[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injuries-sci\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injuries-sci":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,47,0,25,[9,45,83,108,144,169,203,228,255,282,307,331,357,380,409,433,457,488,508,530,556,583,598,624,650],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100054261","ai-guided-predictions-of-blood-pressure-dysregulation-using-perfusion-index-as-a-novel-biomarker-in-persons-with-spinal-cord-injury-100054261",false,"NCT07699094","AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury","Inclusion Criteria:\n\n* You have had a spinal cord injury (SCI: C4-T12) for more than one year and the SCI was graded as ASIA Impairment Scale (AIS) A or B (unable to voluntarily move your legs)\n* You can also be a gender and age-matched (±5 years) able-bodied (AB) control subject (similar gender and age to a subject with SCI).\n* Subjects with SCI and AB controls must be between 18 and 75 years of age.\n* If you are going to participate, you must avoid caffeine and alcohol, maintain normal salt and water intake, and avoid strenuous exercise for 24 hours prior to the study visit.\n\nExclusion Criteria:\n\n* You have cardiovascular, kidney, or untreated thyroid disease\n* You have a traumatic brain injury (TBI)\n* You have diabetes mellitus\n* You have an acute illness or infection\n* You are dehydrated\n* You smoke\n* You are pregnant\n* You have broken, inflamed, or otherwise fragile skin\n* Your Body Mass Index (BMI) is more than 30 kg\u002Fm2",true,"ALL","18 Years","75 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI can be 18-75 years of age, male or female, neurological level of injury C4-T12, ASIA Impairment Scale (AIS: A or B: motor complete) or gender and healthy age-matched able-bodied (AB) controls.\n\nThe main question this study aims to answer is: can PI reliably predict change in SBP during a cool temperature challenge? We hypothesize that PI can be used as a biomarker of SBP in persons with SCI.\n\nResearchers will compare the relationship of 1) changes in PI and SBP and 2) relationship of changes in other vital signs to SBP, during the cool temperature challenge. The researchers aim to determine if PI can be used as a biomarker of SBP in persons with SCI during a cool temperature challenge (experimental group\u002Farm). Able-bodied controls (control group\u002Farm) will receive the same intervention (cool challenge) as the experimental group.\n\nDuring the study, participants will be asked to wear only shorts and a T-shirt so that their skin can be exposed to the warm and cool temperatures of the 2 rooms.\n\nWe will put put on non-invasive sensors (taped or attached on the surface of your body) to measure PI, BP, and other vital signs. We will record these measurements while you are seated in a wheelchair for 10 minutes in a warm room and up to 90 minutes in a cool room.",[28,29,30,31],"Spinal Cord Injuries (SCI)","Blood Pressure","Thermoregulation","Perfusion Index","RECRUITING","2026-07-07",{"date":35,"type":36},"2026-07-13","ACTUAL",{"date":38,"type":22},"2026-07-01",{"date":40,"type":22},"2028-06-30",{"name":42,"class":43},"James J. Peters Veterans Affairs Medical Center","FED",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":44},"100580737","cardiovascular-function-and-response-to-stimulation-within-the-first-year-after-spinal-cord-injury-100580737","NCT06841198","Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury","Assessing Cardiovascular Effects: Is There a Time Too Early for Spinal Stimulation in Acute SCI? A Year-Long Evaluation of Autonomic Function Following Injury","For the main study:\n\nInclusion Criteria:\n\n* Individuals with a spinal cord injury undergoing inpatient rehabilitation at the Kessler Institute for Rehabilitation\n* Between 18-75 years old\n* 7-50 days after injury\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* Individuals experiencing low blood pressure after the injury\n* American Spinal Injury Association Impairment Scale (AIS) A or B\n\nExclusion Criteria:\n\n* A ventilator is needed for breathing.\n* Devices such as brain\u002Fspine\u002Fnerve stimulators, a cardiac pacemaker\u002Fdefibrillator, or intra-cardiac lines are present in the body.\n* There is a significant disease affecting the blood vessels or signals in the heart, or a recent heart attack (myocardial infarction) has occurred.\n* A new medication has been prescribed to treat blood pressure or a heart problem within the last five days (excluding midodrine).\n* There is a known infection in the body (e.g., urinary tract infection) or a current illness (e.g., recent diagnosis of deep vein thrombosis (DVT) or other blood clotting issues, and\u002For a pressure injury that might interfere with the study).\n* There is a history of seizures.\n* Pregnancy.\n\nFor the spin-off study ice-water vs ice-wrap test (see description in study arms):\n\n\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n\nInclusion:\n\nAge 18-75.\n\nInclusion for individuals with SCI:\n\n* Injury sustained more than 6 months ago\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* American spinal injury association impairment scale (AIS) A - D\n\nExclusion:\n\nFoot lesions, uses a ventilator, devices such as brain\u002Fspine\u002Fnerve stimulators, significant or recent cardiovascular disease, known infection in the body",{"count":53,"type":22},15,[25],"The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure.\n\nThe main questions are:\n\nHow does stimulation affect blood pressure over the year? What is the level of cardiovascular activation throughout the year?\n\nThe study will start during the inpatient stay at the Kessler Institute for Rehabilitation and continue after discharge as an outpatient, totaling about 20-29 sessions over the year.",[28,57,58,59],"Orthostatic Hypotension, Dysautonomic","Cardiovascular","Transcutaneous Spinal Stimulation",[61,62,63,64,65,66,67,68,69,70,71,72,73],"Transcutaneous Spinal Cord Stimulation","spinal cord stimulation","orthostatic hypotension","blood pressure","cardiovascular","neuromodulation","acute spinal cord injury","chronic spinal cord injury","inpatient rehabilitation","tilt testing","cold pressor test","ambulatory blood pressure monitoring","autonomic dysfunction following spinal cord injury","2026-06-26",{"date":38,"type":36},{"date":77,"type":36},"2025-04-01",{"date":79,"type":22},"2026-11",{"name":81,"class":82},"Kessler Foundation","OTHER",{"id":84,"slug":85,"hasResults":12,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":44},"100635533","high-intensity-walking-rehabilitation-in-outpatient-subacute-spinal-cord-injury-100635533","NCT07553923","High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury","High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury Rehabilitation: An Effectiveness-implementation Hybrid Study","Inclusion Criteria:\n\n* Adult (≥ 18 years of age)\n* Sustained a SCI within the past year\n* Motor incomplete SCI - classified as American Spinal Injury Association (ASIA) Impairment Scale levels C or D\n* Able to stand and initiate reciprocal steps through voluntary lower extremity movement but may require maximal physical assistance of at least one person and may include assistive devices (SWAT level 2A or above)\n* Indicate a walking-related goal on admission to outpatient physical therapy\n\nExclusion Criteria:\n\n* Medical or movement restriction(s) that limit high-intensity standing or walking rehabilitation (e.g., weight bearing restriction to lower extremities, cardiovascular constraints)\n* Inability to understand or communicate verbally in English",{"count":7,"type":22},[25],"People with incomplete spinal cord injury (SCI) often have some preserved movement and may regain walking ability, but recovery can be limited, and more effective rehabilitation approaches are needed.The goal of this clinical trial is to learn if high-intensity walking rehabilitation can improve walking recovery and overall neurological recovery in individuals with subacute SCI. The investigators are also exploring the process of incorporating this type of physical therapy approach in an outpatient rehabilitation setting.\n\nThe main questions it aims to answer are:\n\n* Does high-intensity walking rehabilitation improve walking ability, compared to usual care for individuals with subacute spinal cord injury?\n* What are some of the barriers and facilitators to delivering high-intensity walking rehabilitation in an outpatient setting?\n\nThe investigators will compare usual care rehabilitation to a high-intensity rehabilitation program to see if higher-intensity physical therapy leads to better walking outcomes and improved recovery. The study will also explore how feasible it is to deliver this type of program in a real-world outpatient rehabilitation setting and gather perspectives from both participants and clinicians.\n\nParticipants will:\n\n* Attend regular outpatient physical therapy sessions focused on walking rehabilitation\n* Receive either usual care or a higher-intensity walking program delivered by their physical therapist\n* Have their activities, heart rate, step counts, and self-reported effort during therapy sessions monitored\n* Complete walking, balance, and neurophysiological assessments at the start and end of rehabilitation\n* Wear an activity monitor for one week at the beginning and end of the study to measure daily activity outside of therapy\n* Participants who receive the higher-intensity intervention may participate in an interview to share their experiences with rehabilitation",[28],[95,96,97,98],"high-intensity","subacute","walking","physical therapy","2026-06-24",{"date":101,"type":36},"2026-06-29",{"date":103,"type":36},"2026-05-26",{"date":105,"type":22},"2027-10",{"name":107,"class":82},"University of Alberta",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":140,"leadSponsor":142,"locationsCount":44},"100642982","radio-frequency-rf-bladder-monitor-100642982","NCT07639541","Radio-frequency (RF) Bladder Monitor","Inclusion Criteria:\n\n* Age \\> 18\n* Able\u002Fwilling to sit (or stand) in place for the time it takes for bladder to fill once.