[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-anesthesia-induced-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-anesthesia-induced-hypotension":63},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,79,106,128,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100631139","investigation-of-the-role-of-internal-jugular-vein-collapsibility-index-in-predicting-spinal-anesthesia-induced-hypotension-in-preeclamptic-parturients-100631139",false,"NCT07496788","Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotension in Preeclamptic Parturients","Inclusion Criteria:\n\n* Age between 18 and 45 years\n* ASA physical status II-III\n* Diagnosed with preeclampsia\n* Scheduled for cesarean delivery under spinal anesthesia with cesarean urgency classified as Lucas category 3-4\n* Gestational age ≥28 weeks\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Cesarean urgency classified as Lucas category 1-2\n* Gestational age \\\u003C28 weeks\n* ASA physical status ≥ IV\n* Known renal disease\n* Cardiac instability or known arrhythmia\n* Requirement of general anesthesia or sedation\n* Inability to provide informed consent","FEMALE","18 Years","45 Years",{"count":19,"type":20},96,"ESTIMATED","1 Day","OBSERVATIONAL","This prospective, single-center observational study aims to evaluate the predictive value of the internal jugular vein collapsibility index (IJVCI) for spinal anesthesia-associated hypotension in preeclamptic parturients (gestational age ≥28 weeks) undergoing cesarean delivery classified as Lucas category 3-4. Preoperative IJVCI will be measured using ultrasonography before spinal anesthesia during spontaneous and deep respiration. The incidence of hypotension within the first 20 minutes after spinal anesthesia will be recorded. The diagnostic performance of IJVCI in predicting hypotension will be analyzed.",[25,26,27],"Spinal Anesthesia-Induced Hypotension","Preeclampsia","Cesarean Section",[26,29,30,31,32,27,33,34],"Spinal Anesthesia","Hypotension","Internal Jugular Vein","Collapsibility Index","Ultrasonography","Hemodynamic Monitoring","NOT_YET_RECRUITING","2026-03-23",{"date":38,"type":39},"2026-03-27","ACTUAL",{"date":41,"type":20},"2026-05-01",{"date":43,"type":20},"2026-07-25",{"name":45,"class":46},"Ankara City Hospital Bilkent","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100624567","internal-jugular-vein-ultrasound-for-predicting-hypotension-in-geriatric-patients-undergoing-spinal-anesthesia-100624567","NCT07411313","Internal Jugular Vein Ultrasound for Predicting Hypotension in Geriatric Patients Undergoing Spinal Anesthesia","The Role of Internal Jugular Vein Ultrasonography in Predicting Hypotension in Geriatric Patients Undergoing Spinal Anesthesia: A Prospective Observational Study (Protocol ID: 2023-12\u002F509)","IJV-SPINAL","Inclusion Criteria:\n\n* Age ≥65 years\n* Scheduled to undergo surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Did not provide written informed consent\n* Undergoing emergency surgery\n* Body mass index (BMI) ≥40 kg\u002Fm²\n* Receiving angiotensin-converting enzyme (ACE) inhibitors\n* Pre-spinal systolic blood pressure \\\u003C90 mmHg or mean arterial pressure \\\u003C70 mmHg\n* Unable to tolerate the supine position\n* Left ventricular ejection fraction \\\u003C40%\n* Requiring sedoanalgesia in addition to spinal anesthesia or conversion to general anesthesia",true,"ALL","65 Years",{"count":60,"type":20},85,"Spinal anesthesia-induced hypotension is a common and clinically significant complication in geriatric patients. Accurate preoperative assessment of intravascular volume status may help identify patients at risk. Internal jugular vein (IJV) ultrasonography is a noninvasive and easily applicable bedside method that reflects venous volume status. This prospective observational study aims to evaluate the role of preoperative IJV ultrasonographic measurements in predicting hypotension following spinal anesthesia in geriatric patients. Patients aged 65 years and older undergoing elective surgery under spinal anesthesia will be included. Preoperative IJV diameter, cross-sectional area, and collapsibility index will be measured using ultrasonography. Hemodynamic parameters will be monitored intraoperatively, and the occurrence of hypotension after spinal anesthesia will be recorded. The predictive value of IJV ultrasonographic parameters for post-spinal hypotension will be analyzed",[63,64,31,33],"Spinal Anesthesia Induced