[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injuries":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,168,0,25,[9,44,83,107,134,161,182,205,228,251,277,297,323,349,368,385,404,426,452,473,505,530,555,591,614],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642177","hybrid-hiit-fes-cycling-program-on-individuals-with-spinal-cord-injury-to-improve-health-100642177",false,"NCT07648173","Hybrid HIIT-FES Cycling Program on Individuals With Spinal Cord Injury to Improve Health","The Effects of a Hybrid HIIT-FES Cycling Program on Individuals With Spinal Cord Injury to Improve Cardiovascular and Metabolic Health","Inclusion Criteria:\n\n* men and women ages 21-70 years\n* C4-T12 SCI American Spinal Injury Association Impairment Scale A, B, and C as per International Standards for Neurological Classification of SCI\n* ≥1 years post-SCI\n* Participants must be able to perform voluntary arm cycling.\n\nExclusion Criteria:\n\n* pressure wounds on buttocks or feet\n* unhealed bone fractures or history of fragility fractures\n* uncontrolled cardiovascular disease\n* uncontrolled Type-2 diabetes\n* severe osteoporosis (T score below -4)\n* uncontrolled autonomic dysreflexia\n* orthopedic or other problems that preclude leg and arm cycling.","ALL","21 Years","70 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","Project Summary\u002FAbstract Obesity and metabolic syndrome (obesity, dyslipidemia, hyperglycemia, hypertension) are epidemic in the spinal cord injured (SCI) population. A recent study assessing the body composition and metabolic syndrome rates of 72 motor complete chronic SCI individuals revealed an obesity rate of over 90% and a metabolic syndrome rate of 60%. These results are significantly higher than in the general population. As such individuals with SCI typically have systemic inflammation and an accelerated trajectory towards cardiometabolic disease, and early mortality. Although the accelerated trajectory is multi-factorial, substantial evidence implicates sedentary behavior and low physical activity levels as significant contributing factors. Exercise strategies for individuals with SCI have included upper body arm crank exercise (ACE), functional electrical stimulation leg cycling exercise (FES-LCE), or a combination of the two (FES Hybrid Exercise). These modalities have yielded modest improvements in physical fitness and cardiometabolic risk profiles in individuals with SCI. FES-LCE reportedly increased lean-to-fat mass ratio, enhanced peripheral blood flow and vasoreactivity, and increased bone mass in the paralyzed legs. In addition, FES-LCE improves metabolic function as evidenced by increased glucose disposal. There is evidence that high-intensity interval training exercise can increase muscle mass and improve cardiovascular fitness with considerably less time commitment than non-interval activities. However, given many individuals with SCI respond poorly to the onset of training a primer exercise program for the extremely deconditioned muscles is recommended for optimal results. The investigators intend to investigate the optimization of benefits by using a novel hybrid FES cycling protocol (FES legs cycling plus voluntary arms cycling) combined with high intensity interval training (HIIT) and preceded by a preparatory muscle strengthening program called \"peripheral remodeling intermittent muscular exercise (PRIME) to prepare the deconditioned muscles for the more intense exercise in the hybrid HIIT-FES cycling program. The investigators hypothesize that individuals in the PRIME + hybrid HIIT-FES cycling program will demonstrate significantly greater cardiometabolic health and functional benefits than the control group receiving standard of care range of motion exercises.",[28],"Spinal Cord Injuries",[30],"Hybrid functional electrical stimulation cycling","RECRUITING","2026-06-30",{"date":34,"type":35},"2026-07-02","ACTUAL",{"date":37,"type":35},"2026-03-03",{"date":39,"type":22},"2027-08-31",{"name":41,"class":42},"William Carey University","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":67,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":43},"100644654","impact-of-transcutaneous-spinal-stimulation-on-blood-pressure-and-orthostasis-in-spinal-cord-injury-100644654","NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician","18 Years","75 Years",{"count":55,"type":22},10,[25],"The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[28,59,60,61,62,63,64,65,66],"Hypotension","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Central Nervous System Disease","Nervous System Diseases","Blood Pressure",[68,69,70,71,72],"transcutaneous spinal cord stimulation","spinal stimulations","orthostatic hypotension","blood pressure","neuromodulation","NOT_YET_RECRUITING","2026-06-24",{"date":76,"type":35},"2026-06-29",{"date":78,"type":22},"2026-09",{"date":80,"type":22},"2028-12",{"name":82,"class":42},"Kessler Foundation",{"id":84,"slug":85,"hasResults":12,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":43},"100571953","repetitive-transcranial-magnetic-stimulation-therapy-in-spinal-cord-injury-related-neuropathic-pain-100571953","NCT06726954","Repetitive Transcranial Magnetic Stimulation Therapy in Spinal Cord Injury Related Neuropathic Pain","Efficacy of Repetitive Transcranial Magnetic Stimulation Therapy in Neuropathic Pain Associated With Spinal Cord Injury; Randomized Controlled Trial","Inclusion Criteria:\n\nAged 18-75 years Physician-diagnosed spinal cord injury for at least 3-months Neuropathic pain for at least 3-months Pain not attributable to any other conditions\n\nExclusion Criteria:\n\n* Having an important comorbid disease such as severe heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, uncontrolled hypertension,arrhythmia, pacemaker)\n* Neurodegenerative disease\n* Epilepsy\n* History of antiepileptic drug use\n* Cognitive dysfunction\n* Lower extremity peripheral nerve injury\n* Increased intracranial pressure or uncontrolled migraine\n* Infection on the skin in the application area.\n* Having a brain lesion or a history of drug use that will affect the seizure threshold.\n\nAny TMS-related contraindications, for example:\n\n* Pacemaker\n* Metallic implant\n* Previous seizure\n* Psychiatric disorders (excluding depression and anxiety)\n* Malignancy\n* Current pregnancy",{"count":91,"type":22},63,[25],"The aim of our study is to investigate the effect of different protocols of high-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) therapy added to the rehabilitation program on neuropathic pain,depression, quality of life and quality of sleep compared to each other and placebo group in participants with spinal cord injury.",[28,95],"Neuropathic Pain",[97,98,95],"Transcranial Magnetic Stimulation","Spinal Cord Injury",{"date":100,"type":35},"2026-06-26",{"date":102,"type":35},"2024-12-16",{"date":104,"type":22},"2026-12-30",{"name":106,"class":42},"Afyonkarahisar Health Sciences University",{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":43},"100555426","feasibility-of-the-braingate2-neural-interface-system-in-persons-with-tetraplegia-bg-tablet-01-100555426","NCT06511934","Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)","Intuitive, Complete Neural Control of Tablet Computers for Communication","BG-Tablet-01","Inclusion Criteria:\n\n* Clinical diagnosis of spinal cord injury, brainstem stroke, muscular dystrophy, amyotrophic lateral sclerosis or other motor neuron disorders\n* Complete or incomplete tetraplegia (quadriplegia)\n* Must live within a three-hour drive of the Study site\n* Prior enrollment in BrainGate2 clinical trial (NCT00912041)\n\nExclusion Criteria:\n\n* Visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses\n* Chronic oral or intravenous steroids or immunosuppressive therapy\n* Other serious disease or disorder that could seriously affect ability to participate in the study\n\n(There are additional exclusion criteria)","80 Years",{"count":117,"type":22},6,[25],"People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with paralysis.",[121,122,123,28,124],"Brainstem Stroke","ALS","Tetraplegia","Cervical Spinal Cord Injury","2026-06-22",{"date":127,"type":35},"2026-06-25",{"date":129,"type":35},"2024-07-22",{"date":131,"type":22},"2027-07-30",{"name":133,"class":42},"Leigh R. Hochberg, MD, PhD.",{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":145,"conditions":146,"keywords":147,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":43},"100463679","phase-2-using-smartphones-to-improve-physical-activity-levels-of-individuals-with-spinal-cord-injury-100463679","NCT05317832","Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury","mHealth-based Just-In-Time Adaptive Intervention to Improve Physical Activity Levels of Individuals With Spinal Cord Injury","Inclusion Criteria: Participants with SCI will be included if they are:\n\n* 18-75 years of age\n* have a traumatic or non-traumatic SCI (classification of neurological level of injury at cervical level 5 (C5) and below)\n* are at least 6-months post-SCI\n* use a manual or a power wheelchair as their primary means of mobility (\\>80% of time)\n* can use their arms to exercise\n* show readiness to physical activity as assessed by the Physical Activity Readiness Questionnaire\n* have experience using a smartphone and smartwatch.