\n* No implanted devices\n* Able to toilet\u002Fvoid independently\n* No pregnancy\n\nExclusion Criteria:\n\n* Age \\\u003C 18\n* Implanted devices (e.g., pacemakers)\n* Unable to toilet without assistance\n* Unable to stay relatively still for the time it takes bladder to fill once\n* Pregnancy",{"count":115,"type":22},40,[25],"The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management. The study aims to learn whether the device can monitor bladder filling and estimate bladder volume non-invasively.\n\nThe main questions the study aims to answer are:\n\n1. Can the MW-based monitoring system distinguish between non-full and full bladder states?\n2. How accurately do MW-based bladder volume estimates agree with ultrasound bladder scans and voided urine volumes?\n3. Is the wearable monitoring system feasible, comfortable, and usable for individuals with SCI?\n\nParticipants will:\n\n1. Complete questionnaires about bladder symptoms and quality of life\n2. Wear up to six non-invasive MW sensors on the lower pelvic region\n3. Undergo two bladder filling and voiding cycles during the study visit\n4. Have MW measurements collected approximately every five minutes during bladder filling\n5. Undergo ultrasound bladder scans and bladder volume measurements for comparison\n6. Complete a post-study usability and comfort survey",[28,119,120],"Neurogenic Lower Urinary Tract Dysfunction","Neurogenic Bladder (NB)",[122,123,119,124,125,126,127,128,129,130,131,132,133,134],"Spinal Cord Injury","Neurogenic Bladder","Bladder Monitoring","Bladder Management","Microwave Sensing","Radio-Frequency Sensing","Wearable Medical Device","Bladder Fullness Detection","Bladder Volume Estimation","Non-Invasive Monitoring","Assistive Technology","Pilot Feasibility Study","Urology","NOT_YET_RECRUITING","2026-06-05",{"date":138,"type":36},"2026-06-10",{"date":38,"type":22},{"date":141,"type":22},"2027-03-31",{"name":143,"class":82},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":145,"slug":146,"hasResults":12,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":165,"leadSponsor":167,"locationsCount":44},"100569140","improving-heart-health-in-individuals-with-sci-using-home-based-virtual-gaming-100569140","NCT06690372","Improving Heart Health in Individuals With SCI Using Home-Based Virtual Gaming","Improving Cardiometabolic Health in Individuals With SCI Using Home-Based Interactive Virtual Gaming","Inclusion Criteria:\n\n* be low risk for developing a cardiovascular event during vigorous exercise according to ACSM\n* be at least 18 years of age;•\n* ASIA level A-D;\n* wheelchair use for at least 75% of community mobility (non-ambulatory);\n* report low amounts of physical activity as determined by the Physical Activity Scale for Individuals with Physical Disabilities (PASIPD). Participants whose combined scores for item 3 (moderate sport or recreation) and 4 (strenuous sport or recreation) ≤10 MET hours per week, will be considered physically inactive.\n\nExclusion Criteria:\n\n* consistent or activity-exacerbated upper extremity pain of at least 4\u002F10;\n* angina or myocardial infarction within the last year, or other major barriers to upper-extremity exercise;\n* inability to elevate arms above 45°,\n* significant spasticity\n* complete upper extremity impairment.",{"count":152,"type":22},16,[25],"What is the ultimate applicability of the research? Individuals with SCI face several challenges when trying to engage in exercise following injury. Barriers to engagement include cost, transportation, and lack of SCI accessible resources. At the same time, individuals with SCI are at risk of developing negative health consequences (e.g., cardiovascular disease) associated with physical inactivity. A critical need exists to improve relevant, accessible, and sustainable home-based exercise interventions for individuals with SCI to lower the risk of developing secondary comorbid diseases from physical inactivity and to promote wellness. This research will investigate a fun and novel in-home virtual reality system aimed toward improving physical fitness of individuals SCI with the ultimate goal of improving physical, emotional, and psychosocial quality of life. Virtual reality gaming has been used for a long time to improve physical fitness, but there have yet to be virtual reality games designed specifically for individuals with SCI. The explicit aim of this research is therefore to develop a therapeutic technology that will be widely accessible to individuals with SCI.\n\nWhat persons with SCI and\u002For their caregivers will it help, and how will it help them? We aim to provide a readily available exercise platform for individuals with SCI, across a spectrum of physical function. Research has shown that individuals with SCI are particularly prone to be physically inactive. The consequences of physical inactivity have been well documented and include negative outcomes in physical, psychological, and social health with reduced quality of life. For the current study, we will refine our existing virtual reality exercise platform, VR-Move with a focus on non ambulatory individuals with bilaterally preserved C6 function. Our focus on using the exercise platform for this cohort of the SCI population is meant to provide a basis for developing and catering to the platform for higher levels of SCI injury (higher quadriplegic). From our previous work with virtual reality interventions in SCI, we recognize that this product can be widely used by individuals across the age spectrum independently of their home environment.\n\nWhat are the potential clinical applications, benefits, and risks? The proposed virtual reality exercise platform, VR-Move, is intended to provide one of the few accessible exercise modalities designed specifically for individuals with SCI and is readily adaptable across the clinical spectrum - including clinic and self-guided home use. There are no known risks associated with this research.\n\nHow will the pilot clinical trial advance the research findings along the translational spectrum? This project aims to refine and assess timely therapeutic technology with the specific intention of translating study findings into a clinically validated, widely accessible health product that can be deployed and implemented within the home. The project likewise demonstrates collaboration between academia, industry (a veteran-owned business), and veteran SCI communities. Project completion will offer initial validation of a novel health promoting modality (i.e., virtual reality exercise) informed by individuals living with SCI and experts in SCI to be relevant and responsive to specific health\u002Fexercise needs of persons living with SCI. Larger clinical trial testing will subsequently inform product commercialization and dissemination. The resulting platform, developed for unattended in-home use, is expected to make a meaningful contribution to SCI health and physical fitness, accessibility, and quality of life.\n\nWhat is the projected time it may take to achieve a person-related outcome? The team is purposefully refining the existing exercise platform, VR-Move, so that it can be easily implemented within people's homes or in clinic settings. Pending findings from the pilot clinical study, this exercise platform would be available immediately to individuals with SCI\n\nWhat are the likely contributions of the proposed research project to advancing the field of SCI research, patient care, and\u002For quality of life? The proposed study may make significant contributions across several areas. First, it will facilitate fruitful clinical data and basic lines of scientific inquiry regarding the application of the physical activity paradigm. The study will also increase our knowledge regarding the importance of consumer advocate-driven research for individuals with SCI. Second, low-activity following SCI is consistently associated with reduced quality of life among individuals with SCI and their families; access to an inexpensive portable intervention will therefore significantly improve quality of life among those affected by low-activity SCI.",[28],[157,158,159,160],"spinal cord injury","cardiometabolic risk","virtual reality exercise","physical activity","2026-06-01",{"date":163,"type":36},"2026-06-03",{"date":38,"type":22},{"date":166,"type":22},"2027-08-31",{"name":168,"class":82},"Drexel University",{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":17,"minAge":177,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":4},"100638294","abdominal-stimulation-to-improve-cough-after-spinal-cord-injury-100638294","NCT07626931","Abdominal Stimulation to Improve Cough After Spinal Cord Injury","Abdominal Function Electrical Stimulation to Improve Cough Peak Flow After Spinal Cord Injury: A Multicenter Randomized Controlled Trial","COUFES","Inclusion Criteria:\n\n1. Adults (≥ 22 years of age) admitted to rehabilitation with a new SCI.\n2. New non-progressive SCI occurring in the past 3 to 8 weeks.\n3. Neurological level of injury of C1-T5.\n4. American Spinal Injuries Association Impairment Scale A to C.\n5. CPF of \\\u003C160 L\u002Fmin (Note: A CPF of \\\u003C270 L\u002Fmin has been shown to be associated with decreased secretion clearance and increased respiratory complications, while a CPF of \\\u003C160 L\u002Fmin has been shown to lead to an ineffective cough).\n6. Not dependent on mechanical ventilation (people dependent on mechanical ventilation are at greatly increased risk of respiratory complications and are excluded due to this heterogeneity).\n7. Able to sit upright.\n8. Expected to remain in rehabilitation for at least another 3 weeks.\n\nExclusion Criteria:\n\n1. Respiratory complications in previous 24 hours (screening out iatrogenic complications).\n2. Chronic respiratory disease.\n3. No contraction of the abdominal wall muscles in response to abdominal NMES.\n4. Open abdominal surgery ≤ 4 weeks prior to enrollment.\n5. Have yet to undergo spinal surgery to stabilize injury, where required.\n6. Body mass index \\>40 kg\u002Fm2.\n7. Pacemaker (external or internal) or implanted electronic device (e.g., a defibrillator).