[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injuries-complete-and-incomplete\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injuries-complete-and-incomplete":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,81,109,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100636163","phase-1-pilot-testing-of-vagus-nerve-stimulation-for-early-spinal-cord-injury-recovery-100636163",false,"NCT07562113","Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery","Pilot Investigation of Transauricular Vagal Nerve Stimulation Safety and Feasibility in Acute Incomplete Spinal Cord Injury Rehabilitation","PIVOTS-Rehab","Inclusion Criteria:\n\n* Phase 1 Age 18 years older SCI (traumatic or non traumatic) undergoing initial inpatient rehabilitation for the SCI Any AIS severity level (A, B, C, D)\n* Phase 2 Completed phase I Participant willing to complete phase II Study physician approves participation in phase II Receives intensive gait training as a part of the care plan\n\nExclusion Criteria:\n\n* Phase 1 Age \\>89 years Pregnant Implanted medical device (e.g. pacemaker, cochlear implant) epilepsy Parkinson's Disease Multiple Sclerosis cerebral shunts documented arrhythmia Ear skin irritation or damage at the electrode contact location intracranial metal implants\n* Phase 2 no exclusion criteria for those who meet inclusion criteria","ALL","18 Years","89 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This study looks at a treatment called transcutaneous auricular vagus nerve stimulation, or taVNS. taVNS uses a small device worn on the ear to gently stimulate a nerve. Researchers want to find out if this treatment is safe and well-tolerated for people who recently had a spinal cord injury (SCI).\n\nThis study will also help researchers learn whether taVNS can be safely added to standard mobility therapy, and whether it might help improve mobility.\n\nThis study has two main goals:\n\n1. To find out whether taVNS is safe and comfortable for people with a recent spinal cord injury.\n2. To get information on whether taVNS may help improve mobility when compared to people who completed rehabilitation before this study started.\n\nThis study has two parts.\n\nIn the first part, participants will wear the taVNS device once for a short period of time. During this part investigators will measure how participant's heart rate and blood pressure may change before, during, and after the stimulation. Investigators will also ask about how the stimulation made participants feel.\n\nIn the second part, participants will wear the taVNS device for a short time right before a mobility therapy session. During this part investigators will measure how participants heart rate and blood pressure may change before, during, and after the stimulation and during and after the walking therapy. Investigators will also ask about how the stimulation made participants feel.",[29],"Spinal Cord Injuries (Complete and Incomplete)",[31,32,33,34],"vagus nerve stimulation","spinal cord injuries","Rehabilitation","walking","NOT_YET_RECRUITING","2026-05-20",{"date":38,"type":39},"2026-05-22","ACTUAL",{"date":41,"type":22},"2026-06-01",{"date":43,"type":22},"2027-12-15",{"name":45,"class":46},"University of Alabama at Birmingham","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":47},"100608640","multisite-transspinal-stimulation-for-augmenting-recovery-in-spinal-cord-injury-100608640","NCT07204184","Multisite Transspinal Stimulation for Augmenting Recovery in Spinal Cord Injury","Cervical and Lumbosacral Transspinal Stimulation to Reconnect the Injured Human Spinal Cord","Inclusion Criteria:\n\n* Willingness to comply with all study procedures and availability for the duration of the study.\n* Ability to understand the consent form and sign the consent form.\n* In good general health as evidenced by medical history.\n* Diagnosed with incomplete SCI (AIS B, C, D).\n* Bone mineral density of the hip (proximal femur) T-score \\\u003C3.5 SD from age- and gender-matched normative data.\n* Lesion above thoracic (T) 10 to ensure absent lower motoneuron lesion.\n* The presence of soleus and FCR H-reflexes.\n* Absent permanent ankle joint contractures prevent passive or active ankle movement because corticospinal and spinal excitability is based on the ankle angle. The ankle straps of the Lokomat also require flexible ankle joints.\n* A diagnosis of first time SCI due to trauma, vascular, or orthopedic pathology.\n* Time after SCI of more than 6 months.\n* Stable medical condition without cardiopulmonary disease or cognitive impairment.\n\nExclusion Criteria:\n\n* Supraspinal lesions.