[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"speech\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:speech":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,45,75,115,138,172,195,212,225,240,277,299,330,358,381,405,426],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100553912","speech-motor-learning-and-retention-aim-3-100553912",false,"NCT06492252","Speech Motor Learning and Retention (Aim 3)","Sensorimotor Basis of Speech Motor Learning and Retention","Inclusion Criteria:\n\n* Fluent English speakers\n* Right-handed\n* Normal hearing\n* No speech disorder or reading disability\n\nExclusion Criteria:\n\n* Cardiac pacemaker\n* Aneurysm clip\n* Heart or Vascular clip\n* Prosthetic valve\n* Metal implants\n* Metal in brain, skull, or spinal cord\n* Implanted neurostimulator\n* Medication infusion device\n* Cochlear implant or tinnitus (ringing in ears)\n* Personal and\u002For family history of epilepsy or other neurological disorders or history of head concussion\n* Psychoactive medications\n* Pregnancy",true,"ALL","18 Years","40 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.",[28],"Speech",[30,31],"Speech Motor Learning","Retention","RECRUITING","2026-05-21",{"date":35,"type":36},"2026-05-26","ACTUAL",{"date":38,"type":36},"2026-05-04",{"date":40,"type":22},"2029-05-31",{"name":42,"class":43},"Yale University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100633762","prediction-of-visual-feedback-effects-on-speech-motor-adaptation-in-healthy-adults-100633762","NCT07530900","Prediction of Visual Feedback Effects on Speech Motor Adaptation in Healthy Adults","Prediction of Visual Feedback Gain in Altered Auditory Feedback Tasks Using Computational Modeling","PVF","Inclusion Criteria:\n\n* Age 18 to 45 years\n* Self-reported English as dominant or equally dominant language (learned English by age 3)\n* No self-reported history of significant speech, language, or hearing difficulty\n* Pass pure-tone hearing screening at 25 dB HL\n* Pass qualitative screening of speech, voice, and resonance based on connected speech sample\n\nExclusion Criteria:\n\n* Learned English after age 3\n* English is not a dominant language\n* History of speech or language disorder, hearing loss, or neurodevelopmental disorder (e.g., autism spectrum disorder, Down syndrome)\n* Failure to pass pure-tone hearing screening\n* Failure to pass qualitative screening of speech, voice, and resonance","45 Years",{"count":55,"type":22},40,[25],"This study examines whether individual differences in how speakers respond to hearing versus physical sensation during speech can predict who benefits most from visual feedback during a speech task. Healthy adults will complete a series of tasks in which auditory feedback is altered in real time through headphones, with and without an added visual display of the speech signal. A computational model will be used to estimate how strongly each participant relies on hearing versus physical sensation when monitoring speech. The study will then test whether this individual profile predicts how much the visual display improves each participant's ability to respond to the altered feedback.",[59,28],"Healthy Volunteers",[61,62,63,64,65],"speech motor control","altered auditory feedback","biofeedback","sensorimotor adaptation","computational modeling","2026-05-07",{"date":68,"type":36},"2026-05-11",{"date":70,"type":36},"2026-04-27",{"date":72,"type":22},"2026-11-30",{"name":74,"class":43},"New York University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":96,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":44},"100488116","effect-of-a-novel-topical-composition-on-the-incidence-of-severe-oral-mucositis-in-head--neck-cancer-radiated-patients-and-quality-of-life-assessed-by-proms-100488116","NCT05635929","Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.","Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs. A Two Phases Study, Part of STOP OM PROJECT. Phase 2, Single Arm, Interventional, Longitudinal, Clinical Trial.","STOPOMP","Inclusion Criteria:\n\nAcute Phase\n\n* Patients diagnosed with Head \\& Neck cancer who will undergo radiotherapy (with or without concomitant chemotherapy)\n* Patients who are able to read, understand, and complete the questionnaire.\n* Patients over 18 years of age.\n\nChronic Phase\n\n* Patients who have completed radiotherapy treatment at least 6 months before study enrollement.\n* Patients who are able to read, understand, and complete the questionnaire.\n* Patients over 18 years of age.\n\nExclusion Criteria:\n\nAcute Phase\n\n* Patients who are unable to properly use the products.\n* Patients who do not consent to participate in the study.