[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"speech-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:speech-disorders":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,112,141,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":36,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100371514","orthognathic-speech-pathology-phonetic-contrasts-of-patients-with-dental-discrepancies-pre--and-post-treatment-analyses-100371514",false,"NCT04117360","Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses","Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dentofacial Discrepancies With Pre- and Post-Treatment Analyses","OSP","Inclusion Criteria:\n\n* Jaw surgery patient at UNC with a skeletal open bite, underbite or overjet greater than 5mm.\n* Age 15-40 years\n\nExclusion Criteria:\n\n* Hearing loss\n* Learned English as a second language\n* Significant regional accent, as characterized by a speech pathologist\n* Developmental delay, performing several grade levels below age bracket\n* history of craniofacial disorder\n* genetic syndrome associated with known craniofacial presentation\n* history of craniofacial trauma\n* history of prior craniofacial surgery (excluding extractions and dental procedures)\n* Jaw surgery without fixed orthodontic appliances","ALL","15 Years","40 Years",{"count":21,"type":22},180,"ESTIMATED","OBSERVATIONAL","The investigators are studying how speech is effected by jaw and tooth position in jaw surgery patients. Eighty percent of our jaw surgery patients have speech pathologies, compared to five percent of the general population, but speech pathologists do not understand why. The investigators hypothesize that open bites and underbites prevent most patients from being able to pronounce words normally and surgical correction will lead to improvement in speech. Patients will be audio recorded speaking and patients' tongue gestures ultrasound recorded before and after their jaw surgeries to observe what changes occur in their speech and tongue movements.",[26,27,28,29,30,31,32,33,34,35],"Dentofacial Abnormalities","Dentofacial Deformities","Dentofacial Anomalies, Including Malocclusion","Malocclusion","Malocclusion in Children","Dentofacial Disharmony","Skeletal Malocclusion","Skeletal Malformation","Speech Sound Disorder","Speech Disorders",[31,37,34,38,39,40],"Skeletal malocclusion","Spectral Moment Analysis","Tongue Ultrasound","Orthognathic Surgery","RECRUITING","2026-06-10",{"date":44,"type":45},"2026-06-12","ACTUAL",{"date":47,"type":45},"2019-09-11",{"date":49,"type":22},"2028-03",{"name":51,"class":52},"University of North Carolina, Chapel Hill","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":82,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100496255","cognitive-reserve-and-response-to-speech-language-intervention-in-bilingual-speakers-with-primary-progressive-aphasia-100496255","NCT05741853","Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia","Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)\n* Bilingual in Spanish and Catalan or bilingual in Spanish and English\n* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable\n* Intervention study: Score of 15 or higher on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination\n\nExclusion Criteria:\n\n* Other central nervous system or medical diagnosis that can cause symptoms\n* Other psychiatric diagnosis that can cause symptoms\n* Significant, uncorrected visual or hearing impairment that would interfere with participation\n* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)\n* Intervention Study: Score of less than 15 on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination",true,{"count":63,"type":22},60,"INTERVENTIONAL",[66],"NA","Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.\n\nThe overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how \"strong\" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.",[69,70,71,72,73,74,75,76,77,78,35,79,80,81],"Primary Progressive Aphasia","Dementia","Dementia, Frontotemporal","Alzheimer Disease","Neurodegenerative Diseases","Frontotemporal Lobar Degeneration","Apraxia, Motor","Dysarthria","Communication Disorders","Language Disorders","Neurocognitive Disorders","Aphasia","Bilingual Aphasia",[83,84,85,69,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102],"Dementia, ADRD","Bilingualism","Multilingualism","Bilingual Primary Progressive Aphasia","Cognitive Reserve","Language Decline","Bilingual Language Decline","Speech-Language Therapy","Bilingual Speech-Language Therapy","Spanish speakers","Spanish-Catalan Bilinguals","Spanish-English Bilinguals","Hispanic","Catalán","Catalan","Spanish","Castellano","Speech Therapy","Latino","Cognition","2026-06-08",{"date":42,"type":45},{"date":106,"type":45},"2023-05-01",{"date":108,"type":22},"2027-11-30",{"name":110,"class":52},"Stephanie Grasso",3,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":64,"phases":122,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":53},"100492667","clinical-feasibility--validation-of-the-virtual-reality-glenxrose-speech-language-therapies-100492667","NCT05695131","Clinical Feasibility & Validation of the Virtual Reality GlenxRose Speech-Language Therapies","Clinical Implementation, Feasibility, & Validation of the Virtual Reality Delivered GlenxRose Speech-Language Therapies to Improve Patient Adherence and Treatment Outcomes","Inclusion Criteria:\n\n* Adults receiving speech-language therapy at the Glenrose Rehabilitation Hospital (Edmonton, AB, Canada; Alberta Health Services)\n* Presence of a speech disorder\n* Proficiency in English\n* Able to provide signed informed consent to participate in the study\n\nExclusion Criteria:\n\n* Severe cognitive impairments and\u002For behavioural impairments\n* Communication disorders that impact comprehension of verbal commands and understanding of scale used in the study\n* Previous history of neurological or psychiatric disorder\n* Substance use disorders","18 Years",{"count":121,"type":22},30,[66],"Factors related to successful rehabilitation are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors. Furthermore, surrounding salience, patients may lose interest or find an intervention boring after a few sessions. It is well documented that nonadherence not only impacts rehabilitation for the patient but can also further prolong treatment, and increase hospital and clinician costs, in addition to a higher prevalence of future comorbidities. Therefore, strategies that improve patient adherence can significantly help optimize patient care and treatment outcomes.