\n8. Known or expected to be pregnant.\n9. Placed on a palliative\u002Fsupportive care only pathway.\n10. Receiving any of the following as standard of care:\n\n    * Abdominal FES\n    * Inspiratory or Expiratory muscle training\n    * Transcutaneous or implanted thoracolumbar spinal stimulation\n11. Participating in any of the following:\n\n    * A study with the same or similar primary endpoint\n    * A study investigating electrical stimulation or respiratory muscle therapy\n    * Any study in which the investigator determines may interfere with the results of this study\n12. Unable or unwilling to comply with protocol requirements, including assessments, tests, and follow-up visits including facial or dental trauma.\n13. Any other medical condition which in the opinion of the Investigator will make participation medically unsafe or interfere with the study results.\n14. Unable to provide informed consent.\n15. Unwilling to provide informed consent.","22 Years",{"count":179,"type":22},150,[25],"The goal of this clinical trial is to learn if abdominal functional electrical stimulation (FES) using the VentFree Respiratory Muscle Stimulator improves cough strength in adults with a new spinal cord injury (SCI). It will also learn about the safety of abdominal FES in this population. The main questions it aims to answer are:\n\nDoes abdominal FES improve cough peak flow (a measure of cough strength) compared to cough training alone? Does abdominal FES reduce the number of respiratory complications (such as pneumonia or atelectasis)? What medical problems do participants have when receiving abdominal FES?\n\nResearchers will compare abdominal FES (active treatment) to supervised cough training without stimulation (control) to see if abdominal FES improves cough function after spinal cord injury.\n\nParticipants will:\n\nReceive abdominal FES or perform supervised cough training 5 days per week for up to 6 weeks during inpatient rehabilitation Have cough strength and breathing function measured at the start of the study and every week during treatment Complete quality of life and bowel function questionnaires at multiple time points Have a follow-up visit or phone call 4 weeks after completing treatment",[28,183],"Respiratory Insufficiency",[185,186,187,188,189,190,191,192],"Spinal Cord Injuries","Functional Electrical Stimulation","Cough Peak Flow","Respiratory Muscles","Abdominal Muscles","Tetraplegia","Rehabilitation","Muscle Strength","2026-05-29",{"date":195,"type":36},"2026-06-04",{"date":197,"type":22},"2026-08",{"date":199,"type":22},"2028-06",{"name":201,"class":202},"Liberate Medical","INDUSTRY",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":23,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":221,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":44},"100616472","epidural-spinal-cord-stimulation-for-restoring-walking-in-spinal-cord-injury-100616472","NCT07306052","Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury","Safety and Efficacy of Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury","Inclusion Criteria:\n\n* Age between 16 and 70 years.\n* Diagnosed with traumatic spinal cord injury for ≥ 6 months and ≤ 60 months.\n* American Spinal Injury Association Impairment Scale (AIS) grade B-D.\n* Spinal cord injury level above T10;\n* Walking Index for Spinal Cord Injury II (WISCI II) score ≤ 13.\n* Completion of a standard conventional rehabilitation program prior to enrollment.\n* Preserved upper limb function sufficient for self-propelling a manual wheelchair.\n* Sitting balance grade ≥ 1.\n* Ability to elicit clear electromyographic responses in lower limb muscles (e.g., rectus femoris, biceps femoris, gastrocnemius, tibialis anterior) upon transcutaneous electrical spinal cord stimulation at the T12-L1 vertebral levels.\n* Willingness to voluntarily participate, and commitment to compliance with all necessary postoperative rehabilitation, assessments, and follow-up visits.\n\nExclusion Criteria:\n\n* History of myocardial infarction or stroke within the past 6 months.\n* Diagnosis of psychiatric disorders with active suicidal ideation or risk.\n* Current pregnancy or planned pregnancy during the study period.\n* Bleeding tendency or coagulopathy (prothrombin time ≥18 seconds).\n* History of alcohol or substance abuse or dependence.\n* Intellectual disability, cognitive impairment, or personality disorders.\n* Other chronic medical conditions that may interfere with rehabilitation (e.g., unhealed severe fractures, hepatic or renal failure, severe anemia, etc.).\n* Implantation of cardiac pacemakers, cardioverters, or defibrillators.\n* Any other condition deemed inappropriate for participation by the investigators.","16 Years","70 Years",{"count":213,"type":22},12,[25],"The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) combined with rehabilitation training for the reconstruction of walking in patients with chronic spinal cord injury (SCI) classified as AIS B-D. The main questions it aims to answer are:\n\nDoes the intervention of EES combined with rehabilitation significantly improve walking capacity? Is the combined intervention a safe approach for this patient population? Researchers will compare participants' functional assessments before EES implantation and at 2, 4, 7, 10, and 13 months post-implantation to evaluate the longitudinal effects. The primary assessments include the Walking Index for Spinal Cord Injury II (WISCI II), the Spinal Cord Independence Measure (SCIM III), and the adverse event. Secondary outcome measures encompass the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), the Functional Independence Measure (FIM), the Modified Ashworth Scale (MAS), the Penn Spasm Frequency Scale, the 10-Meter Walk Test (10mWT), the 6-Minute Walk Test (6minWT), and pain Visual Analogue Scale (VAS) scores. Neurophysiological and imaging evaluations, including electromyography (EMG), motor evoked potentials (MEPs), somatosensory evoked potentials (SEPs), and positron emission tomography-computed tomography (PET-CT), will be conducted preoperatively and at 6 months postoperatively to explore the mechanisms of neuroplasticity.\n\nParticipants will:\n\nUndergo surgical implantation of an EES device. Receive personalized EES parameter programming combined with rehabilitation training (≥2 hours daily) post-operatively.\n\nComplete a series of standardized functional and clinical outcome assessments at scheduled follow-up intervals.\n\nUndergo scheduled neurophysiological and metabolic imaging studies. Report any adverse events throughout the study duration.",[28],[218,219,220],"Epidural Electrical Stimulation","Spincal cord stimulation","Spincal cord injury",{"date":193,"type":36},{"date":223,"type":36},"2025-12-12",{"date":225,"type":22},"2027-06",{"name":227,"class":82},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":237,"briefSummary":238,"conditions":239,"keywords":240,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":44},"100640963","combined-tms-tscs-for-lower-limb-rehabilitation-in-chronic-incomplete-sci-100640963","NCT07595497","Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI","A Randomized Controlled Trial Comparing Combined TMS-tSCS Neuromodulation Versus tSCS Alone Lower Limb Rehabilitation in Chronic Incomplete SCI","Inclusion Criteria\n\n* Age 18-65 years at enrolment\n* Chronic traumatic spinal cord injury, defined as ≥12 months post-injury\n* Incomplete spinal cord injury, AIS grade C or D\n* Neurological level of injury from C2 to L1\n* Baseline Lower Extremity Motor Score (LEMS) \\>10 points\n* Medically stable\n* Able to provide informed consent\n* Able to commit to the full study duration\n* Able to attempt the 10-Meter Walk Test and 6-Minute Walk Test, with or - without assistive devices and standby assistance\n\nExclusion Criteria\n\n* History of seizures or epilepsy\n* Implanted electronic devices, such as: Pacemaker, Cochlear implant, Deep brain stimulator, Spinal cord stimulator, Metallic implants in the head or spine\n* Pregnancy or planned pregnancy\n* Active psychiatric disorder or cognitive impairment\n* Concomitant neurological conditions, such as: Stroke, Traumatic brain injury and Neuropathy\n* Skin breakdown at electrode sites\n* Current participation in another clinical trial\n* History of skull surgery or craniotomy\n* Use of medications that alter cortical excitability within the past 2 weeks","65 Years",{"count":21,"type":22},[25],"he goal of this clinical trial is to learn if combined brain and spinal cord stimulation using TMS-tSCS can improve leg strength and walking recovery in adults with chronic incomplete spinal cord injury.\n\nThe main questions it aims to answer are:\n\nDoes combined TMS-tSCS improve lower limb motor function more than tSCS alone? Is combined TMS-tSCS safe and does it improve walking speed, independence, muscle activity, spasticity, and nerve pathway function?\n\nResearchers will compare combined TMS-tSCS with tSCS alone with sham TMS to see if adding brain stimulation leads to better recovery than spinal stimulation alone.\n\nParticipants will:\n\nAttend 32 treatment sessions over 16 weeks. Receive either combined TMS-tSCS or tSCS with sham TMS. Undergo assessments of leg strength, walking speed, daily function, muscle stiffness, muscle activity, and nerve pathway function before and after treatment.",[28],[241,242,243,157,244,245],"lower extremity motor score","motor rehabilitation","Neuromodulation","Transcranial Magnetic Stimulation","transcutaneous spinal cord stimulation","2026-05-12",{"date":248,"type":36},"2026-05-19",{"date":250,"type":22},"2027-01-01",{"date":252,"type":22},"2028-03-01",{"name":254,"class":82},"National University Hospital, Singapore",{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":17,"minAge":262,"maxAge":235,"enrollmentInfo":263,"targetDuration":4,"studyType":23,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":44},"100638828","combined-rtms-and-tscs-for-upper-limb-recovery-in-cervical-sci-100638828","NCT07586644","Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI","Combined Repetitive Transcranial Magnetic Stimulation and Transcutaneous Spinal Cord Stimulation for Upper Limb Recovery in Chronic Incomplete Cervical Spinal Cord Injury: Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Chronicity: More than 12 months post-injury at enrollment\n* Injury type: Traumatic or non-traumatic incomplete cervical SCI, neurological level C2 to C8\n* AIS classification: Grade C or D\n* UEMS: 10 to 20 out of 25 on the more impaired side; lower bound 10 ensures sufficient voluntary activation for task training and elicitable MEPs, upper bound avoids ceiling effects.