[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spastic-hemiplegia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spastic-hemiplegia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,47,78,106,134,161,189],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639778","robot-assisted-versus-conventional-physical-therapy-for-hand-in-sub-acute-stroke-100639778",false,"NCT07615569","Robot-assisted Versus Conventional Physical Therapy for Hand in Sub-acute Stroke","ROCHAS","Inclusion Criteria:\n\n* Both male and female adults aged 30-50 years diagnosed with post-stroke spastic hemiplegia confirmed by a neurologist.\n* Stroke duration 2 weeks to 6 months (sub acute stage) with medically stable condition.\n* Presence of mild to moderate upper-limb spasticity using screening test(Modified Ashworth Scale score 1-3).\n* Ability to comprehend and follow simple verbal instructions using screening test (MMSE ≥ 24).\n\nExclusion Criteria:\n\n* No history of upper-limb orthopedic surgery or botulinum toxin injections in the last 6 months.\n* History of recurrent or uncontrolled seizure disorders, progressive neurological diseases, or unstable cardiovascular conditions.\n* Participation in any intensive upper-limb rehabilitation program (CIMT, bimanual training, task-specific training, robotic therapy, FES therapy) within the past 6 months.\n* Comorbid conditions affecting upper-limb function (fractures, severe arthritis, peripheral nerve injuries).","ALL","30 Years","50 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare the effectiveness of robotic-assisted physiotherapy and conventional physiotherapy in improving hand function among patients with sub-acute stroke. Stroke often results in weakness, reduced hand strength, impaired dexterity, and difficulty performing daily activities due to upper-limb motor dysfunction. Early rehabilitation targeting hand recovery is essential to improve independence and quality of life.\n\nA total of 30 participants with sub-acute post-stroke spastic hemiplegia will be recruited from the University of Lahore Hospital and randomly assigned into two groups. The intervention group will receive robotic-assisted physiotherapy focused on repetitive, task-specific wrist and finger extension training using a robotic hand\u002Fwrist device, while the control group will receive conventional therapist-led upper-limb rehabilitation exercises. Both groups will undergo treatment sessions lasting 30-45 minutes, five days per week for four weeks.\n\nOutcome measures will include hand muscle strength assessed using a hand-held dynamometer, hand dexterity evaluated through the Action Research Arm Test (ARAT), and functional improvement measured using the Fugl-Meyer Assessment for Upper Extremity (FMA-UE). Additional measures such as spasticity, activities of daily living, and quality of life will also be recorded. Assessments will be conducted at baseline, during treatment, and after completion of the intervention period by a blinded assessor.\n\nThe study is expected to determine whether robotic-assisted physiotherapy provides greater improvements in hand strength, dexterity, and upper-limb functional recovery compared to conventional physiotherapy in individuals recovering from stroke. Findings from this research may contribute to evidence-based rehabilitation strategies for improving upper-limb outcomes after stroke.",[27,28,29],"Stroke","Spastic Hemiplegia","Upper Limb Motor Impairment",[27,31,32,33],"Robotic-assisted physiotherapy","Conventional physiotherapy","Hand rehabilitation","RECRUITING","2026-05-31",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":21},"2026-05-22",{"date":42,"type":21},"2026-06-23",{"name":44,"class":45},"Montiha Azeem","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100626285","evaluation-of-brain-mri-changes-in-cerebral-palsy-patients-100626285","NCT07433647","Evaluation of Brain MRI Changes in Cerebral Palsy Patients","Evaluation of Brain Changes in Cerebral Palsy Patients","Inclusion Criteria:\n\n* Have multiple MRI scans of brain and\u002For spinal cord spaced at least 24 months apart\n* Between 18-80 years of age with at least one MRI scan after the age of 18\n* No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration\n* Inclusion in CPRN registry\n* diagnosis of Cerebral Palsy\n* \\>18 years of age\n* Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)\n\nExclusion Criteria:\n\n* History of more than one seizure in lifetime\n* History of known degenerative genetic disorder\n* History of brain tumor, abscess, or multiple sclerosis\n* History of moderate or severe head trauma\n* History of metal implants in head",true,"18 Years","80 Years",{"count":20,"type":21},"2 Years","OBSERVATIONAL","Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.\n\nThis will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries.\n\nThe investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.",[62,63,64,28],"Cerebral Palsy","Spastic Diplegia","Spastic Quadriplegia",[66,67,68],"brain volume","cortical thickness","aging","2026-05-11",{"date":71,"type":38},"2026-05-13",{"date":73,"type":38},"2023-06-20",{"date":75,"type":21},"2029-07-01",{"name":77,"class":45},"Columbia University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100634331","biomechanical-muscle-properties-and-balance-in-children-with-spastic-hemiplegia-100634331","NCT07538297","Biomechanical Muscle Properties and Balance in Children With Spastic Hemiplegia","Muscle Biomechanical Properties and Postural Control During Static and Dynamic Standing in Children With Spastic Hemiplegia","BMPB-HCP","Inclusion Criteria:\n\n* Their age will range from 6 to 12 years.