[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-anesthesia":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,32,0,25,[9,47,80,106,131,152,178,200,221,249,274,297,326,353,379,406,437,464,491,513,542,563,586,607,628],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100645234","pupillary-light-reflex-to-predict-post-spinal-hypotension-in-elective-cesarean-delivery-100645234",false,"NCT07678723","Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery","Pupillary Light Reflex for Predicting Hypotension Risk After Spinal Anesthesia for Elective Cesarean Section: A Prospective Observational Cohort Study","Inclusion Criteria:\n\nASA II Term pregnancy ≥37 weeks Singleton pregnancy Elective cesarean section Age 18-45 years Written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders Diabetes mellitus Cardiovascular disease Neurological or autonomic disorders Ophthalmic disease Medications affecting autonomic function BMI \\>40 kg\u002Fm² Failed spinal anesthesia",true,"FEMALE","18 Years","45 Years",{"count":22,"type":23},200,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.",[27,28,29],"Hypotension","Spinal Anesthesia","Cesarean Delivery",[31,32,28,27,33,34],"Pupillary Light Reflex","Pupillometry","Cesarean Section","Obstetric Anesthesia","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":23},"2026-06-28",{"date":43,"type":23},"2026-10-31",{"name":45,"class":46},"Al-Azhar University","OTHER",{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100641802","patient-controlled-remimazolam-sedation-under-spinal-anesthesia-100641802","NCT07661810","Patient-controlled Remimazolam Sedation Under Spinal Anesthesia","Patient-controlled Remimazolam Sedation During Primary Hip Arthroplasty Under Spinal Anesthesia: an Open-Label Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 19 to 70 years with an ASA (American Society of Anesthesiologists) physical status of I or II who are undergoing primary hip arthroplasty under spinal anesthesia.\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Patients with contraindications to spinal anesthesia\n* Patients who do not consent to intraoperative sedation\n* Patients with contraindications to remimazolam\n* Patients with a history of allergy or hypersensitivity to remimazolam\n* Patients with a baseline MOAA\u002FS (Modified Observer's Assessment of Alertness\u002FSedation) score of 4 or lower\n* Pregnant women","ALL","19 Years","70 Years",{"count":58,"type":23},104,"INTERVENTIONAL",[61],"NA","The goal of this clinical trial is to compare the efficacy of patient-controlled sedation (PCS) versus clinician-controlled sedation (CCS) using remimazolam in adult patients undergoing primary hip arthroplasty under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does patient-controlled sedation significantly reduce the total consumption of remimazolam compared to clinician-controlled sedation?\n* Are there differences in secondary outcomes, such as sedation depth , sedation-related adverse events, frequency of airway interventions, and patient\u002Fsurgeon satisfaction?\n\nResearchers will compare the PCS group to the CCS group to see if the patient-controlled method leads to a reduction in total remimazolam consumption while maintaining effective sedation.\n\nParticipants will:\n\n* Be randomly assigned to either the PCS group or the CCS group.\n* In the PCS group: Receive an initial 0.05 mg\u002Fkg remimazolam dose over 1 minute. If deeper sedation is desired, the patient can self-administer a 1 mg bolus of remimazolam via a button press, which has a 1-minute lockout interval.\n* In the CCS group: Receive an initial 0.05 mg\u002Fkg remimazolam dose over 1 minute, followed by a continuous infusion starting at 0.3 mg\u002Fkg\u002Fh. The clinician will assess the MOAA\u002FS score every 10 minutes and adjust the infusion rate to maintain a target MOAA\u002FS score of 3.",[64,28,65,66],"Hip Arthroplasty","Remimazolam","Patient-controlled Sedation",[68,69,70,71],"patient-controlled sedation","remimazolam","spinal anesthesia","hip arthroplasty","2026-06-16",{"date":74,"type":39},"2026-06-22",{"date":38,"type":23},{"date":77,"type":23},"2027-05-31",{"name":79,"class":46},"Seoul National University Hospital",{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100627544","the-effect-of-preoperative-anxiety-level-on-vasovagal-events-during-spinal-anesthesia-and-the-incidence-of-vasovagal-events-100627544","NCT07450014","The Effect of Preoperative Anxiety Level on Vasovagal Events During Spinal Anesthesia and the Incidence of Vasovagal Events","Inclusion Criteria:\n\n* American Soicety of Anesthesiologists (ASA) I-II Patients\n* 18-65 years patients\n\nExclusion Criteria:\n\n* Patients who did not wish to participate in the study voluntarily\n* patients for whom spinal anesthesia is contraindicated\n* Pregnant and breastfeeding women\n* ASA III-IV-V patients","65 Years",{"count":88,"type":23},1500,"To determine the anxiety levels of patients undergoing spinal anesthesia before surgery and to observe the effect of this anxiety level on vasovagal events that may be observed during spinal anesthesia.",[28,91],"Anxiety",[93,94],"Amsterdam Preoperative Anxiety and Information Scale","sencop","RECRUITING","2026-04-22",{"date":98,"type":39},"2026-04-28",{"date":100,"type":39},"2026-04-15",{"date":102,"type":23},"2026-09-15",{"name":104,"class":46},"Sanliurfa Mehmet Akif Inan Education and Research Hospital",1,{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":86,"enrollmentInfo":112,"targetDuration":4,"studyType":59,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":105},"100633953","effect-of-anterior-iliac-block-on-postoperative-analgesia-and-patient-satisfaction-in-inguinal-hernia-repair-surgery-100633953","NCT07533383","Effect of Anterior Iliac Block on Postoperative Analgesia and Patient Satisfaction in Inguinal Hernia Repair Surgery","Inclusion Criteria:\n\n* 18-65 years patient\n* American Society of Anesthesiologists(ASA) I-II patient\n\nExclusion Criteria:\n\n* Patients who declined to participate in the study\n* Patients with contraindications to the anterior iliac block\n* Pregnant or breastfeeding patients\n* Patients classified as ASA III, IV, or V",{"count":113,"type":23},80,[61],"Inguinal hernia repair is one of the most commonly performed surgical procedures worldwide and presents challenges in anesthesia selection and postoperative pain management. Spinal anesthesia is frequently preferred due to its advantages, such as avoiding neuromuscular blockers and endotracheal intubation. Effective postoperative analgesia is essential for improving patient comfort and reducing opioid consumption.\n\nThe anterior iliac block, a recently described technique, has emerged as a potential alternative to conventional regional anesthesia methods, offering wider nerve coverage and possibly improved analgesia. However, evidence regarding its efficacy and safety remains limited.