[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"speech-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:speech-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642955","wireless-implantable-mandarin-chinese-speech-neuroprosthesis-evaluation-100642955",false,"NCT07647315","Wireless Implantable Mandarin Chinese Speech Neuroprosthesis Evaluation","WISE","Inclusion Criteria:\n\n* Age 18 to 80 years (inclusive), any gender.\n* Clinically diagnosed with speech disorders, including locked-in syndrome, severe dysarthria, aphasia with preserved auditory comprehension, or late-stage ALS-related language dysfunction, secondary to stroke, traumatic brain injury, amyotrophic lateral sclerosis (ALS), or other motor neuron diseases.\n* The subject, or the subject with the assistance of their legal representative, is willing to follow the investigator's instructions, adhere to all protocol-specified procedures, and complete all required follow-up.\n* The subject and their legal representative fully understand the purpose and significance of the trial; the subject voluntarily agrees to participate and signs the informed consent form\n\nExclusion Criteria:\n\n* Subjects with any previously implanted metallic objects or devices (e.g., pacemakers, defibrillators, neurostimulators, cochlear implants), except for dental metal implants or implants assessed to have no impact on the trial.\n* Subjects who have been on long-term anticoagulant or antiplatelet therapy prior to screening, with antiplatelet drugs discontinued for less than 2 weeks before surgery; or subjects with hematological or autoimmune disorders (e.g., aplastic anemia, systemic lupus erythematosus); or subjects with clinically significant coagulation test abnormalities during the screening period.\n* Subjects assessed by an anesthesiologist to be unable to tolerate anesthesia and surgery.\n* Subjects assessed by the investigator to have nervous system diseases (e.g., cerebrovascular lesions, intracranial infections, neurodegenerative diseases, epilepsy) or a history of craniocerebral trauma, resulting in severe brain function impairment or marked EEG abnormalities.\n* Subjects with physiological or pathological conditions that may lead to poor healing of scalp wounds.\n* Subjects in the acute infection phase or suffering from other severe infections.\n* Subjects with cognitive impairment or psychotic symptoms.\n* Subjects with severe dysfunction of vital organs (heart, lung, liver, kidney, etc.), malignant tumors or autoimmune diseases, who are deemed ineligible for this clinical trial by investigators.\n* Subjects judged by investigators to have an expected survival time of less than 1 year.\n* Subjects with drug abuse or alcohol dependence.\n* Pregnant or breastfeeding women, or subjects planning to become pregnant during the trial period.\n* Subjects currently participating in clinical trials of drugs or other medical devices.\n* Subjects unable to understand or read Chinese.\n* Other circumstances under which investigators consider the subject unsuitable to participate in this clinical trial","ALL","18 Years","80 Years",{"count":20,"type":21},4,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, single-arm clinical trial is designed to preliminarily evaluate the safety and efficacy of an implantable wireless brain-computer interface (BCI) system (manufactured by Shanghai StairMed Technology Co., Ltd.) in enabling subjects with speech disorders to achieve brain-controlled interaction and communication. Eligible subjects will undergo surgical implantation of the device and receive brain-control training. All participants will be followed for an expected period of 12 months. During the follow-up, adverse events, serious adverse events, and device deficiencies will be recorded, and efficacy data on brain-controlled interaction and communication will be collected. The goal is to conduct an initial assessment of the safety and effectiveness of the investigational device in achieving brain-controlled effects in the target population.",[27],"Speech Disorder","NOT_YET_RECRUITING","2026-06-09",{"date":31,"type":32},"2026-06-15","ACTUAL",{"date":34,"type":21},"2026-06-30",{"date":36,"type":21},"2028-12-30",{"name":38,"class":39},"Shanghai StairMed Technology