false,"NCT07694804","Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","Isolated Versus Combined Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","PNF-TOT-CP","Inclusion Criteria:\n\n* Children aged 6 to 12 years.\n* Clinical diagnosis of spastic diplegic cerebral palsy.\n* Gross Motor Function Classification System (GMFCS) Levels I-III.\n* Ability to understand and follow simple verbal instructions.\n* Medically stable and able to participate in physiotherapy sessions.\n* Parent or legal guardian willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Orthopedic surgery involving the upper or lower extremities within the previous 6 months.\n* Botulinum toxin injections administered within the previous 6 months.\n* Severe visual, hearing, or cognitive impairments that would interfere with assessment or treatment.\n* Uncontrolled epilepsy or other unstable neurological or medical conditions.\n* Fixed upper extremity contractures or musculoskeletal deformities preventing participation in the intervention.\n* Participation in another structured upper extremity rehabilitation program during the study period.\n* Failure to obtain informed consent from a parent or legal guardian.","ALL","6 Years","12 Years",{"count":21,"type":22},63,"ESTIMATED","INTERVENTIONAL",[25],"NA","Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities. Proprioceptive Neuromuscular Facilitation (PNF) and Task-Oriented Training (TOT) are commonly used rehabilitation approaches to improve motor function; however, evidence comparing their individual and combined effects on upper extremity function remains limited.\n\nThis randomized controlled trial aims to compare the effects of PNF alone, TOT alone, and a combined PNF plus TOT intervention on upper extremity function in children with spastic diplegic cerebral palsy. Sixty-three children aged 6 to 12 years with Gross Motor Function Classification System (GMFCS) levels I to III will be randomly assigned to one of three intervention groups. Each group will receive supervised 45-minute treatment sessions, three times per week for six weeks.\n\nUpper extremity function, functional independence, and joint range of motion will be assessed at baseline, mid-intervention (3 weeks), and post-intervention (6 weeks) using the Melbourne Assessment of Unilateral Upper Limb Function (MA2), Pediatric Evaluation of Disability Inventory-Functional Skills Scale (PEDI-FSS), and goniometric measurements. The findings of this study are expected to provide evidence regarding the most effective rehabilitation approach for improving upper extremity function in children with spastic diplegic cerebral palsy.",[28,29],"Cerebral Palsy","Spastic Diplegia",[31,32,33,34,35],"Spastic diplegic cerebral palsy","Proprioceptive neuromuscular facilitation","Task-oriented training","Motor function","Functional independence","RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2026-02-17",{"date":44,"type":22},"2026-07-08",{"name":46,"class":47},"Ibadat International University, Islamabad","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100642673","action-observation-therapy-in-children-with-spastic-diplegia-100642673","NCT07651111","Action Observation Therapy in Children With Spastic Diplegia","Effect of Live Versus Video Action Observation Training on Balance and Gait in Children With Spastic Diplegia","AOT\u002FCP","Inclusion Criteria:\n\n* Children of diplegia who walk by a crouch gait.\n* The age of the selected children will range from 4 to 7 years old.\n* Degree of spasticity will range from 1 to 1+, according to modified Ashworth scale (MAS).\n* They will be selected as Level II according to Gross motor function classification system (GMFCS).\n* They will be able to understand the tasks and researchers' instructions.\n* Their heights are not less than 1 meter to be able to see the screen of the Biodex balance system.\n\nExclusion Criteria:\n\n* Visual or auditory impairments.\n* Vestibular impairments.\n* Fixed deformities of the upper, lower limbs, and the spine.\n* Botulinum toxin (Botox) injection for the last six months.\n* Orthopedic surgeries in the last six months.","4 Years","7 Years",{"count":60,"type":22},45,[25],"The aim of this study is to compare the effect of live versus video action observation training (AOT) on balance and gait in children with spastic diplegia.",[29],"NOT_YET_RECRUITING","2026-06-11",{"date":67,"type":40},"2026-06-16",{"date":69,"type":22},"2026-06-20",{"date":71,"type":22},"2026-09-30",{"name":73,"class":47},"Cairo University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":19,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},"100638455","effect-of-vestibular-rehabilitation-on-postural-sway-and-energy-expenditure-in-children-with-spastic-diplegia-100638455","NCT07617935","Effect of Vestibular Rehabilitation on Postural Sway and Energy Expenditure in Children With Spastic Diplegia","Inclusion Criteria:\n\n1. The age of the selected children will be ranged from 8 to 12 years old.\n2. Degree of spasticity is ranging from 1+to 2 according to modified Ashworth scale\n3. The level of motor function of the children will be levels I-II according to Gross Motor Function Classification System\n4. They are able to follow instructions and understand commands.