\n\nThis study aims to evaluate the effect of the anterior iliac block on postoperative analgesia duration and patient satisfaction in patients undergoing inguinal hernia surgery.",[117,118,28],"Anterior Ilıac Block","Hernia Surgery",[120,121,122,70],"hernia surgery","postoperative pain","numeric rating scale","2026-04-09",{"date":125,"type":39},"2026-04-16",{"date":127,"type":23},"2026-04-30",{"date":129,"type":23},"2027-04-30",{"name":104,"class":46},{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":18,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":59,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100632594","effects-of-high-flow-humidified-oxygen-on-umbilical-artery-acid-base-balance-in-cesarean-section-under-spinal-anesthesia-100632594","NCT07515716","Effects of High Flow Humidified Oxygen on Umbilical Artery Acid-base Balance in Cesarean Section Under Spinal Anesthesia","The Effectiveness of Binaural Beats on Midazolam Requirement During Cesarean Section With Spinal Anesthesia","Inclusion Criteria:\n\n* Pregnant women aged 20 years or older with American Society of Anesthesiologists (ASA) physical status class 2-3 who are scheduled to undergo cesarean section under spinal anesthesia.\n\nExclusion Criteria:\n\nA. Emergency surgery B. Patients in whom massive hemorrhage is anticipated, such as those with placenta previa C. Multiple pregnancy, preterm birth at less than 36 weeks of gestation, intrauterine growth restriction, or fetal anomalies D. History of hospitalization for preterm labor within the past 4 weeks requiring tocolytic therapy E. Respiratory diseases requiring oxygen therapy (e.g., moderate or severe asthma, chronic obstructive pulmonary disease) F. Individuals who are unable to read the consent form (e.g., illiterate individuals or foreigners who cannot read Korean)","20 Years",{"count":22,"type":23},[61],"Spinal anesthesia is the most commonly used anesthetic technique for cesarean section in developed countries, but vasodilation and a decrease in systemic vascular resistance caused by sympathetic blockade result in hypotension in 7-74% of parturients. The fetus receives oxygen from the mother via uteroplacental blood flow, and because uteroplacental circulation during pregnancy has minimal autoregulation, uterine blood flow changes in proportion to maternal blood pressure. Therefore, a reduction in uterine blood flow due to maternal hypotension can lead to fetal hypoxia or acidosis and is associated with low Apgar scores after birth.\n\nOxygen administration may offer potential benefits, such as improving maternal cerebral perfusion and preventing fetal ischemic injury, and thus low-flow oxygen via a conventional nasal cannula is commonly used. However, there are few studies evaluating the effects of high-flow oxygen administration on fetal well-being during cesarean section under spinal anesthesia. Low-flow oxygen delivery through a conventional nasal cannula, which is commonly used during cesarean section under spinal anesthesia, results in a fraction of inspired oxygen (FiO₂) of less than 40% due to dilution with ambient air. In contrast, OptiFlow THRIVE (Fisher and Paykel Healthcare, Panmure, Auckland, New Zealand) is a device capable of delivering high-flow oxygen through a nasal interface, allowing administration of 100% oxygen to the mother and potentially providing greater protection against fetal ischemic injury. Delivering non-humidified oxygen at flow rates above 10 L\u002Fmin causes significant discomfort in awake patients, but OptiFlow THRIVE passes the gas through a heated humidification chamber immediately before delivery, enabling the administration of warmed and humidified oxygen even at high flow rates. Therefore, this study aims to compare high-flow nasal cannula oxygen therapy initiated upon operating room admission with conventional low-flow nasal cannula oxygen therapy during cesarean section under spinal anesthesia, assessing their effects on maternal hemodynamic parameters and, ultimately, on fetal acid-base status.",[143,33,28],"Pregnancy","2026-03-31",{"date":146,"type":39},"2026-04-07",{"date":146,"type":23},{"date":149,"type":23},"2027-03-31",{"name":151,"class":46},"Yonsei University",{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":12,"sex":18,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":105},"100631382","predicting-spinal-hypotension-in-cesarean-section-100631382","NCT07499947","Predicting Spinal Hypotension in Cesarean Section","The Value of Waist Circumference, Body Mass Index, and Modified Shock Index in Predicting Spinal Anesthesia-Induced Hypotension During Cesarean Section: A Prospective Observational Study","prediction","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) Class II\n2. Having regular antenatal visits\n3. Singleton pregnancy at ≥37 weeks of gestation\n4. Pregnant women aged 18-45 -\n\nExclusion Criteria:\n\n1. Those with eclampsia, those with preeclampsia\n2. Undergoing an emergency cesarean section\n3. Those with bleeding diathesis and those receiving anticoagulant therapy\n4. With a history of carotid artery stenosis,\n5. Cardiovascular disease,\n6. Hypertension,\n7. Chronic obstructive pulmonary disease,\n8. Heart rhythm outside of sinus\n9. Patients with a history of cerebrovascular disease\n10. Alcoholism or psychiatric illness\n11. Placenta previa, accreta, and percreta","18 Months","45 Months",{"count":163,"type":23},321,"This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section. While spinal anesthesia is preferred for its rapid onset, SAIH remains a frequent complication risking maternal and fetal safety. The study enrolled parturients at Erciyes University, excluding those with hypertension or extreme weight\u002Fheight. Preoperative measurements included BMI, waist circumference (WC), body roundness index (BRI), and modified shock index (MSI). Following standardized spinal anesthesia with hyperbaric bupivacaine (Harten's dosage), hemodynamic parameters and sensory block levels were monitored. This research aims to determine whether BRI and WC offer superior predictive utility compared with conventional markers such as BMI and MSI to enhance individualized risk assessment in obstetric anesthesia.",[28,33,27],[167,168,169,27],"Bupivacaine","Cesarean","Spinal anesthesia","2026-03-30",{"date":144,"type":39},{"date":173,"type":39},"2026-03-16",{"date":175,"type":23},"2026-11-30",{"name":177,"class":46},"TC Erciyes University",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":105},"100631426","preoperative-shock-indexes-and-post-spinal-hypotension-in-cesarean-surgery-100631426","NCT07500519","Preoperative Shock Indexes and Post-Spinal Hypotension in Cesarean Surgery","Predictive Performance of Preoperative Shock Index and Modified Shock Index for Hypotension Following Spinal Anesthesia in Elective Cesarean Surgery","Inclusion Criteria:\n\n* Patients over 18 years old\n* ASA II-III patients undergoing elective cesarean section\n\nExclusion Criteria:\n\n* ASA IV patients\n* Patients with known neurologic or psychiatric disorders\n* Patients with clinically significant cardiovascular, respiratory, hepatic, renal or metabolic disease\n* Patients with alcohol or drug addiction\n* Mentally disabled patients\n* Patients with BMI\\>30\n* Patients who develop massive bleeding or coagulopathy",{"count":186,"type":23},300,"This