[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"speech-perception\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:speech-perception":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,77,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100622180","cochlear-implant-recipients-comprehensive-longitudinal-evaluation-100622180",false,"NCT07380269","Cochlear Implant Recipients: Comprehensive Longitudinal Evaluation","Comprehensive Follow-up and Evaluation for Cochlear Implant Patients for All Ages","CIRCLE","Inclusion Criteria:\n\n* Patients with severe or greater hearing loss (≥65 dB) scheduled to receive cochlear implant (CI) treatment.\n* No restrictions on age or gender.\n* Native language is Mandarin Chinese.\n* The subject and\u002For their legal guardian must provide informed consent prior to the study, voluntarily sign a written informed consent form, and be willing to undergo follow-up assessments at the specified time points.\n* Ability to communicate effectively with the researcher with the help of a guardian and comply with the researcher's requirements. For young children without mature language skills, ability to cooperate with the help of a guardian.\n* The subject's guardian has a correct understanding of the trial and realistic expectations of potential benefits.\n\nExclusion Criteria:\n\n* Presence of other severe diseases unsuitable for cochlear implantation surgery.\n* Significant psychological problems or mood disorders (e.g., notable anxiety, depression, or behavioral disorders) that would preclude cooperation with training and follow-up.\n* Neurological diseases (e.g., epilepsy, cerebral palsy) that may affect auditory processing ability.\n* Concurrent participation in other interventional studies involving drugs or behavioral interventions that may affect auditory rehabilitation during the study period.\n* Any other condition considered by the investigator to make the subject unsuitable for participation in this clinical study.","ALL",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This study aims to assess hearing and speech perception, as well as quality of life, in deaf patients of all ages before and after cochlear implantation, and to explore differences across age groups and treatment subtypes, thereby providing evidence for personalized hearing and speech rehabilitation.",[24,25,26,27,28],"Hearing Loss","Hearing Loss, Sensorineural","Deafness","Cochlear Implantation","Speech Perception",[30,31,32,33,34,35,36,37],"Cochlear Implant","Pediatric Cochlear Implantation","Adult Cochlear Implantation","Auditory Rehabilitation","Speech Recognition","Quality of Life","Cognitive Function","Observational Cohort","RECRUITING","2026-01-27",{"date":41,"type":42},"2026-02-02","ACTUAL",{"date":44,"type":42},"2025-08-22",{"date":46,"type":20},"2030-09",{"name":48,"class":49},"Eye & ENT Hospital of Fudan University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100534358","a-comparative-analysis-of-speech-perception-between-cochlear-implant-patients-and-dfnb9-patients-receiving-gene-therapy-100534358","NCT06237790","A Comparative Analysis of Speech Perception Between Cochlear Implant Patients and DFNB9 Patients Receiving Gene Therapy","Inclusion Criteria:\n\n* Patients with congenital hearing loss with hearing thresholds ≥65 dB receive either gene therapy (previously received gene therapy and standardized postoperative rehabilitation and follow-up or plan to receive gene therapy), or cochlear implant surgery. Healthy participants with bilateral hearing thresholds within the normal range (≤20 dB), generally matched to the gene therapy group and the cochlear implant group by age and sex.\n* Age ≥ 6 months old, regardless of gender.\n* Mandarin Chinese as the native language.\n* Participants and their guardians must provide informed consent before the trial, voluntarily sign a written consent form, and commit to follow-up at specified time points.\n* Capable of effective communication with researchers under the guardian's assistance and willing to cooperate and comply with the researchers' requirements.\n* The participant's guardians should have a correct understanding of the trial and appropriate expectations regarding potential benefits.\n\nExclusion Criteria:\n\n* Presence of other otological disorders that may interfere with the surgical outcome or interpretation of study endpoints, such as middle\u002Finner ear dysplasia or malformations that affected the therapeutic effect revealed in CT\u002FMRI scans within 3 months, vestibular-cochlear nerve abnormalities, acute\u002Fchronic otitis media, Meniere's disease, etc.\n* Presence of other severe congenital diseases.\n* Presence of severe systemic diseases or in the acute onset of diseases, such as pulmonary tuberculosis, active hepatitis B or C infection, active herpes zoster infection, pancreatitis, renal insufficiency, etc.\n* Individuals with low immunity, a history of immune deficiency or organ transplantation.\n* Individuals with a history of neurological or mental disorders, such as epilepsy or dementia.\n* Patients with contraindications for surgery or anesthesia assessed by a surgeon, anesthetist, or designated personnel, such as cardiovascular or cerebrovascular events in the past 6 months, allergies to the planned medications, etc.\n* Gene therapy group: gene therapy did not restore hearing; Cochlear implant group: presence of hereditary syndromic deafness or other conditions that seriously affect the efficacy evaluation.