\n\nExclusion Criteria:\n\n1. Bone and tendon lengthening surgeries within last 6 months.\n2. Lung and heart diseases and disorders.\n3. Vision or hearing problems\n4. Children with fixed deformities.\n5. Children with epilepsy.\n6. Recent intramuscular Botulinum toxin injection or orthopedic surgery within last 6 months.","8 Years",{"count":82,"type":22},30,[25],"this study will be conducted To determine the effect of vestibular rehabilitation training on postural sway and energy expenditure in children with spastic cerebral palsy and To determine any relation between postural sway and energy expenditure in children with spastic cerebral palsy.",[29],"2026-05-24",{"date":88,"type":40},"2026-06-01",{"date":88,"type":22},{"date":91,"type":22},"2026-09-01",{"name":73,"class":47},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":17,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":104,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":48},"100626285","evaluation-of-brain-mri-changes-in-cerebral-palsy-patients-100626285","NCT07433647","Evaluation of Brain MRI Changes in Cerebral Palsy Patients","Evaluation of Brain Changes in Cerebral Palsy Patients","Inclusion Criteria:\n\n* Have multiple MRI scans of brain and\u002For spinal cord spaced at least 24 months apart\n* Between 18-80 years of age with at least one MRI scan after the age of 18\n* No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration\n* Inclusion in CPRN registry\n* diagnosis of Cerebral Palsy\n* \\>18 years of age\n* Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)\n\nExclusion Criteria:\n\n* History of more than one seizure in lifetime\n* History of known degenerative genetic disorder\n* History of brain tumor, abscess, or multiple sclerosis\n* History of moderate or severe head trauma\n* History of metal implants in head",true,"18 Years","80 Years",{"count":82,"type":22},"2 Years","OBSERVATIONAL","Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.\n\nThis will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries.\n\nThe investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.",[28,29,108,109],"Spastic Quadriplegia","Spastic Hemiplegia",[111,112,113],"brain volume","cortical thickness","aging","2026-05-11",{"date":116,"type":40},"2026-05-13",{"date":118,"type":40},"2023-06-20",{"date":120,"type":22},"2029-07-01",{"name":122,"class":47},"Columbia University",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":48},"100551020","a-motor-learning-intervention-to-target-walking-performance-in-ambulant-children-with-cerebral-palsy-100551020","NCT06454656","A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy","A \"MOtor Learning Based Intervention for Lower Extremities (MOBILE)\" to Target Walking Performance in Ambulant Children With Cerebral Palsy: A Feasibility Study","MOBILE","Inclusion Criteria:\n\n* Primary diagnosis of Cerebral Palsy (GMFCS Levels I-III)\n* Has a specific walking related goal\n* Has capacity to follow instruction\n* Has a primary caregiver who can support a home program\n\nExclusion Criteria:\n\n* Has had surgery within 6 months of intervention start date\n* Has had botox\u002F baclofen within 3 months of intervention start date\n* Has a dual diagnosis that impacts ability to follow instruction\n* Has a significant cognitive impairment","17 Years",{"count":133,"type":22},14,[25],"The goal of this clinical trial is to learn if a new therapy approach to improve walking ability in children with Cerebral Palsy is acceptable to the children and the families in a community setting.\n\nThe main questions we look to answer are:\n\n1. Do the children\u002Fteens tolerate the therapy and feel that it is helpful?\n2. Do the parents\u002F families feel the therapy helps and is easy to commit to?\n3. Do the children\u002Fteens complete all their therapy sessions and assessments as planned?\n\nThe participants will trial the therapy for 30 hours over 6 weeks and will perform assessments before and after to see if they meet their goals. They will also be interviewed to see how they felt about the therapy when they finish.",[28,137,29,138],"Walking, Difficulty","Hemiplegic Cerebral Palsy",[140,141,142],"Motor Learning Theory","Neuroplasticity","Neurological Rehabilitation","2026-04-09",{"date":145,"type":40},"2026-04-14",{"date":147,"type":40},"2024-08-12",{"date":149,"type":22},"2027-06",{"name":151,"class":47},"Royal College of Surgeons, Ireland",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":48},"100626637","effect-of-brain-gym-exercises-on-balance-and-quality-of-life-in-children-with-spastic-diplegia-100626637","NCT07438223","Effect Of Brain Gym Exercises On Balance And Quality Of Life In Children With Spastic Diplegia","Inclusion Criteria:\n\n1 - Children with spastic diplegia who have balance problems in standing and gait.\n\n2-Degree of spasticity ranges from 1 and 1+, according to modified Ashworth scale (MAS) .\n\n3- The age of children will range from 6 to 8 years old. 4-The height of children will be at least one meter. 5- Children are levels I and II according to GMFCS (Gross Motor Classification System ).