prospective observational study aims to evaluate the predictive performance of preoperative Shock Index (SI) and Modified Shock Index (MSI) for hypotension following spinal anesthesia in elective cesarean surgery. Post-spinal hypotension is a common complication that can affect maternal and fetal outcomes, and early identification of at-risk patients is essential for effective perioperative management.",[28,143,189],"Hypotension Postprocedural",[27,33,28,191],"Shock Index","2026-03-25",{"date":170,"type":39},{"date":195,"type":39},"2025-10-15",{"date":197,"type":23},"2026-08-30",{"name":199,"class":46},"Marmara University",{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":54,"minAge":86,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":105},"100629990","skin-conductance-for-predicting-spinal-anesthesia-induced-hypotension-in-geriatric-urologic-oncology-patients-100629990","NCT07481851","Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients","Skin Conductance as a Predictor of Spinal Anesthesia-Induced Hypotension in Geriatric Oncology Patients","Inclusion Criteria:\n\n* Patients aged 65 years and older\n* Patients scheduled for elective urologic oncology surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Refusal to participate or inability to provide informed consent\n* Contraindication to spinal anesthesia (e.g., infection at puncture site, coagulopathy)\n* Severe cardiac conduction abnormalities or presence of a cardiac pacemaker\n* Severe autonomic dysfunction or known neuropathy affecting autonomic responses\n* Use of medications that significantly affect autonomic nervous system activity\n* Baseline hypotension or hemodynamic instability before spinal anesthesia\n* Inability to obtain reliable skin conductance measurements (e.g., severe skin lesions at electrode placement site)",{"count":208,"type":23},102,"Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery. Early identification of patients at risk for hemodynamic instability remains a major challenge in perioperative management. Skin conductance reflects sympathetic nervous system activity and may provide a noninvasive indicator of autonomic responses. This prospective observational study aims to evaluate whether skin conductance measurements can predict the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. The findings may contribute to improved perioperative monitoring and early risk stratification in this vulnerable patient population.",[27,211,212,28],"Urologic Neoplasms","Aged","2026-03-23",{"date":192,"type":39},{"date":216,"type":39},"2025-12-22",{"date":218,"type":23},"2026-05-01",{"name":220,"class":46},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":231,"conditions":232,"keywords":236,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":105},"100570773","ultrasound-evaluation-of-two-anatomic-landmarks-in-spinal-anesthesia-for-cesarean-section-the-posterior-superior-iliac-spine-vs-iliac-crest-100570773","NCT06711601","Ultrasound Evaluation of Two Anatomic Landmarks in Spinal Anesthesia for Cesarean Section: the Posterior Superior Iliac Spine VS Iliac Crest","Ultrasound Evaluation Of Two Anatomic Landmarks In Spinal Anesthesia For Cesarean Section: The Posterior Superior Iliac Spine vs Iliac Crest","USPSISICL","Inclusion Criteria:\n\n* After obtaining written informed consents,pregnant women at 37-42 weeks of gestation\n\nExclusion Criteria:\n\n* BMI ≥ 40 kg\u002Fm² (to minimize palpation variability), History of lumbar surgery\u002Fdeformity (scoliosis, spondylolisthesis or osteoporotic vertebral collapse), Inability to maintain the flexed lateral decubitus position, Participant withdrawal, Unforeseen anatomical anomalies discovered during screening.",{"count":230,"type":23},660,"Intercristal line as palpation landmarks to identifying the vertebral level is frequently inaccurate.To find more safe and reliable body surface markers and convenient methods to be solved in clinical work.The investigators performed a two-stage study to evaluated the accuracy of intercristal line and the The Posterior Superior Iliac Spine (PSIS) line to identify the lumbar interspinous spaces for spinal anesthesia using ultrasonography in pregnant woman which will provide a second option.",[28,233,234,235],"Ultrasonography","Posterior Superior Iliac Spine","Intercristal Line",[237,238,70,234,239],"cesarean section","ultrasonography","intercristal line","2026-01-30",{"date":242,"type":39},"2026-02-03",{"date":244,"type":39},"2024-10-10",{"date":246,"type":23},"2026-01-23",{"name":248,"class":46},"The Third Affiliated Hospital of Guangzhou Medical University",{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":56,"enrollmentInfo":255,"targetDuration":4,"studyType":59,"phases":257,"briefSummary":258,"conditions":259,"keywords":262,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":269,"leadSponsor":271,"locationsCount":4},"100621913","effect-of-patient-position-on-bupivacaine-dose-requirement-and-hemodynamic-stability-in-spinal-anesthesia-100621913","NCT07376798","Effect of Patient Position on Bupivacaine Dose Requirement and Hemodynamic Stability in Spinal Anesthesia","Inclusion Criteria:\n\n* Age 18-70 years\n* American Society of Anesthesiologists (ASA) physical status classification I-II\n* Scheduled for elective urogenital surgery\n* Suitable candidate for spinal anesthesia\n* Able to read, understand, and provide written informed consent\n* Body Mass Index (BMI) less than 35 kg\u002Fm²\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, infection at injection site, patient refusal)\n* History of neurological disease\n* Spinal deformity or previous spinal surgery\n* History of allergic reaction to local anesthetics (amide-type)\n* ASA physical status classification III or higher\n* Emergency surgery\n* Pregnancy\n* Psychiatric illness preventing effective communication\n* Refusal to participate in the study\n* Unable to understand or provide informed consent",{"count":256,"type":23},100,[61],"This study compares different combinations of local anesthetic doses and patient positions during spinal anesthesia for urogenital surgery. Spinal anesthesia is a common and safe technique where medication is injected into the lower back to numb the body during surgery.\n\nThe study will test two different doses of bupivacaine (a numbing medication): a lower dose (8 mg) and a standard dose (12 mg). It will also test two different patient positions after the spinal injection: lying flat (neutral position) and lying with the head slightly lower than the feet (Trendelenburg position).\n\nParticipants will be randomly assigned to one of four groups:\n\n* Group 1: Lower dose + lying flat\n* Group 2: Lower dose + head-down position\n* Group 3: Standard dose + lying flat\n* Group 4: Standard dose + head-down position\n\nThe study will measure how well the anesthesia works, how high the numbness spreads in the body, and how it affects blood pressure and heart rate. The goal is to find the best combination of dose and position that provides good anesthesia while keeping blood pressure stable.