[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injury-at-c5-c7-level\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injury-at-c5-c7-level":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,80,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100488290","nerve-transfer-surgery-to-restore-upper-limb-function-after-cervical-spinal-cord-injury-100488290",false,"NCT05638191","Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Traumatic, motor-complete cervical SCI (AIS A or B)\n* Male or female, ages 18-70\n* Consent and plan to undergo nerve transfer to restore grasp function in at least one limb\n* Motor grade 4-5 at C5\n* Motor grade 0-1 at C8\u002FT1\n* Injury duration within 6 months at the time of surgery\n* English-speaking and cognitively intact\n* Able to provide informed written consent\n* Able to attend and comply with the testing protocols\n\nExclusion Criteria:\n\n* Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual)\n* Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation","ALL","18 Years","70 Years",{"count":19,"type":20},40,"ESTIMATED","2 Years","OBSERVATIONAL","The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are:\n\n* Does nerve transfer improve hand function in individuals with cervical spinal cord injury?\n* What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery to 1) baseline outcomes and 2) individuals with cervical spinal cord injury who did not undergo nerve transfer.\n\nParticipants who have received nerve transfer surgery as part of their regular medical care will complete functional hand tests, electrodiagnostic assessments, and questionnaires on independence and mood every 3 months for 24 months after surgery.",[25,26,27,28,29,30,31,32],"Spinal Cord Injury","Spinal Cord Injury at C5-C7 Level","SCI - Spinal Cord Injury","Upper Extremity Paralysis","Upper Extremity Dysfunction","Tetraplegia","Upper Extremity Paresis","Cervical Spinal Cord Injury",[34,35,36,37,38,39,40],"spinal cord injury","upper extremity nerve transfer","nerve transfer","SCI","nerve reconstruction","quadriplegia","paresis","RECRUITING","2026-05-27",{"date":44,"type":45},"2026-05-29","ACTUAL",{"date":47,"type":45},"2021-06-03",{"date":49,"type":20},"2028-01",{"name":51,"class":52},"University of British Columbia","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":15,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100505620","grasp-release-assessment-of-a-networked-neuroprosthesis-device-100505620","NCT05863754","Grasp-Release Assessment of a Networked Neuroprosthesis Device","GRANND","Inclusion Criteria:\n\n* Male or female, age \\> 16 years.\n* Cervical level spinal cord injury, as defined by:\n\n  1. International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor level of C1 through C7 and\n  2. American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, or C;\n* Six months or more post-injury (neurostability);\n* Neurologically stable following any nerve transfers affecting the upper extremity (typically, one year post surgery);\n* Musculoskeletally and neurologically stable following any tendon transfers affecting the upper extremity (typically, 6-months).\n* Peripheral nerve innervation to upper extremity muscles, including a grade 3\u002F5 or higher Stimulated Manual Muscle Test (SMMT) strength in at least two of the following muscles in one arm:\n\n  1. Adductor Pollicus, Abductor Pollicus Brevis (AbPB), Flexor Pollicus Longus (FPL), Extensor Pollicus Longus (EPL)\u002FExtensor Pollicus Brevis (EPB), Extensor Digitorum Communis (EDC), Flexor Digitorum Superficialis (FDS), Flexor Digitorum Profundus (FDP), Pronator Quadratus (PQ), Extensor Carpi Ulnaris (ECU), Extensor Carpi Radialis Brevis (ECRB), Extensor Carpi Radialis Longus (ECRL), Flexor Carpi Ulnaris (FCU), Flexor Carpi Radialis (FCR), First Dorsal Interosseous(1DI), triceps,\n  2. At least two of the grade 3\u002F5 or higher excitable muscles must also have grade 2\u002F5 or lower voluntary strength;\n* Good proximal upper extremity strength as defined by biceps\u002Fbrachialis\u002Fbrachioradialis strength of 2\u002F5 or higher on Manual Muscle Test on the side intended for implantation;\n* Medically stable;\n* Able to understand and provide informed consent.\n\nExclusion Criteria:\n\n* Other neurological conditions (MS(multiple Sclerosis), diabetes with peripheral nerve involvement); Associated peripheral nerve \u002F brachial plexus injury\n* Progressive SCI;\n* Co-existing cervical spine pathology (syrinx, unstable segment)\n* Active implantable medical device (AIMD) such as a pacemaker or defibrillator;\n* Active untreated infection such as pressure injury, urinary tract infection, pneumonia;\n* History of coagulopathy, HIV, cardiopulmonary disease, bradycardia, poorly controlled autonomic dysreflexia, or chronic obstructive pulmonary disease that would preclude safe participation in the trial as determined by the investigator;\n* Unhealed fractures that prevent functional use of arm;\n* Extensive upper extremity denervation (fewer than two excitable hand muscles);\n* Involvement in other ongoing clinical studies that exclude concurrent involvement in this study;\n* Disorder or condition that requires MRI monitoring;\n* Mechanical ventilator dependency;\n* Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant);\n* Presence of disease that might interfere with participant safety, compliance, or evaluation of the condition under study;\n* Other significant medical findings that, in the opinion of the investigator, preclude safe participation