\n* Grip strength: MMT grade 3 or higher in finger flexors (C8 myotome) on at least one side.\n* Hand function: Able to transfer at least 1 block across the partition within 60 seconds on the more impaired side.\n* Sitting tolerance: Able to tolerate upright seated posture in own wheelchair for at least 1 continuous hour without symptomatic orthostatic hypotension or pressure-related discomfort requiring position change.\n* Medical stability: No acute medical complications\n* Informed consent: Able to provide written informed consent and comply with the study schedule\n* Medications: Stable regimen for 4 weeks prior, AND participant plus clinician agreement that dosage (baclofen, tizanidine, botulinum toxin) remains unchanged throughout the 12-week intervention; any change logged as protocol deviation\n* Surgical clearance: Cleared by neurosurgeon or orthopedic surgeon for participation in tSCS-based rehabilitation\n\nExclusion Criteria:\n\n* Seizure history: History of seizures or epilepsy\n* Implanted devices: Intracranial metallic implants, cochlear implants, cardiac pacemakers, or other implanted electronic devices. Cervical spinal instrumentation (e.g., posterior rods, plates, or screws at C2 to T1) is not an exclusion for tSCS provided overlying skin is intact; participants with hardware directly beneath planned electrode sites will undergo low-intensity test stimulation during screening, and electrode placement will be shifted by one interspace if current distortion, focal discomfort, or unexpected motor thresholds are observed. Intracranial hardware remains an absolute exclusion for iTBS.\n* Prior craniotomy: Prior neurosurgical procedure involving craniotomy\n* Pregnancy: Currently pregnant or intending to become pregnant during the study period\n* Psychiatric or cognitive: Active psychiatric illness (eg, untreated major depression, psychosis) or cognitive impairment precluding informed consent\n* Concurrent neurological disease: Progressive or degenerative neurological condition (eg, multiple sclerosis, motor neuron disease)\n* Concurrent trials: Participation in another interventional rehabilitation or neurostimulation trial\n* Skin integrity: Skin lesions or breakdown at electrode placement sites (scalp or posterior cervical spine)\n* Cortical excitability medications: Medications known to alter cortical excitability (eg, antiepileptic drugs, high-dose benzodiazepines) that cannot be stabilized for at least 2 weeks prior to enrollment\n* Severe spasticity: Modified Tardieu Scale muscle reaction grade 4 (unfatigable clonus \\>10 s) at elbow or wrist flexors on the more impaired side, or spasticity judged by the treating physician as unresponsive to optimised pharmacological management.","21 Years",{"count":21,"type":22},[25],"This clinical trial investigates whether combining cortical and spinal neuromodulation can improve upper limb motor recovery in adults with chronic incomplete cervical spinal cord injury (SCI). Restoring upper limb function is the top rehabilitation priority for individuals with tetraplegia, yet effective interventions remain limited.\n\nThe study combines transcutaneous spinal cord stimulation (tSCS), which enhances spinal circuit excitability, with intermittent theta burst stimulation (iTBS), a form of repetitive transcranial magnetic stimulation that increases cortical excitability and strengthens descending motor pathways. While each approach has shown independent promise, their combined use has not been evaluated in a controlled trial.\n\nEligible participants are adults aged 21-65 with chronic (\\>12 months post-injury) incomplete cervical SCI (ASIA Impairment Scale grade C or D, levels C2-C8). A total of 24 participants will be randomised 1:1 to either combined iTBS and tSCS plus standardised upper limb rehabilitation, or tSCS plus rehabilitation alone, across 24 sessions over 12 weeks.\n\nThe primary outcome is change in Upper Extremity Motor Score from baseline to week 12. Secondary outcomes cover functional performance, independence, spasticity, corticospinal excitability, quality of life, and goal attainment. Assessments occur at baseline, post-intervention, and at 4- and 12-week follow-up.\n\nAs a pilot randomised controlled trial, this study will generate the first controlled evidence on adjunctive cortical neuromodulation alongside tSCS-based rehabilitation, while also producing feasibility data to inform the design of a future definitive multicentre trial.",[28],[245,268,269,270,271,66,272,273],"intermittent theta burst stimulation","repetitive transcranial magnetic stimulation","cervical spinal cord injury","upper limb rehabilitation","convergent neuromodulation","tetraplegia","2026-05-08",{"date":276,"type":36},"2026-05-14",{"date":278,"type":22},"2027-03-30",{"date":280,"type":22},"2028-12-30",{"name":254,"class":82},{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":23,"phases":291,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":44},"100641234","spasticity-in-sci-following-acute-intermittent-hypoxia-100641234","NCT07583498","Spasticity in SCI Following Acute Intermittent Hypoxia","Does the Administration of Acute Intermittent Hypoxia in Persons With Chronic Spinal Cord Injury Make Spasticity Worse?","Inclusion Criteria:\n\n* Age \\>= 18\n* Non-progressive spinal Cord injury at least 6 months prior\n* Level of injury between C1-C8\n* ISNCSCI ASIA classification C or D\n* Measurable Spasticity\n\nExclusion Criteria:\n\n* Pre-existing hypoxic pulmonary disease\n* Positive Covid-Pneumonia diagnosis within 1 year of visit\n* Uncontrolled hypertension \\>140\u002F90 mmHg\n* Individuals who are currently pregnant\u002Fnursing or planning on becoming pregnant\n* Individuals with a tracheostomy or who utilize mechanical ventilation\n* A botulinum toxin injection to upper extremity musculature within the past 3 months\n* Currently taking Baclofen\n* Congestive Heart Failure\n* Cardiac arrhythmias\n* Uncontrolled diabetes mellitus\n* Chronic obstructive pulmonary disease\n* Emphysema\n* Severe Asthma\n* Previous myocardial infarction\n* Carotid\u002Fintracerebral artery stenosis\n* Orthopedic injuries or surgeries that impact the ability to use the upper extremity\n* History of Epilepsy",{"count":290,"type":22},10,[25],"This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.",[28],[295,296,297],"Hypoxia","Spasticity","Reflex","2026-05-07",{"date":300,"type":36},"2026-05-13",{"date":302,"type":36},"2026-03-17",{"date":304,"type":22},"2028-03",{"name":306,"class":82},"Zev Rymer",{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":235,"enrollmentInfo":313,"targetDuration":4,"studyType":23,"phases":314,"briefSummary":315,"conditions":316,"keywords":318,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":44},"100638308","the-effectiveness-of-transcutaneous-sacral-neuromodulation-techniques-magnetic-stimulation-and-electrical-stimulation-on-detrusor-overactivity-in-patients-with-spinal-cord-injury-100638308","NCT07578532","The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury","Inclusion Criteria:\n\n* 18-65 years old Traumatic and non-traumatic suprasacral SCI; Detrusor overactivity confirmed by urodynamics (spontaneous and\u002For provocative detrusor contraction during the filling phase will be accepted as detrusor overactivity) Patients who have been receiving anticholinergic and\u002For sympathomimetic treatment for the last 3 months and whose pharmacological medical treatment dose has not been changed since the last urodynamic examination will be included in the study.\n\nExclusion Criteria:\n\n* Patients with a cardiac pacemaker,\n* Patients diagnosed with epilepsy,\n* Patients with a metal implant within a 10 cm radius of the area where the treatment will be applied,\n* Patients who have received botox injection to the bladder in the last 6 months,\n* Patients who have received any neuromodulation technique in the last 6 months,\n* Patients who have undergone surgical procedure for neurogenic bladder,\n* Patients with another neurological disease that may affect neurogenic bladder (Parkinson's, polyneuropathy, neurodegenerative disease, cerebrovascular disease, etc.)\n* Patients with acute urinary tract infection,\n* Patients diagnosed with bladder outlet obstruction (urethral stricture, benign prostatic hyperplasia, etc.) will not be included in the study.",{"count":115,"type":22},[25],"The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female patients aged 18-65 with suprasacral Spinal Cord Injury (SCI) whose DOA is confirmed by urodynamics and is refractory to anticholinergic medication. The main question(s) aims to answer :\n\nIs there a difference between SMS and SES in their effect on objective urodynamic parameters, such as maximum detrusor pressure during filling and bladder compliance? Is there a difference between SMS and SES in reducing the frequency of incontinence episodes and improving the Neurogenic Bladder Dysfunction Score? Researchers will compare Sacral Magnetic Stimulation and Sacral Electrical Stimulation to see if there are differences in their effects on urodynamic measures, clinical symptoms, and patient satisfaction\u002Fdiscomfort.\n\nParticipants will:\n\nBe randomly assigned to one of two intervention groups: Sacral Magnetic Stimulation or Sacral Electrical Stimulation.\n\nReceive 20 sessions of the assigned transcutaneous sacral stimulation technique (5 times a week for 20 minutes per session).\n\nUndergo a series of evaluations before and after the 20 treatment sessions, including:\n\nUrodynamic assessment (cystometry + EMG). Clinical assessments (3-day bladder diary, Neurogenic Bladder Dysfunction Score, Neurogenic Bowel Dysfunction Score, Spinal Cord Independence Measure - SCIM).