[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,76,104,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100626074","empowerment-program-to-reduce-treatment-of-asymptomatic-bacteriuria-in-veterans-with-spinal-cord-injury-100626074",false,"NCT07430904","Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury","Direct to Consumer Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury and Neurogenic Bladder","Inclusion Criteria:\n\n* Veterans with SCI\u002FD and neurogenic bladders who have been treated for at least one UTI in the past year\n* Have access to a telephone\n* Have not been involved in the development phase of the program\n\nExclusion Criteria:\n\n* Non-Veterans\n* Veterans without SCI\u002FD or neurogenic bladder\n* Patients with dementia who would not be able to provide consent or respond to interview prompts\n* Patients who do not receive primary care at the MEDVAMC\n* Veterans who participated in the development of the empowerment program","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Antimicrobial resistance is a major public health concern that worsens healthcare outcomes. Antibiotic resistant organisms occur more often in Veterans with spinal cord injury or disease (SCI\u002FD) given their frequent exposure to antibiotics, recurrent hospitalizations, and common use of urinary catheter devices. Veterans with SCI\u002FD are also at risk for overtreatment with antibiotics when they do not need them, particularly for over-diagnosed urinary tract infections. The investigators plan to create a patient empowerment program with input of Veterans with SCI\u002FD \\[and their providers\\] to help guide their decisions and next steps when they have a change in bladder symptoms. The program will give Veterans with SCI\u002FD the tools to speak up to their provider and advocate for themselves to avoid receiving unnecessary antibiotics. This program is highly innovative, as it puts Veterans with SCI\u002FD in charge of thoughtful antibiotic use, or antibiotic stewardship.",[26,27],"Spinal Cord Injury","Spinal Cord Disease",[29,30,31,26,27,32],"Asymptomatic Bacteriuria","Antimicrobial Stewardship","Veteran Healthcare","Neurogenic Bladder","NOT_YET_RECRUITING","2026-04-01",{"date":36,"type":37},"2026-04-02","ACTUAL",{"date":39,"type":20},"2026-07-01",{"date":41,"type":20},"2032-06-30",{"name":43,"class":44},"VA Office of Research and Development","FED",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100624682","spinal-cord-stimulation-combined-with-motor-training-in-non-traumatic-sci-a-prospective-interventional-study-100624682","NCT07412808","Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study","Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function in Non-traumatic Spinal Cord Injury: an Interventional, Prospective, Monocentric Study","Neuro-scs-002","Inclusion Criteria:\n\n1. Diagnosis of NTSCI at least one year before presentation;\n2. Complete or incomplete spinal cord damage (ASIA grade A, B or C) conditioning chronic neuropathic pain and motor impairment;\n3. Age ≥ 18 years;\n4. Indication to spinal cord stimulation surgery for chronic pain;\n5. Being unable to stand or step independently;\n6. No current anti-spasticity medication regimen;\n7. No botox injections in the prior 3 months;\n8. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study;\n9. Willingness and ability to comply with scheduled visits and other trial procedures.\n\nExclusion Criteria:\n\n1. Any person unable to lie still within the environment of the MRI scanner for the required period to perform the study and those where MRI scanning is contraindicated;\n2. Pregnancy or breastfeeding;\n3. Any significant psychiatric disease;\n4. Use of illicit drugs;\n5. Unstable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate standing or stepping;\n6. Painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training;\n7. Spinal cord involvement above the D1 segment;\n8. Severe peripheral neuropathies or damage to the cauda equine.",{"count":55,"type":20},10,[23],"Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI). The investigators will enroll ten research participants with clinically incomplete\u002Fcomplete SCI (patients with paraplegia or severe paraparesis) who will undergo SCS subsequently assisted by motor rehabilitation training for restoring motor function at IRCCS Ospedale San Raffaele, Milan, Italy. The main goal of the project is to evaluate the improvement in motor function generated by the combination of SCS and locomotor training. In line with recently published studies, the investigators propose that daily locomotor training in the presence of SCS with continuous stimulation parameters setting will enable the SCI individuals to stand and step independently while bearing full weight.",[27,59],"Spinal Cord Injuries (Complete and Incomplete)",[61,62,63,64,65],"motor restoration","rehabilitation","chronic pain","neuromodulation","spasticity","2026-02-09",{"date":68,"type":37},"2026-02-17",{"date":70,"type":20},"2026-03",{"date":72,"type":20},"2029-04",{"name":74,"class":75},"Albano