\n\nExclusion Criteria: Participants will be excluded if they have:\n\n* any secondary complications that medically restrict their activity in any way such as cardiovascular disease, pressure injuries, contractures, and infections\n* are diagnosed with traumatic brain injury.",{"count":142,"type":22},196,[144],"PHASE2","The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate the integration of a JITAI with a web-based physical activity intervention program. We hypothesize that the integration of web-based physical activity intervention program with JITAI will result in significantly higher physical activity levels compared to the standard web-based physical activity intervention program alone. A secondary objective of this study is to extend existing algorithms that use commercial wearable technology to robustly detect physical activity behaviors to facilitate the delivery of tailored just-in-time actionable feedback and physical activity recommendations for individuals with SCI.",[28],[148,149,150,151,152],"spinal cord injuries","physical activity","wearable sensors","mobile health","just-in-time adaptive intervention","2026-06-19",{"date":74,"type":35},{"date":156,"type":35},"2023-05-25",{"date":158,"type":22},"2027-06-30",{"name":160,"class":42},"Temple University",{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":167,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":43},"100595234","development-of-a-novel-evaluation-scale-of-mental-body-representation-mbr-for-adults-with-spinal-cord-injury-100595234","NCT07029802","Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury","Inclusion Criteria:\n\nControl group\n\n* Uninjured adults (from the contact list with the Brain Body Mind lab or through fliers or StudyFinder)\n* 18+ years old adults\n\nSCI group\n\n* 18+ years old, participants with an incomplete or complete SCI of ≥ 1 year\n* medically stable\n* able to read and understand English\n* having access to the internet\u002FiPad\u002Fcomputer\u002Fphone and willing to come in for an in-person testing at the University of Minnesota.\n\nExclusion Criteria:\n\nSCI group\n\n* Uncontrolled seizure disorder;\n* cognitive impairment and\u002For communicative disability (e.g., due to brain injury) preventing them from following directions or from learning;\n* ventilator dependency;\n* major medical complications;\n* pressure ulcers hindering prolonged sitting or lying down.",true,{"count":169,"type":22},80,"OBSERVATIONAL","The purpose of this study is twofold: (1) Develop a new evaluation scale for mental body representations (MBR, i.e., body awareness and visuospatial body maps) for adults with spinal cord injury (SCI) with and without neuropathic pain. (2) Assess the psychometric properties of usability, reliability, and validity of the new evaluation scale This is a cross-sectional observational study design. For Aim 1, this study will involve initial item generation for a novel MBR evaluation scale for SCI through email communication, and individual interviews proctored remotely through Zoom, or, if preferred by the participant, in-person. For Aim 2, the study will include a Zoom call for consenting and questionnaires, as well as an in-person visit where participants will be tested with the new SCI-BodyMap evaluation scale, and a questionnaire asking about the usability and satisfaction of the new evaluation scale.",[28],"2026-06-16",{"date":175,"type":35},"2026-06-18",{"date":177,"type":35},"2024-11-18",{"date":179,"type":22},"2027-06-15",{"name":181,"class":42},"University of Minnesota",{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":204},"100604267","arc-im-system-to-manage-symptomatic-blood-pressure-instability-secondary-to-chronic-spinal-cord-injury-100604267","NCT07147296","ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury","Empower BP","Inclusion Criteria:\n\n1. Aged 18 years or above, and no older than 75 years at the time of enrollment.\n2. Clinical evidence of Orthostatic Hypotension (blood pressure drop of 20mmHg systolic or 10mmHg diastolic) measured during Head Up Tilt Table assessment (HUTT, within 10 minutes) with current standard of care if any. 2 out of 3 tests must meet OH criteria.\n3. Clinical evidence of sustained hypotension (average systolic Blood pressure ≤ 110 mmHg) when measured each minute for 10 minutes while seated and in the absence of supportive compressive garments and medication.\n4. Evidence of symptomatic hypotension as determined by a non-zero OHSA total score\n5. A Spinal cord injury at the neurologic level between C2 and T6 inclusive.\n6. American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification A, B, C, or D.\n7. Traumatic (non-progressive) chronic spinal cord injury with minimum 12 months post-injury prior to study entry.\n8. Average A-P diameter of the sponal canal ≥ 13 mm, measured on MRI at the disc space at level(s) planned for implantation\n9. Stable medical, physical, and psychological condition as considered by the investigators.\n10. Stable dose of blood pressure medication for 30-days prior to enrollment into the study . Stability will be defined as no changes to medication regimens based on treating physician instructions.\n11. Subjects who are on long-term antihypertensive treatment must discontinue these medications no less than 30 days prior to enrollment in the study. This requirement does not apply to antihypertensive agents administered for the acute management of autonomic dysreflexia (AD)\n12. If the subject requires daily continuous support from a personal caregiver, the presence of a caregiver during the study visits is mandatory.\n13. Willing and able to provide informed consent.\n14. Stated willingness to comply with all study procedures and availability for the duration of the study.\n15. Willing and able to comply with the instructions for use, operate the study devices, and comply with this clinical investigation plan\n\nExclusion Criteria:\n\n1. Subject has an autoimmune etiology of spinal cord dysfunction\u002Finjury.\n2. Subject has diseases and conditions that would increase the morbidity and mortality of the surgical procedures required by the study.\n3. Subject has a history of physiologic hypotension prior to SCI\n4. Subject has a history of unexpected blood pressure instability related to medications\n5. Inability to withhold antiplatelet\u002Fanticoagulation agents perioperatively.\n6. History of myocardial infarction or cerebrovascular event within the past 6 months. or\n7. History of chronic\u002Frecurrent severe cardiac arrythmias (e.g., ventricular tachycardia, ventricular fibrillation, third degree atrioventricular block)\n8. Evidence of clinically significant underlying cardiac conditions on Holter monitoring performed at screening including but not limited to arrhythmias (e.g., atrial fibrillation, ventricular tachycardia),\n9. Evidence of ischemic changes or prolonged QT interval (QTc \\> of 450 ms for males and 470 ms for females) identified on EKG during screening,\n10. Subjects with a known diagnosis of heart failure, including but not limited to New York Heart Association (NYHA) Class I-IV, or with evidence of clinically significant left ventricular dysfunction (ejection fraction \\\u003C 40%) as determined by echocardiogram during screening or within the past 6 months,\n11. Current renal\u002Fkidney, hepatic, or other concomitant disorders deemed severe by the Investigator including those ones that could be linked to severe autonomic dysreflexia.\n12. Requires continuous ventilator support.\n13. Imaging (MRI, CT, X-ray) findings within the last 12 months that contraindicate lead placement\n14. Known allergic reaction to implanted materials\n15. Requires continuous\u002Ffrequent\u002Fany transcutaneous spinal cord stimulation treatment.\n16. Has any active implanted medical device (e.g. baclofen pump, pacemaker).\n17. Inability to receive a pre-operative MRI.\n18. Female subject who is pregnant, breastfeeding or planning to become pregnant or breastfeed. Women of child-bearing potential must have a negative pregnancy test completed at baseline visit per site standard test.\n19. Presence of pressure sore at time of screening or baseline graded stage 3 or 4 .\n20. Subject is enrolled or intends to participate in another clinical drug and\u002For device study or registry that may interfere with the results of this study, as determined by ONWARD Medical personnel.