[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"speech-intelligibility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:speech-intelligibility":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,74,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100582195","cochlear-implant-speech-in-noise-processing-100582195",false,"NCT06860152","Cochlear Implant Speech in Noise Processing","O15-PET Imaging of Cochlear Implant Speech in Noise Processing","Cochlear Implant subjects (enrollment is planned at N=120) - Inclusion criteria:\n\n1. Between 18 and 99 years of age.\n2. Have a cochlear implant activated for more than one year.\n3. Eligible for research under the Iowa Cochlear Implant Project VIII.\n4. Ability to understand and willingness to sign a written informed consent document.\n5. Severe hearing loss after age 16.\n\nNormal Hearing subjects (enrollment is planned at N=30) - Inclusion criteria:\n\n1. Between 18 and 99 years of age.\n2. Have age typical hearing.\n3. Eligible for research under the Iowa Cochlear Implant Project VIII.\n4. Ability to understand and willingness to sign a written informed consent document.\n\nExclusion criteria (all groups):\n\n1. Medical history includes seizure disorder, head injury, neurologic, metabolic, cardiovascular disease, or previous cerebrovascular event (unless approved by PI).\n2. Female self-reporting pregnancy. A urine pregnancy test will be performed prior to injection of the radiopharmaceutical.\n3. Currently taking medications which may affect cerebral blood flow (e.g., papaverine, ginkgo biloba, acetazolamide).\n4. Uncontrolled intercurrent illness that would limit compliance with study requirements per investigator.","ALL","18 Years","99 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study will help us in understanding the neural mechanisms by which listeners with a cochlear implant detect speech in noisy environments.",[27,28,29],"Hearing Loss, Adult-Onset","Speech Intelligibility","Hearing Loss, Extreme","RECRUITING","2026-05-11",{"date":33,"type":34},"2026-05-14","ACTUAL",{"date":36,"type":34},"2024-11-14",{"date":38,"type":21},"2028-03-31",{"name":40,"class":41},"Craig D. Workman, PhD","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":62,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100467352","fall-risk-assessment-and-speech-intelligibility-enhancement-using-in-ear-device-100467352","NCT05365646","Fall Risk Assessment and Speech Intelligibility Enhancement Using In-ear Device","Inclusion Criteria:\n\n* Age 55 years or older\n* Bilateral hearing aid user\n* Able to consent in English\n* Having access to a phone capable of running the mobile app required for the study\n* Screen for fall risk (\"Yes\" to any question: Feels unsteady when standing or walking? Worries about falling? Has fallen in past year? If the participant has fallen: how many times? were they injured\u002Fhurt?)\n* Ambulatory without need for a wheelchair\n\nExclusion Criteria:\n\n* People with mobility restrictions (e.g., wheelchair bound) that would prevent the performance of the functional assessments.\n* People with severe movement (e.g., Advanced Parkinson's disease) or cognitive (e.g., advanced dementia) disorders that would prevent the individual from either performing the functional assessments, or would lead to restricted activities that would prevent motion data from being collected according to the goal of the study.\n* Inability to understand, consent, and complete requirements including verbal instructions and non-ambulatory\u002Fwheelchair-dependent.",true,"55 Years",{"count":52,"type":21},350,[24],"The purpose of this study is to develop and validate methods to use hearing aids equipped with embedded sensors and artificial intelligence to assist in the assessment of fall risk and in the implementation of interventions aimed at reducing the risk of falling, as well as to improve speech intelligibility in quiet and in background noise, track physical activity, and social engagement. The investigators hope is that the knowledge that is generated through this study will ultimately translate to the clinical setting and will help reduce the likelihood that individuals experience a fall, and improve the quality of hearing in individuals who wear hearing aids.",[56,57,58,59,60,61,28],"Hearing Loss","Dizziness","Vertigo","Fall Related Injury Risk","Fall Prevention","Imbalance",[63,64],"Fall risk","Hearing loss","2026-04-25",{"date":67,"type":34},"2026-04-28",{"date":69,"type":34},"2022-05-23",{"date":71,"type":21},"2026-10",{"name":73,"class":41},"Stanford University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100560722","benefits-of-choir-for-older-adults-with-unaddressed-hearing-loss-wp2-100560722","NCT06580847","Benefits of Choir for Older Adults With Unaddressed Hearing Loss (WP2)","Speech-in-noise, Psychosocial, and Heart Rate Variability Outcomes of Group Singing or Audiobook Club Interventions for Older Adults With Unaddressed Hearing Loss: a SingWell Project Multisite, Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Adults aged 60 years and older;\n2. Bilateral mild-to-moderate hearing loss (20-49 dB hearing level), measured using four-frequency pure-tone average across both ears (4FPTA) measured at 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz;\n3. Unaddressed hearing loss (i.e., participants must not currently use a hearing aid, cochlear implant, or assistive listening device);\n4. No significant cognitive impairment, to be assessed with the Montreal Cognitive Assessment for people with hearing impairment (MoCA-H), with participants requiring a score ≥ 24;\n5. Not use a pacemaker or anti-arrhythmic agents\u002Fmedications;\n6. Not currently participating in regular active music learning (e.g., choir, formal music training) or audiobook clubs within the last