\n\nPatient-reported outcomes (Treatment Satisfaction Level - Likert Scale, Treatment Discomfort Level - Visual Analog Scale)",[28,317],"Detrusor Overactivity",[157,319,320,321],"transcutenous sacral magnetic stimulation","transcutenous sacral electrical stimulation","detrusor overactivity","2026-05-06",{"date":324,"type":36},"2026-05-11",{"date":326,"type":36},"2025-03-26",{"date":328,"type":22},"2026-09-26",{"name":330,"class":82},"Ankara City Hospital Bilkent",{"id":332,"slug":333,"hasResults":12,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":23,"phases":340,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":44},"100605834","fall-prevention-among-people-with-spinal-cord-injury-and-multiple-sclerosis-who-use-wheelchairs-and-scooters-100605834","NCT07167680","Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters","Development and Validation of a mHealth Fall Management Program - Phase III","Inclusion Criteria:\n\n* 18 years old or older.\n* History of Multiple Sclerosis (MS) or Spinal Cord Injury (SCI).\n* Able to transfer independently or with minimal to moderate assistance.\n* Unable to walk 25 feet or more\n* Have experienced at least 1 fall in the past three years.\n* Have a care partner to assist the participant when practicing physical skills.\n* Have access to a smartphone\u002FiPad.\n* Have a stable internet connection.\n\nExclusion Criteria:\n\n* Multiple sclerosis exacerbation in the past 30 days, or are unable to remain in an upright position for an hour.\n* Impaired cognition (a score of 10 or above on the Short Blessed Test).",{"count":339,"type":22},120,[25],"The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care.\n\nThis study will compare two groups of participants:\n\n1. One group will use the iROLL-O+ app, which offers personalized fall prevention tools and strategies.\n2. The other group will receive fall prevention information from a well-known program developed by the Centers for Disease Control and Prevention (CDC), called STEADI, which stands for Stopping Elderly Accidents, Deaths, and Injuries.\n\nThis study includes adults living with Spinal Cord Injury (SCI) or Multiple Sclerosis (MS) who use a wheelchair or scooter every day. The research team aims to determine which approach is more effective in reducing falls and improving confidence in performing daily activities.",[28,343],"Multiple Sclerosis",[345,346,347,157,348,349],"wheelchair","fall prevention","mobile application","multiple sclerosis","education",{"date":324,"type":36},{"date":352,"type":36},"2025-09-01",{"date":354,"type":22},"2027-12-01",{"name":356,"class":82},"University of Illinois at Urbana-Champaign",{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":17,"minAge":210,"maxAge":364,"enrollmentInfo":365,"targetDuration":4,"studyType":23,"phases":366,"briefSummary":367,"conditions":368,"keywords":369,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":44},"100601083","epidural-electrical-stimulation-in-spinal-cord-injury-100601083","NCT07105878","Epidural Electrical Stimulation in Spinal Cord Injury","Epidural Electrical Stimulation for Motor and Sensory Function Reconstruction in Spinal Cord Injury","Inclusion Criteria:\n\n* Spinal Cord Injury, ASIA B-D;\n* Spinal cord injury level above T10;\n* Diagnosed with spinal cord injury for ≥ 8 months and ≤ 36 months;\n* WISCI II score \\\u003C 13;\n* No significant improvement in motor dysfunction after rehabitation over the past 2 months.\n* An expected survival period of ≥ 12 months.\n* Subjects voluntarily participate in this study, sign the informed consent form, have good compliance, cooperate with necessary postoperative rehabilitation training and tests, and assist in follow-up visits.\n\nExclusion Criteria:\n\n* Subjects with other severe organic neurological diseases, mental illnesses other than anxiety\u002Fdepression.\n* Subjects with hemorrhagic diathesis or coagulation dysfunction (prothrombin time \\[PT\\] ≥ 18 seconds).\n* Subjects with a history of alcohol or drug abuse or dependence.\n* Subjects with mental retardation, cognitive dysfunction, or personality disorders.\n* Subjects with a history of electroconvulsive therapy or those requiring continuous electrotherapy.\n* Subjects with implanted cardiac pacemakers, cardioverters, or defibrillators. Expected survival period \\\u003C 1 year.","60 Years",{"count":290,"type":22},[25],"The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) in motor and sensory function Reconstruction in chronic spinal cord injury (SCI) patients classified as ASIA B-D. The main questions it aims to answer are:\n\nDoes EES treatment significantly improve motor and sensory function in patients with SCI compared to baseline? Is EES a safe intervention for this patient population? Researchers will compare participants' motor function, sensory function, and quality of life assessments before EES implantation, immediately after activation of the device, and at 1, 3, and 6 months post-implantation to evaluate the longitudinal effects of EES.\n\nParticipants will:\n\nUndergo surgical implantation of an EES device in the epidural space. Have the EES device activated and receive personalized stimulation parameter adjustments during follow-up visits.\n\nComplete regular motor and sensory function assessments using standardized protocols.\n\nParticipate in structured rehabilitation training sessions while using the EES device.\n\nReport any adverse events and complete quality of life questionnaires at specified follow-up intervals.",[28],[218,185,370,371],"Sensor function reconstruction","Motor function reconstruction","2026-04-21",{"date":374,"type":36},"2026-04-24",{"date":376,"type":36},"2025-03-01",{"date":378,"type":22},"2026-12-31",{"name":227,"class":82},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":390,"phases":4,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":44},"100628864","invasive-home-ventilation-in-denmark-100628864","NCT07467187","Invasive Home Ventilation in Denmark","The Evolution of Invasive Home Mechanical Ventilation in Denmark","HOMEVENT DK","Inclusion Criteria:\n\n* Patients are included if they have or have had a respiratory certified personale care assistent during the period 2016-2025.\n\nExclusion Criteria:\n\n* Not tracheostomized\n* Tracheostomized but on spontaneous breathing throughout 1 January 2016 - 31 December 2025\n* Not discharged to home, assisted living, nursing home, or rehabilitation during 1 January 2016 - 31 December 2025",{"count":389,"type":22},450,"OBSERVATIONAL","The aim of this study is to describe national trends over the past 10 years in patients receiving invasive home mechanical ventilation (HMV) in Denmark. This includes indications for invasive HMV, diagnostic groups, and one-year mortality.",[393,394,28,395,396,397,398,399],"Neuromuscular Diseases (NMD)","ALS (Amyotrophic Lateral Sclerosis)","Duchenne Muscular Dystrophy (DMD)","SMA - Spinal Muscular Atrophy","MSA - Multiple System Atrophy","Tracheostomized Patients","Tracheostomy","2026-04-15",{"date":402,"type":36},"2026-04-20",{"date":404,"type":36},"2026-04-13",{"date":406,"type":22},"2028-09-01",{"name":408,"class":82},"Rigshospitalet, Denmark",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":12,"sex":17,"minAge":415,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":419,"conditions":420,"keywords":421,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":44},"100632918","exploring-the-feasibility-and-benefits-of-implementing-pelvic-floor-muscle-training-during-inpatient-rehabilitation-for-people-with-spinal-cord-injury-100632918","NCT07519928","Exploring the Feasibility and Benefits of Implementing Pelvic Floor Muscle Training During Inpatient Rehabilitation for People With Spinal Cord Injury","Inclusion Criteria:\n\n1. Are at least 19 years of age.\n2. Have a traumatic or non-traumatic SCI\n3. Are able to perform a voluntary anal contraction\n4. Present with bladder or urinary tract dysfunction from SCI\n5. Are a current inpatient at GF Strong Rehabilitation Center and are expected to remain as an inpatient for at least 6 weeks after the time of consent.\n6. Are able to speak and understand English.\n\nExclusion Criteria:\n\n1. Present with symptoms of lower motor neuron injury to the sacral segments (e.g. negative anal and bulbocavernosus reflexes)\n2. Present with any other condition besides SCI that impacts the pelvic floor muscles or other pelvic structures\n3. Are planning to receive intra-detrusor Botox injections in the next 3 months\n4. Have a brain injury or other condition that interferes with their ability to follow instructions\n5. Are using a ventilator\n6. Have severe and unmanaged spasticity (involuntary muscle tightness or spasms) or contractures (prolonged muscle\u002Fjoint stiffness)\n7. Are unable to tolerate transfers to or lie on a physical therapy table\n8. Experience severe pain that interferes with their ability to participate in pelvic floor muscle training","19 Years",{"count":417,"type":22},50,[25],"The goal of this clinical study is to determine the feasibility and explore the potential benefits of pelvic floor muscle training during inpatient SCI rehabilitation on urinary, bowel, and sexual function and quality of life in people with SCI. The main questions it aims to answer are:\n\n1. What is the feasibility of recruiting inpatients from SCI rehabilitation to a pelvic floor muscle training program?\n2. What is the feasibility and acceptance of the implementation of a pelvic floor muscle training program in SCI inpatient rehabilitation?\n3. What are the potential effects of a pelvic floor muscle training program implemented in SCI inpatient rehabilitation on bladder, bowel, and sexual function and quality of life?