\n21. Presence of other anatomic or comorbid conditions, or other medical, social, or psychologic conditions such as severe uncontrolled neuropathic pain, depression, history of alcohol or substance abuse, history of schizophrenia or psychotic illness, severe personality disorder or other significant psychiatric or cognitive disorders that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements of the clinical investigation.",{"count":190,"type":22},60,[25],"Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (\\>1 year after SCI).\n\nThe primary effectiveness outcome will be evaluated through subject-reported ADFSCI and seated blood pressure assessments at 3 months post-implant.\n\nFollowing a baseline screening period and the surgical implantation of the ARC-IM System, subjects will be randomized with a 2:1 ratio into an active or control arm for 3 months. All the subjects will undergo therapy activation sessions (into either Group 1: active intervention, or Group 2: intervention aimed to mimic the active intervention without the active component) within 21 days of the surgical implant and will then commence independent at-home use of ARC-IM Therapy. At the 3 Month timepoint, after all assessments are conducted, all subjects will transition to the open-label period in order to receive the active version of the ARC-IM System in an open-label fashion. All subjects will undergo therapy programming sessions following Month 3.",[28,194],"Blood Pressure Disorders","2026-06-15",{"date":173,"type":35},{"date":198,"type":35},"2025-10-17",{"date":200,"type":22},"2029-03",{"name":202,"class":203},"ONWARD Medical, Inc.","INDUSTRY",13,{"id":206,"slug":207,"hasResults":12,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":17,"minAge":211,"maxAge":19,"enrollmentInfo":212,"targetDuration":4,"studyType":23,"phases":213,"briefSummary":214,"conditions":215,"keywords":216,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100601385","cuneiform-nucleus-cnf-deep-brain-stimulation-for-gait-facilitation-following-spinal-cord-injury-100601385","NCT07109804","Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury","Inclusion Criteria:\n\n* Male or female subjects between ages of 22-70\n* At least 1 year post SCI\n* Confirmed SCI according to SCI clinician according to clinical history and the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) \u002F American Spinal Injury Association (ASIA) criteria as documented in the American Spinal Injury Association Impairment Scale (AIS) on examination. Other disorders of gait will be excluded by history and a neurological examination.\n* Persons with incomplete injury grades of ASIA C or D who can stand with support and who have some voluntary leg function and a maximum walking capacity of Walking Index for spinal cord injury - level II (WISCI-II) level 9 or less.\n* Injury level T10 and above.\n* Ability to stand with moderate body weight support for at least 5 minutes.\n* Stable medical and physical condition.\n* Able to commit to training\u002Fevaluation sessions over 6 months and for longer periodic follow-up.\n\nExclusion Criteria:\n\n* Individuals with high-moderate to severe depression -Beck Depression Inventory II (BDI II) ≥ 25).\n* Individuals with cognitive impairment indicated by a score of less than 24 on the Folstein Mini-Mental State Examination 2nd ed. (MMSE).\n* Individuals with alcohol use disorder. The Alcohol Use Disorder Identification Test (AUDIT) will be used to measure harmful patterns of alcohol consumption over the past year. A cutoff score of 8 will be used to identify and exclude those with moderate to severe alcohol use behavior.\n* Individuals with substance abuse. The Drug Abuse Screening Test (DAST-10) will be used to identify problematic substance abuse behavior over the past year. A cutoff score of 6 will be used to identify and exclude those with moderate to severe drug use behavior.\n* The presence of major medical co-morbidities and other surgical contra-indications such as coagulopathy as defined by past medical history and abnormal lab work at the investigator\u002Fsurgeon's discretion.\n* Individuals with a Berg Balance score \\\u003C 21.\n* Individuals with a history of traumatic brain injury (TBI), seizures, severe autonomic dysreflexia, dysphagia or osteoporosis.\n* History of prior intracranial surgery or known lesions.\n* Individuals that require diathermy, repetitive transcranial magnetic stimulation, electroconvulsive therapy, or serial brain MRIs.\n* Individuals with non-MRI compatible metallic implants in their head or body, and with metallic implants and other implantable devices in the body that could be affected by DBS.\n* Individuals with active implantable devices anywhere in the body (e.g., cardiac pacemaker, defibrillator, implanted medication pump).\n* Individuals who are pregnant desire to become pregnant during the study.\n* Individuals who are breastfeeding.\n* Individuals with intractable orthostatic hypotension despite treatment.\n* Individuals with a recent history of limb fracture, ligamentous injury, active pressure sores or unstable skin structures (e.g., skin grafts and chest tubes).","22 Years",{"count":117,"type":22},[25],"This is a study about deep brain stimulation (DBS) as an investigational treatment for walking impairment following spinal cord injury (SCI). The purpose of this study is to assess the feasibility and inform on the safety, and efficacy of CnF DBS to improve gait in SCI patients with incomplete injury who cannot effectively walk overground",[28],[98,217],"deep brain stimulation","2026-06-10",{"date":220,"type":35},"2026-06-12",{"date":222,"type":22},"2026-10-30",{"date":224,"type":22},"2027-12-31",{"name":226,"class":42},"University of Miami",2,{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":227},"100400620","assessment-of-the-efficacy-and-safety-of-eess-in-patients-with-incomplete-spinal-cord-injuries-100400620","NCT04496609","Assessment of the Efficacy and Safety of EESS in Patients With Incomplete Spinal Cord Injuries","Assessment of the Efficacy and Safety of Epidural Electrical Stimulation of the Lumbosacral Spinal Cord in the Symptomatic Treatment of Motor, Vesico-sphincter and Genito-sexual Disorders in Patients With Incomplete Spinal Cord Injuries","Parastim","Inclusion Criteria:\n\n* Aged between 18 and 65 years inclusive\n* Male or female\n* Incomplete ASIA B or C spinal cord lesion with level of lesion located above T10 (sensation preserved below level of lesion)\n* Absence of significant motor deficit of the upper limbs or recovered motor deficit (muscular score ≥ 4\u002F5)\n* Patient with spinal cord injury at least 2 years old and considered stable not walking\n* Spinal cord lesion determined by spinal cord MRI (intramedullary hypersignal)\n* Patient who can benefit from an iterative rehabilitation programme\n* Patient with stable health condition with no cardiopulmonary disease\n* Patient with orthopaedic condition compatible with verticality and walking\n* Persistence of adductor reflexes up to L2\n* Patient with no current neuromodulation implant: spinal cord neurostimulator, brain, peripheral nerve or intrathecal treatment\n* Patient with no coagulopathy, cardiac risk factors or other medical risk factors significant for surgery\n* Local anatomical conditions compatible with implantation of the epidural electrode (determined by MRI of the spinal cord)\n* Person who benefits from or is entitled to a social security scheme\n* Having provided signed informed consent\n\nExclusion Criteria:\n\n* Significant cerebral lesion on a previous cerebral MRI\n* Psychiatric or cognitive disorder history (known or detected during the consultation with the psychologist)\n* Protected adult patients\n* Pregnant (determined by a negative pregnancy test) or breastfeeding women\n* Respiratory failure (vital capacity \\\u003C 50%) (surgery in prone position)\n* Repeated urinary infections (≥3 per year)\n* Planned absence that may hinder participation in the study (travelling abroad, relocation, imminent moving)\n* Patients with spasms (PENN scale \\> 2)\n* Cauda equina syndrome\n* Patients presenting with a contraindication to an MRI being carried out: i) pacemaker, ii) non-MRI-compatible heart valve, iii) clips, stents, coils, etc. that are not MRI-compatible, iv) cochlear implant, v) metal foreign body, etc.)\n* Patients presenting with a contraindication to MEPs being carried out (notably wearing of ferromagnetic material, heart stimulator)\n* Patients on oral anticoagulants\n* Patients with botulinic toxin injection\n* Patients with bedsore\n* Undernourished patients (BMI \\\u003C 19)","65 Years",{"count":238,"type":22},14,[25],"Neurological disability caused by traumatic lesions of the spinal cord is a significant challenge for medicine and society. These lesions, leading to sublesional central nervous system dysfunction, include sensorimotor, vesico-sphincter and genito-sexual disorders. To date, there is no treatment that enables spinal cord function to be restored.