\n\nThis research may help doctors choose the safest and most effective anesthesia approach for each patient based on their individual needs.",[28,260,261,167],"Hemodynamic Changes","Patient Positions",[28,167,263,264],"Patient Positioning","hemodynamic changes","2026-01-21",{"date":267,"type":39},"2026-01-29",{"date":240,"type":23},{"date":270,"type":23},"2026-06-30",{"name":272,"class":273},"University of Health Sciences Balikesir Hospital Eduation and Research","OTHER_GOV",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":54,"minAge":281,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":295,"locationsCount":105},"100619042","femoral-vein-diameter-to-predict-intraoperative-hypotension-in-geriatric-patients-undergoing-orthopedic-surgery-under-spinal-anesthesia-100619042","NCT07339475","Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia","Evaluation of Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 60 years.\n* American Society of Anesthesiologists (ASA) physical state I-II.\n* Body mass index (BMI) ≤35 kg\u002Fm². Patients above this value will be excluded because obesity may cause technical difficulty and poor image quality in femoral vein ultrasound assessment.\n* Elective lower-limb orthopedic surgery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patients refusing to participate.\n* History of psychiatric illness or seizures.\n* Absolute contraindications to spinal anesthesia: infection at the puncture site, severe coagulopathy\u002Fanticoagulation \\[defined as platelet count \\\u003C75,000\u002FµL, International Normalized Ratio (INR) \\>1.5, Activated Partial Thromboplastin Time (aPTT) \\>1.5 times control, or the use of anticoagulants such as warfarin, heparin, low molecular weight heparin, or direct oral anticoagulants within the recommended safety interval for neuraxial anesthesia\\], severe hypovolemia, increased intracranial pressure, or known allergy to local anesthetics.\n* Severe cardiac disease, including left ventricular ejection fraction \\\u003C30%, Severe valvular heart disease (e.g., critical aortic stenosis), clinically significant arrhythmias (atrial fibrillation with uncontrolled ventricular rate \\>120 bpm, frequent ventricular ectopy or sustained ventricular tachyarrhythmia) and congestive heart failure such as New York Heart Association (NYHA) class III-IV.\n* Severe uncontrolled hypertension, defined as persistent mean arterial pressure (MAP) ≥120 mmHg or systolic blood pressure (SBP) ≥180 mmHg and\u002For diastolic blood pressure (DBP) ≥110 mmHg despite medical therapy.\n* Severe respiratory diseases (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage III-IV chronic obstructive pulmonary disease, or forced vital capacity (FVC) \\\u003C50% predicted).\n* Baseline bradycardia (\\\u003C50) or mean arterial blood pressure less than 60mmHg.\n* Emergency surgeries.","60 Years",{"count":283,"type":23},43,"The study aims to assess whether the transverse diameter of the right common femoral vein (RCFV) in the inguinal region could reflect the degree of post-spinal hypotension during elective orthopedic surgery.",[286,287,288,28],"Femoral Vein Diameter","Intraoperative Hypotension","Orthopedic Surgery","2026-01-05",{"date":291,"type":39},"2026-01-14",{"date":293,"type":39},"2025-12-01",{"date":38,"type":23},{"name":296,"class":46},"Cairo University",{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":306,"conditions":307,"keywords":313,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":105},"100612666","machine-learning-for-predicting-spinal-anesthesia-duration-100612666","NCT07256548","Machine Learning for Predicting Spinal Anesthesia Duration","Comparative Evaluation of Machine Learning Algorithms for Predicting Spinal Anesthesia Termination Time","Inclusion Criteria:\n\n1. Patients scheduled to undergo total knee arthroplasty between November 2025 and March 2026 at the Kocaeli City Hospital Operating Theaters.\n2. Patients who have provided written informed consent to participate in the study.\n3. Patients whose surgery is planned under spinal anesthesia.\n4. Patients for whom complete clinical data can be obtained during the study period.\n5. Adults aged 18 years or older, classified as American Society of Anesthesiologist's (ASA) Physical Status I or II.\n\nExclusion Criteria:\n\n1. Patients who were converted to general anesthesia during surgery or initially operated under general anesthesia.\n2. Patients who required postoperative intensive care unit (ICU) admission following anesthesia.\n3. Patients who developed surgical complications and for whom postoperative mobilization could not be planned.\n4. Patients with cognitive impairment preventing them from completing pain assessment scales in the postoperative period.\n5. Patients with neuropathic pain, multiple sclerosis, or other neuromotor disorders will be excluded from the study.",{"count":305,"type":23},140,"Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications. However, predicting its duration is critical for patient safety and effective postoperative management. This study evaluates the usability of machine learning (ML) algorithms to predict the termination time of spinal anesthesia and the patient's readiness for mobilization. Using demographic, surgical, and anesthetic variables, ML models were trained to estimate anesthesia duration. Accurate predictions may improve intraoperative planning, optimize postoperative care, and enhance patient outcomes. Integrating ML-based predictive systems into anesthesia practice can contribute to safer, more efficient, and personalized perioperative management.",[28,308,309,310,311,312],"Machine Learning","Knee Arthroplasty, Total","Spinal Anesthesia Duration","Postoperative Care","Postoperative Acute Pain",[70,314,315,316,317],"machine learning","Knee arthroplasty","spinal anesthesia duration","Acute postoperative pain",{"date":319,"type":39},"2025-12-08",{"date":321,"type":39},"2025-10-31",{"date":323,"type":23},"2026-03-01",{"name":325,"class":273},"Kocaeli City Hospital",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":281,"enrollmentInfo":333,"targetDuration":4,"studyType":59,"phases":335,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":105},"100614228","intrathecal-dexmedetomidine-fentanyl-combination-versus-fentanyl-alone-as-adjuvant-to-bupivacaine-in-spinal-anesthesia-for-above-knee-amputation-in-sarcomas-of-lower-extremity-100614228","NCT07276867","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity: A Randomized, Comparative Study","Inclusion Criteria:\n\n* Age from 18 to 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of II-III.\n* Height between 150-185 cm.\n* Body mass index between 18-35 kg\u002Fm².\n* Scheduled for above-knee amputation due to lower limb sarcomas.\n\nExclusion Criteria:\n\n* Allergy to any of the investigated drugs.\n* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.\n* Contraindications to spinal anesthesia.\n* Pregnancy or lactation.