\n* Mild degree of spasticity ranged from 1 to 1+ according to Modified Ashworth Scale\n* Their motor function will be at level I and II according to Gross Motor Function Classification System GMFCS\n* They will be able to follow instructions during evaluation procedures.\n* Their caregivers are of a good command of the English language.\n\nExclusion Criteria:\n\n* Botulinum toxin injections in the last 6 months.\n* The presence of visual or auditory impairments.\n* Surgical interference in upper, lower limbs and\u002For spine.\n* Muscloskeletal problems or fixed deformities in the spine and\u002For upper or\u002Fand lower extremities.\n* Seizures.","6 Years","12 Years",{"count":89,"type":21},40,"this study will be conducted to investigate the relationship between muscle tone and dynamic stiffness during balance control and postural stability in children with spastic hemiplegia",[28],[93,94,95],"biomechanical Properties","balance","spastic hemiplegia","NOT_YET_RECRUITING","2026-04-12",{"date":99,"type":38},"2026-04-20",{"date":101,"type":21},"2026-04-17",{"date":103,"type":21},"2026-07-01",{"name":105,"class":45},"South Valley University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":55,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100625351","spinal-mobility-in-children-with-cerebral-palsy-ndt-bobath-and-exergaming-100625351","NCT07421505","Spinal Mobility in Children With Cerebral Palsy: NDT-Bobath and Exergaming","Spinal Mobility in Children With Cerebral Palsy Undergoing NDT-Bobath Therapy and Exergaming-based Therapy","Inclusion Criteria:\n\n* Written informed consent from parents\u002Fguardians and the child (if capable)\n* GMFCS levels I-III (mild to moderate motor limitations)\n* Ability to maintain standing position\n* Ability to follow instructions and perform exercises\n* No prior exergaming therapy\n* No implanted electronic devices\n* No acute infections or inflammatory conditions\n* No metabolic disorders affecting bioimpedance measurements\n\nExclusion Criteria:\n\n* GMFCS levels IV-V\n* Orthopedic surgery within the past 12 months\n* Seizure episodes within the past 6 months\n* Cognitive or behavioral impairments preventing cooperation\n* Severe spinal deformities (scoliosis \\>40° or other significant changes)\n* Attendance at therapy sessions \\\u003C85%",{"count":114,"type":21},42,[24],"The purpose of this study is to evaluate changes in spinal mobility in the cervical, thoracic, and lumbar regions in children with cerebral palsy aged 10-15 years. The study will compare outcomes between standard NDT-Bobath therapy supplemented with exergaming in a sitting position and exergaming in a standing position. Postural stability, body composition, and functional parameters will also be assessed.\n\nParticipants will complete a socio-medical questionnaire and undergo baseline measurements of spinal mobility, cervical range of motion, postural stability (using Podoscan and Zebris platform), body height, and body composition (using SECA stadiometer and Tanita bioimpedance analyzer).\n\nThe intervention will last 3 months and include twice-weekly 60-minute therapy sessions. Group I will receive NDT-Bobath therapy supplemented with exergaming in a sitting position, while Group II will receive NDT-Bobath therapy with exergaming in a standing position.\n\nAfter the intervention, participants will undergo post-intervention measurements and a follow-up evaluation three months later to assess the persistence of any changes.",[118,28],"Spastic Diplegia Cerebral Palsy",[120,121,122,123],"Cerebral palsy","Spinal mobility","NDT-Bobath therapy","Exergaming","2026-02-16",{"date":126,"type":38},"2026-02-19",{"date":128,"type":21},"2026-02",{"date":130,"type":21},"2026-06",{"name":132,"class":45},"Wroclaw University of Health and Sport Sciences",2,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":46},"100602153","clinical-and-ultrasonographic-evaluation-of-the-efficacy-of-extracorporeal-shock-wave-therapy-eswt-in-post-stroke-spasticity-100602153","NCT07119801","Clinical and Ultrasonographic Evaluation of the Efficacy of Extracorporeal Shock Wave Therapy (ESWT) in Post-Stroke Spasticity","Clinical and Ultrasonographic Evaluation of the Efficacy of Extracorporeal Shock Wave Therapy (ESWT) in Post-Stroke Spasticity: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 35 and 65 years.\n* First-ever stroke episode confirmed by MRI and\u002For CT scan.\n* Clinical diagnosis of hemiplegia.\n* More than 6 months post-stroke.\n* A Modified Ashworth Scale (MAS) score between 1 and 3 for wrist flexor spasticity.\n\nExclusion Criteria:\n\n* History of more than one stroke episode\n* Stroke onset more than ten years ago\n* Stroke onset less than 6 months ago\n* Age over 65 (to limit the effects of aging on muscle structure)\n* Contraindications for ESWT (e.g., cancer, local tumor or active infection in the treatment area, pregnancy, coagulation disorders, pacemaker or other electronic\u002Fmetallic implants)\n* Severe aphasia or serious communication problems\n* Presence of fixed contracture in the wrist\n* Patients who have received botulinum toxin or phenol nerve block injections within the last 6 months\n* Medically unstable patients (e.g., uncontrolled hypertension, diabetes mellitus, or severe cardiac, hepatic, or renal disease)","35 Years","65 Years",{"count":144,"type":21},32,[24],"This research evaluate the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) for treating spasticity in the wrist flexor muscles (flexor carpi ulnaris - FCU and flexor carpi radialis - FCR) of chronic stroke patients.