\n\nPreclinical studies have been able to demonstrate the recovery of locomotor activity with a combination of locomotor training, pharmacological intervention and epidural electrical stimulation of the lumbosacral spinal cord (EESS) in adult rats with spinal cord transection. An American team have recently been able to show that EESS, combined with locomotor training, caused neurological improvement in four paraplegic patients, with electromyographic muscular activation patterns similar to those observed during walking. In fact, these authors also showed an improvement, under stimulation, of the VS and GS functions, but with no detailed documentation.\n\nStarting with a conceptual and preclinical rationale, and with proof of clinical concept demonstrated in several reported cases, we propose a clinical trial with an original cross-over design to validate the hypothesis that EESS combined with training in patients with incomplete spinal cord injuries would, with a good tolerance profile, allow motor, vesico-sphincter (VS) and genito-sexual (GS) disorders to be restored in patients with incomplete spinal cord injuries.",[28],"2026-06-09",{"date":244,"type":35},"2026-06-11",{"date":246,"type":35},"2021-07-12",{"date":248,"type":22},"2029-07-12",{"name":250,"class":42},"Hopital Foch",{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":258,"targetDuration":4,"studyType":23,"phases":260,"briefSummary":261,"conditions":262,"keywords":266,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":43},"100642849","development-of-a-pain-rehabilitation-program-for-chronic-pain-after-sci-100642849","NCT07634796","Development of a Pain Rehabilitation Program for Chronic Pain After SCI","Feasibility of a New Digital Pain Rehabilitation Program for People With SCI","Inclusion Criteria:\n\n* two years since injury\n* Stable pain medication?\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* Alcohol or drug abuse\n* does not understand Swedish",{"count":259,"type":22},32,[25],"Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model. This is, however, not standard care for people with chronic pain after a spinal cord injury (SCI) due to a biomedical focused perspective of SCI and lack of adapted programs.\n\nThe aims of this feasibility study:\n\n1. Develop a new digital pain rehabilitation program, adapted for the needs of people living with an SCI.\n2. To investigate the feasibility and acceptability of a new digital pain rehabilitation program.",[28,263,95,264,265],"Chronic Pain","Interprofessional Team Collaboration","Pain Management",[267,268],"participatory design","feasibility study","2026-06-02",{"date":242,"type":35},{"date":272,"type":22},"2026-10-01",{"date":274,"type":22},"2027-09",{"name":276,"class":42},"Umeå University",{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":19,"enrollmentInfo":284,"targetDuration":4,"studyType":23,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":295,"locationsCount":43},"100637085","dorsal-root-ganglion-stimulation-after-lower-motor-neuron-damage-100637085","NCT07619300","Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage","Pilot Study: Dorsal Root Ganglion Stimulation After Spinal Cord Injury-Related Lower Motor Neuron Damage","Inclusion Criteria:\n\n* Traumatic and non-traumatic spinal cord injury (SCI)\n* ASIA Impairment Scale (AIS) A-D\n* SCI below the tenth thoracic vertebral level\n* Greater than 1 year post-SCI\n* Intact spinal reflexes at or below injury level in 1 or more muscles\n\nExclusion Criteria:\n\n* Currently a prison inmate, or awaiting trial, related to criminal activity\n* Pregnancy at the time of screening for trial enrollment\n* Active, untreated urinary tract infection\n* Unhealed decubitus ulcer\n* Unhealed skeletal fracture\n* Spinal abnormality that may impede percutaneous implantation of spinal electrodes\n* Untreated clinical diagnosis of psychiatric disorder\n* Joint contractures that impede typical range of motion\n* Non-MRI-compatible implanted medical devices\n* Other implanted stimulation devices (e.g., deep brain stimulator, cardiac pacemaker, diaphragmatic pacer, etc.)\n* Active participation in an interventional clinical trial which, based on the research team's assessment, may compromise protocol compliance, safety, and\u002For validity of data collected during this study\n* History of clinically diagnosed cardiopulmonary disorder, such as severe orthostatic hypotension, which may impede participation in rehabilitation activities such as changes in body position such as supine-to-sit-to-stand activities, prolonged standing, or stepping\n* History of frequent and\u002For severe autonomic dysreflexia\n* History of seizure disorder\n* Any illness or condition which, based on the research team's assessment, will compromise with the patient's ability to comply with the protocol, patient safety, or the validity of the data collected during this study",{"count":43,"type":22},[25],"The purpose of this study is to study sensorimotor circuit activity generated in response to temporarily implanted dorsal root ganglion stimulation by recording from muscles of the lower extremities as well as functional outcomes achieved over a 10-day rehabilitation program in an individual with lower motor neuron injury.",[28,288],"Lower Motor Neuron Disease","2026-06-01",{"date":291,"type":35},"2026-06-03",{"date":293,"type":22},"2026-07",{"date":274,"type":22},{"name":296,"class":42},"Peter J. Grahn, Ph.D.",{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":305,"targetDuration":4,"studyType":23,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":227},"100494899","feasibility-of-the-braingate2-neural-interface-system-in-persons-with-tetraplegia-100494899","NCT05724173","Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia","Single Neuron Population Dynamics in Human Speech Motor Cortex for a Speech Prosthesis","BG-Speech-01","Inclusion Criteria:\n\n* Between 18 and 80 years of age.\n* Participants must have a diagnosis of amyotrophic lateral sclerosis (ALS) as verified by a clinical expert in neurologic diseases.\n* Participants with a diagnosis of ALS with anarthria, or severe dysarthria with decline in the preceding four months.\n* Must be within a three-hour drive of the Study site and geographically stable for at least 15 months after enrollment.\n\nExclusion Criteria:\n\n* Visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses\n* Chronic oral or intravenous steroids or immunosuppressive therapy\n* Other serious disease or disorder that could seriously affect ability to participate in the study\n\n(There are additional exclusion criteria)",{"count":306,"type":22},3,[25],"The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.",[310,311,123,28,312,313,314,315],"Anarthria","Dysarthria","Amyotrophic Lateral Sclerosis","Brain Stem Infarctions","Locked in Syndrome","Muscular Dystrophies","2026-05-29",{"date":269,"type":35},{"date":319,"type":35},"2023-10-18",{"date":321,"type":22},"2027-07-31",{"name":133,"class":42},{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":330,"targetDuration":4,"studyType":23,"phases":332,"briefSummary":308,"conditions":333,"keywords":335,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":117},"100126292","braingate2-feasibility-study-of-an-intracortical-neural-interface-system-for-persons-with-tetraplegia-100126292","NCT00912041","BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia","BrainGate2","Inclusion Criteria:\n\n* Clinical diagnosis of spinal cord injury, brainstem stroke, muscular dystrophy, amyotrophic lateral sclerosis or other motor neuron disorders\n* Complete or incomplete tetraplegia (quadriplegia)\n* Must live within a three-hour drive of the Study site\n* (There are additional inclusion criteria)\n\nExclusion Criteria:\n\n* Visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses\n* Chronic oral or intravenous steroids or immunosuppressive therapy\n* Other serious disease or disorder that could seriously affect ability to participate in the study\n* (There are additional exclusion criteria)",{"count":331,"type":22},27,[25],[123,28,312,313,314,334],"Muscular Dystrophy",[336,337,338,339,340,341],"Brain computer interface","Assistive device","Environmental control","Communication device","quadriplegia","tetraplegia","2026-05-28",{"date":289,"type":35},{"date":345,"type":4},"2009-05",{"date":347,"type":22},"2038-12",{"name":133,"class":42},{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":167,"sex":17,"minAge":52,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":23,"phases":357,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":43},"100609119","acute-and-chronic-repercussion-of-spinal-cord-stimulation-after-spinal-cord-injury-100609119","NCT07210411","Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury","Inclusion criteria\n\n* Age 18-50.\n* American Spinal Injury Association Impairment Scale A-D,64 to encompass a representational spectrum of autonomic dysfunction after spinal cord injury.