\n\nExclusion Criteria:\n\n1. Children with visual or auditory problems.\n2. Children with intellectual disability.\n3. Children have been injected with Botox injection or have done surgery in the last 6 months.",{"count":159,"type":22},44,[25],"Statement of the problem Do brain gym exercises affect balance and quality of life in children with spastic diplegia?\n\nNull hypotheses:\n\n1. There will be no significant effect of brain gym exercises on balance in children with spastic diplegia.\n2. There will be no significant effect of brain gym exercises on quality of life in children with spastic diplegia.",[163,29],"Cerebral Palsy (CP)",[165,166,167,168,169],"Brain gym exercises","Cerebral palsy","Diplegia","Balance","Quality of life","2026-02-22",{"date":172,"type":40},"2026-02-27",{"date":174,"type":40},"2025-12-01",{"date":88,"type":22},{"name":73,"class":47},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":19,"enrollmentInfo":183,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":48},"100568062","effect-of-multisensory-motor-imagery-training-on-muscle-performance-and-coordination-in-children-with-spastic-diplegia-100568062","NCT06676332","Effect of Multisensory Motor Imagery Training on Muscle Performance and Coordination in Children With Spastic Diplegia","Inclusion Criteria:\n\n* Their age will be ranged from 8-12 years.\n* Mild degree of spasticity ranged from 1 to 1+ according to Modified Ashworth Scale\n* Their motor function will be at level I and II according to Gross Motor Function Classification System GMFCS\n* They will be able to follow instructions during evaluation and treatment.\n\nExclusion Criteria:\n\n* \\- Cardiovascular or respiratory disorders.\n* Botulinium muscular injection in the last 6 months\n* Surgical interference in lower limbs and\u002For spine.\n* Muscloskeletal problems or fixed deformities in the spine and\u002For lower extremities.\n* Seizures.\n* Visual or hearing impairment",{"count":82,"type":22},[25],"PURPOSE:\n\nThe current study aims to:\n\n* Determine the effect of multisensory motor imagery training on muscle performance including (peak torque, work, power) of trunk and knee flexors and extensors in children with spastic diplegia.\n* Determine the effect of multisensory motor imagery training on coordination, strength and agility in children with spastic diplegia.\n\nBACKGROUND: Multisensory motor imagery training has an effect on muscle performance and coordination in children with spastic diplegia\n\nHYPOTHESES: There will be no effect of multisensory motor imagery training on muscle performance, coordination and strength and agility in children with spastic diplegic CP.\n\nRESEARCH QUESTION: Is there an effect of multisensory motor imagery training on coordination, strength and agility in children with spastic diplegia?",[29,187],"Motor Imagery","2025-02-15",{"date":190,"type":40},"2025-02-18",{"date":192,"type":40},"2024-11-16",{"date":194,"type":22},"2025-05",{"name":73,"class":47},{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":48},"100536878","role-of-dynamic-movement-intervention-in-children-with-spastic-diplegia-100536878","NCT06270550","Role of Dynamic Movement Intervention in Children with Spastic Diplegia","Efficacy of Dynamic Movement Intervention on Children with Spastic Diplegia","Inclusion criteria:\n\n* Age ranged from 4-7 years.\n* They can walk alone short distance and climb stairs holding on rail (Grade I \\& II according to GMFCS).\n* They can understand and execute instructions.\n* They will be medically stable.\n* Degree of spasticity will be ranged from 1 to 1+ degree according to the Modified Ashworth Scale.\n\nExclusion criteria:\n\n* Visual impairment (visual loss- cataract- myopia- hyperopia).\n* Hearing impairment (deafness)\n* Cognitive problem.\n* Uncontrolled Convulsions.\n* Orthopedic surgery for the affected lower limbs within one year.\n* Botulinum toxin injection within the last 6 months or within the study period.",{"count":204,"type":22},40,[25],"The study aims to investigate the effect of dynamic movement intervention approach on static and dynamic balance, quality of step length and cadence of walking pattern of children with spastic diplegic cerebral palsy.",[29],[209],"Dynamic Movement Intervention","2025-02-10",{"date":212,"type":40},"2025-02-12",{"date":214,"type":22},"2025-03-01",{"date":216,"type":22},"2025-09-01",{"name":73,"class":47},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":17,"minAge":224,"maxAge":101,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":48},"100250222","cortical-plasticity-in-spastic-diplegia-after-selective-dorsal-rhizotomy-100250222","NCT02535936","Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy","Inclusion Criteria:\n\n* Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery\n\nExclusion Criteria:\n\n* No Selective Dorsal Rhizotomy surgery","3 Years",{"count":226,"type":22},15,[25],"The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.",[29],[28],"2024-12-05",{"date":233,"type":40},"2024-12-11",{"date":235,"type":4},"2015-08",{"date":237,"type":22},"2031-01-01",{"name":239,"class":47},"The University of Texas Health Science Center, Houston"]