\n* Presence of psychiatric illness or chronic pain conditions.",{"count":334,"type":23},58,[61],"The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.",[338,339,340,167,28,341,342,343],"Intrathecal","Dexmedetomidine","Fentanyl","Above Knee Amputation","Sarcomas","Lower Extremity","2025-11-30",{"date":346,"type":39},"2025-12-11",{"date":348,"type":39},"2025-10-20",{"date":350,"type":23},"2026-04-01",{"name":352,"class":46},"National Cancer Institute, Egypt",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":59,"phases":363,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":378,"locationsCount":105},"100603669","dexamethasone-versus-magnesium-sulphate-as-an-adjuvant-to-bupivacaine-in-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-elective-caesarean-section-under-spinal-anesthesia-100603669","NCT07139522","Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia","The Efficacy of Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age from 18 to 35 years.\n* Full-term, singleton, pregnant women.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for elective cesarean delivery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Refusal of the patient.\n* Emergency caesarean sections.\n* Patients having chronic diseases as asthma, cardiovascular disorders (Significant arrhythmias, Severe Valvular diseases, congenital heart diseases, ischemic heart disease, cardiomyopathy, deep venous thrombosis ,and pulmonary embolism)\n* Renal impairment (Creatinine level ≥ 2mg\u002Fdl, urea ≥ 25mg\u002FdL), liver impairment \\[Alanine aminotransferase (ALT) \\\u003C 45 U\u002FL, Aspartate aminotransferase (AST) \\\u003C 45 U\u002FL\\].\n* Allergy to the drug enrolled in the study.\n* Body mass index (BMI) ≥ 35 kg\u002Fm2.\n* Hypertensive disorders of pregnancy.\n* Contraindication to spinal anesthesia, such as coagulopathy \\[platelet count \\\u003C150.000, international normalized ratio (INR) \\> 1.2\\], or local infection.\n* Requirement for conversion to general anesthesia after spinal anesthesia will also be excluded.","35 Years",{"count":362,"type":23},150,[61],"This study aims to compare the efficacy of adding dexamethasone and magnesium sulfate as an adjuvant to bupivacaine in bilateral erector spinae block in postoperative pain control in patients undergoing caesarean section under spinal anesthesia.",[366,367,368,369,370,371,33,28],"Dexamethasone","Magnesium Sulphate","Adjuvant","Ultrasound","Erector Spinae Plane Block","Postoperative Analgesia","2025-08-18",{"date":374,"type":39},"2025-08-24",{"date":376,"type":39},"2023-12-01",{"date":293,"type":23},{"name":296,"class":46},{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":4,"enrollmentInfo":386,"targetDuration":4,"studyType":59,"phases":388,"briefSummary":389,"conditions":390,"keywords":392,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":105},"100572132","effect-of-music-listened-during-knee-arthroplasty-with-spinal-anesthesia-on-anxiety-pain-and-cortisol-levels-100572132","NCT06729294","Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels","Effect of Binaural Beat Music Played During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels.","Inclusion Criteria:\n\n* Patients who are older than 18 years,\n* Who have undergone unilateral knee arthroplasty under spinal anesthesia for the first time,\n* Who can communicate verbally,\n* Who are in the ASA 1-2-3 group,\n* Who do not have a neurological or psychiatric diagnosis will be included in the study.\n* Since cortisol levels will be measured in our study, the first cases of the day will be included in the study.\n\nExclusion Criteria:\n\n* Patients who refused to participate in the study were those with hearing impairment due to age or disease,\n* Those who had any contraindications for spinal anesthesia,\n* Those who were transferred to intensive care after the procedure,\n* Those who developed complications during and after the procedure,\n* Those who underwent general anesthesia,\n* Those whose type of anesthesia was changed during surgery.",{"count":387,"type":23},40,[61],"The aim of this study is to examine the effects of binaural beat music played during spinal anesthesia knee arthroplasty on anxiety, pain and cortisol levels. The study was planned as a randomized controlled experimental design study. The hypotheses of the study are as follows;\n\n* Binaural beat music played during spinal anesthesia knee arthroplasty has no effect on anxiety.\n* Binaural beat music played during spinal anesthesia knee arthroplasty has an effect on anxiety.\n* Binaural beat music played during spinal anesthesia knee arthroplasty has no effect on pain levels.\n* Binaural beat music played during spinal anesthesia knee arthroplasty has an effect on pain levels.\n* Binaural beat music played during spinal anesthesia knee arthroplasty has no effect on cortisol levels.\n* Binaural beat music played during spinal anesthesia knee arthroplasty has an effect on cortisol levels.\n\nA sample group will be formed with 20 patients in the intervention group and 20 patients in the control group. Binaural beat music will be played in the intervention group during the surgical procedure, and routine interventions will be applied to the control group.\n\nData collection in the intervention group is as follows;\n\n* Patients will be interviewed in the surgery clinic before surgery and the descriptive characteristics form and the State Anxiety Inventory Form will be filled out.\n* The 1st measurement of hemodynamic data will be recorded immediately before the surgery\n* A musical concert will be started as soon as the surgery begins\n* The musical concert will end when the surgery ends\n* The 2nd measurement will be recorded immediately after the surgery ends\n* In the post-surgery collection unit, the State Anxiety Inventory Form and the Visual Comparison Scale will be used, and a blood sample will be taken to determine cortisol values.\n\nThe control group data collection methods are as follows;\n\n* Patients will be interviewed in the surgical clinic before surgery and the descriptive characteristics form and the State Anxiety Inventory Form will be filled in\n* The first measurement of hemodynamic data will be recorded immediately before the surgical procedure\n* The second measurement will be recorded immediately after the surgical procedure is completed\n* Blood samples will be taken in the post-surgical recovery unit to determine the State Anxiety Inventory Form, Visual Comparison Scale and cortisol values.",[28,391],"Knee Arthroplasty",[393,394,395,396],"binaural beat music","anxiety","pain","cortisol","2025-08-14",{"date":399,"type":39},"2025-08-20",{"date":401,"type":39},"2025-02-01",{"date":403,"type":23},"2026-02",{"name":405,"class":46},"Nuh Naci Yazgan University",{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":412,"eligibilityCriteria":413,"healthyVolunteers":17,"sex":54,"minAge":19,"maxAge":281,"enrollmentInfo":414,"targetDuration":4,"studyType":59,"phases":416,"briefSummary":418,"conditions":419,"keywords":424,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":105},"100601981","phase-4-d-fab-pour-trial-dexmedetomidine-vs-fentanyl-as-adjuvants-to-bupivacaine-on-postoperative-urinary-retention-100601981","NCT07117565","D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention","Comparison of Intrathecal Dexmedetomidine Versus Intrathecal Fentanyl