\n* Neurological level of injury, C6-T8, as defined by the International Standards for Neurological Classification of Spinal Cord Injury.64 Incorporating level of injury over this broad range to capture the spectrum of autonomic dysfunction. Individuals with injuries below T8 will not be included to ensure transcutaneous spinal cord stimulation does not occur over the injury\u002Fglial scar, where it may have altered properties. The C6 level was chosen to ensure hand cold pressor stimuli triggers above level sympathetic activation.\n* Time since injury of greater than six months, given early changes in spinal cord connectivity and recovery prior to this.\n* Both individuals with and without currently implanted epidural spinal cord stimulators will be enrolled.\n* Twenty uninjured controls will also be enrolled.\n\nExclusion criteria\n\n* History of clinically diagnosed cardiovascular disease, diabetes, autonomic neuropathies, neurological disorders (with exception of spinal cord injury for individuals in those cohorts), or are active smokers.\n* Individuals who are taking betablockers, antihypertensives, or other sympathetically active medications which they are unable to hold.\n* Women who are pregnant or lactating, given known hormonal influences on autonomic regulation.65,66\n* Cognitive issues preventing informed consent for participation.\n* Body mass index \\>30 kg\u002Fm2 for the uninjured controls only given increased risk of prediabetes and potential confounding normative values.\n* taking or being administered a medication known to potentially have adverse interactions with phenylephrine\n* in the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results","50 Years",{"count":169,"type":22},[25],"The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \\& cardiovascular function in participants with spinal cord injury.",[28],"2026-05-26",{"date":342,"type":35},{"date":363,"type":35},"2026-03-05",{"date":365,"type":22},"2031-04-01",{"name":367,"class":42},"Mayo Clinic",{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":374,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":43},"100609121","longitudinal-autonomic-characterization-as-a-predictor-for-secondary-medical-complications-post-sci-100609121","NCT07210437","Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI","Inclusion criteria\n\n* 18-75 years old\n* Spinal cord injury with neurological level of injury from C6-T12\n* ASIA Impairment Scale A-D.\n* Either acute SCI \\\u003C3 months prior (n=10) or chronic SCI (\\>1 year since injury, n=8).\n\nExclusion criteria\n\n* Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment);\n* Women who are pregnant or lactating\n* Taking or being administered a medication known to potentially have adverse interactions with phenylephrine\n* In the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.",{"count":375,"type":22},18,[25],"The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.",[28],{"date":342,"type":35},{"date":381,"type":35},"2026-01-31",{"date":383,"type":22},"2028-06-01",{"name":367,"class":42},{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":167,"sex":17,"minAge":52,"maxAge":355,"enrollmentInfo":391,"targetDuration":4,"studyType":23,"phases":393,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":398,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":43},"100400372","deciphering-preserved-autonomic-function-after-spinal-cord-injury-100400372","NCT04493372","Deciphering Preserved Autonomic Function After Spinal Cord Injury","Inclusion Criteria:\n\nAll subjects\n\n\\- age 18-50 years old.\n\nParticipants with spinal cord injury\n\n* Adult onset, traumatic spinal cord injury.\n* American Spinal Injury Association Impairment Scale, A-D, to encompass a spectrum of autonomic dysfunction after spinal cord injury.\n* Neurological level of injury, C1-T12, as defined by the International Standards for Neurological Classification of Spinal Cord Injury. Incorporating level of injury down to T12 to encompass a broad range of autonomic dysfunction.\n\nExclusion Criteria:\n\n* History of cardiovascular disease, hypertension, neurologic disorders (with exception of spinal cord injury), or diabetes.\n* Women who are pregnant or lactating.\n* Currently taking blood thinners.\n* Pacemaker, implanted defibrillator, or intrathecal pump incompatible with MRI scanning.\n* Cognitive issues preventing informed consent for participation.\n* Body mass index \\>30 kg\u002Fm2 for controls, in an effort to limit effects of early cardiovascular disease and diabetes in control population. Body mass index has not proven to be a good estimate of these factors following spinal cord injury.",{"count":392,"type":22},69,[25],"This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically suffer. Focusing on blood pressure regulation, the most precise metric with broad clinical applicability, the investigators will perform laboratory-based tests to probe the body's ability to generate autonomic responses. For both individuals with spinal cord injury and uninjured controls, laboratory-based experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate signals. The investigators anticipate that those with autonomic dysfunction after spinal cord injury will exhibit abnormalities in these precise metrics. The investigators will further have research participants wear a smart watch that tracks skin electrical conductance, heart rate, and skin temperature, which can all provide clues as to the degree of autonomic dysfunction someone may suffer at home. The investigators will look to see if any substantial connections exist between different degrees of preserved autonomic function and secondary autonomic complications from spinal cord injury. In accomplishing this, the investigators hope to give scientists important insights to how the autonomic nervous system works after spinal cord injury and give physicians better tools to manage these secondary autonomic complications.",[28,396,397,60],"Autonomic Imbalance","Autonomic Dysreflexia",{"date":342,"type":35},{"date":400,"type":35},"2020-11-13",{"date":402,"type":22},"2026-09-08",{"name":367,"class":42},{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":167,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":410,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":412,"conditions":413,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":43},"100550146","pain-phenotyping-in-patients-with-neuropathic-pain-after-spinal-cord-injury-100550146","NCT06443281","Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury","Inclusion Criteria:\n\n* Spinal injury cohort - general inclusion criteria:\n* Aged between 18-80 years\n* Traumatic and non-traumatic etiology\n* Para- and tetraplegic SCI\n* Complete and incomplete SCI\n* SCI with and without neuropathic pain\n* Additional inclusion criteria for longitudinal study:\n* SCI since less than one month\n* Additional inclusion criteria for cross-sectional study:\n* SCI since more than one year\n* Control cohorts with peripheral neuropathy:\n* General inclusion criteria:\n* Aged between 18-80 years\n* Neurological disorder affecting the peripheral nervous system (i.e., peripheral neuropathy)\n* Peripheral neuropathy with or without neuropathic pain\n* Additional inclusion criteria for longitudinal study:\n* Peripheral neuropathy since less than one month\n* Additional inclusion criteria for cross-sectional study:\n* Peripheral neuropathy since more than one year\n* Control cohorts without neuropathy \u002F healthy volunteers\n* General inclusion criteria:\n* Aged between 18-80 years\n* No medical condition affecting the peripheral and\u002For central nervous system (e.g., pain, systemic disease, psychological disorder)\n\nExclusion Criteria:\n\n* Inability to follow study instructions\n* Pregnancy\n* Medically manifested psychological disorder\n* Medical condition affecting the peripheral and\u002For central nervous system other than the desired experimental condition (e.g., additional peripheral neuropathy in the SCI cohort)",{"count":411,"type":22},300,"The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain after SCI. The functionality of the nociceptive pathway in humans as well as its plastic changes following SCI will be inferred with sophisticated sensory and pain phenotyping using quantitative sensory testing (i.e., psychophysical measures), objective neurophysiological measures of pain processing and the recording of pain-related autonomic responses (i.e., galvanic skin response, cardiovascular measures and pupil dilation). In addition, the interplay between the somatosensory and autonomic nervous system and its association with the development and maintenance of neuropathic pain after SCI will be investigated.",[28,414,415,416],"Pain, Neuropathic","Nociceptive Pain","Neuropathy","2026-05-12",{"date":419,"type":35},"2026-05-15",{"date":421,"type":35},"2024-04-17",{"date":423,"type":22},"2030-04-30",{"name":425,"class":42},"University of Zurich",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":433,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":436,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":43},"100488777","nomad-p-kafo-study-100488777","NCT05644522","Nomad P-KAFO Study","Power Forward Study: A Cross-Sector, Multisite Clinical Trial of a Powered Knee-Ankle-Foot Orthosis","Inclusion Criteria:\n\n* Regular and compliant use of a unilateral or bilateral KAFO or SCO or other passive KAFOs for impairment due to neurological or neuromuscular disease, orthopedic disease, or trauma\n* Cognitive ability to understand and follow the study protocol; willingness to provide informed consent\n* Willing to wear and charge an activity monitor for three-months home trials.