Luigi","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100620988","enhancing-rehabilitation-participation-in-patients-with-scid-using-motivational-interviewing-100620988","NCT07364773","Enhancing Rehabilitation Participation in Patients With SCI\u002FD Using Motivational Interviewing","Enhancing Rehabilitation Participation in Patients With Spinal Cord Injury or Disorder Using Motivational Interviewing","Therapist Inclusion Criteria:\n\n* Inpatient therapist specializing in spinal cord injury patients for at least 3 months;\n* Practicing at the designated SCI inpatient units at Shirley Ryan AbilityLab, Baylor Scott \\& White Institute for Rehabilitation and University of Washington-Harborview Medical Center;\n* Willing to audio record conversations during regularly-scheduled rehabilitation therapy sessions with patients;\n* Willing and able to participate in 16 hours of MI training; and\n* Willing to receive feedback on MI skills.\n\nTherapist Exclusion Criteria:\n\n* Inability to speak and understand English\n* Inpatient therapist specializing in spinal cord injury patients for less than 3 months; and\n* Unwilling or unable to follow the study protocol\n\nPatient Inclusion Criteria:\n\n* Adults (18+)\n* Presence of a traumatic or non-traumatic spinal cord injury\n* Inpatient in the spinal cord injury unit of the three study sites\n* Has a physical or occupational therapist who is a participant in the study\n\nPatient Exclusion Criteria:\n\n* Inability to speak and understand English\n* Cognitive deficits\n* Unwilling to allow for therapy sessions to be recorded",{"count":84,"type":20},180,[23],"The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI\u002FD) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are trained in a counseling style called motivational interviewing. We want to answer the following questions:\n\n1. Do inpatients with SCI\u002FD treated by physical therapists (PTs) and occupational therapists (OTs) who receive MI training and coaching demonstrate greater therapy participation compared to those treated by therapists who do not receive MI training and coaching?\n2. Do inpatients with SCI\u002FD treated by PTs and OTs who receive MI training and coaching demonstrate greater functional improvement at discharge from inpatient rehabilitation and greater community integration at 6 months after discharge compared to those treated by therapists who do not receive MI training and coaching?\n3. What are the potential moderators and mediators of the effect of training and coaching on MI skills on therapy participation?\n\nResearchers will compare patient participation level and other outcomes of inpatients with SCI\u002FD treated by PTs and OTs who receive MI training and coaching with those treated by therapists who do not receive MI training and coaching.\n\nTherapist participants will:\n\n1. Audio record 2 therapy sessions per week with each enrolled SCI patient participant\n2. Half of the therapists will attend a 16-hour training on MI skills and 2 practice therapy session\n\nPatient participants will:\n\n1. Consent to audio recording of their therapy sessions\n2. Complete one brief survey near the time of their discharge and another survey 6 months later",[88,27],"Spinal Cord Injuries (SCI)",[26,90,91,92],"Spinal Cord Disorder","Motivational Interviewing","Rehabilitation","RECRUITING","2026-01-16",{"date":96,"type":37},"2026-01-23",{"date":98,"type":37},"2025-11-01",{"date":100,"type":20},"2027-04-20",{"name":102,"class":75},"Shirley Ryan AbilityLab",3,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100591508","phase-1-guttmann-neurorecovery---viability-safety-and-efficacy-of-intrathecal-whartons-jelly-mesenchymal-stem-cells-and-transcutaneous-spinal-cord-stimulation-in-chronic-spinal-cord-injury-rehabilitation-100591508","NCT06981338","Guttmann NeuroRecovery - Viability, Safety, and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation","Guttmann NeuroRecovery - Viability, Safety, and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation: A Pilot Study","GNR-SCI-01","Inclusion Criteria:\n\n* Individuals aged 16-70 years (parental consent required for 16-18-year-olds)\n* Single traumatic spinal cord injury (AIS A-C) at C1-T12 levels\n* Chronic injury (1-5 years post-injury)\n* Stable medical condition with life expectancy \\>2 years\n* Ability to attend follow-up visits and comply with all study procedures\n* Written informed consent (and parental consent for minors)\n* Sufficient cognitive capacity to understand the study\n* For women of childbearing potential: use of effective contraception (hormonal, intrauterine device, barrier methods, sterilization, or post-menopausal status \\>1 year)\n\nExclusion Criteria:\n\n* Severe comorbidities (e.g., cardiovascular instability, active infections)\n* Individuals requiring mechanical ventilation\n* Contraindications for tSCS (e.g., implanted devices)\n* Pregnancy or breastfeeding\n* Neurodegenerative diseases\n* Significant haematological\u002Fbiochemical abnormalities\n* Active or recent (≤5 years) malignancy without complete remission\n* Positive serology for HIV, hepatitis B virus, hepatitis C virus, or syphilis\n* Communication barriers (language, aphasia)\n* Concurrent participation