[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-anesthesia-for-cesarean-section\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-anesthesia-for-cesarean-section":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100636577","phase-4-adding-dexmedetomidine-or-clonidine-to-spinal-anesthesia-for-cesarean-delivery-100636577",false,"NCT07567495","Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery","Inclusion Criteria:\n\n* Pregnant women undergoing cesarean delivery with spinal anesthesia\n\nExclusion Criteria:\n\n* Significant cardiovascular, psychiatric or respiratory disease\n* using opioids or with chronic pain syndrome\n* Multiple gestation\n* BMI \\>40 kg\u002Fm2\n* Quaternary or greater cesarean\n* \\\u003C 37 weeks gestation\n* Non-English or Spanish speaking\n* planned vertical skin incision\n* planned vertical (classical) uterine incision\n* allergy to clonidine, dexmedetomidine or other study drug","FEMALE","18 Years",{"count":18,"type":19},150,"ESTIMATED","INTERVENTIONAL",[22],"PHASE4","This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery. When added to standard spinal anesthesia consisting of bupivacaine (a local anesthetic) and fentanyl and morphine (two opioids), these medications may decrease some of the pulling\u002Ftugging\u002Fpressure sensations that patients sometimes feel during cesarean delivery, may prolong the anesthetic time, and may decrease postoperative pain.",[25,26,27,28,29,30],"Cesarean Delivery","Cesarean Delivery; Neuraxial Opioids","Spinal Anesthesia for Cesarean Section","Dexmedetomidine","Clonidine","Postoperative Analgesia",[32,33,34,35,36,37],"cesarean","dexmedetomidine","clonidine","spinal","anesthesia","Adrenergic alpha-2 Receptor Agonists","NOT_YET_RECRUITING","2026-04-30",{"date":41,"type":42},"2026-05-05","ACTUAL",{"date":44,"type":19},"2026-06",{"date":46,"type":19},"2028-05",{"name":48,"class":49},"Columbia University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":15,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":20,"phases":62,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100617730","phase-4-hemodynamics-during-cesarean-delivery-under-spinal-anesthesia-with-norepinephrine-versus-ephedrine-100617730","NCT07322419","Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine","Echocardiographic Evaluation of Cardiac Output During Cesarean Delivery Under Spinal Anesthesia Using Norepinephrine Versus Ephedrine: A Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists physical status II.\n* Singleton, full term pregnancy.\n* Scheduled cesarean delivery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Height \\\u003C150 or \\>180 cm.\n* Weight \\\u003C60 or \\>110 kg.\n* Body mass index (BMI) \\\u003C18.5 or ≥35 kg\u002Fm².\n* Women presenting in labor.\n* Any contraindication to spinal anesthesia: increased intracranial pressure, coagulopathy, or local skin infection.\n* Chronic or pregnancy-induced hypertension.\n* Baseline systolic blood pressure \\>140 mm Hg.\n* Hemoglobin \\\u003C10 g\u002Fdl.\n* Diabetes mellitus, cardiovascular, cerebrovascular, or renal disease.\n* Polyhydramnios or known significant fetal abnormalities.\n* Current administration of vasoactive drugs such as: beta blockers, salbutamol, or thyroxin.","19 Years","40 Years",{"count":61,"type":19},200,[22],"Echocardiography will be used to measure cardiac output and calculate other important hemodynamic variables in healthy patients with full-term singleton pregnancy during cesarean delivery under conventional spinal anesthesia using 2 different vasopressor drugs: norepinephrine in 1 group versus ephedrine in another group.",[25,27],[66,67,68,69],"Cesarean delivery","Spinal anesthesia","Echocardiography","Hemodynamics","RECRUITING","2026-01-12",{"date":73,"type":42},"2026-01-14",{"date":75,"type":42},"2026-01-01",{"date":77,"type":19},"2026-12-31",{"name":79,"class":49},"Mansoura University"]