\n\nExclusion Criteria:\n\n* Flexion contracture in the knee and\u002For hip joint in excess of 15 degrees\n* Non-correctable knee varus\u002Fvalgus in excess of 15 degrees\n* Severe spasticity\n* Inability to stabilize the trunk with or without assistive devices (crutches, canes, etc.)","89 Years",{"count":435,"type":22},36,[25],"The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobility, balance, frequency of falls, and quality of life in individuals with lower-extremity impairments compared to their own brace, over three months of daily home and community use.\n\nParticipants will:\n\n* Wear a sensor that records everyday activities and mobility.\n* Perform measures of mobility and different activities of participation using their own brace.\n* Perform measures of mobility and different activities of participation using the Nomad powered KAFO",[439,440,28,441,334,442],"Cerebrovascular Accident","Post-polio Syndrome","Multiple Sclerosis","Paralysis","2026-05-07",{"date":445,"type":35},"2026-05-11",{"date":447,"type":35},"2024-03-01",{"date":449,"type":22},"2027-12",{"name":451,"class":42},"Shirley Ryan AbilityLab",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":4,"eligibilityCriteria":458,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":459,"targetDuration":4,"studyType":23,"phases":461,"briefSummary":462,"conditions":463,"keywords":464,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":467,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":43},"100471845","improving-adherence-to-spinal-cord-injury-exercise-guidelines-using-smartphone-technology-and-e-coaching-100471845","NCT05424172","Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching","Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study","Inclusion Criteria: Phase 1\n\n* Individual with diagnosis of SCI, formal or informal caregiver of an individual with an SCI, or clinician that regularly sees individuals with SCI\n* 18-80 years of age\n* English-speaking\n* Willing to download the study apps\n\nExclusion Criteria: Phase 1\n\n* Severe visual or cognitive problems that would affect the ability to complete the study\n* Does not own, or is unable to use a smartphone\n\nInclusion Criteria: Phase 2 and 3\n\n* Individual with diagnosis of SCI, complete (only paraplegia) or incomplete, cervical C3- C4 and below\n* 18-80 years of age\n* English-speaking\n* Use a wheelchair as primary means of mobility or walk with or without assistive equipment\n* At least 1-year post-SCI\n* Not adhering to SCI-specific exercise guidelines as ascertained by self-report or during structured phone interview\n* Interested in increasing exercise levels\n* Ownership of a smartphone that can be used for the study and has a data plan\n* Willing to successfully download and learn to use the study apps\n* Able and willing to give written consent and comply with study procedures, including multiple in person follow-up visits\n\nExclusion Criteria: Phase 2 and 3\n\n* Trauma or surgery in the past three months\n* An active stage 3 or 4 pressure ulcer\n* Medically unstable to perform the home-based exercise as determined by Dr. Chen and his team, the evaluating physical therapist, or the participants' primary care physician.\n* Unable to use at least one set of extremities to exercise\n* Enrolled in a structured exercise program over the past three months\n* Severe visual or cognitive problems that would affect the ability to complete the study\n* Does not own, or is unable to use a smartphone",{"count":460,"type":22},50,[25],"The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding health apps preferences for optimal consumer use, (2) conducting a usability study of the customized app to determine the quality and implement further changes for optimization, and (3) conducting a sequential multiple assignment randomized trial (SMART) to determine the most effective adaptive intervention to improve exercise adherence. A SMART trial will be used to determine when and how to adapt dosage, timing, and delivery to increase adherence and address low-response behaviors. In Stage-I, the investigators will compare outcomes among participants using a generic, non-interactive exercise app (Group 1) to a customized, interactive app that can gain information through frequent Ecological Momentary Assessments (EMA) that will be used to modify each participant's exercise programs (Group 2). After 12 weeks, participants who are not meeting the exercise guidelines at least 50% of the time will also be asked to participate in motivational interviewing-based e-coaching either two or four times per month in addition to their originally assigned intervention (Stage-II). By completing these three phases, this project addresses deficiencies in exercise levels and compliance by implementing an individualized exercise prescription, an adaptive intervention for low responders, a way to address barriers to exercise, and a free smartphone app for broad implementation.",[28],[465,466],"Exercise","Telemedicine",{"date":445,"type":35},{"date":469,"type":35},"2022-11-02",{"date":471,"type":22},"2026-08-31",{"name":451,"class":42},{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":479,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":23,"phases":483,"briefSummary":485,"conditions":486,"keywords":490,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":503,"locationsCount":227},"100559091","phase-1-bacteriophage-therapy-in-spinal-cord-injury-patients-with-bacteriuria-100559091","NCT06559618","Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria","A Phase 1B Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria","Phage","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study.\n3. Adult (\\> age 18) with a diagnosis of Spinal Cord Injury\u002FDisease (SCI\u002FD) and neurogenic bladder. Eligible participants may include inpatients in the SCI care unit or outpatients receiving care at participating sites, regardless of the underlying cause of SCI (e.g., trauma, tumors or demyelinating).\n4. ASB with E. coli present in a quantity of ≥ 104 CFU\u002FmL.\n5. Require an indwelling (transurethral or suprapubic) or intermittent catheterization for bladder drainage.\n6. Women of childbearing potential and men with female partners of childbearing potential must use two forms of effective contraception during the study and for two weeks afterwards.\n7. Participant will be hospitalized during the 7 days of treatment or will be willing to attend clinic visits either (a) daily for the 7 days of treatment, or (b) on Day 1 and Day 7 of dosing. On Day 1, the participant will receive in-person training on instillation of the IP into the bladder.\n\nExclusion Criteria:\n\n1. Unable to provide informed consent for themselves.\n2. Received a new antibiotic expected to kill the Gram-negative organisms in the urine between initial enrollment urine culture and the time of randomization.\n3. History of neutropenia, defined by ANC \\\u003C 1000 per µL within 6 months prior to screening.\n4. History of organ transplantation.\n5. Presence of a surgically modified bladder, except for a repaired ruptured bladder.\n6. HIV with a CD4 count \\\u003C 200 cells per µL.\n7. Unstable vital signs (e.g., fever, hypotension)\n8. Symptoms of active urinary tract infection defined as fever, autonomic dysreflexia, generalized increase in spasticity, bladder spasms, new sweating, increase or change in lower abdominal pain, increase in burning or pain when passing urine, increase in burning or pain during catheterization, blood in the urine, or an increased sensation of urinary urgency (MedStar Health, Urinary Symptom Questionnaires for Neurogenic Bladder \\[USQNB\\]). The presence of any one of these symptoms, unless explained by a non-urinary or non-infectious condition, will be an exclusion criterion.\n9. Known urinary obstruction.\n10. Medical devices in the urinary tract (other than urinary catheters)\n11. Unless deemed acceptable by the sponsor-investigator, prescription drugs, OTC medications and supplements that acidify the urine are excluded.