in another clinical trial (within 30 days)\n* Recent intrathecal medication or immunosuppressants (within 60 days)\n* Multi-level spinal lesions or lesions \\>3 spinal segments on MRI\n* Contraindications for lumbar puncture\n* Planned spinal surgery within 24 months\n* Inability to participate in rehabilitation\n* Known allergies to stem cell preparation components","16 Years","70 Years",{"count":55,"type":20},[116,117],"PHASE1","PHASE2","This clinical trial primarily aims to evaluate the safety and feasibility of a combined therapeutic approach for chronic spinal cord injury (SCI). The study will investigate whether the combination of intrathecal Wharton's jelly mesenchymal stem cells and transcutaneous spinal cord stimulation (tSCS) is safe and viable in individuals with chronic traumatic SCI.\n\nThe trial will enrol 10 participants aged 16-70 with traumatic SCI (cervical or thoracic levels C1-T12) classified as ASIA Impairment Scale A-C, who are 1-5 years post-injury. Participants will receive three intrathecal injections of Wharton's jelly mesenchymal stem cells, each containing 30 million viable cells (±30%), administered intrathecally at the L3-L4 level. This cellular therapy will be combined with transcutaneous spinal cord stimulation and intensive neurorehabilitation.\n\nParticipants will undergo comprehensive assessments over a 12-month follow-up period to monitor safety, feasibility, and secondarily to evaluate potential improvements in motor, sensory, and autonomic functions. Additional annual follow-up will continue for 2 years after study completion to evaluate long-term safety.",[88,26,120,27],"Traumatic Spinal Cord Injuries",[122,123,124,125,126,127,128,129,130,131],"Mesenchymal Stem Cells","Spinal Cord Injuries","Cell- and Tissue-Based Therapy","Intrathecal Administration","Neuroplasticity","Spinal Cord Stimulation","Safety","Clinical Trials, Phase I","Electric Stimulation Therapy","Feasibility Study","2025-05-21",{"date":134,"type":37},"2025-05-25",{"date":136,"type":20},"2025-09-01",{"date":138,"type":20},"2028-12-31",{"name":140,"class":75},"Institut Guttmann",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":148,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":151,"briefSummary":152,"conditions":153,"keywords":154,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":45},"100569744","paired-spinal-cord-and-peripheral-nerve-stimulation-to-recover-hand-function-in-sci-100569744","NCT06698224","Paired Spinal Cord and Peripheral Nerve Stimulation to Recover Hand Function in SCI","Paired Spinal Cord and Peripheral Nerve Stimulation for Hand Function Recovery in Humans Post Cervical SCI","For SCI participants:\n\nInclusion Criteria:\n\n* At least 18 years of age\n* Non-progressive cervical SCI\n* Greater than or equal to 6-months post spinal cord injury\n* Stable medical condition\n* Viable median and ulnar nerve as evident from MMR and M-Wave recordings\n* Wrist extensor and finger flexors score between 1-3 for both upper extremity for ISNCSCI motor assessment.\n\nExclusion Criteria:\n\n* Ventilator Dependent\n* Untreated fracture or pressure ulcer\n* Untreated psychiatric disorder or ongoing drug abuse\n* Cardiac, respiratory, bladder, renal, or other untreated medical disorder unrelated to SCI\n* Skeletal muscle Botox injections less than 6 months prior\n* Previous tendon transfer of the arm or arms\n* Any implanted pump (i.e., baclofen pump, pain pump, etc.) prior to randomization\n* Pregnant at the time of enrollment or planning to become pregnant during the course of the study\n* Unable or unwilling to wean from anti-spasticity medications\n* History of seizure or epilepsy\n* Metal in Head\n* Cochlear implant\n* Implanted brain stimulators\n* Aneurysm clips\n* Increased intracranial pressure (which lowers seizure threshold)\n* Cardiac pacemaker\n* Personal or family history of epilepsy\n* Tricyclic antidepressants or neuroleptics (which lower seizure threshold)\n\nFor healthy volunteer\u002Fparticipants:\n\nInclusion Criteria:\n\n* At least 18 years of age\n\nExclusion Criteria:\n\n* Neurological injury or disease\n* Pregnant at the time of enrollment or planning to become pregnant during the course of the study\n* Personal or family history of seizure or epilepsy\n* Tricyclic antidepressants or neuroleptics (which lower seizure threshold)",true,{"count":150,"type":20},14,[23],"Individuals who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and\u002For weakness of their arms and hand muscles. This project aims to test the effects of pairing spinal cord and nerve stimulation combined with physical therapy training in recovering arms and hand function. The long-term goal is to provide better therapies that will improve the ability of individuals with spinal cord injuries to use their arms and hands to perform everyday tasks, similar to injury before.",[26,27,88],[155,156,157,158,159],"Spinal cord injury","Hand function","Spinal cord stimulation","Paired stimulation","Physical therapy","2024-11-18",{"date":162,"type":37},"2024-11-20",{"date":164,"type":20},"2025-01-02",{"date":166,"type":20},"2026-11-01",{"name":168,"class":75},"Kessler Foundation"]