as Adjuvants to Bupivacaine on Post-Operative Urinary Retention in Lower Limb Surgery","D-FAB-POUR","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Scheduled for elective lower limb surgery under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status II or III\n* Minimum height of 150 cm (to ensure uniform drug volume)\n* Able to understand the study procedures and provide written informed consent (in English or Nepali)\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (e.g., coagulopathy, infection at injection site, hemodynamic instability)\n* Known allergy or hypersensitivity to bupivacaine, fentanyl, or dexmedetomidine\n* Chronic pain conditions or long-term opioid use\n* Neurological, Cardiac, Renal, or uncontrolled diabetic conditions\n* Current treatment for prostatic pathology or use of alpha-2 blockers\n* Presence of a Foley's catheter preoperatively\n* Estimated surgical duration: \\>2.5 hours\n* Inability or unwillingness to provide informed consent",{"count":415,"type":23},190,[417],"PHASE4","This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery. The main focus of the study is to see which combination causes fewer problems with urination after surgery - a condition known as postoperative urinary retention (POUR). POUR can lead to discomfort, delayed recovery, and a need for catheterization. Dexmedetomidine is a newer drug that may help reduce this problem compared to fentanyl, which is more commonly used but may increase the risk of urinary retention. This trial will help determine which medication combination provides better pain relief while reducing urinary side effects. The study is being conducted as a randomized, double-blind trial at a hospital in Nepal and will include 190 adult patients.\n\n\\-",[28,420,339,340,421,167,422,288,423],"Postoperative Complications","Anesthesia, Spinal","POUR","Urinary Retention Postoperative",[425,169,426,339,340,427],"Postoperative urinary retention","Intrathecal adjuvants","Perioperative complications","2025-08-09",{"date":430,"type":39},"2025-08-12",{"date":432,"type":23},"2025-09-15",{"date":434,"type":23},"2026-11-25",{"name":436,"class":46},"Tribhuvan University Teaching Hospital, Institute Of Medicine.",{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":54,"minAge":444,"maxAge":86,"enrollmentInfo":445,"targetDuration":4,"studyType":59,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":105},"100601727","comparative-study-between-spinal-anesthesia-versus-general-anesthesia-in-supine-percutaneous-nephrolithotomy-operation-100601727","NCT07114250","Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Supine Percutaneous Nephrolithotomy Operation","Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Patients Undergoing Supine Percutaneous Nephrolithotomy","Inclusion Criteria:\n\n* Age more than 21 years old.\n* Both sexes.\n* American Society of Anesthesiologists physical status (I- II).\n* Patient with single renal stone size 2-3cm prepared for supine Percutaneous nephrolithotomy\n\nExclusion Criteria:\n\n* Patient refusal.\n* Pregnancy\n* Morbid obese with Body mass index \\> 35 kg\u002Fm2.\n* Contraindication for spinal anesthesia.\n* Renal anomalies (horseshoe kidney, ectopic kidney).\n* Presence of multiple stones or staghorn stones.","22 Years",{"count":446,"type":23},70,[61],"The aim of this study is to evaluate the efficacy of spinal anesthesia as an alternative to general anesthesia in PCNL operation in supine position.",[28,450,451],"Percutaneous Nephrolithotomy","General Anesthesia",[451,453,28,454],"Percutaneous nephrolithotomy","Nephrolithiasis","2025-08-04",{"date":457,"type":39},"2025-08-11",{"date":459,"type":23},"2026-05-30",{"date":461,"type":23},"2026-12-30",{"name":463,"class":46},"Tanta University",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":17,"sex":18,"minAge":471,"maxAge":472,"enrollmentInfo":473,"targetDuration":4,"studyType":59,"phases":475,"briefSummary":476,"conditions":477,"keywords":479,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":489,"locationsCount":105},"100599719","phase-4-dexamethasone-in-prolonging-the-duration-of-spinal-anesthesia-among-pregnant-patients-100599719","NCT07088146","Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients","Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) class: II and above.\n* Elective Cesarean section under Spinal Anesthesia.\n\nExclusion Criteria:\n\n* Gestational diabetes\n* Body mass index \\>35 kg\u002Fm2\n* Diabetes mellitus\n* Adrenal insufficiency\n* Chronically receiving steroids\n* Allergic to study medications\n* Sensory block level less than T4","16 Years","40 Years",{"count":474,"type":23},110,[417],"Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.",[28,478],"Post Operative Analgesia",[480,481,482],"Adjuvants","Sub-Arachnoid Block","C-section","2025-07-19",{"date":485,"type":39},"2025-07-28",{"date":487,"type":39},"2025-07-20",{"date":348,"type":23},{"name":490,"class":46},"Rawalpindi Medical College",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":498,"minAge":499,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":59,"phases":501,"briefSummary":502,"conditions":503,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":510,"leadSponsor":512,"locationsCount":105},"100598687","general-anesthesia-versus-spinal-anesthesia-with-local-anesthetic-infiltration-for-buccal-mucosal-graft-in-urethroplasty-100598687","NCT07074730","General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty","General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Male patient age ≥ 21 years.\n* American Society of Anesthesiologists (ASA) classification I-II.\n* Patient scheduled for urethroplasty.\n\nExclusion Criteria:\n\n* Patients who are taking analgesics for chronic illness or have a history of substance abuse.\n* Patients who are unable to describe their postoperative pain (e.g., neuropsychiatric disorder).\n* Patients with known local anesthetics and opioid allergy.\n* Patients with infection at the site of the needle puncture.","MALE","21 Years",{"count":256,"type":23},[61],"This study aims to compare general anesthesia and spinal anesthesia with local anesthetic infiltration for buccal mucosal graft (BMG) in urethroplasty.",[451,28,504,505,506],"Local Anesthetic Infiltration","Buccal Mucosal Graft","Urethroplasty",{"date":508,"type":39},"2025-07-22",{"date":483,"type":39},{"date":511,"type":23},"2027-03-01",{"name":463,"class":46},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":54,"minAge":19,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":59,"phases":522,"briefSummary":523,"conditions":524,"keywords":528,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":540,"locationsCount":4},"100592101","ultrasound-guided-peng-block-vs-femoral-nerve-block-for-analgesia-before-spinal-anesthesia-in-hip-fracture-surgery-100592101","NCT06989047","Ultrasound-Guided PENG Block vs Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Hip Fracture Surgery","Comparative Study of Preoperative Ultrasound-Guided Pericapsular Nerve Group Block and Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Proximal Femur Fracture