\n\nParticipants will be asked to complete a series of assessments (questionnaires, physical assessments) before and after a 6-week intervention of pelvic floor physical therapy.",[28],[122,422,423,424],"Physiotherapy","Physical Therapy","Pelvic Floor Muscles","2026-04-11",{"date":400,"type":36},{"date":428,"type":22},"2026-04-01",{"date":430,"type":22},"2028-03-31",{"name":432,"class":82},"University of British Columbia",{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":440,"targetDuration":4,"studyType":23,"phases":442,"briefSummary":443,"conditions":444,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":44},"100538769","virtual-peer-coaching-in-manual-wheelchair-skills-100538769","NCT06295146","Virtual Peer Coaching in Manual Wheelchair Skills","Improving Manual Wheelchair Skills Through Remote Training","Inclusion Criteria:\n\nCoaches:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for at least 50% of mobility\n\nCoaches with paraplegia:\n\n\\- Able to complete all skills targeted by the intervention, except stair ascent, (WST-Q item scores 2) independently.\n\nCoaches with tetraplegia:\n\n\\- Able to complete all skills targeted by the intervention with or without assistance\n\nTrainees:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for 50% of mobility\n* Access to an Internet-ready device with video capabilities.\n* Access to a spotter for practicing wheelchair skills\n* Desire training for at least 5 of the 16 skills targeted by the training program\n\nExclusion Criteria:\n\n* none",{"count":441,"type":22},132,[25],"The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained. Then, trainees will be enrolled into one of three interventions: intervention with remote feedback (Group 1), and a wait list control group (Group 2).",[445,446,122,447,28],"Wheelchair","Paraplegia","Tetraplegia\u002FTetraparesis","2026-04-08",{"date":450,"type":36},"2026-04-14",{"date":452,"type":36},"2024-06-25",{"date":454,"type":22},"2027-12-30",{"name":456,"class":82},"University of Pittsburgh",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":461,"acronym":462,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":464,"enrollmentInfo":465,"targetDuration":4,"studyType":23,"phases":467,"briefSummary":468,"conditions":469,"keywords":477,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":44},"100633072","interfacing-with-neurotechnology-to-expand-neural-throughput-intent-100633072","NCT07521930","Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)","INTENT","Inclusion Criteria:\n\n* Complete or incomplete tetraplegia (quadriplegia), tetraparesis (quadriparesis), severe ataxia, or disabling motor impairments in both upper limbs, based on neurological exam. In addition, these motor impairments may be combined with severe motor-related speech impairment (dysarthria or anarthria), as in Locked In Syndrome (LIS) and amyotrophic lateral sclerosis (ALS), including the bulbar variant of ALS.\n* Clinical diagnosis must be established for the etiology of motor impairments, including brainstem stroke\\*, traumatic spinal cord injury (SCI), or progressive and irreversible neuromuscular disease, including muscular dystrophy and motor neuron disease, including amyotrophic lateral sclerosis (ALS). \\*Brain stem stroke is defined as an acute onset of neurological deficit with clinical features of brain stem or cerebellar dysfunction lasting more than 24 hours together with computed tomography (CT) or magnetic resonance imaging (MRI) evidence of ischemic infarction or parenchymal hemorrhage.\n* Candidates with traumatic spinal cord injury must have a complete or incomplete tetraplegia or tetraparesis (ASIA Impairment Scale A, B, C) with an injury level of C6 or higher.\n* Candidates with tetraplegia or tetraparesis from traumatic SCI and other non-progressive neurological disorders must have an upper extremity motor score (UEMS, ISNCSCI) of 7 or less in each of the upper extremities. Candidate must also have less than antigravity strength (\\\u003C 3) throughout the lower limbs.\n* Candidates with progressive conditions with shortened life expectancy, such as ALS, must have less than antigravity strength (\\\u003C3) throughout the upper limbs.\n* Persistence of motor impairments at least 12 months prior to enrollment if due to a non-progressive neurological cause such as stroke or spinal cord injury\n* Meeting surgical safety criteria, including surgical clearance by the participant's primary healthcare provider, study physicians, and any necessary consultants\n* Ability to communicate reliably, such as through speech or eye movement\n* Stable psychosocial support system with caregiver capable of monitoring participant throughout the study\n* Ability and willingness to travel to study location up to five days per week for the duration of the study\n* Ability to understand and comply with study session instructions\n* Corrected visual acuity sufficient for use of computer monitor\n\nExclusion Criteria:\n\n* Psychiatric conditions or cognitive impairments that would interfere with obtaining informed consent or fully participating in study activities.\n* Individuals with active implanted devices, including devices that are incompatible with magnetic resonance imaging (MRI).\n* Contraindications to MRI or anticipated need for an MRI during the study period\n* Medical conditions contraindicating device implantation surgery (for example significant pulmonary, cardiovascular, metabolic, or renal impairments making the surgical procedure unsafe)\n* Chronic anti-coagulation and medical contraindication to temporary suspension for surgery\n* Medical conditions contraindicating chronic device implantation (e.g. osteomyelitis, chronic infection, poorly controlled diabetes, cancer, severe autoimmune disorder, epilepsy, poor wound healing)\n* Participants with dental caries and a significant risk of dental or periodontal infection\n* Chronic oral or intravenous use of steroids or immunosuppressive therapy\n* Active cancer within the past year or ongoing chemotherapy\n* Uncontrolled autonomic dysreflexia within the past 3 months\n* Hydrocephalus with or without an implanted ventricular shunt\n* Other chronic, unstable medical conditions that could interfere with subject participation.\n* Persistent suicidal ideation within the past 12 months.\n* History of substance use disorder within the past year\n* Pregnancy (confirmation through blood test)\n* Nursing an infant, planning to become pregnant, or not using adequate birth control","80 Years",{"count":466,"type":22},5,[25],"The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility for more details) to control and receive feedback from assistive devices.",[447,470,471,472,28,473,474,475,476],"Amyotrophic Lateral Sclerosis (ALS)","Muscular Disorders, Atrophic","Brain Stem Stroke","Muscular Dystrophies","Muscular Atrophy, Progressive","Pontine Hemorrhage","Pontine Infarction",[478,479],"Assistive device","Brain Computer Interface","2026-04-02",{"date":404,"type":36},{"date":483,"type":22},"2026-06",{"date":485,"type":22},"2028-12",{"name":487,"class":82},"Johns Hopkins University",{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":495,"targetDuration":4,"studyType":23,"phases":496,"briefSummary":497,"conditions":498,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":44},"100622661","health-information-for-persons-with-spinal-cord-injury-100622661","NCT07386522","Health Information for Persons With Spinal Cord Injury","Reaching Persons With Spinal Cord Injury With Important Health Information Through a Text-messaging Intervention: Adaptation and Pilot Study","Inclusion Criteria:\n\n* 18 years of age or older\n* Diagnosis of SCI\n* At least 3 months from date of injury or illness\n* Identify at least one secondary health condition (pain, pressure injury, bladder\u002Fbowel dysfunction, and psychosocial distress) that impacts daily life\n* Live in the community\n* English as primary language\n* Ability and willingness to use their own smartphone to receive and respond to text messages for the 16-week study period\n* Ability and willingness to participate in two full assessments and an additional four check ins during the 16-week study period\n\nExclusion Criteria:\n\n\\- Current admission in a hospital or in-patient rehabilitation facility",{"count":115,"type":22},[25],"The goal of this pilot study is to design and feasibility test a mobile phone text messaging (SMS) self-management intervention for persons with spinal cord injury (PwSCI). The project will focus on providing a 16-week text messaging intervention on the secondary health conditions of bowel\u002Fbladder management, pain, pressure injury, and psychosocial health. Our hopes are to reduce the impact of secondary health conditions (SHC) for PwSCI.\n\nThe project hopes to test whether the developed self-management program will be feasible and superior to a control group. determine the feasibility and efficacy of the SMS intervention main questions the study aims to answer are:\n\nParticipants will:\n\nComplete an initial assessment Participate in a 16-week text messaging program using their mobile phones Complete 4-week check-ins Complete a post assessment\n\nThe main question\\[s\\] it aims to answer \\[is\u002Fare\\]:\n\n\\[primary hypothesis or outcome measure 1\\]? \\[primary hypothesis or outcome measure 2\\]? If there is a comparison group: Researchers will compare \\[arm information\\] to see if \\[insert effects\\].\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[28],"2026-03-10",{"date":501,"type":36},"2026-03-11",{"date":503,"type":36},"2026-02-05",{"date":505,"type":22},"2026-10-30",{"name":507,"class":82},"Washington University School of Medicine",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":210,"maxAge":235,"enrollmentInfo":515,"targetDuration":4,"studyType":23,"phases":517,"briefSummary":518,"conditions":519,"keywords":520,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":44},"100623509","spatiotemporal-tscs-in-spinal-cord-injury-100623509","NCT07397559","Spatiotemporal tSCS in Spinal Cord Injury","Spatiotemporal Control of Transcutaneous Spinal Cord Stimulation for Motor Function in SCI","Inclusion Criteria:\n\n1. Age between 16 and 65 years.\n2. Have a spinal cord injury (neurological level C3-T12) that occurred ≥1 year (chronic stage) prior to enrollment.\n3. American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification C or D\n4. Able to voluntarily contract (motor score ≥ 1) at least two leg muscles (visual or palpable contraction).