year; and\n7. Sufficient language capacity to understand and complete the test materials. Note: all materials will be presented written and\u002For aurally in English at the sites located in Canada, United States of America, and Australia; Dutch at the Netherlands site; and German at the Germany site.","60 Years",{"count":83,"type":21},210,[24],"Unaddressed age-related hearing loss is highly prevalent among older adults, typified by negative consequences for speech-in-noise perception and psychosocial wellbeing. There is promising evidence that group singing may enhance speech-in-noise perception and psychosocial wellbeing. However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. Hence, to address these concerns, this SingWell Project study utilizes an appropriate sample size, multisite, randomized controlled trial approach, with a robust preplanned statistical analysis.\n\nThe objective of the study is to explore if group singing may improve speech-in-noise perception and psychosocial wellbeing for older adults with unaddressed hearing loss.\n\nThe investigators designed an international, multisite, randomized controlled trial to explore the benefits of group singing for adults aged 60 years and older with unaddressed hearing loss. After undergoing an eligibility screening process and completing an information and consent form, the investigators intend to recruit 210 participants that will be randomly assigned to either group singing or an audiobook club (control group) intervention for a training period of 12-weeks. The study has multiple timepoints for testing, that are broadly categorized as macro (i.e., pre- and post-measures across the 12-weeks), or micro timepoints (i.e., pre- and post-measures across a weekly training session). Macro measures include behavioural measures of speech and music perception, and psychosocial questionnaires. Micro measures include psychosocial questionnaires and heart-rate variability.\n\nThe investigators hypothesize that group singing may be effective at improving speech perception and psychosocial outcomes for older adults with unaddressed hearing loss-more so than participants in the control group.",[87,28,88],"Hearing Loss, Age-Related","Psychosocial Functioning",[64,90,91],"speech in noise","psychosocial wellbeing","2025-09-13",{"date":94,"type":34},"2025-09-18",{"date":96,"type":34},"2025-04-15",{"date":98,"type":21},"2026-09",{"name":100,"class":41},"Toronto Metropolitan University",7,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":49,"sex":16,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100439075","speech-perception-and-high-cognitive-demand-100439075","NCT04997577","Speech Perception and High Cognitive Demand","Auditory-cognitive Training Paradigm (NIH P01 Project - Speech Perception With High Cognitive Demand)","Inclusion Criteria:\n\n* Aged between 65 - 85 years\n* Normal hearing (pure tone thresholds ≤ 25 dB HL from 250 - 8000 Hz)\n* Self-reported normal or corrected-to-normal vision\n* Dominant language: American English\n* Education: a high school diploma or higher education level\n\nExclusion Criteria:\n\n* Middle-ear or inner-ear pathology\n* Non-native speaker of English\n* Inability to complete all training sessions within a pre-specified time window (e.g., due to unexpected schedule restrictions)\n* Learning disorders\n* Metal in body that induces a data artifact for MEG recording (e.g., excessive metal dental work) or that poses a safety issue in the MRI portion (e.g., pacemakers, neural implants, metal plates or joints, shrapnel, and surgical staples)\n* Claustrophobia or any condition that would be exacerbated by the scanning environment's lighting, sounds, etc. (e.g., migraines)\n* A non-removable hairstyle or hair accessory that would prevent the participant from fitting comfortably in the MEG or MRI head coil\n* Currently under a medical provider's care for a closed head injury\n* Currently taking psychoactive stimulant (e.g., amphetamines), depressant (e.g., benzodiazepines), mood stabilizing (e.g., lithium), anti-psychotic, or anti-seizure medications or drugs of abuse\n* Currently pregnant (only for MRI)","65 Years","85 Years",{"count":112,"type":21},100,[24],"With advancing age, adults experience increasing speech understanding difficulties in challenging situations. Currently, speech-in-noise difficulties are rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults do not have decreased hearing sensitivity. The goal of the \"Speech Perception and High Cognitive Demand\" project is to evaluate the benefit of a new auditory-cognitive training paradigm. In the present study neural (as measured by pupillometry and magnetoencephalography) and behavioral changes of speech-in-noise perception from pretest to posttest will be examined in older adults (age 65 - 85 years) assigned to one of three training groups: 1) Active Control Group: sessions of watching informational videos, 2) Auditory Training Group: sessions of auditory training listening to one of two speakers in everyday scenarios (e.g., driving directions) and needing to recall what one speaker said in the previous sentence, and 3) Auditory-cognitive training group: identical to the auditory training group, except participants will be asked to remember information from two previous sentences. Changes in speech-in-noise perception will be examined for the three groups of older adults and gains will be compared to a control group of young, normal hearing adults (18-30 years) that is not part of the clinical trial and will not undergo any training.",[28,116],"Aging",[118,116,119],"Auditory-cognitive training","Speech-in-noise perception","2025-04-03",{"date":122,"type":34},"2025-04-08",{"date":124,"type":34},"2021-09-27",{"date":126,"type":21},"2027-12-31",{"name":128,"class":41},"University of Maryland, College Park",2]