in the trial.","16 Years",{"count":62,"type":20},13,"INTERVENTIONAL",[65],"NA","The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.",[26,68,69],"Spinal Cord Injuries","Spinal Cord Injury Cervical","2025-12-17",{"date":72,"type":45},"2025-12-19",{"date":74,"type":45},"2022-01-23",{"date":76,"type":20},"2028-12-01",{"name":78,"class":52},"MetroHealth Medical Center",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":15,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":63,"phases":90,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":109,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":79},"100234426","multi-functional-neuroprosthetic-system-for-restoration-of-motor-function-in-spinal-cord-injury-100234426","NCT02329652","Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury","NNP-UE+T","Inclusion Criteria:\n\n* Diagnosis of cervical level spinal cord injury, either complete or incomplete; International Standards for Neurological Classification of Spinal Cord Injury (INCSCI) motor level of C4 through C8; American Spinal Injury Impairment Scale (AIS) grade A, B, C, or D; six months or more post-injury\n* Biceps\u002Fbrachialis\u002Fbrachioradialis strength of 2\u002F5 or higher on Manual Muscle Test\n* Peripheral nerve innervation to upper extremity and trunk muscles, including a grade 3\u002F5 or higher stimulated strength (Manual Muscle Test) in at least two of the following muscles in one arm: adductor pollicis, abductor pollicis brevis, flexor pollicis longus, extensor pollicis longus, extensor digitorum communis, flexor digitorum superficialis, flexor digitorum profundus, pronator quadratus, extensor carpi ulnaris, extensor carpi radialis brevis, extensor radialis longus, flexor carpi ulnaris, flexor carpi radialis, first dorsal interosseous; and in at least two of the following muscles: left\u002Fright gluteus maximus, left\u002Fright erector spinae, left\u002Fright quadratus lumborum,\n* Age \\> 16 years\n* Medically stable - cleared for surgery\n* Able and willing to take part in study\n\nExclusion Criteria:\n\n* Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant)\n* Other neurological conditions (multiple sclerosis, diabetes with peripheral nerve involvement)\n* History of coagulopathy, HIV, severe cardiopulmonary disease, severe bradycardia, severe autonomic dysreflexia, or chronic obstructive pulmonary disease.\n* Active untreated infection such as decubitus ulcer, urinary tract infection, pneumonia\n* Presence of other active implantable medical devices with unknown or untested interaction with the NNP implant\n* Active implantable medical device (AIMD) such as a pacemaker or defibrillator, with the exception of the implanted stimulator-telemeter (IST) or implanted receiver stimulator (IRS) systems developed by the Cleveland Functional Electrical Stimulation Center\n* Unhealed fractures that prevent functional use of arm or trunk\n* Less than six months post-injury (neuroprosthesis implantation delayed until criteria met)\n* Extensive upper extremity denervation (fewer than two stimulatable hand muscles and two stimulatable trunk muscles)\n* Involvement in other ongoing clinical studies that exclude concurrent until criteria met)\n* Disorder or condition that require MRI monitoring\n* Mechanical ventilator dependency\n* Progressive SCI In subjects who are undergoing bilateral implantation, subjects should not have a history of autonomic dysreflexia, hypertension, diabetes or any condition which requires frequent blood pressure monitoring or frequent venipuncture.\n* Adverse interaction between system components and typical electromagnetic (EM) sources in subject's home and work environments, including wheelchair or other active implantable devices.","17 Years",{"count":89,"type":20},30,[65],"This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury.\n\nFunding Sources:\n\nFDA OOPD NIH NINDS",[68,26,69,93,94],"Spinal Cord Injury at C5-C7 Level With Complete Lesion","Spinal Cord Injury at C5-C7 Level With Incomplete Lesion",[96,97,98,99,100,101,102,103,104,105,106,107,108],"Neuroprosthesis","Functional Electrical Stimulation","Grasp","Posture","Standing","Function","Recovery","Device","Stimulation","Implant","Reach","Independence","Activities of Daily Living",{"date":72,"type":45},{"date":111,"type":45},"2014-12-01",{"date":113,"type":20},"2031-12-31",{"name":115,"class":52},"Anne Bryden",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":15,"minAge":16,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":63,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100537011","neuromodulation-with-spinal-stimulation-methods-100537011","NCT06272279","Neuromodulation With Spinal Stimulation Methods","Inclusion Criteria:\n\n* spinal cord injury C4 to L4\n* ability to understand and follow directions\n\nExclusion Criteria:\n\n* history of seizures, head injury, concussion, unexplained loss of consciousness or if they lived with an implanted cochlear stimulator, brain\u002Fneurostimulator, cardiac pacemaker, medication infusion device or live with metal implants in their body or if they are pregnant.",true,"65 Years",{"count":125,"type":20},24,[65],"This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled. A variety of stimulation parameters and outcome measures will be assessed.",[68,26,129,130],"Paraplegia, Spinal","Paraplegia, Incomplete","2025-02-05",{"date":133,"type":45},"2025-02-10",{"date":135,"type":45},"2024-03-01",{"date":137,"type":20},"2026-02-15",{"name":139,"class":52},"University of Manitoba",2]