[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injuries-and-disorders-scid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injuries-and-disorders-scid":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100628060","cardiac-morphology-and-function-in-individuals-with-autonomic-dysreflexia-100628060",false,"NCT07456722","Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia","Assessment of Cardiac Morphology and Function in Individuals With and Without Autonomic Dysreflexia Due to Spinal Cord Injury or Disease","HEART_REMOD_AD","Inclusion Criteria:\n\n* adults aged 18 years or older\n* long-term (\\>10 years), motor-complete SCI\u002FD (AIS A and B)\n* Group A (24 individuals): high-level (\\>Th6) SCI\u002FD and autonomic dysreflexia\n* Group B (24 individuals): low-level (\\\u003CTh10) SCI\u002FD without autonomic dysreflexia\n* signed informed consent\n\nExclusion Criteria:\n\n* congenital heart defects\n* valvular disease(s)\n* cardiomyopathy\n* medium to severe arrhythmia\n* myocardial infarction\n* comorbidities causing morphologic heart changes including primary hypertension, aortic stenosis\n* comorbidities causing arterial hypertension\n* use of anti-hypertensive treatment\n* smokers\n* individuals after sacral deafferentation surgery\n* pregnancy\n* active implanted medical devices\n* claustrophobia\n* inability to comply with the measurement procedures","ALL","18 Years",{"count":20,"type":21},48,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI\u002FD) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI\u002FD (above Th6) who have AD and 24 individuals with low-level SCI\u002FD (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling.\n\nAll 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI\u002FD population.",[25,26,27],"Autonomic Dysreflexia","Spinal Cord Injuries and Disorders (SCI\u002FD)","Cardiac Remodeling","NOT_YET_RECRUITING","2026-03-09",{"date":31,"type":32},"2026-03-11","ACTUAL",{"date":34,"type":21},"2026-05-01",{"date":36,"type":21},"2028-10-31",{"name":38,"class":39},"Swiss Paraplegic Research, Nottwil","NETWORK",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":40},"100625539","using-non-invasive-brain-and-spinal-cord-stimulation-to-improve-arm-and-hand-function-after-spinal-cord-injury-100625539","NCT07423949","Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury","Combining Non-invasive Brain and Spinal Cord Stimulation for Improving Arm and Hand Function Following Spinal Cord Injury.","Inclusion Criteria:\n\n1. At least 19 years of age and no older than 75 years at the time of enrollment. Previous research has demonstrated the safety and efficacy of stimulation-based interventions in adults up to 75 years of age. The lower age limit reflects the legal age for independent informed consent in British Columbia.7,8\n2. Non-progressive cervical SCI from C2-C8 inclusive\n3. AIS classification B, C or D\n4. Indicated for upper extremity training procedures by the participant's treating physician, occupational therapist, or physical therapist\n5. GRASSP-Prehension score ≥10 or GRASSP-Strength score ≥30\n6. Minimum 12 months after injury (i.e., chronic SCI)\n7. If prescribed anti-spasticity or pain medications, must be at a stable dose for at least 4 weeks before commencing study procedures\n8. Stable management of spinal cord related clinical issues (e.g., spasticity management, autonomic dysreflexia)\n9. Capable of providing informed consent\n\nExclusion Criteria:\n\n1. Has any unstable or significant medical condition that is likely to interfere with study procedures or likely to confound study endpoint evaluations, such as severe neuropathic pain, depression, mood disorders or other cognitive disorders\n2. Has been diagnosed with autonomic dysreflexia that is severe, unstable and uncontrolled\n3. History of additional neurologic disease, such as stroke, multiple sclerosis and traumatic brain injury\n4. History of seizures (e.g. epilepsy).\n5. Any implanted metal (other than dental implants) in the skull or presence of pacemakers, stimulators, or medication pumps in the trunk.