Hypotension","Geriatric",[66,67,30,33,68],"Geriatric patients","Spinal anesthesia","Internal jugular vein","RECRUITING","2026-02-11",{"date":72,"type":39},"2026-02-13",{"date":74,"type":39},"2024-01-03",{"date":76,"type":20},"2026-02-10",{"name":78,"class":46},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":57,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100620924","height-based-and-conventional-spinal-anaesthetic-dosing-in-geriatric-patients-100620924","NCT07363941","HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS","COMPARISON OF HEMODYNAMIC AND ANAESTHETIC OUTCOMES BETWEEN HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS UNDERGOING LOWER LIMB ORTHOPAEDIC SURGERIES","Inclusion Criteria:\n\nIndividuals aged 60 to 80 years. Either gender (male or female). Patients who are ASA physical status I-III. Individuals scheduled to undergo elective lower limb orthopaedic surgeries (e.g., fracture fixation, total knee replacement, open reduction and internal fixation).\n\nPatients planned to receive spinal anaesthesia as the primary anaesthetic technique.\n\nThose who provide informed written consent for participation in the study.\n\nExclusion Criteria:\n\nIndividuals exhibiting a stature inferior to 150 cm. Patients receiving anti-hypertensive drugs or those on beta blockers or beta-agonists.\n\nPatients with a history of neurological disease like CVA or Parkinsonism. Patients presenting with sepsis (≥ 2 positive SIRS criteria with positive aseptically obtained blood or wound culture).\n\nPatients with a history of coagulation disorders like haemophilia or vWD or those with a history of anti-platelet drug intake in the last 2 weeks.\n\nIndividuals possessing a documented history of hypersensitivity reactions to pharmacological agents utilized in the research.\n\nPatients who will be diagnosed with a skin infection at the spinal needle puncture site.\n\nPatients undergoing emergency orthopaedic procedures requiring immediate intervention","60 Years","80 Years",{"count":89,"type":20},104,"INTERVENTIONAL",[92],"NA","The goal of this clinical trial is to find out whether height-based dosing of spinal anaesthesia provides better hemodynamic stability and anesthetic outcome than conventional fixed dosing in elderly patients undergoing lower limb orthopaedic surgery.The main questions this study aims to answer are:\n\n1. Does height-based spinal anaesthetic dosing reduce the risk of hypotension and bradycardia during surgery as compared to conventional fixed dosing?\n2. Does it improve anaesthetic outcomes, such as the onset and duration of sensory and motor block?",[95,63,96],"Geriatric Population","Spinal Anesthesia in Elderly Patients","2026-01-15",{"date":99,"type":39},"2026-01-23",{"date":101,"type":39},"2026-01-03",{"date":103,"type":20},"2026-05-04",{"name":105,"class":46},"Shaheed Mohtarma Benazir Bhutto Institue of Trauma",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":112,"enrollmentInfo":113,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100597351","effect-of-vitamin-d-deficiency-on-the-frequency-and-severity-of-spinal-anesthesia-induced-hypotension-in-pregnant-women-undergoing-cesarean-section-100597351","NCT07057362","Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Scheduled for elective cesarean delivery under spinal anesthesia\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean sections\n* History of significant cardiovascular disease (e.g., arrhythmia, heart failure)\n* Known neurological disorders affecting autonomic function\n* Current vitamin D supplementation within the past 30 days\n* Inability to undergo blood sampling or provide valid hemodynamic data\n* Contraindication to spinal anesthesia","40 Years",{"count":114,"type":20},140,"Spinal anesthesia-induced hypotension remains a common and significant complication during cesarean sections, posing risks for both mother and fetus. Vitamin D deficiency, frequently observed in pregnant women, is associated with altered vascular function and potential hemodynamic instability. This prospective observational study aims to investigate whether vitamin D deficiency is associated with an increased incidence and severity of spinal anesthesia-induced hypotension in pregnant women undergoing elective cesarean delivery. Vitamin D levels will be measured preoperatively, and intraoperative hemodynamic parameters will be closely monitored. The findings could contribute to improved management strategies