\n* Any other conditions for which the investigators consider the subject unsuitable for participation in this clinical study.",true,"6 Months",{"count":60,"type":20},180,"This cohort study aims to explore the trends and differences in multidimensional perceptual levels of patients after cochlear implants or gene therapy, as well as to comprehensively assess the efficacy of gene therapy for congenital deafness, thus providing a reference for making a well-rounded postoperative rehabilitation protocol for gene therapy patients.",[24,63,28],"Genetic Disease",[65,66,67,30,28],"Congenital Hearing Loss","DFNB9","Gene Therapy","2025-08-27",{"date":70,"type":42},"2025-09-04",{"date":72,"type":42},"2024-04-06",{"date":74,"type":20},"2026-12-22",{"name":48,"class":49},6,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":57,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":50},"100594828","perceptual-evaluation-and-rehabilitation-system-development-for-congenital-hearing-loss-100594828","NCT07024524","Perceptual Evaluation and Rehabilitation System Development for Congenital Hearing Loss","Development and Application of A Multimodal Perceptual Evaluation and Precision Rehabilitation System in Congenital Deafness","Inclusion Criteria:\n\nFor Congenital Deafness Group: Patients with congenital hearing loss with hearing thresholds ≥65 dB who have received hearing aids, cochlear implantation, or gene therapy; Age between 1 and 35 years old, regardless of gender.\n\nFor Healthy Controls Group: Participants with normal hearing thresholds (≤20 dB) whose age and gender matched to the patient group.\n\nMandarin Chinese as the native language. Participants and\u002For their guardians must provide informed consent before the trial, voluntarily sign a written consent form, and commit to receive evaluation at specified time points.\n\nCapable of effective communication with researchers under the guardian's assistance and willing to cooperate and comply with the researchers' requirements.\n\nParticipants and\u002For their guardians should have a correct understanding of the trial and appropriate expectations regarding potential benefits.\n\nExclusion Criteria:\n\nPresence of other otological disorders that may interfere with the surgical outcome or interpretation of study endpoints, such as otitis media, Meniere's disease, etc.\n\nPresence of other severe congenital diseases, such as congenital heart disease. Presence of severe systemic diseases or in the acute onset of diseases, such as pulmonary tuberculosis, active hepatitis B or C infection, active herpes zoster infection, pancreatitis, renal insufficiency, etc.\n\nIndividuals with low immunity, a history of immune deficiency or organ transplantation.\n\nIndividuals with a history of neurological, mental disorders, or moderate-to-severe cognitive dysfunction, such as epilepsy, dementia, autism spectrum disorders, etc.\n\nAny other conditions for which the investigators consider the subject unsuitable for participation in this clinical study.","1 Year","35 Years",{"count":87,"type":20},210,"INTERVENTIONAL",[90],"NA","This study aims to establish a novel multimodal evaluation and precision rehabilitation system for patients with congenital hearing loss who have received hearing aids, cochlear implantation, or emerging gene therapy. The proposed system will integrate age-stratified difficulty levels, combined with a gamified interaction platform or software designed to assess and train three core perceptual domains: auditory speech perception, music perception, and spatial hearing capabilities.",[65,67,28,93,94],"Rehabilitation","Reliability and Validity",[96,97,98,99,100,101,93],"Congenital hearing loss","Gene therapy","Multimodal assessment","Auditory speech perception","Music perception","Spatial hearing","2025-07-24",{"date":104,"type":42},"2025-07-28",{"date":106,"type":42},"2025-07-04",{"date":108,"type":20},"2028-05-05",{"name":48,"class":49},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":57,"sex":17,"minAge":117,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":88,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":50},"100527780","music-based-interventions-aging-alzheimers-disease-100527780","NCT06152211","Music-Based Interventions, Aging, Alzheimer's Disease","Using Music-Based Interventions to Improve the Quality of Life and Wellbeing of Older Adults With or at Risk of Alzheimer's Disease","Inclusion Criteria:\n\n* Visual and Auditory Acuity: Adequate visual and auditory acuity, with correction if necessary.\n* Language Proficiency: Fluency in English to ensure complete testing.\n\nExclusion Criteria:\n\n* Hearing Loss: Severe hearing loss not correctable with aids.\n* Neurological and Otologic Conditions: History of known neurological or otologic conditions.\n* Psychiatric Disorders: Current severe psychiatric disorders (past disorders not included).\n* Medical Conditions: Unstable or serious medical conditions that could limit participation in assessments or weekly meetings.\n* Cognitive Function: Impaired cognitive function, indicated by a score of less than 26 on the Montreal Cognitive Assessment (MoCA).\n* Music Training: Current or past professional music training, defined as 3 years of regular, formal practice, excluding typical educational curriculum music classes or singing in worship services.","65 Years",{"count":119,"type":20},66,[90],"Using a randomized controlled trial design, the investigators will examine the effects of music engagement through choir training on the hearing, communication, and psychosocial well-being of older adults, particularly those at heightened risk of developing dementia.",[28,123,124],"Anxiety","Social Behavior",[126],"music, choir, aging, dementia, APOE ε4","2024-07-31",{"date":129,"type":42},"2024-08-02",{"date":131,"type":20},"2024-10-01",{"date":133,"type":20},"2025-12-30",{"name":135,"class":49},"University of Southern California"]