\n\nSpasticity, a common complication after a stroke, causes muscle stiffness, pain, and functional limitation, leading to increased healthcare costs and a lower quality of life. Current treatments like medication and injections have significant drawbacks, such as side effects and high costs, creating a need for new, non-invasive, and effective methods.\n\nThe study highlights that traditional methods for assessing spasticity, like the Modified Ashworth Scale (MAS), are subjective. It proposes using objective, non-invasive ultrasound techniques-specifically strain elastography (to measure muscle stiffness) and echogenicity (to assess muscle tissue quality)-for a more reliable evaluation.\n\nThe primary goal of this research is to be the first to investigate the short- and long-term effects of ESWT on the FCR and FCU muscles using these objective ultrasound measures alongside traditional clinical scales. The findings are expected to help standardize ESWT treatment protocols and promote the use of objective ultrasound data for the management and follow-up of post-stroke spasticity.",[27,28,148],"Extracorporal Shockwave Therapy (ESWT)",[95,150,151],"extracorporeal shockwave therapy","spasticity of the wrist flexors","2025-09-23",{"date":154,"type":38},"2025-09-29",{"date":156,"type":38},"2025-09-05",{"date":158,"type":21},"2026-08-20",{"name":160,"class":45},"Pamukkale University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":4},"100603378","functional-electrical-stimulation-with-mirror-therapy-on-upper-limb-functions-and-quality-of-life-in-hemiplegic-children-100603378","NCT07135739","Functional Electrical Stimulation With Mirror Therapy on Upper Limb Functions and Quality of Life in Hemiplegic Children","Effect of Functional Electrical Stimulation With Mirror Therapy on Upper Limb Functions and Quality of Life in Hemiplegic Children","FESMT","Inclusion Criteria:\n\n* Their age will range from 5 to 10 years.\n* Spasticity grade range from 1+ to 2, according to Modified Ashworth Scale (\n* They will be able to follow instructions.\n\nExclusion Criteria:\n\nChildren will be excluded if they have any of the following criteria:\n\n* Loss of sensation\n* The presence of visual impairments.\n* Musculoskeletal problems or fixed deformities in the upper extremities.\n* Seizures.\n* Surgical interference in upper limbs.","5 Years","10 Years",{"count":89,"type":21},[24],"The goal of this clinical trial is to To investigate the combined effect of functional electrical stimulation and mirror therapy on:Quality of life and UL function in children with hemiplegia,Their age will be ranged from 5 to 10 years. The main question\\[s\\] it aims to answer \\[is\u002Fare\\]:Does the combination of functional electrical stimulation and mirror therapy have effects on upper limb function and Quality of life in children with hemiplegia? They will be randomly assigned into two groups, control group (A) will receive physical therapy program and study group(B) will receive same physical therapy program as control group (A) in addition FES combined with mirror therapy.",[175,28],"Upper Limb Paresis",[177,178,179],"hemiplegic cerebral palsy","functional electrical stimulation","mirror therapy","2025-08-20",{"date":182,"type":38},"2025-08-22",{"date":184,"type":21},"2025-09-01",{"date":186,"type":21},"2026-11-01",{"name":188,"class":45},"Rabab Mustafa Abdo",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":55,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":203,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":46},"100316689","tdcs-and-bimanual-therapy-for-children-with-hemiplegic-cerebral-palsy-100316689","NCT03402854","tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosis of congenital hemiplegic cerebral palsy\n* Ability to lift and grasp light objects with affected hand\n* Ability to extend wrist of affected hand 15 degrees\n* Ability to follow instructions and provide informed assent\n* Parent(s) able to provide informed consent\n\nExclusion Criteria:\n\n* Seizures after age 2 years\n* Spasticity medication within 6 months before study\n* Selective dorsal rhizotomy\n* Surgery in affected upper extremity within year before study",{"count":196,"type":21},80,[24],"The goal of this study is to test the efficacy of transcranial direct current stimulation combined with bimanual training on hand function in children with unilateral spastic cerebral palsy (USCP). Children who enroll in the protocol will be randomized to receive either sham (not stimulating) tDCS plus bimanual training, or active (stimulating) tDCS plus bimanual training.",[62,200,201,202,28],"Hemiplegic Cerebral Palsy","Spastic Hemiplegic Cerebral Palsy","Spastic Hemiparesis",[204,205,206,207,208,209],"pediatric","children","non-invasive brain stimulation","transcranial direct current stimulation","bimanual training","hand training","2024-07-15",{"date":212,"type":38},"2024-07-16",{"date":214,"type":38},"2019-12-01",{"date":216,"type":21},"2025-08-31",{"name":218,"class":45},"Burke Medical Research Institute"]