\n5. Use of prescription medication(s) for control of spasticity has not changed in the last 2 weeks\n6. Able to provide consent\n7. Ability to follow multiple instructions and communicate pain or discomfort\n\nExclusion Criteria:\n\n1. Progressive spinal lesions, including degenerative disorders of the spinal cord\n2. Pregnant, planning to become pregnant, or currently breastfeeding\n3. History of cardiopulmonary disease or cardiac symptoms\n4. Implanted stimulators of any type (baclofen pump, epidural spinal stimulator, cardiac defibrillator, pace-maker, etc.)\n5. Presence of orthopedic conditions that would negatively affect participation in leg exercise\n6. History of autonomic dysreflexia that is severe, unstable, and\u002For uncontrolled\n7. Unstable or significant medical conditions that can interfere with exercise or neurophysiological evaluations, such as severe neuropathic pain, depression, mood disorders, or other cognitive disorders\n8. Spasms that limit the ability to participate in leg exercise activity\n9. Breakdown in skin area that will be in contact with electrodes",{"count":516,"type":22},48,[25],"Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in muscle recruitment compared to invasive approaches limits the type of rehabilitation exercises that can be practiced. This project studies how spatial, frequency, and amplitude control of stimulation can be used to selectively target different neural pathways and muscle groups.",[28],[157,245,521],"rehabilitation","2026-02-09",{"date":524,"type":36},"2026-02-12",{"date":526,"type":36},"2026-01-19",{"date":528,"type":22},"2030-08-31",{"name":507,"class":82},{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":364,"enrollmentInfo":537,"targetDuration":4,"studyType":390,"phases":4,"briefSummary":539,"conditions":540,"keywords":542,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":44},"100615541","ultrasonographic-evaluation-of-talar-cartilage-thickness-in-patients-with-spinal-cord-injury-100615541","NCT07293949","Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury","Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury: A Cross-Sectional Case-Control Study","Inclusion Criteria:\n\n* Aged between 18 to 60 years,\n* Cervical, thoracal or lumber level of spinal cord injury\n* AIS (American Spinal Injury Association Impairment Scale) Level A, B, C, or D\n* Assisted ambulation of any kind\n* Literacy\n* Giving oral and written consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with sacral level injury\n* AIS E\n* MAS 4 level of spasticity\n* History of any lower extremity operation\n* History of fracture\n* Botulinum toxin injection in the last 6 months\n* Existing diagnosis of any rheumatologic or endocrine diseases",{"count":538,"type":22},76,"Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via ultrasound), functional status, spasticity, and ambulation levels.",[28,541],"Osteoarthritis (OA)",[157,543,544,545],"osteoarthritis","musculoskeletal ultrasound","talar cartilage","2026-01-30",{"date":548,"type":36},"2026-02-02",{"date":550,"type":36},"2025-12-20",{"date":552,"type":22},"2026-03-01",{"name":554,"class":555},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":563,"targetDuration":4,"studyType":23,"phases":564,"briefSummary":565,"conditions":566,"keywords":568,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":577,"completionDateStruct":579,"leadSponsor":581,"locationsCount":44},"100578647","self-balancing-personal-exoskeleton-for-sci-site-2-100578647","NCT06814015","Self-balancing Personal Exoskeleton for SCI (Site 2)","Empowering Mobility in People With Spinal Cord Injury With a Hands-free, Self-balancing Personal Exoskeleton","SCI user inclusion Criteria:\n\n* Any gender, age 18 years or older;\n* Motor complete or incomplete SCI with lesions at or above T6;\n* ≥ 6 months post SCI;\n* Able and willing to attend 9 to 10 visits1 to the center, including sessions of training and assessments of one-to-three hours duration;\n* Able to read, understand, and provide informed consent;\n* Living in the US and speaks English.\n\nSCI user exclusion Criteria:\n\n* Diagnosis of neurological injury other than SCI;\n* Progressive condition that would be expected to result in changing neurological status;\n* Severe concurrent medical disease, illness or condition judged to be contraindicated by the site physician;\n* Unhealed or unstable traumatic or high impact lower extremity fracture of any duration that is, in the clinical judgement of the study physician, exclusionary for standing and walking;\n* Knee (proximal tibia and\u002For distal femur) BMD \\\u003C0.60 gm\u002Fcm2;\n* Total hip BMD T-scores \\\u003C -3.5;\n* Fragility, minimal trauma, or low impact fracture of the lower extremity since SCI;\n* Untreatable severe spasticity judged to be contraindicated by the site physician;\n* Untreated\u002Funcontrolled hypertension, as judged to be contraindicated by the site physician;\n* Unresolved orthostatic hypotension (change from baseline seated BP to a fall in 20mmHg SBP and\u002For fall in 10mmHG DBP and symptoms when standing), or as judged to be contraindicated by the site physician;\n* Open or unhealed skin pressure sores, abrasions, or bruises at any of the contact points of the exoskeleton;\n* Morphological contraindications to the use of the device;\n* Uncorrectable leg length discrepancy over 2 cm (about 0.79 in) when using additional correction tools;\n* Unable to effectively operate the device with a hand-control interface, due to functional and\u002For cognitive impairment, evaluated based on the ability to manipulate the joystick in all direction, press and identify buttons on the hand control interface.\n* Improper fitting in the device;\n* Psychopathology documentation in the medical record that may conflict with study objectives;\n* Pregnancy or women who plan to become pregnant during the study period;\n* Concurrent participation in another interventional trial;\n* History of uncontrolled autonomic dysreflexia;\n* Presence colostomy and\u002For urostomy;\n* Ventilator use at the time of the exoskeleton use;\n* Insufficient strength and performance capability (the ability to transfer into\u002Fout of the device or perform other training tasks with assistance).\n\nCompanion inclusion Criteria:\n\n* Any gender, age 18 years or older;\n* Willingness to attend 9 to 10 visits to the center, including sessions of training and assessments of one-to-three hours duration with the SCI user;\n* Able to read, understand and provide informed consent;\n* Living in the US and speaks English.\n\nCompanion exclusion Criteria:\n\n* Inability to communicate with an assistant due to cognitive and language disorders;\n* Any disease, concomitant injury, or condition that interferes with the performance or interpretation of the protocol- specified assessments;\n* Insufficient strength and performance capability, evidenced by the ability to hold and retain the device in case of unbalance\u002Ffall;\n* Insufficient availability to complete the study;\n* Concurrent participation in another interventional trial.",{"count":21,"type":22},[25],"This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).",[28,567],"Paraplegia and Tetraplegia",[122,569,570,571,572,573,574],"Robotics","Community use","Hands-free exoskeleton","Overground exoskeleton","Walking","Self-balancing","2026-01-29",{"date":548,"type":36},{"date":578,"type":36},"2025-03-31",{"date":580,"type":22},"2026-05-31",{"name":582,"class":202},"Wandercraft",{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":561,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":589,"targetDuration":4,"studyType":23,"phases":590,"briefSummary":565,"conditions":591,"keywords":592,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":593,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":597,"locationsCount":44},"100575845","self-balancing-personal-exoskeleton-for-sci-100575845","NCT06777576","Self-balancing Personal Exoskeleton for SCI","SCI user inclusion Criteria:\n\n* Any gender, age 18 years or older;\n* Motor complete or incomplete SCI with lesions at or above T6;\n* ≥ 6 months post SCI;\n* Able and willing to attend 9 to 10 visits1 to the center, including sessions of training and assessments of one-to-three hours duration;\n* Able to read, understand, and provide informed consent;\n* Living in the US and speaks English.\n\nSCI user exclusion Criteria:\n\n* Diagnosis of neurological injury other than SCI;\n* Progressive condition that would be expected to result in changing neurological status;\n* Severe concurrent medical disease, illness or condition judged to be contraindicated by the site physician;\n* Unhealed or unstable traumatic or high impact lower extremity fracture of any duration that is, in the clinical judgement of the study physician, exclusionary for standing and walking;\n* Knee (proximal tibia and\u002For distal femur) BMD \\\u003C0.60 gm\u002Fcm2;\n* Total hip BMD T-scores \\\u003C -3.5;\n* Fragility, minimal trauma, or low impact fracture of the lower extremity since SCI;\n* Untreatable severe spasticity judged to be contraindicated by the site physician;\n* Untreated\u002Funcontrolled hypertension, as judged to be contraindicated by the site physician;\n* Unresolved orthostatic hypotension (change from baseline seated BP to a fall in 20mmHg SBP and\u002For fall in 10mmHG DBP and symptoms when standing), or as judged to be contraindicated by the site physician;\n* Open or unhealed skin pressure sores, abrasions, or bruises at any of the contact points of the exoskeleton;\n* Morphological contraindications to the use of the device;\n* Uncorrectable leg length discrepancy over 2 cm (about 0.79 in) when using additional correction tools;\n* Unable to effectively operate the device with a hand-control interface, due to functional and\u002For cognitive impairment, evaluated based on the ability to manipulate the joystick in all direction, press and identify buttons on the hand control interface.