\n* Patients who were being treated for another type of cancer.\n\nChronic Phase\n\n* Patients using medications such as pilocarpine, cevimeline, etc., to treat xerostomia.\n* Patients who do not consent to participate in the study.",{"count":84,"type":22},63,[25],"The use of a novel topical mucosa composition (XCM-OM118) comprising 2-(trimethylazaniumyl) acetate; (2R,3R,4S)-pentane-1,2,3,4,5-pentol; Hexadecanoic acid; (9Z, 12Z)-octadeca-9,12-dienoic acid; octadecanoic acid; (Z)-hexadec-9-enoic acid; (Z)-octadec-9-enoic acid) delivered as a gel and a mouthwash is to be studied in regard to its effect on the incidence of severe oral mucositis in Head \\& Neck cancer radiated patients. Patient reported outcome measures seem to be an effective tool to obtain a greater knowledge of the physical and emotional state of patients, being used in this study to assess quality of life of Head \\& Neck cancer radiated patients.",[88,89,90,91,28,92,93,94,95],"Oral Mucositis","Quality of Life","Mucositis","Pain","Saliva","Radiation Toxicity","Chemotherapeutic Toxicity","Head and Neck Cancer",[88,97,98,91,99,100,101,102,103,95,104],"Cancer Therapy Toxic Effect","Cancer Support","Ulcers","Treatment Interruptions","Oral Mucosa","Radiotherapy","Chemotherapy","Severe Oral Mucositis","2026-04-10",{"date":107,"type":36},"2026-04-15",{"date":109,"type":36},"2022-10-11",{"date":111,"type":22},"2027-03",{"name":113,"class":114},"Mucosa Innovations, S.L.","INDUSTRY",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":44},"100534029","vowel-space-expansion-sensorimotor-adaptation-100534029","NCT06233513","Vowel Space Expansion Sensorimotor Adaptation","Behavioral and Neural Measures of Speech Motor Control","Inclusion Criteria:\n\n* English-speaking adults\n* normal hearing and speech\n* no history of stroke or neurological conditions\n\nExclusion Criteria:\n\n* Native language other than English\n* Any neurological disorders other than the disorder of interest\n* Any history of hearing disorders\n* Uncorrected vision problems that prevent participants from seeing visually-presented stimuli\n* Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent\n* Vulnerable populations (minors and prisoners)",{"count":123,"type":22},117,[25],"The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to perceive their own speech errors and to learn new speech sounds. 117 participants will be enrolled into this part of the study and can expect to be on study between 1 day (Experiment 1) and 4 weeks (Experiment 2).",[28],[61,128],"vocal learning","2026-04-08",{"date":131,"type":36},"2026-04-09",{"date":133,"type":36},"2024-02-15",{"date":135,"type":22},"2026-06",{"name":137,"class":43},"University of Wisconsin, Madison",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":145,"targetDuration":147,"studyType":148,"phases":4,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":162,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":44},"100616085","velopharyngeal-insufficiency-after-maxillomandibular-advancement-osteotomy-in-obstructive-sleep-apnea-patients-100616085","NCT07301021","Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients","VPIMMA","Inclusion Criteria:\n\n* Age \\> 18 years\n* Mild to severe OSA\n* Indication for MMA for OSA treatment\n\nExclusion Criteria:\n\n* patients who underwent other adjunctive procedures at the time of MMA (e.g., multipiece le Fort osteotomy, TMJ reconstruction\n* Previous history of orthognathic surgery\n* Previous history of orthognathic surgery\n* Previous history of oropharyngeal surgery (UPPP or multi-level surgery)\n* Cleft palate and syndromic patients\n* Neuromusculair diseases which causes VPI, dysphagia or dysarthria\n* Incapacity",{"count":146,"type":22},28,"2 Years","OBSERVATIONAL","The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome (OSAS). A speech therapist evaluates nasality, speech, and swallowing before and after the surgery.",[151,152,153,28],"Velopharyngeal Insufficiency","Swallowing","Nasality",[155,156,157,158,159,160,161],"maxillomandibular advancement","obstructive sleep apnea","velopharyngeal insufficiency","speech therapy","swallowing","nasality","speech","NOT_YET_RECRUITING","2026-03-18",{"date":165,"type":36},"2026-03-20",{"date":167,"type":22},"2026-05-01",{"date":169,"type":22},"2027-12-01",{"name":171,"class":43},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":16,"sex":17,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":182,"studyType":148,"phases":4,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":162,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100629296","research-on-speech-development-trajectories-and-predictive-models-in-children-with-autism-spectrum-disorder-100629296","NCT07472829","Research on Speech Development Trajectories and Predictive Models in Children With Autism Spectrum Disorder","Inclusion Criteria:\n\n* Diagnosed as typically developing children by two or more associate chief physicians.