Co., Ltd.","INDUSTRY",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":40},"100613242","velopharyngeal-dysfunction-in-head--neck-cancer-patients-pilot-study-100613242","NCT07264036","Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study","Injectable Augmentation Outcomes in Post-Radiation Head and Neck Cancer Patients With Velopharyngeal Dysfunction","Inclusion Criteria:\n\nEnglish-speaking adults (≥18 years) History of head and neck cancer treated with surgical resection, chemoradiation, or both Presence of perceptual hypernasality on clinical assessment\n\nExclusion Criteria:\n\nPre-existing or suspected non-cancer-related causes of velopharyngeal dysfunction Contraindications to pharyngeal wall augmentation Requirement for more intensive active cancer surveillance Planned future surgical or medical treatments to the pharynx that would interfere with participation",{"count":49,"type":21},20,[24],"Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), a problem with closure between the soft palate and throat that can cause nasal-sounding speech, food or liquid leaking into the nose, difficulty swallowing, and reduced quality of life. This study aims to better understand VPD in this population and to evaluate whether pharyngeal wall augmentation (plumping up the back wall of the throat) can improve speech and swallowing.\n\nParticipants will undergo a multidisciplinary assessment including physical examination, flexible nasolaryngoscopy, speech recording and acoustic analysis, nasometry, clinical swallowing evaluation, and fiberoptic endoscopic evaluation of swallowing (FEES).\n\nAim 1: Determine the prevalence, severity, and functional impact of VPD in head and neck cancer survivors.\n\nAim 2: Assess the feasibility and usefulness of advanced diagnostic tools for VPD.\n\nThe investigators hypothesize that high nasalance scores (\\>1 SD above normal) will accurately predict VPD with at least 75% positive predictive value and will correlate with worse communication-related quality of life (CPIB).\n\nThe investigators also hypothesize that participants with VPD will have more pharyngeal residue or nasal regurgitation on FEES, and that these findings will be associated with lower swallowing-related quality of life (SWAL-QOL).\n\nAim 3: Evaluate the effectiveness of pharyngeal wall augmentation injections for improving speech intelligibility and swallowing function.\n\nThe investigators expect that this treatment will lead to measurable changes in both objective assessments and patient-reported outcomes. The results will help improve diagnosis and management of VPD in head and neck cancer survivors.",[53,54,55,56,27],"Velopharyngeal Insufficiency","Head and Neck Cancer","Survivorship","Dysphagia",[58,59,60,61,62,63],"velopharyngeal dysfunction","hypernasal speech","pharyngeal wall augmentation","nasometry","head and neck cancer","survivorship","RECRUITING","2026-04-27",{"date":67,"type":32},"2026-04-28",{"date":69,"type":32},"2026-03-24",{"date":71,"type":21},"2027-07-01",{"name":73,"class":74},"Vanessa Torrecillas","OTHER",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":40},"100583284","voiceitt-for-people-with-impairments-in-speech-100583284","NCT06874322","Voiceitt for People With Impairments in Speech","Inclusion Criteria:\n\n* Age 13 or older\n* moderately severe speech dysarthria due to conditions such as CP, stroke, ALS or Parkinson's Disease, etc.\n* Ability to understand and follow instructions for using the Voiceitt app.\n\nExclusion Criteria:\n\n* Severe cognitive impairments that prevent the understanding of the Voiceitt app and required training.\n* Patients who have additional speech impairments other than dysarthria, such as significant aphasia or verbal apraxia.\n* Severe physical impairments that prevent interaction with the app.\n* Non-English speakers.","13 Years",{"count":49,"type":21},[24],"The primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the Voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (CP), stroke, Amyotrophic Lateral Sclerosis (ALS), or Parkinson's disease.",[86,27],"Speech Impairment",[86,88,89,90,91,92,93,94,95],"voice recognition tool","dictation tool","voice recognition app","dictation app","voiceitt app","speech disabilities","dysarthria","moderate dysarthria","2025-08-04",{"date":98,"type":32},"2025-08-08",{"date":100,"type":32},"2025-06-25",{"date":102,"type":21},"2026-08",{"name":104,"class":74},"University of Pittsburgh"]