\n6. Participant has undergone electrode implantation surgery.","19 Years","75 Years",{"count":51,"type":21},24,"INTERVENTIONAL",[54],"NA","Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with tetraplegia. Although rehabilitation and emerging neuromodulation approaches can support meaningful gains, many individuals experience persistent limitations in reaching and grasping. Current noninvasive stimulation strategies typically target the brain OR the spinal cord alone, despite strong reciprocal interactions between these structures. Cervical transcutaneous spinal cord stimulation (tSCS) can enhance upper limb function. Cerebellar stimulation, given its key role in sensorimotor integration and modulation of corticospinal excitability, represents a promising but underexplored therapeutic target. Theta burst stimulation (TBS), a rapid form of repetitive transcranial magnetic stimulation (TMS), induces lasting changes in cortical excitability and may promote associative plasticity when paired with spinal cord stimulation. This double-blind, randomized, sham-controlled pilot trial (n=24) will evaluate the feasibility, preliminary efficacy, and mechanisms of combined cerebellar TBS + cervical tSCS in people with chronic cervical SCI (AIS B, C or D). Participants will either receive cerebellar TBS + cervical tSCS, tSCS only, or sham stimulation while engaging in functional task practice such as pinching and grasping 3x\u002Fweek for 8 weeks. Feasibility outcomes include adherence, retention, and safety. Efficacy will be assessed using the GRASSP strength sub-score and KINARM-based measures of sensorimotor control. Mechanistic outcomes will assess changes in cortical and spinal cord functional connectivity using resting state fMRI, corticospinal excitability using motor evoked potentials, and spinal excitability using the H reflex. Findings will establish whether combined cerebellar TBS and cervical tSCS is feasible, safe, and capable of enhancing upper limb recovery.",[26],[58,59,60,61,62,63,64,65],"Spinal cord injury","Transcutaneous Spinal Cord Stimulation","Cerebellar Theta Burst Stimulation","Arm and Hand Function","Upper Limb Motor Control","Transcranial Magnetic Stimulation","Neuroimaging","Neurophysiology","2026-02-13",{"date":68,"type":32},"2026-02-20",{"date":70,"type":21},"2026-03-01",{"date":72,"type":21},"2031-02-28",{"name":74,"class":75},"University of British Columbia","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":52,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":40},"100606766","motoneuron-recruitment-and-motor-evoked-potential-up-conditioning-mep-in-spinal-cord-injury-sci-100606766","NCT07179822","Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)","Can MEP Conditioning Improve Corticospinal Recruitment of Motoneurons in Chronic Cervical SCI?","Inclusion Criteria:\n\n* Adult (≥18 yrs old)\n* a history of injury to spinal cord at or above C6\n* neurologically stable (\\>1 year post SCI)\n* medical clearance to participate\n* weak wrist extension at least unilaterally\n* expectation that current medication will be maintained without change for at least 3 months.\n\n  * Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted. (Because only neurologically stable subjects will enter this study, medication changes will be unlikely.)\n  * In participants with bilateral wrist extension weakness in whom Extensor Carpi Radialis (ECR) MEP can be elicited in both arms, the more severely impaired arm is studied. In participants with unilateral wrist weakness or in participants with bilateral wrist weakness in whom an ECR MEP can be elicited in only one arm, that arm is studied.\n\nExclusion Criteria:\n\n* motoneuron injury\n* unstable medical condition\n* cognitive impairment (because the studied intervention is a learning-based intervention)\n* a history of epileptic seizures\n* a pre-existing or confounding neurological condition (e.g., history of MS, Stroke, Parkinson's disease)\n* metal implants in the cranium\n* implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)\n* no measurable MEP elicited in the ECR\n* inability to produce any voluntary ECR EMG activity\n* extensive use of functional electrical stimulation to the arm on a daily basis (as it may interfere with or augment the effects of MEP conditioning itself)\n* pregnancy (due to changes in posture and potential medical instability)\n* inability or unwillingness of subject or legal guardian\u002Frepresentative to give informed consent",{"count":84,"type":21},15,[54],"The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement problems after injuries. Spinal cord injury causes damage to the brain-to-muscle connection. However, when the injury is \"incomplete\", there is a possibility that some of the brain-to-muscle pathways are still connected and may be trained to improve movement function. For examining brain-to-muscle pathways, investigators use a transcranial magnetic stimulator. Investigators hope that the results of this research study will help us develop new treatments for people who have movement disabilities. This study will require about 42 visits over the first 14 weeks, and another 6 visits over an additional 3 months. Each visit will take about 1 ½ hours.",[26,88],"Spinal Cord Injury",[90,91],"Movement Disorders","Rehabilitation Studies","RECRUITING","2025-11-20",{"date":95,"type":32},"2025-11-26",{"date":97,"type":32},"2025-11-03",{"date":99,"type":21},"2027-09-30",{"name":101,"class":75},"Medical University of South Carolina"]