\n* Improper fitting in the device;\n* Psychopathology documentation in the medical record that may conflict with study objectives;\n* Pregnancy or women who plan to become pregnant during the study period;\n* Concurrent participation in another interventional trial;\n* History of uncontrolled autonomic dysreflexia;\n* Presence colostomy and\u002For urostomy;\n* Ventilator use at the time of the exoskeleton use.\n\nCompanion inclusion Criteria:\n\n* Any gender, age 18 years or older;\n* Willingness to attend 9 to 10 visits to the center, including sessions of training and assessments of one-to-three hours duration with the SCI user;\n* Able to read, understand and provide informed consent;\n* Living in the US and speaks English.\n\nCompanion exclusion Criteria:\n\n* Inability to communicate with an assistant due to cognitive and language disorders;\n* Any disease, concomitant injury, or condition that interferes with the performance or interpretation of the protocol- specified assessments;\n* Insufficient strength and performance capability, evidenced by the ability to hold and retain the device in case of unbalance\u002Ffall;\n* Insufficient availability to complete the study;\n* Concurrent participation in another interventional trial.",{"count":21,"type":22},[25],[28,567],[122,569,570,571,572,573,574],{"date":548,"type":36},{"date":595,"type":36},"2025-02-12",{"date":580,"type":22},{"name":582,"class":202},{"id":599,"slug":600,"hasResults":12,"nctId":601,"briefTitle":602,"officialTitle":603,"acronym":4,"eligibilityCriteria":604,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":605,"targetDuration":4,"studyType":23,"phases":606,"briefSummary":607,"conditions":608,"keywords":610,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":44},"100605656","virtual-walking-to-reduce-chronic-neuropathic-pain-in-subjects-with-sci-100605656","NCT07165353","Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI","Virtual Walking With Habitual Feedback to Reduce Chronic Neuropathic Pain in Individuals With Spinal Cord Injury","Inclusion Criteria:\n\n* Sufficient knowledge of German language to understand the instructions, assessments and to fill in questionnaires.\n* Age ≥ 18y, ≤ 75y\n* Chronic traumatic or non-traumatic SCI (\\>6 month after SCI) with an SCI severity grade AIS A, B, C or D\n* At or below level spinal cord injury neuropathic pain on trunk or lower extremities diagnosed by a neurologist following the ISCIP classification (Bryce et al., 2012) of at least 4\u002F10 intensity on a NRS (Langford et al., 2023)\n* Ability to draw with a pen\n\nExclusion Criteria:\n\n* \\- Serious psychiatric disorders, which are accompanied by imminent or current acute harm to oneself or others, or which require inpatient psychiatric treatment for other reasons, or other indications of a foreseeable, seriously harmful effect of participation in the study based on the clinical impression from the psychological screening interview\n* Participants with a walking ability more than 5 minutes without walking aids\n* Pregnancy (anamnestic) in women of child-bearing age (18-49 years)\n* Known epilepsy\n* neurological disorders (multiple sclerosis, ALS, Guillan-Barré Syndrome, congenital disorders, polyneuropathy)",{"count":115,"type":22},[25],"About 70% of people with a spinal cord injury in Switzerland have chronic pain that lasts more than 3 to 6 months. This pain can be caused by muscle or joint problems, or by nerve damage (neuropathic pain). Neuropathic pain is often hard to treat, and current treatments may cause side effects or not work well.\n\nThis study will test whether virtual walking from different visual perspectives can reduce chronic neuropathic pain and improve quality of life after spinal cord injury. We will also compare which perspective works best.\n\nTo better understand how the training works, we will use two tests-quantitative sensory testing (QST) and contact heat-evoked potentials (CHEPs)-to measure changes in the pain and nerve systems.",[28,609],"Neuropathic Pain Due to Spinal Cord Injury",[611,612,613,614,157],"neuropathic pain","virtual walking","virtual reality","spinal cord injury pain",{"date":616,"type":36},"2026-01-21",{"date":618,"type":36},"2026-01-20",{"date":620,"type":22},"2027-11-30",{"name":622,"class":623},"Swiss Paraplegic Research, Nottwil","NETWORK",{"id":625,"slug":626,"hasResults":12,"nctId":627,"briefTitle":628,"officialTitle":628,"acronym":4,"eligibilityCriteria":629,"healthyVolunteers":12,"sex":17,"minAge":210,"maxAge":4,"enrollmentInfo":630,"targetDuration":632,"studyType":390,"phases":4,"briefSummary":633,"conditions":634,"keywords":635,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":642,"lastUpdatePostDateStruct":643,"startDateStruct":645,"completionDateStruct":647,"leadSponsor":648,"locationsCount":44},"100621255","turkish-translation-and-content-validity-of-the-nottwil-environmental-factors-inventory-nefi-in-persons-with-spinal-cord-injury-100621255","NCT07368244","Turkish Translation and Content Validity of the Nottwil Environmental Factors Inventory (NEFI) in Persons With Spinal Cord Injury","Inclusion Criteria:\n\n* Adults (\\>=16 years) with a diagnosis\u002Fhistory of spinal cord injury (traumatic or non-traumatic)\n* Living in Turkey\n* Able to read\u002Funderstand Turkish and provide informed consent\n* Clinically stable to complete questionnaires\n\nExclusion Criteria:\n\n* Fully recovered from SCI \u002F no longer living with SCI-related functional consequences (as defined by your protocol)\n* Severe cognitive\u002Fcommunication limitations preventing valid completion\n* Any condition judged by investigators to preclude participation",{"count":631,"type":22},405,"1 Month","This observational methodology study will produce a Turkish version of the Nottwil Environmental Factors Inventory (NEFI-TR) within one month using a standardized translation and cultural adaptation process. Content validity will be assessed using an expert panel (and, if applicable, cognitive debriefing with adults with spinal cord injury) to ensure relevance, clarity, and comprehensibility of each item in the Turkish context.",[28],[636,637,638,639,640,641],"InSCI","Nottwil Environmental Factors Inventory","NEFI","Turkish","cultural adaptation","content validity","2026-01-18",{"date":644,"type":36},"2026-01-26",{"date":646,"type":36},"2026-01-01",{"date":503,"type":22},{"name":649,"class":82},"Istanbul Medeniyet University",{"id":651,"slug":652,"hasResults":12,"nctId":653,"briefTitle":654,"officialTitle":655,"acronym":4,"eligibilityCriteria":656,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":657,"targetDuration":4,"studyType":23,"phases":659,"briefSummary":660,"conditions":661,"keywords":663,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":675},"100620988","enhancing-rehabilitation-participation-in-patients-with-scid-using-motivational-interviewing-100620988","NCT07364773","Enhancing Rehabilitation Participation in Patients With SCI\u002FD Using Motivational Interviewing","Enhancing Rehabilitation Participation in Patients With Spinal Cord Injury or Disorder Using Motivational Interviewing","Therapist Inclusion Criteria:\n\n* Inpatient therapist specializing in spinal cord injury patients for at least 3 months;\n* Practicing at the designated SCI inpatient units at Shirley Ryan AbilityLab, Baylor Scott \\& White Institute for Rehabilitation and University of Washington-Harborview Medical Center;\n* Willing to audio record conversations during regularly-scheduled rehabilitation therapy sessions with patients;\n* Willing and able to participate in 16 hours of MI training; and\n* Willing to receive feedback on MI skills.\n\nTherapist Exclusion Criteria:\n\n* Inability to speak and understand English\n* Inpatient therapist specializing in spinal cord injury patients for less than 3 months; and\n* Unwilling or unable to follow the study protocol\n\nPatient Inclusion Criteria:\n\n* Adults (18+)\n* Presence of a traumatic or non-traumatic spinal cord injury\n* Inpatient in the spinal cord injury unit of the three study sites\n* Has a physical or occupational therapist who is a participant in the study\n\nPatient Exclusion Criteria:\n\n* Inability to speak and understand English\n* Cognitive deficits\n* Unwilling to allow for therapy sessions to be recorded",{"count":658,"type":22},180,[25],"The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI\u002FD) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are trained in a counseling style called motivational interviewing. We want to answer the following questions:\n\n1. Do inpatients with SCI\u002FD treated by physical therapists (PTs) and occupational therapists (OTs) who receive MI training and coaching demonstrate greater therapy participation compared to those treated by therapists who do not receive MI training and coaching?\n2. Do inpatients with SCI\u002FD treated by PTs and OTs who receive MI training and coaching demonstrate greater functional improvement at discharge from inpatient rehabilitation and greater community integration at 6 months after discharge compared to those treated by therapists who do not receive MI training and coaching?\n3. What are the potential moderators and mediators of the effect of training and coaching on MI skills on therapy participation?\n\nResearchers will compare patient participation level and other outcomes of inpatients with SCI\u002FD treated by PTs and OTs who receive MI training and coaching with those treated by therapists who do not receive MI training and coaching.\n\nTherapist participants will:\n\n1. Audio record 2 therapy sessions per week with each enrolled SCI patient participant\n2. Half of the therapists will attend a 16-hour training on MI skills and 2 practice therapy session\n\nPatient participants will:\n\n1. Consent to audio recording of their therapy sessions\n2. Complete one brief survey near the time of their discharge and another survey 6 months later",[28,662],"Spinal Cord Disease",[122,664,665,191],"Spinal Cord Disorder","Motivational Interviewing","2026-01-16",{"date":668,"type":36},"2026-01-23",{"date":670,"type":36},"2025-11-01",{"date":672,"type":22},"2027-04-20",{"name":674,"class":82},"Shirley Ryan AbilityLab",3]