Fixation","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for proximal femur fracture fixation under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Ability to understand and use the Visual Analog Scale (VAS)\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy\n* Local infection at the injection site\n* Known allergy to local anesthetics or magnesium sulfate\n* Severe cardiopulmonary disease \\[American Society of Anesthesiologists (ASA) ≥ IV\\]\n* Preexisting diabetic or other neuropathies\n* Chronic opioid use\n* Contraindication to spinal anesthesia\n* Cognitive impairment or inability to comprehend Visual Analog Scale (VAS)",{"count":521,"type":23},60,[61],"This study will compare two types of ultrasound-guided nerve blocks-Pericapsular Nerve Group (PENG) block and Femoral Nerve Block (FNB)-to evaluate their effectiveness in reducing pain before spinal anesthesia in patients who will undergo surgery for proximal femur fractures. Proximal femur fractures will continue to be common, especially in older adults, and often will cause severe pain that will make it difficult to position patients for spinal anesthesia. Both nerve blocks will aim to reduce pain, improve comfort during spinal anesthesia, and decrease the need for postoperative pain medication.\n\nA total of 60 adult patients who will undergo proximal femur fracture fixation under spinal anesthesia will be enrolled and randomly assigned to receive either a Pericapsular Nerve Group (PENG) block or a femoral nerve block before the procedure. The study will monitor patients' pain scores using the Visual Analog Scale (VAS) at multiple time points, including during positioning and throughout the first 24 hours after surgery. It also will evaluate how long it will take before the patients require rescue pain medication, and how much total pain medication will be needed.",[525,526,527,28],"Proximal Femur Fracture","Hip Fracture","Pain Management",[529,530,531,28,532,533],"Pericapsular Nerve Group Block (PENG)","Femoral Nerve Block (FNB)","Ultrasound-Guided Nerve Block","Hip Surgery","Regional Anesthesia","2025-05-16",{"date":536,"type":39},"2025-05-25",{"date":538,"type":23},"2025-05-30",{"date":459,"type":23},{"name":541,"class":46},"Ain Shams University",{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":549,"targetDuration":4,"studyType":59,"phases":551,"briefSummary":552,"conditions":553,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":105},"100570509","effect-of-preemptive-education-on-the-incidence-of-maternal-intraoperative-shivering-in-elective-cesarean-delivery-100570509","NCT06708169","Effect of Preemptive Education on the Incidence of Maternal Intraoperative Shivering in Elective Cesarean Delivery","Effect of Preemptive Education on the Incidence of Maternal Intraoperative Shivering in Elective Cesarean Delivery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 19 years or older\n* Gestational age 37 weeks or above\n* Elective surgey\n\nExclusion Criteria:\n\n* Emergency surgery\n* Any sign of onset of labor\n* Difficulty with communication\n* Contraindications of spinal anesthesia\n* Pre-eclampsia",{"count":550,"type":23},130,[61],"The goal of this study is to learn about the effect of preemptive education on reducing intraoperative maternal shivering in elective cesarean delivery. The main question it aims to answer is:\n\nDoes preemptive education by anesthesiologists reduce intraoperative maternal shivering in elective cesarean delivery?",[554,28],"Shivering","2025-05-12",{"date":557,"type":39},"2025-05-15",{"date":559,"type":39},"2024-12-09",{"date":561,"type":23},"2026-08-31",{"name":79,"class":46},{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":572,"conditions":573,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":585},"100587395","frequency-of-occurrence-and-risk-factors-of-postoperative-nausea-and-vomiting-during-elective-c-section-under-spinal-anesthesia-with-preventive-medication-100587395","NCT06927830","Frequency of Occurrence and Risk Factors of Postoperative Nausea and Vomiting During Elective C-section Under Spinal Anesthesia With Preventive Medication","Incidence and Risk Factors of Postoperative Nausea and Vomiting (PONV) During Elective C-Section Under Spinal Anesthesia With Multimodal Antiemetic Prophylaxis","Inclusion Criteria:\n\nAny patient requiring elective caesarean section under spinal anesthesia, at a gestational age \\>37 weeks of amenorrhea in the context of a single-fetal pregnancy.\n\nExclusion Criteria:\n\nFailure to understand the French language; Contraindication to locoregional anesthesia; Nausea and\u002For vomiting in the 24 hours preceding the procedure; Type 1 or type 2 insulin-requiring non-gestational diabetes; Allergy or contraindication to one of the products used in the usual management protocol; Severe preeclampsia; Height \\\u003C150 cm",{"count":571,"type":23},400,"The aim of this study is to learn about the incidence and risk factors of nausea and vomiting during planned caesarean section under spinal anesthesia.\n\nThe main question it aims to answer is : What are the incidence and risks factors of postoperative nausea and vomiting (NV) during planned caesarean section under spinal anesthesia with administration of intrathecal morphine and multimodal antiemetic prophylaxis ?\n\nPatients who will be managed according to the standard protocol in use in the department will have to answer specific questions about NV in the post-interventional recovery room and on 2 further visits in the first 24 hours post-caesarean section.",[574,29,28,575],"Nausea and Vomiting, Postoperative","Antiemetic Therapy","2025-04-14",{"date":578,"type":39},"2025-04-15",{"date":580,"type":39},"2025-03-19",{"date":582,"type":23},"2026-04",{"name":584,"class":46},"University of Liege",2,{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":54,"minAge":593,"maxAge":594,"enrollmentInfo":595,"targetDuration":4,"studyType":59,"phases":596,"briefSummary":597,"conditions":598,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":604,"leadSponsor":606,"locationsCount":4},"100577692","phase-4-age-based-and-weight-based-bupivacaine-dosing-for-pediatric-spinal-anesthesia-for-elective-infra-umbilical-surgeries-100577692","NCT06801600","Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries","A Comparative Study Between Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia in Children Undergoing Elective Infra-Umbilical Surgeries: A Randomized Double-Blinded Controlled Trial","Inclusion Criteria:\n\n* ASA I and II\n* Both genders\n* Elective infra-umbilical surgeries with anticipated duration ≤ 90 minutes.\n\nExclusion Criteria:\n\n* Guardian refusal.\n* Children with major congenital heart disease, including septal defects.\n* Patients with neuromuscular disorders or high intracranial pressure.\n* Children with spinal deformities or morbid obesity (BMI above the 99th percentile).\n* Children with a history or family history of coagulation disorders.\n* Children with local infection at the site of skin puncture for spinal anesthesia.\n* Children with known allergy to bupivacaine.\n* Surgeries requiring head down (Trendelenburg) or prone position.