\n* Gender- and age-matched to the ASD group.\n* Participants whose native language is Chinese.\n\nExclusion Criteria:\n\n* Participants not meeting the age requirement.\n* Presence of orofacial motor and swallowing dysfunction.\n* Hearing impairment.\n* Participants whose native language isn't Chinese.\n* Neurological disorders (such as encephalitis or seizures) and comorbid psychiatric disorders.","18 Months","60 Months",{"count":181,"type":22},120,"3 Months","Recent studies indicate that children with ASD have a significantly higher risk of co-occurring speech sound disorders than typically developing children. Early atypical speech development may be a critical yet overlooked bottleneck hindering their language improvement. Given the unique phonetic features of Mandarin, it is essential to investigate speech development in Mandarin-speaking children with ASD. This study aims to construct developmental trajectories and establish early identification and prognosis prediction models for this population.",[28,185],"Autism Spectrum Disorder (ASD)","2026-03-14",{"date":188,"type":36},"2026-03-17",{"date":190,"type":22},"2026-03-10",{"date":192,"type":22},"2027-12-31",{"name":194,"class":43},"Children's Hospital of Chongqing Medical University",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":26,"conditions":203,"keywords":204,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":211,"locationsCount":44},"100551993","speech-motor-learning-and-retention-aim-1-100551993","NCT06467305","Speech Motor Learning and Retention (Aim 1)",{"count":201,"type":22},160,[25],[28],[30,31],"2026-02-17",{"date":207,"type":36},"2026-02-19",{"date":209,"type":36},"2024-10-01",{"date":40,"type":22},{"name":42,"class":43},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":26,"conditions":219,"keywords":220,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":221,"startDateStruct":222,"completionDateStruct":223,"leadSponsor":224,"locationsCount":44},"100553879","speech-motor-learning-and-retention-aim-2-100553879","NCT06491823","Speech Motor Learning and Retention (Aim 2)",{"count":181,"type":22},[25],[28],[30,31],{"date":207,"type":36},{"date":209,"type":36},{"date":40,"type":22},{"name":42,"class":43},{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":235,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":238,"leadSponsor":239,"locationsCount":44},"100551992","speech-motor-learning-and-retention-master-protocol-100551992","NCT06467292","Speech Motor Learning and Retention (Master Protocol)",{"count":231,"type":22},330,[25],"The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.",[28],[30,31],{"date":207,"type":36},{"date":209,"type":36},{"date":40,"type":22},{"name":42,"class":43},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":16,"sex":17,"minAge":247,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":23,"phases":251,"briefSummary":252,"conditions":253,"keywords":257,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":44},"100623124","virtual-reality-as-a-tool-for-training-public-speaking-skills-in-higher-education-students-100623124","NCT07392554","Virtual Reality as a Tool for Training Public Speaking Skills in Higher Education Students","Virtual Reality as a Tool for Training Public Speaking Skills in Higher Education Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Higher education student\n* Speaking french fluently\n\nExclusion Criteria:\n\n* Hearing impairment\n* Voice or fluency disorder at the time of the study","20 Years","30 Years",{"count":250,"type":22},80,[25],"According to the scientific literature, public speaking (PS) is an important skill for students to master. However, a large proportion of students do not feel comfortable speaking in public. PS anxiety impacts oral communication (i.e., voice and fluency). These changes can affect speaker's academic and professional success, as well as his credibility. Performing a high-quality PPP with confidence is therefore rarely an innate skill, but fortunately it can be trained and improved. Therefore, training PS skills in representative settings is crucial but often challenging for PS professionals (e.g., speech therapists, vocologists, coaches).