\n12. Stage 4 or greater chronic kidney disease\n13. Pregnant or breastfeeding female\n14. Three or more episodes of autonomic dysreflexia in prior 30 days; defined as those patients who have a SCI and who have had a documented sudden increase in systolic blood pressure of greater than 40 mmHg due to an irritation or stimulation (including bladder or bowel irritation) below the level of the SCI. Autonomic dysreflexia can include findings of hypertensive crisis or emergency, clinically significant bradycardia\u002Ftachycardia, severe headache or other severe reaction requiring an acute intervention. The sponsor-investigator will evaluate if a history of severe autonomic dysreflexia is suspected but not clearly identified.\n15. In the opinion of the sponsor-investigator, medical or psychiatric illness that would interfere with participation such as active, severe, progressive, or uncontrolled hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, or neurologic disease.",{"count":482,"type":22},30,[484],"PHASE1","This is a Phase 1b study to assess the safety, tolerability, PK, and PD of investigational phage therapy (IP) in adults with SCI and bladder colonization (ASB). It is a single-center, randomized, double-blind, placebo-controlled study in adults with SCI with neurogenic bladders and bacteriuria who use indwelling catheters, or who require intermittent catheterization for bladder drainage.",[487,28,488,489],"Bacteriuria","Asymptomatic Bacteriuria","Escherichia Coli",[491,487,492,98,493,494,495,496],"Bacteriophage","Phage Therapy","Intravesicular infusion","Neurogenic Bladder","Intermittent catheterization","Randomized clinical trial","2026-05-01",{"date":499,"type":35},"2026-05-05",{"date":501,"type":35},"2025-02-03",{"date":80,"type":22},{"name":504,"class":42},"Barbara Trautner",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":236,"enrollmentInfo":512,"targetDuration":4,"studyType":23,"phases":514,"briefSummary":515,"conditions":516,"keywords":517,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":43},"100540182","transcutaneous-spinal-cord-stimulation-combined-with-arm-bike-for-cardiovascular-recovery-in-sci-100540182","NCT06313515","Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI","Transcutaneous Spinal Cord Stimulation Combined With Arm Crank Exercise for Cardiovascular Recovery in Cervical and Upper Thoracic SCI","Inclusion Criteria:\n\n* Are between 21-65 years of age.\n* Chronic SCI (non-progressive, with complete motor paralysis) at or above the T6 spinal cord segment.\n* Greater than ten months post injury or diagnosis, at least 6 months from any spinal surgery.\n* American Spinal Injury Association Impairment Scale (AIS) A, B for SCI.\n* Have stable medical condition without cardiopulmonary disease that would contraindicate participation in intensive training or testing activities.\n* Cleared for strenuous exercise with arm bike by a primary physician of the subject (the clearance for intensive training with arm bike is obtained verbally or through a written form by a primary physician.)\n* Willing and able to comply with all clinic visits and study-related procedures.\n* Able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator).\n* Have no painful musculoskeletal dysfunction, unhealed fracture, pressure sore, or active infection that may interfere with testing.\n* Are with stable management of spinal cord related clinical issues (i.e., spasticity management).\n* Women of childbearing potential must not be intending to become pregnant, currently pregnant, or lactating. The following conditions apply:\n\n  -----Women of childbearing potential must agree to use adequate contraception during the period of the trial and for at least 28 days after completion of treatment. Effective contraception includes abstinence.\n* Sexually active males with female partners of childbearing potential must agree to use effective contraception during the period of the trial and for at least 28 days after completion of treatment.\n* Are volunteering to be involved in this study.\n* Has adequate social support to be able to participate in training and assessment sessions, up to 3 sessions per week, for the duration of up to 6 months within the study period.\n* Must provide informed consent.\n\nExclusion Criteria:\n\n* Have autoimmune etiology of spinal cord dysfunction\u002Finjury\n* Have history of additional neurologic disease, such as stroke, MS, traumatic brain injury, etc.\n* Have peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.)\n* Have rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.)\n* Are ventilator dependent.\n* Have clinically significant, unmanaged, depression, ongoing alcohol and\u002For drug abuse.\n* Use any medication or treatment that in the opinion of the investigators indicates that it is not in the best interest of the participant to participate in this study.\n* Have Intrathecal baclofen pump.\n* Have cardiovascular, respiratory, bladder, or renal disease unrelated to SCI or presence of hydronephrosis or presence of obstructive renal stones.\n* Have severe acute medical issue that in the investigators' judgement would adversely affect the participant's participation in the study. Examples include, but are not limited to acute urinary tract infections, active heterotopic ossification, newly changed antidepressant medications \\[tricyclics\\], debilitating muscle pain, pressure sores, or unstable diabetes.\n* Have pacemakers, stimulators, medication pumps in the trunk, deep brain stimulators, metallic devices in the head such as aneurysm clips\u002Fcoils and stents, vagus nerve stimulators.\n* Take more than 40 mg of Baclofen per day\n* Have severe anemia (Hgb\\\u003C8 g\u002Fdl or Hgb,80 g\u002FL) or hypovolemia as measured by hematocrit via blood test in the last six months.\n* Are a member of the investigational team or his\u002Fher immediate family.\n* Have undergone electrode implantation surgery.\n* Have signs of lower motor neuron impairment (i.e., concomitant conus medullaris\u002Fcauda equina injury).\n* Have history of severe allergy (i.e. allergic reaction that could not be treated with antihistaminic medication)\n* Have malabsorption syndrome, primary hyperthyroidism, and\u002For hypogonadism.\n* Have a history of seizures.\n* Have chronic headaches or migraines.",{"count":513,"type":22},16,[25],"Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities. The goal of this randomized trial is to test combinatory therapy of moderate arm-crank exercise paired with non-invasive transcutaneous spinal cord stimulation (tSCS) for cardiovascular recovery in adults aged 21-65 following chronic motor-complete spinal cord injury (SCI) at or above the thoracic sixth spinal segment (≥T6).\n\nThe main questions the study aims to answer are:\n\n* Conduct tSCS mapping to determine the most effective location and stimulation intensity for BP control in individuals with motor-complete SCI ≥ T6.\n* Evaluate the effects 8 weeks of targeted tSCS paired with arm-crank exercise compared to sham stimulation with exercise on improving cardiovascular function in individuals with motor-complete SCI ≥T6.\n* Evaluate the dosage-response of 8 weeks vs. 16 weeks of targeted tSCS paired with arm-crank exercise on cardiovascular function in individuals with motor-complete SCI ≥T6.\n* Explore the mechanisms involved in cardiovascular recovery with long-term tSCS paired with arm-crank exercise.\n\nParticipants will:\n\n* Receive either transcutaneous spinal cord stimulation or \"sham\" spinal cord stimulation while exercising on an arm-crank bicycle in the first 8 weeks.\n* Come in for approximately 60 visits over a 6-month period. This includes 2, 8-week periods where the investigators will ask participants to come in 3x per week for spinal cord stimulation and exercise.\n* During assessment visits the researchers will perform a variety of exams including a neurologic, cardiovascular, pulmonary, physical, and autonomic exam, and will ask questions about quality of life and functioning. Assessment procedures also include stool sample and nasal swab collection.