for pregnant patients at risk of severe hypotension.",[117,118,27],"Spinal Anesthesia-induced Hypotension","Vitamin D Deficiency","2026-01-02",{"date":121,"type":39},"2026-01-06",{"date":123,"type":39},"2025-03-01",{"date":125,"type":20},"2025-12-30",{"name":127,"class":46},"Duzce University",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":135,"targetDuration":137,"studyType":22,"phases":4,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100594124","renal-functions-in-preeclamptic-pregnant-women-using-neutrophil-gelatinase-associated-lipocalin-ngal-and-standard-renal-function-tests-100594124","NCT07015359","Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Evaluation of the Effect of Spinal Anesthesia-Induced Hypotension on Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Inclusion Criteria:\n\n* Patients classified as ASA physical status II-III\n* Pregnant women aged 18-45 years, diagnosed with preeclampsia and scheduled for elective cesarean section, will be included in the study.\n\nExclusion Criteria:\n\n* Patients who are unable to read, understand, or sign the informed consent form\n* Patients with a diagnosed renal disease\n* Patients who do not wish to participate in the study\n* Patients with ASA physical status greater than III\n* Patients younger than 18 or older than 45 years\n* Patients requiring sedation or undergoing general anesthesia\n* Patients with cardiac instability\n* Patients with known arrhythmias",{"count":136,"type":20},46,"6 Months","Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes mellitus, renovascular disease and congestive heart failure. Mean arterial pressure (MAP) below 55-60 mmHg has been associated with postoperative AKI. Traditional diagnostic criteria for AKI include increased serum creatinine levels and oliguria. However, creatinine levels do not rise until more than half of renal function is lost. Serum and urine NGAL levels rise earlier-within 24-48 hours-making it a promising early biomarker.\n\nIn our study, hypotension is defined as systolic blood pressure \\\u003C100 mmHg or a \\>30% decrease in MAP. Patients requiring ephedrine under these conditions will be evaluated as the hypotension group and compared with non-hypotensive patients in terms of NGAL, BUN (blood urea nitrogen), creatinine, and GFR (Glomerular Filtration Rate) values at baseline and at the 4th postoperative hour.",[140,141,142,63,143],"Anesthesia","Spinal Aneshtesia","Acute Kidney Failure","Preeclampsia (PE)",[26,30,145,146,147],"NGAL","Creatinine","AKI","2025-06-08",{"date":150,"type":39},"2025-06-11",{"date":148,"type":20},{"date":153,"type":20},"2025-10-20",{"name":155,"class":46},"Nihan Aydin Guzey",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":112,"enrollmentInfo":163,"targetDuration":4,"studyType":90,"phases":165,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":47},"100580414","comparison-between-efficacy-of-norepinephrine-and-phenylephrine-boluses-for-prevention-of-spinal-anaesthesia-induced-hypotension-in-obstetrical-patients-undergoing-emergency-cesarean-section-a-double-blind-randomized-controlled-trial-100580414","NCT06836986","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION- A Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n1. American society of anesthesiologists II and III patients\n2. Age 18-40years\n3. Gestational age 32 weeks and above\n\nExclusion Criteria:\n\n1. Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.\n2. Baseline mean arterial pressure less than 70 mmHg.\n3. Antepartum hemorrhage\u002Fintraoperative blood loss greater than 1000ml\n4. history indicative of cardiovascular or neurological disease.\n5. known fetal abnormality.\n6. Patients taking serotonin reuptake inhibitor, Tricyclic antidepressants,monoamine oxidase inhibitors.\n7. Maternal situations requiring immediate administration of general anesthesia",{"count":164,"type":20},124,[92],"The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are:\n\nDoes norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension.\n\nParticipants will:\n\nBe administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded",[63],[169,170,171,172,173],"Spinal anesthesia induced hypotension","Emergency lower segment cesarean section","Norepinephrine bolus","Prophylactic","Phenylephrine","2025-02-16",{"date":176,"type":39},"2025-02-20",{"date":178,"type":39},"2024-12-31",{"date":180,"type":20},"2025-03-31",{"name":182,"class":46},"Dow University of Health Sciences"]