\n\nThis project examines how oral communication skills training including simulations in virtual reality (VR) supports the acquisition of effective oral PS skills. Using acoustic analyses, outcomes from participants in the intervention group (N = 40) will be compared with those of a wait-list control group (N = 40) to determine whether significant differences emerge in filled pauses, speech rate, and vocal intonation during PS. Changes in PS self-efficacy will also be assessed. Regarding secondary outcomes, the study will evaluate changes in self-reported and physiological PS anxiety, as well as self-reported confidence as a speaker. Finally, self-perceived vocal effort during PS will be examined.",[254,28,255,256],"Voice","Virtual Reality Simulation","Healthy Adult",[258,259,254,260,261,262,263,264,265,266,267],"Public Speaking","Oral Communication","Speech Fluency","Speech Therapy","Virtual Reality","Students","Training","Glossophobia","Anxiety","Verbal Behavior","2026-01-30",{"date":270,"type":36},"2026-02-06",{"date":272,"type":22},"2026-03",{"date":274,"type":22},"2026-12",{"name":276,"class":43},"University of Liege",{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":283,"targetDuration":4,"studyType":23,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":44},"100561392","intelligibility-and-acoustic-speech-performance-of-cadcam-milled-titanium-partial-dentures-100561392","NCT06589570","Intelligibility and Acoustic Speech Performance of CAD\u002FCAM Milled Titanium Partial Dentures","Inclusion Criteria:\n\n* Patients with Class IV Kennedy Classification partial edentulism.\n* Sufficient occluso-gingival height of its clinical crown\n* Full opposing arch or restored with acceptable restoration\n* Edentulous ridge covered by healthy firm muco-periosteum\n* The abutment teeth had apparently good periodontal condition\n* Adequate inter-arch space\n* All patients were apparently in good general health\n* Only patients who can be easily motivated to achieve and maintain good oral hygiene were selected\n\nExclusion Criteria:\n\n* without abnormal bony irregularity or sever lingual undercut\n* with no signs of mobility or inflammation with no tissue undercut\n* Patients with shallow floor of the mouth, prominent lingual tori, bony undercuts and lingual inclined teeth were all excluded\n* no tempro-mandibular joint disorders\n* free from systemic diseases as diabetes mellitus",{"count":284,"type":22},12,[25],"Partial dentures play a crucial role in restoring oral function and aesthetics for patients with missing teeth. Traditionally, these prostheses have been fabricated using materials such as acrylic resin or cobalt-chromium alloys. However, advancements in digital dentistry have introduced new materials and manufacturing techniques, including computer-aided design and computer-aided manufacturing (CAD\u002FCAM) milled titanium. While titanium offers advantages such as biocompatibility, lightweight properties, and corrosion resistance, its impact on speech performance remains understudied.",[28,288,289],"Denture, Partial, Removable","CAD-CAM","2025-09-01",{"date":292,"type":36},"2025-09-03",{"date":294,"type":36},"2024-09-09",{"date":296,"type":22},"2025-12-06",{"name":298,"class":43},"Badr University",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":305,"eligibilityCriteria":306,"healthyVolunteers":16,"sex":17,"minAge":307,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":329},"100552914","talk-with-me-baby-to-enhance-the-early-home-language-environment-100552914","NCT06479278","Talk With Me Baby to Enhance the Early Home Language Environment","Talk With Me Baby: Leveraging Well-Child Care to Enhance the Early Home Language Environment for Rural and Underserved Children","TWMB","Inclusion Criteria:\n\nFor this study, each child-caregiver dyad will consist of:\n\n1. A caregiver who will receive TWMB during routine WCC visits for their child at participating clinics, and\n2. The child of the above caregiver for whom the WCC visits are conducted.\n\nA potential caregiver participant must meet all the following inclusion criteria to enroll in the study:\n\n1. Be the age of majority, or older, as defined by the state of residency.\n2. Able to complete study measures in English.\n3. Have the legal authority to consent to participate for themselves and to consent on behalf of their child.\n\nTo proceed to the follow-up portion of the study the caregiver (dyad) must have a LENA baseline assessment score that is ≤ 75th percentile compared to a child's age-referenced normative data.\n\nA potential child participant must meet all the following inclusion criteria to be enrolled in the study:\n\n1. Receive WCC at a participating clinic from a participating provider.\n2. Be zero to nine months (+ 0-30 days) old at enrollment.\n3. Was born at full term (\\> 37 weeks gestation).