\n* Neuropathies of the peripheral nervous system.\n* Significant degenerative neurological disorders of the spine or spinal cord.\n* Diagnosed with AIS A.\n* Presence of pressure sores.\n* Advanced urinary tract infection.\n* Neoplastic or vascular disorders of the spine or spinal cord.\n* Participation in an ongoing research study or new rehabilitation program.\n* Pregnant women or women who suspect they may be or may become pregnant will be excluded from participation because the risks of thoracolumbar stimulation to the fetus are unknown.\n* People with cochlear implants, pacemakers, implanted infusion device, and\u002For implanted stimulators of any type and purpose will be excluded to avoid their malfunction due to stimulation.","70 Years",{"count":57,"type":22},36,[59],"NA","A well-established rehabilitation strategy for improvements of standing and walking ability in persons with spinal cord injury (SCI) is step training on a motorized treadmill with body weight support. A promising intervention is stimulation of the spinal cord through the skin (transspinal). No single intervention is likely to significantly improve long-term function after SCI on its own. Rather, combinatorial treatments that work synergistically and can be used at different clinical settings is the answer to target recovery in people with SCI. The objective of this clinical trial is to develop a non-invasive combinatorial intervention that can be used worldwide in different clinical settings. The investigators will use cervical and lumbosacral transspinal stimulation to augment the benefits of locomotor training and affect vital body functions after SCI. The investigators will deliver non-invasive cervical and lumbosacral transspinal stimulation alone or with step training to improve upright posture, walking, bladder, sex, and bowel function in persons with incomplete SCI. The noninvasive nature of the intervention holds minimal risk that outweighs the benefits.",[29],[63,64,65,66,67,68,69,70],"transspinal stimulation","robotic gait training","locomotor training","non-invasive","multi-modal rehabilitation","clinical biomarkers","neurophysiological biomarkers","sensorimotor recovery","RECRUITING","2026-03-16",{"date":74,"type":39},"2026-03-18",{"date":76,"type":39},"2026-02-19",{"date":78,"type":22},"2028-06-30",{"name":80,"class":46},"Maria Knikou, PT, MBA, PhD",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":47},"100610284","development-of-optimal-sensory-feedback-strategies-to-maximize-function-after-tetraplegia-100610284","NCT07225582","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia: A Sub-study of the Reconnecting the Hand and Arm to the Brain (ReHAB) Clinical Trial","Inclusion Criteria:\n\n1. Enrolled in the ReHAB clinical trial and received ReHAB system components via implantation surgery.\n2. Willingness and availability to follow the study protocol.\n\nExclusion Criteria:\n\n1. Lack of function or operability of all implanted ReHAB system components\n2. Severe pain or other chronic medical condition that would prevent the participant from completing study-related activities","22 Years","65 Years",{"count":91,"type":22},3,[59],"The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the \"Reconnecting the Hand and Arm to the Brain (ReHAB)\" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also have received electrodes around the nerves in their arm. In this clinical trial, participants will receive two types of electrical stimulation:\n\n* Intracortical microstimulation (ICMS) which involves sending small electrical pulses to the part of the brain that processes sensation.\n* Peripheral nerve stimulation (PNS) which involves sending small electrical pulses to the nerves in the arm that transmit sensations from the hand.\n\nResearchers will try different patterns of stimulation for both ICMS and PNS and study how the participants perceive the sensations from the different stimulation patterns. The researchers will also study how combining ICMS and PNS affects the perceived sensations.",[95,29],"Spinal Cord Injury Cervical",[97,98,99,100],"spinal cord injury","tetraplegia","intracortical microstimulation","peripheral nerve stimulation","2026-02-17",{"date":76,"type":39},{"date":104,"type":39},"2026-01-13",{"date":106,"type":22},"2030-09-01",{"name":108,"class":46},"Case Western Reserve University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":47},"100624682","spinal-cord-stimulation-combined-with-motor-training-in-non-traumatic-sci-a-prospective-interventional-study-100624682","NCT07412808","Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study","Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function in Non-traumatic Spinal Cord Injury: an Interventional, Prospective, Monocentric Study","Neuro-scs-002","Inclusion Criteria:\n\n1. Diagnosis of NTSCI at least one year before presentation;\n2. Complete or incomplete spinal cord damage (ASIA grade A, B or C) conditioning chronic neuropathic pain and motor impairment;\n3. Age ≥ 18 years;\n4. Indication to spinal cord stimulation surgery for chronic pain;\n5. Being unable to stand or step independently;\n6. No current anti-spasticity medication regimen;\n7. No botox injections in the prior 3 months;\n8. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study;\n9. Willingness and ability to comply with scheduled visits and other trial procedures.\n\nExclusion Criteria:\n\n1. Any person unable to lie still within the environment of the MRI scanner for the required period to perform the study and those where MRI scanning is contraindicated;\n2. Pregnancy or breastfeeding;\n3. Any significant psychiatric disease;\n4. Use of illicit drugs;\n5. Unstable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate standing or stepping;\n6. Painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training;\n7. Spinal cord involvement above the D1 segment;\n8. Severe peripheral neuropathies or damage to the cauda equine.",{"count":118,"type":22},10,[59],"Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI). The investigators will enroll ten research participants with clinically incomplete\u002Fcomplete SCI (patients with paraplegia or severe paraparesis) who will undergo SCS subsequently assisted by motor rehabilitation training for restoring motor function at IRCCS Ospedale San Raffaele, Milan, Italy. The main goal of the project is to evaluate the improvement in motor function generated by the combination of SCS and locomotor training. In line with recently published studies, the investigators propose that daily locomotor training in the presence of SCS with continuous stimulation parameters setting will enable the SCI individuals to stand and step independently while bearing full weight.",[122,29],"Spinal Cord Disease",[124,125,126,127,128],"motor restoration","rehabilitation","chronic pain","neuromodulation","spasticity","2026-02-09",{"date":101,"type":39},{"date":132,"type":22},"2026-03",{"date":134,"type":22},"2029-04",{"name":136,"class":46},"Albano Luigi",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":148,"conditions":149,"keywords":155,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":47},"100613698","msci-mobile-health-app-for-veterans-with-sci-and-caregivers-100613698","NCT07269977","mSCI: Mobile Health App for Veterans With SCI and Caregivers","mSCI: mHealth for Supporting Psychosocial Health of Military Service Members With SCI and Their Family Caregivers","Inclusion Criteria:\n\n* Veterans with SCI or Family caregivers of Veterans with SCI\n* Have access to the Internet and a computer to participate in a Zoom call\n* Able to speak and understand English to provide informed consent.\n\nExclusion Criteria:\n\n* Serious mental illness requiring psychiatric hospitalization",true,{"count":146,"type":22},100,"OBSERVATIONAL","Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation. Military caregivers (Family Caregivers of wounded or disabled Veterans) reported similar negative effects of becoming a caregiver on their physical and mental health.\n\nUsing results from our previous work in mHealth interventions for individuals with SCI, we developed a dual-target intervention for both individuals with SCI and their caregivers.\n\nThe overall objective of this research study is to conduct translational research focused on adapting and tailoring the interactive Mobile Health and Rehabilitation (iMHere) 2.0 system to meet the needs of Veterans with SCI and their family caregivers, expanding the psychosocial intervention, and evaluating the feasibility of implementing the iMHere system among Veterans with SCI and their family caregivers.",[150,151,29,152,153,154],"Spinal Cord Injuries (SCI)","Spinal Cord Injury","Family Caregivers","Families of Veterans","Disabled Veterans",[151,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172],"Veterans","Veterans with SCI","SCI","SCI\u002FD","Spinal Cord Injuries","Spinal Cord Disorder","Family caregiver","Primary caregiver","mobile health app","smartphone app","Imhere","Veterans support","paralyzed veterans","disabled veterans","mobile health support","mobile health","telemedicine","2025-12-05",{"date":175,"type":39},"2025-12-12",{"date":177,"type":39},"2025-12-01",{"date":179,"type":22},"2029-11",{"name":181,"class":46},"University of Pittsburgh"]