\n\nResearchers will compare those who receive tSCS and do moderate arm-crank exercise to those who receive a sham stimulation and do moderate arm-crank exercise to see if tSCS is effective at improving cardiovascular and autonomic functioning in those with SCI.",[28],[518,519,520],"Transcutaneous Spinal Cord Stimulation","Arm-Bike Exercise","Cardiovascular Function","2026-04-29",{"date":523,"type":35},"2026-05-06",{"date":525,"type":35},"2024-04-01",{"date":527,"type":22},"2027-02-01",{"name":529,"class":42},"University of Washington",{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":536,"eligibilityCriteria":537,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":236,"enrollmentInfo":538,"targetDuration":4,"studyType":23,"phases":539,"briefSummary":540,"conditions":541,"keywords":542,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":43},"100430037","locomotor-and-bladder-function-in-individuals-with-acute-spinal-cord-injury-100430037","NCT04879862","Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury","Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury","MC-PP-3","Inclusion Criteria:\n\n1. At least 18 years of age\n2. non-progressive SCI\n3. stable medical condition\n4. Inability to stand and step independently\n5. unable to voluntarily move all individual joints of the legs\n6. no current anti-spasticity medication regimen\n7. must not have received botox injections in the prior six months\n8. Bladder dysfunction as a result of SCI\n9. SCI between T1 and T10\n10. no greater than 1 year post injury\n\nExclusion Criteria:\n\n1. ventilator dependent\n2. untreated painful musculoskeletal dysfunction, fracture or pressure sore\n3. untreated psychiatric disorder or ongoing drug abuse\n4. cardiovascular, respiratory, bladder, or renal disease unrelated to SCI\n5. pregnant at the time of enrollment or planning to become pregnant during the time course of the study.",{"count":513,"type":22},[25],"The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epidural stimulation may be a method for improving stepping, standing and bladder function in individuals with spinal cord injury. With the use of epidural stimulation, the investigators propose to investigate how well the participant can stand and walk and how well the participant's bladder can store or hold urine as well as void or empty urine. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries that are unable to stand or walk and have impaired bladder function.",[28],[543,544,545],"locomotion","epidural stimulation","bladder function","2026-04-28",{"date":548,"type":35},"2026-05-04",{"date":550,"type":35},"2022-04-04",{"date":552,"type":22},"2029-04-28",{"name":554,"class":42},"Claudia Angeli",{"id":556,"slug":557,"hasResults":12,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":167,"sex":17,"minAge":52,"maxAge":115,"enrollmentInfo":562,"targetDuration":4,"studyType":23,"phases":564,"briefSummary":565,"conditions":566,"keywords":574,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":589,"locationsCount":43},"100453331","non-invasive-bci-controlled-assistive-devices-100453331","NCT05183152","Non-invasive BCI-controlled Assistive Devices","Non-invasive Brain-computer Interfaces for Control of Assistive Devices","Inclusion Criteria:\n\n1. Able-bodied participants:\n\n   * good general health\n   * normal or corrected vision\n   * no history of neurological\u002Fpsychiatric disease\n   * ability to read and understand English (Research Personnel do not speak Spanish)\n2. Subjects with motor disabilities\n\n   * motor deficits due to: unilateral and bilateral stroke \u002F spinal cord injury \u002F motor neuron diseases (i.e. amyotrophic lateral sclerosis, spino-cerebellar ataxia, multiple sclerosis) \u002F muscular diseases (i.e. myopathy) \u002F traumatic or neurological pain \u002F movement disorders (i.e. cerebral palsy) \u002F orthopedic \u002F traumatic brain injury \u002F brain tumors\n   * normal or corrected vision\n   * ability to read and understand English\n   * ability to provide informed consent\n\nExclusion Criteria:\n\n1. Subjects with motor disabilities\n\n   * short attentional spans or cognitive deficits that prevent the subject from concentrating during the whole experimental session\n   * heavy medication affecting the central nervous system (including vigilance)\n   * concomitant serious illness (e.g., metabolic disorders)\n2. All participants\n\n   * factors hindering EEG\u002FEMG acquisition and the delivery of non-invasive electrical stimulation (e.g., skin infection, wounds, dermatitis, metal implants under electrodes)\n   * criteria identified in safety guidelines for MRI and TMS, in particular metallic implants",{"count":563,"type":22},100,[25],"Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement without actually performing it. Brain-computer interfaces (BCIs) can decode SMRs to control assistive devices and promote functional recovery. Despite rapid advancements in non-invasive BCI systems based on EEG, two persistent challenges remain: First, the instability of SMR patterns due to the non-stationarity of neural signals, which may significantly degrade BCI performance over days and hamper the effectiveness of BCI-based rehabilitation. Second, differentiating MI patterns corresponding to fine hand movements of the same limb is still difficult due to the low spatial resolution of EEG. To address the first challenge, subjects usually learn to elicit reliable SMR and improve BCI control through longitudinal training, so a fundamental question is how to accelerate subject training building upon the SMR neurophysiology. In this study, the investigators hypothesize that conditioning the brain with transcutaneous electrical spinal stimulation, which reportedly induces cortical inhibition, would constrain the neural dynamics and promote focal and strong SMR modulations in subsequent MI-based BCI training sessions - leading to accelerated BCI training. To address the second challenge, the investigators hypothesize that neuromuscular electrical stimulation (NMES) applied contingent to the voluntary activation of the primary motor cortex through MI can help differentiate patterns of activity associated with different hand movements of the same limb by consistently recruiting the separate neural pathways associated with each of the movements within a closed-loop BCI setup. The investigators study the neuroplastic changes associated with training with the two stimulation modalities.",[567,568,28,569,570,571,572,573,441],"Motor Disorders","Healthy","Muscular Diseases","Motor Neuron Disease","Stroke","Traumatic Brain Injury","Movement Disorders",[575,576,577,578,579,580,581,582],"motor deficits","able-bodied, healthy","unilateral and bilateral stroke","spinal cord injury","motor neuron diseases","muscular diseases (i.e. myopathy)","traumatic or neurological pain","movement disorders","2026-04-27",{"date":497,"type":35},{"date":586,"type":35},"2021-06-16",{"date":588,"type":22},"2028-12-30",{"name":590,"class":42},"University of Texas at Austin",{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":236,"enrollmentInfo":598,"targetDuration":4,"studyType":23,"phases":599,"briefSummary":600,"conditions":601,"keywords":602,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":43},"100583909","diet-and-exercise-solutions-to-postprandial-hypotension-100583909","NCT06882460","Diet and Exercise Solutions to Postprandial Hypotension","Lifestyle Solutions to Postprandial Hypotension in Spinal Cord Injury","Inclusion Criteria:\n\n* Spinal cord injury (SCI) between C4 and T12 who require use of wheelchair for daily mobility\n* AIS A or B\n* \\>1-year post-injury\n\nExclusion Criteria:\n\n* Currently pregnant of breast-feeding\n* Type 1 or 2 diabetes\n* Previous gut augmentation bariatric surgery\n* Neurological impairment other than SCI\n* History of uncontrolled autonomic dysreflexia\n* History of bone fractures\n* Use of abdominal binder or anti-hypotensive drugs\n* Fitted with pacemaker or defibrillator\n* Currently receiving electrical stimulation training or in the previous year",{"count":204,"type":22},[25],"The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.",[28],[603,604,605],"postprandial hypotension","electrical stimulation","low-glycemic diet","2026-04-22",{"date":583,"type":35},{"date":609,"type":35},"2025-05-15",{"date":611,"type":22},"2026-12-01",{"name":613,"class":42},"Ohio State University",{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":618,"acronym":619,"eligibilityCriteria":620,"healthyVolunteers":12,"sex":17,"minAge":621,"maxAge":115,"enrollmentInfo":622,"targetDuration":4,"studyType":23,"phases":624,"briefSummary":625,"conditions":626,"keywords":627,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":637,"locationsCount":4},"100488110","phase-2-no-ad-use-of-nitric-oxide-no-donors-for-the-prevention-of-autonomic-dysreflexia-ad-during-bowel-care-following-sci-100488110","NCT05635851","NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI","NO AD","Inclusion Criteria:\n\n* participants must have had a traumatic spinal cord injury at least one year ago\n* regular bowel care routine\n* can communicate in English\n\nExclusion Criteria:\n\n* cauda equina or conus lesions\n* currently use ventilator\n* colostomy, or do not perform regular bowel care\n* skin breakdown (pressure sores)\n* cannot communicate in English\n* under 19 years old\n* possibly or certainly pregnant\n* medical\u002Fpsychiatric condition or substance abuse that is likely to affect ability to complete study\n* currently using medications containing PDE-5 inhibitors\n* currently using medications containing GTN\n* allergy to GTN","19 Years",{"count":623,"type":22},26,[144],"This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.",[28,397],[578,628,71,629,630],"autonomic dysreflexia","bowel care management","defecation",{"date":632,"type":35},"2026-04-23",{"date":634,"type":22},"2026-12",{"date":636,"type":22},"2028-02",{"name":638,"class":42},"Simon Fraser University"]