\n4. Was born in a singleton birth (i.e., was the only child delivered during the birth).","0 Months","9 Months",{"count":310,"type":22},66,[25],"The goal of this clinical trial is to learn if the Talk With Me Baby (TWMB) program improves the home-language environment for at-risk families with children ages two to six months when primary care providers deliver the program during well-child checkups. The main question it aims to answer is:\n\nWill the TWMB program increase the time a caregiver talks to their infant?\n\nParticipants will:\n\n1. Come to at least four well-child checkups\n2. Receive the TWMB program from the provider during the checkups\n3. Record their conversations with their infant before they receive the program and after they receive the program four times.",[314,28,315,316,317,318],"Language Development","Infant Development","Infant Behavior","Language, Child","Language","2025-08-27",{"date":321,"type":36},"2025-08-29",{"date":323,"type":36},"2025-02-03",{"date":325,"type":22},"2026-08-31",{"name":327,"class":328},"IDeA States Pediatric Clinical Trials Network","NETWORK",2,{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":337,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":340,"briefSummary":341,"conditions":342,"keywords":345,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":44},"100529047","impact-of-anterior-cross-bite-treatment-on-childrens-speech-performance-100529047","NCT06168695","Impact of Anterior Cross Bite Treatment on Children's Speech Performance","Impact of Anterior Dental Cross Bite Treatment on Children's Speech Performance and Their Quality of Life","Inclusion Criteria:\n\n* healthy cooperative children aged 8-10 years\n* have at least one or more maxillary permanent incisors in a crossbite relationship\n* fully erupted four first permanent molars\n* Angle Class I molar relationship and Class I skeletal relationship\n* the mother language of all the subjects was Arabic.\n\nExclusion Criteria:\n\n* Children with systemic illness or previous history of speech therapy\n* children who are ill-habituated or unable to follow up\n* children with previous orthodontic treatment\n* uncooperative children\n* Anterior skeletal or functional crossbite\n* presence of sucking habits","8 Years","10 Years",{"count":21,"type":22},[25],"The goal of this prospective, single-arm clinical trial is to evaluate the speech performance of children with anterior dental crossbite before and after correction. Also, to assess the impact of early interceptive orthodontic treatment in the mixed dentition stage to correct the anterior dental crossbite on the quality of life of children.\n\nFifty children of both sexes aged from 8 to 10 years were enrolled and evaluated using the study's inclusion \\& exclusion criteria. before beginning interceptive orthodontic treatment, each child underwent full mouth treatment. then, using a removable anterior expansion screw along with posterior bite planes to treat the anterior crossbite. All children were subjected to the Protocol of speech evaluation before appliance insertion and after complete correction of anterior crossbite. Also, the Child Perceptions Questionnaire (CPQ 8-10) in the Brazilian version was used to gauge how the anterior crossbite affected the children's oral health-related quality of life.",[343,344,28,89],"Cross Bite","Malocclusion",[346,161,347,348],"crossbite","expansion screw","quality of life","2025-04-15",{"date":351,"type":36},"2025-04-18",{"date":353,"type":36},"2023-02-04",{"date":355,"type":22},"2025-06",{"name":357,"class":43},"Tanta University",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":362,"acronym":363,"eligibilityCriteria":364,"healthyVolunteers":16,"sex":17,"minAge":365,"maxAge":366,"enrollmentInfo":367,"targetDuration":4,"studyType":23,"phases":369,"briefSummary":370,"conditions":371,"keywords":4,"overallStatus":162,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100537781","elicitation-of-steady-state-audiovisual-responses-in-6--and-10-month-old-infants-100537781","NCT06282289","Elicitation of Steady-state Audiovisual Responses in 6- and 10-month-old Infants","AV-SSR-I","Inclusion Criteria:\n\n* be 6 or 10 months old (+\u002F- 2 weeks)\n* have received age-appropriate information on the experiment\n* their legal guardians have received appropriate information and given their oral consent.\n\nExclusion Criteria:\n\n* A neurological disorder (visual, auditory, motor, executive)\n* Developmental delay","6 Months","10 Months",{"count":368,"type":22},64,[25],"The goal of this study is to investigate the preferential responses of speech neural systems in infants.\n\nThe main question it aims to answer is to determine whether the oscillatory synchronization capacity is associated with children's language level (i.e. vocabulary).