\n\nOne avenue to increase patient adherence is through the gamification of rehabilitation therapies using virtual reality (VR). Gamification of rehabilitation therapy can make mass practice required in rehabilitation therapies seemingly fun and more personally engaging for the patient. Additionally, the immersive experience achieved through VR can further promote salience and be customizable to individual patient requirements. As VR systems are now highly portable and relatively simple to utilize, they can provide an excellent opportunity to continue rehabilitation practice on the home front. Overall, the VR gamification of rehabilitation may increase adherence by shifting patients' perspectives of therapy as tedious, boring, or a hassle, to a fun and engaging game that ultimately helps their recovery processes.\n\nThe GlenXRose VR-delivered speech-language therapies (Cognitive Projections Lab, University of Alberta) have been developed and piloted in collaboration with the Glenrose Rehabilitation Hospital with the overall goal of increasing patient adherence, treatment outcomes, and satisfaction with vocal therapy. The proposed studies are to investigate the feasibility of implementing this technology in routine clinical care (specific to voice disorders), obtaining clinician feedback, examining associated financial costs, and continuing to examine the effect of the GlenXRose VR speech-language therapies on patient adherence and clinical outcomes, compared to traditional clinical care.",[125,35],"Vocal Cord Dysfunction",[127,128,129,130,131],"Vocal","Speech","Speech-Language Pathology","Virtual Reality","VR","2026-05-07",{"date":134,"type":45},"2026-05-12",{"date":136,"type":45},"2023-09-20",{"date":138,"type":22},"2026-06-30",{"name":140,"class":52},"University of Alberta",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":61,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":53},"100476901","gender-disparities-in-voice-outcomes-after-tracheoesophageal-puncture-in-total-laryngectomy-patients-uc-davis-100476901","NCT05489965","Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy Patients (UC Davis)","Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy","Inclusion Criteria:\n\n* Male and female subjects who have completed total laryngectomy and are using TEP\n\nExclusion Criteria:\n\n* Subjects who have not completed total laryngectomy and are not using TEP",{"count":149,"type":22},12,"To perform a multi-site prospective study assessing, both subjectively and objectively, the gender disparities in speech outcomes of patients using TEP after total laryngectomy.\n\nThe investigators hypothesize that speech outcomes, both subjective and objective measures, will be significantly poorer for female patients compared to male patients. The outcome of the study is to prospectively assess both subjective and objective gender disparities in voice and speech outcomes of patients using TEP after total laryngectomy across a multiple institutions. The investigators hypothesize that both subjective and objective measurements of voice, speech and quality of life will be poorer for female patients in comparison to male patients.",[35,152,153,154,155],"Speech Dysfunction","Laryngectomy; Status","Tracheoesophageal Prosthesis","Total Laryngectomy","2026-02-09",{"date":158,"type":45},"2026-02-11",{"date":160,"type":45},"2023-05-31",{"date":162,"type":22},"2026-06-01",{"name":164,"class":52},"University of California, Davis",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":61,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":64,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":53},"100550130","the-mere-measurement-effect-of-patient-reported-outcomes-100550130","NCT06443073","The Mere-measurement Effect of Patient-reported Outcomes","The Mere-measurement Effect in Patient-reported Outcomes: A Randomized Control Trial With Speech Pathology Patients","Inclusion Criteria:\n\nAll patients will be required to have a qualifying disorder known to effect speech as identified below. Patients who meet the eligibility criteria will be invited to participate in the study by the researchers. Eligibility will be assessed prior to enrolment recruitment screening. AKH patients are not targeted for this study. All patients, regardless of geographic location around the world, can be recruited. The study is entirely online.\n\nSubjects must meet the following inclusion criteria for study entry:\n\n* Strong English skills\\*\n* Technology savvy - able to complete online questionnaire\n* Suffering from one of the following:\n\n  * Muscle tension dysphonia\n  * Inducible laryngeal obstruction\n  * Amyotrophic lateral sclerosis (ALS)\n  * Patients after a stroke or other brain injury\u002Fdamage\u002Ftrauma, (aphasia, dysarthria)\n  * Parkinson's disease\n\nExclusion Criteria:\n\n* Under the age of 18",{"count":173,"type":22},170,[66],"The use of patient-reported outcome (PROs) have become increasingly commonplace across many healthcare settings over the past two decades. The value of PROs is now acknowledged by healthcare providers and patients alike. However, to date, little is known about the best practices for formulating PRO measures (PROMS), but even more specifically, the effect had on the responding patients as a result of item word choice, emotional valence, or frequency of use. That is, 1) does the positive or negative wording of items affect the patient's perspective on the latent variable, 2) is there a degree of subliminal influence or measurement effects on their behaviour resulting from exposure to PROs, and finally, 3) is such an effect amplified with repeated exposure?",[177,35,178],"Measurement, Psychological Stress","Assessment, Self","2025-05-13",{"date":181,"type":45},"2025-05-14",{"date":183,"type":45},"2024-05-01",{"date":185,"type":22},"2025-12-22",{"name":187,"class":52},"Medical University of Vienna"]