\n* Unexpected prolongation of surgery \\> 90 minutes.","1 Year","6 Years",{"count":521,"type":23},[417],"Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA). Spinal anesthesia in infants has been linked to a lower incidence of hypotension, hypoxia, bradycardia, and postoperative apnea in comparison to general anesthesia (GA); ensuring a high level of cardiovascular and respiratory stability.\n\nAdditionally, SA has been linked to lower operating room time, post-anesthesia care unit, hospital length of stay, corticosteroid administration, narcotic requirements, postoperative emesis, and cardiopulmonary complications in comparison to GA.\n\nA reduction in systemic blood pressure frequently accompanies neuraxial blocks in adults, necessitating intervention. Nevertheless, spinal, caudal, or epidural blocks administered to children under six years old are not associated with any substantial alterations in blood pressure. In children aged 6 to 10, there is a linear decrease in blood pressure that will reach a plateau at approximately a 30% decrease in those beyond the age of 10. Conversely, younger children require no additional precautions.\n\nBupivacaine, has a narrow therapeutic index in children, and its dosing requires careful consideration to strike a balance between effective anesthesia and the risk of toxicity. The traditional method of dosing bupivacaine in pediatric spinal anesthesia is based on the child's body weight. This weight-based dosing considers the assumption that children's drug clearance correlates with their body mass. However, this approach might not account for the maturational changes in drug handling by pediatric patients or the variability in spinal column length and cerebrospinal fluid volumes, not always proportional to weight but may evolve with age.\n\nEmerging evidence suggests that age-based dosing may be more effective. It hypothesizes that developmental pharmacokinetics, including changes in body composition, organ function, and drug-receptor differences, can influence bupivacaine metabolism and action more significantly than body mass alone. By accounting for the age-related anatomical and physiological changes, age-based dosing could result in more precise and effective anesthesia with a decreased risk of adverse outcomes.\n\nTo the authors knowledge, there is no study comparing age-based and weight-based bupivacaine dosing for pediatric spinal anesthesia in children undergoing elective infra-umbilical surgery.",[28,599,167],"Local Anesthetic","2025-01-25",{"date":602,"type":39},"2025-01-30",{"date":602,"type":23},{"date":605,"type":23},"2025-06-05",{"name":296,"class":46},{"id":608,"slug":609,"hasResults":12,"nctId":610,"briefTitle":611,"officialTitle":612,"acronym":4,"eligibilityCriteria":613,"healthyVolunteers":12,"sex":54,"minAge":86,"maxAge":4,"enrollmentInfo":614,"targetDuration":615,"studyType":24,"phases":4,"briefSummary":616,"conditions":617,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":626,"locationsCount":4},"100574296","frailty-and-spinal-anesthesia-induced-hypotension-in-elderly-100574296","NCT06757439","Frailty and Spinal Anesthesia-Induced Hypotension in Elderly","Effect of Frailty on Spinal Anesthesia-induced Hypotension in Geriatric Patients","Inclusion Criteria:\n\n* 65 and older\n* ASA I-III physical status\n* Undergoing elective surgery under spinal anesthesia\n\nExclusion Criteria:\n\n* Patients with cardiac arrhythmia\n* Patients with severe heart failure\n* Patients with cerebrovascular disease\n* Contraindications to neuraxial anesthesia",{"count":521,"type":23},"1 Day","60 patients aged 65 and older with ASA I-III physical status undergoing elective surgery under spinal anesthesia will be included in the study.\n\nPatients with cardiac arrhythmia, severe heart failure, cerebrovascular disease, or contraindications to neuraxial anesthesia will be excluded. Frailty assessments will be performed using the Clinical Frailty Scale (CFS) version 2.0 by anesthesiologists in preoperative clinics or wards. Participants will be categorized into frail (CFS Level ≥4, Group I) and non-frail (CFS Level ≤3, Group II) groups.\n\nPrior to spinal anesthesia, 8 mL\u002Fkg of crystalloids will be administered. Baseline preoperative mean arterial blood pressure (MABP) and heart rate (HR) will be recorded as the average of three measurements in the supine position.\n\nDuring the study, MABP and HR will be monitored every 2 minutes for the first 20 minutes post-spinal anesthesia, then every 5 minutes until surgery ends. Hypotension (MABP \\\u003C80% of baseline) will be treated with 5 mg intravenous ephedrine, while bradycardia (HR \\\u003C50 beats\u002Fmin) will be treated with 0.5 mg intravenous atropine.",[618,28],"Frailty","2025-01-02",{"date":621,"type":39},"2025-01-03",{"date":623,"type":23},"2025-01-20",{"date":625,"type":23},"2025-03-20",{"name":627,"class":46},"Selcuk University",{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":54,"minAge":86,"maxAge":4,"enrollmentInfo":635,"targetDuration":4,"studyType":59,"phases":636,"briefSummary":637,"conditions":638,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":105},"100573032","ultrasound-guided-midline-vs-landmark-paramedian-continous-spinal-anesthesia-in-the-elderly-100573032","NCT06740994","Ultrasound Guided Midline vs Landmark Paramedian Continous Spinal Anesthesia in the Elderly","Ultrasound Guided Midline Continuous Spinal Anesthesia in the Elderly : is There an Advantage Over Conventional Landmark Paramedian Technique: a Randomized Controlled Trial","Inclusion Criteria:\n\n* all consented patients aged over 65 years old scheduled to undergo surgery for hip fracture under continuous spinal anesthesia with American Society of Anesthesiologists ASA physical status classification from I to III\n\nExclusion Criteria:\n\n* contraindications to spinal anesthesia ( allergy to local anesthetic, coagulopathy, infection at the site of injection)\n* previous history of lumbar spine surgery\n* per operative severe complication with conversion to general anesthesia",{"count":474,"type":23},[61],"Former clinical studies have reported the superiority of the landmark guided paramedian approach above the classical landmark guided midline approach for the continuous spinal anesthesia especially in the elderly. On the other hand, more recent clinical trials have suggested that the use of ultrasound to guide spinal anesthesia will be safer and more effective than the conventional palpation-guided technique.\n\nThe aim of this study will be to compare the conventional \"blind\" landmark paramedian approach to the ultrasound \"modern\" guided midline approach for the continuous spinal anesthesia in the elderly with hip fractures.\n\nPatients will randomly divided into two groups:\n\nGroup(PML): will undergo conventional landmark guided paramedian continuous spinal anesthesia Group (MUS): will undergo ultrasound guided midline continuous spinal anesthesia",[28],"2024-12-17",{"date":641,"type":39},"2024-12-18",{"date":643,"type":39},"2024-04-29",{"date":645,"type":23},"2025-08-31",{"name":647,"class":46},"University Tunis El Manar"]