\n\nParticipants will be presented with synthetically modulated stimuli at three frequency scales: 4 Hz, 5 Hz and 30 Hz.",[28],"2025-02-28",{"date":374,"type":36},"2025-03-03",{"date":376,"type":22},"2025-05",{"date":378,"type":22},"2025-09-21",{"name":380,"class":114},"Institut Pasteur",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":16,"sex":17,"minAge":388,"maxAge":389,"enrollmentInfo":390,"targetDuration":4,"studyType":23,"phases":391,"briefSummary":392,"conditions":393,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":44},"100520178","effects-of-clear-speech-on-listening-effort-and-memory-in-sentence-processing-100520178","NCT06053190","Effects of Clear Speech on Listening Effort and Memory in Sentence Processing","Understanding the Effects of Listening Effort on Sentence Processing and Memory in Sensorineural Hearing Loss: Evidence From Simultaneous Electrophysiology and Pupillometry (Study 2)","Inclusion Criteria:\n\n* Age 60-90\n* Right-handed\n* Native English speaker\n* Scores in the normal range (\\> or = 25 points) on Montreal Cognitive Assessment (MoCA)\n* For adults with hearing loss, a pure-tone average score of \\> 25 dB HL (between 1 - 4kHz)\n\nExclusion Criteria:\n\n* Left-handed (language-related electrophysiological responses of left-handed subjects differ from those of right-handed subjects)\n* History of psychiatric or neurological illnesses (including skull fractures, as this is known to alter electrophysiological response at the scalp)\n* Score of \\\u003C 25 points on the MOCA\n* Use of certain prescription and non-prescription drugs known to alter brain function and the autonomic nervous system, including pupil dilation (e.g., anti-depressants, attention deficit hyperactivity disorder drugs)\n* Any eye disease that would impair the ability to measure pupil dilation (e.g., cataracts, nystagmus, amblyopia)\n* Scores on speech shadowing audibility control task below 50%, suggesting poor intelligibility\n* A display of behavior that would significantly interfere with the validity of data collection or safety during the study;","60 Years","90 Years",{"count":250,"type":22},[25],"Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased risk for the development of dementia in older adulthood. Typical audiological tests and interventions, which focus on measuring and restoring audibility, do not explain the full range of cognitive difficulties that adults with hearing loss experience in speech comprehension. For example, adults with SNHL have to work disproportionally harder to decode acoustically degraded speech. That additional effort is thought to diminish shared executive and attentional resources for higher-level language processes, impacting subsequent comprehension and memory, even when speech is completely intelligible. This phenomenon has been referred to as listening effort (LE). There is a growing understanding that these cognitive factors are a critical and often \"hidden effect\" of hearing loss. At the same time, the effects of LE on the neural mechanisms of language processing and memory in SNHL are currently not well understood. In order to develop evidence-based assessments and interventions to improve comprehension and memory in SNHL, it is critical that the cognitive and neural mechanisms of LE and its consequences for speech comprehension are elucidated. In this project, the investigators adopt a multi-method approach, combining methods from clinical audiology, psycholinguistics, and cognitive neuroscience to address this gap of knowledge. Specifically, the investigators adopt a novel and innovative method of co-registering pupillometry (a reliable physiological measure of LE) and language-related event-related brain potential (ERP) measures during real-time speech processing to characterize the effects of clear speech (i.e., a listener-oriented speaking style that is spontaneously adopted to improve intelligibility when speakers are aware of a perception difficulty on behalf of the listener) on high-level language processes (e.g., semantic retrieval, syntactic integration) and subsequent speech memory in older adults with SNHL. This innovative work addresses a time-sensitive gap in the literature regarding the identification of objective and reliable markers of specific neurocognitive processes impacted by speech clarity and LE in age-related SNHL.",[28,394,395],"Memory, Delayed","Sensorineural Hearing Loss","2025-01-09",{"date":398,"type":36},"2025-01-13",{"date":400,"type":36},"2023-09-12",{"date":402,"type":22},"2025-03-01",{"name":404,"class":43},"University of Utah",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":16,"sex":17,"minAge":411,"maxAge":412,"enrollmentInfo":413,"targetDuration":4,"studyType":23,"phases":414,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":44},"100487995","social-influences-on-sensorimotor-integration-of-speech-production-and-perception-during-early-vocal-learning-100487995","NCT05634356","Social Influences on Sensorimotor Integration of Speech Production and Perception During Early Vocal Learning","Inclusion Criteria:\n\n* infants ca. 7-16 months of age at study onset\n* Infants less than 24 months of age (for follow-up visits only)\n* At least one English-speaking or Spanish-speaking parent in the home who can participate in the study\n* Subjects will include infants with typical hearing, hearing loss, or hearing loss remediated by a hearing aid or cochlear implant.\n\nExclusion Criteria:\n\n* infants who are not exposed to English or Spanish in the home\n* infants who do not have a parent who can participate in the study will be excluded (Caregivers who are not parents will not be eligible to participate in the study)","7 Months","24 Months",{"count":181,"type":22},[25],"The goal of this study is to investigate the role of social factors on speech learning, including production and perception, in infants ranging in age from \\~7-18 months. Infants have either typical hearing or sensorineural hearing loss. The main prediction of the study is that social reinforcement will engender improvements in vocal learning above and beyond gains in hearing in infants with hearing loss. As part of this study:\n\n* The parent and infant engage in a free play session in the playroom while the investigator cues the parent to say simple nonsense words;\n* Infants hear playback of the same words during a second phase.",[395,28],"2024-06-17",{"date":419,"type":36},"2024-06-18",{"date":421,"type":36},"2022-10-12",{"date":423,"type":22},"2025-02-01",{"name":425,"class":43},"University of Southern California",{"id":427,"slug":428,"hasResults":11,"nctId":429,"briefTitle":430,"officialTitle":430,"acronym":4,"eligibilityCriteria":431,"healthyVolunteers":16,"sex":17,"minAge":432,"maxAge":4,"enrollmentInfo":433,"targetDuration":4,"studyType":23,"phases":435,"briefSummary":436,"conditions":437,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":444,"locationsCount":44},"100528741","behavioral-and-neural-characteristics-of-adaptive-speech-motor-control-100528741","NCT06164717","Behavioral and Neural Characteristics of Adaptive Speech Motor Control","General inclusion criteria:\n\n* native speaker of American English\n* no communication or neurological problems (except for subjects in the DBS group)\n* 250-4000 Hz pure tone hearing thresholds equal to or better than 25 dB HL for children and young adults and equal to or better than 35 dB HL for older adults\n* no medications that affect sensorimotor functioning (except for in the DBS group)\n* adult subjects: 18 years of age or older\n* typical children: 4;0 to 6;11 \\[years;months\\] or 10;0 to 12;11 \\[years;months\\])\n\nSpecific inclusion criteria for children:\n\n\\* scoring above the 20th percentile on the Peabody Picture Vocabulary Test (PPVT-5), Expressive Vocabulary Test (EVT-3), Goldman-Fristoe Test of Articulation (GFTA-3), and either Test of Early Language Development (TELD-4) or (for children age 8 or older) Clinical Evaluation of Language Fundamentals (CELF-5).\n\nSpecific inclusion criteria for DBS patients:\n\n\\* bilateral electrodes implanted in either the ventral intermediate nucleus of the thalamus (Vim; a target site for patients with essential tremor) or subthalamic nucleus (STN; a target site for patients with Parkinson's disease)","4 Years",{"count":434,"type":22},507,[25],"This study meets the NIH definition of a clinical trial, but is not a treatment study. Instead, the goal of this study is to investigate how hearing ourselves speak affects the planning and execution of speech movements. The study investigates this topic in both typical speakers and in patients with Deep Brain Stimulation (DBS) implants. The main questions it aims to answer are:\n\n* Does the way we hear our own speech while talking affect future speech movements?\n* Can the speech of DBS patients reveal which brain areas are involved in adjusting speech movements? Participants will read words, sentences, or series of random syllables from a computer monitor while their speech is being recorded. For some participants, an electrode cap is also used to record brain activity during these tasks. And for DBS patients, the tasks will be performed with the stimulator ON and with the stimulator OFF.",[28],"2023-12-01",{"date":440,"type":36},"2023-12-11",{"date":442,"type":36},"2023-01-01",{"date":192,"type":22},{"name":445,"class":43},"University of Washington"]