[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injury-cervical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injury-cervical":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,42,76,117,141,168,202,231,252,288,311,336,374,399,424,451,477,506],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100585519","phase-2-non-invasive-neuromodulation-for-upper-extremity-function-in-spinal-cord-injury-a-crossover-trial-100585519",false,"NCT06903416","Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial","Comparative Evaluation of Non-Invasive Neuromodulation Therapies to Restore Upper Extremity Function in Chronic Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Cervical (C2-C8) level SCI\n* \\> 9 months post-injury\n* Traumatic SCI\n* AIS A-D\n* Stable dose of anti-spasmodics\n\nExclusion Criteria:\n\n* individuals with injury to the nervous system other than to the spinal cord\n* pregnant","ALL","18 Years","75 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life. It will compare transcutaneous spinal cord stimulation and paired corticospinal-motoneuronal stimulation, both combined with rehabilitation. Using a crossover design, participants will receive each therapy for two months, with a one-month washout period in between. Safety, effectiveness, and patient-reported outcomes like daily living ability and quality of life will be assessed, alongside changes in neural excitability. The results of this study may enable us to tailor treatments to individual needs, promoting personalized care and improved outcomes.",[28],"Spinal Cord Injury Cervical","RECRUITING","2026-05-28",{"date":32,"type":33},"2026-05-29","ACTUAL",{"date":35,"type":33},"2025-05-07",{"date":37,"type":21},"2030-03-31",{"name":39,"class":40},"University of Alberta","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":41},"100338009","restoring-motor-and-sensory-hand-function-in-tetraplegia-using-a-neural-bypass-system-100338009","NCT03680872","Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System","Inclusion Criteria:\n\n1. Males and females between 22 and 65 years of age\n2. Individuals with a stable cervical spinal cord injury that have International Standards for the Neurological Classification of SCI (ISNCSCI) motor scores for fingers of 0 - 2 (non-functional) and ISNCSCI sensory scores of 0 - 2 (not normal) on the palmar side\n3. Individuals at least one year from initial spinal cord injury\n4. Individuals that are considered English Proficient due to the study requirements to follow verbal commands during testing sessions\n5. Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation.\n6. Individuals that are willing and able to visit the study center for study procedures that will be 1-3 sessions a week for up to 48 months at 1-4 hours per session.\n7. Have the ability and willingness to undergo upper limb electrodiagnostic and nerve conduction studies\n8. Demonstrate typical amplitude, latency, and conduction velocity in the distal median, ulnar, and radial nerves of at least one upper limb\n\nExclusion Criteria:\n\n1. Individuals participating in another research study that may affect the conduct or results of this study\n2. Individuals having or exhibiting any of the following:\n\n   1. Medical contraindications for diffusion tensor imaging, functional magnetic resonance imaging, electromyography, computed tomography, cortical stimulation, or craniotomies\u002Fsurgeries\n   2. Prior difficulties or allergy to general anesthesia\n   3. Active wound healing or skin breakdown issues\n   4. Stage III-IV pressure ulcers\n   5. Chronically-implanted electronic medical device (e.g. baclofen pump, deep brain stimulator, epidural stimulator, cardiac pacemaker, vagus nerve stimulator, or other)\n   6. Prior tendon transfer to enhance hand function\n   7. History of autoimmune disease\n   8. Cancer\n   9. Biochemical abnormalities of the liver, kidney, or pancreas\n   10. Ventilator dependence\n   11. History of serious mood or thought disorder\n   12. Significant residual clinically evident traumatic brain injury or cognitive impairment\n   13. Uncontrolled autonomic dysreflexia\n   14. Spasticity in the upper extremities that is uncontrolled by pharmacological methods\n   15. Diagnosis of acute myocardial infarction or cardiac arrest within previous 6 months\n   16. Individuals with any type of destruction and\u002For damage to the motor cortex region as determined by fMRI.\n   17. History of a neurological ablation procedure\n   18. History of hemorrhagic stroke\n   19. History of infectious or chronic diseases, such as HIV or tuberculosis\n3. Individuals with any of the following co-morbid conditions that would interfere with study activities or response to treatment:\n\n   1. Life expectancy \\\u003C 3 years\n   2. Severe chronic pulmonary disease\n   3. Intractable seizure disorders\n   4. Local, systemic acute or chronic infectious illness\n   5. Life threatening cardiac arrhythmias\n   6. Severe collagen vascular disorder\n   7. Kidney failure or other major organ systems failures\n4. Individuals with a substance abuse (alcoholism or other) problem\n5. Pregnant women\n6. Prisoners","22 Years","65 Years",{"count":51,"type":21},7,[53],"NA","This is a single-cohort early feasibility trial to determine whether an investigational device called the Bidirectional Neural Bypass System can lead to the restoration of movement and sensation in the hand and wrist of up to seven individuals with tetraplegia.",[56,28],"Spinal Cord Injuries",[58,59,60,61,62,63,64,65,66],"Physical and Rehabilitation Medicine","Biomedical Engineering","Paralysis","Tetraplegia","Quadriplegia","Movement Restoration","Muscle Stimulation","Tactile Sensation","Spinal Cord Stimulation","2026-03-09",{"date":69,"type":33},"2026-03-11",{"date":71,"type":33},"2019-09-30",{"date":73,"type":21},"2028-12",{"name":75,"class":40},"Chad Bouton",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":41},"100620746","upper-limb-rehabilitation-using-non-invasive-spinal-cord-stimulation-100620746","NCT07361627","Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation","Improving Upper Limb Motor Control With Spinal Stimulation","CIME_upperlimb","Inclusion Criteria:\n\n* quadraplegic participants with a subacute spinal cord injury (sSCI), defined as the stage of spinal cord damage occurring between 1 week and 6 months post-injury, that fall within the period of at least one year post-injury\n* 16 years old or above\n* have a lesion between above T2\n* residual upper limb movement\n* have injury level according to ASIA A to D\n* hospitalized in the hospital linked with the research center at Gingras Lindsay Rehabilitation Institute of Montreal, 6300 Darlington, Montreal\n* can provide informed consent (no severe cognitive deficits by MoCA)\n* be able to follow instructions in French or English\n\nExclusion Criteria:\n\n* have a pacemaker\n* have active cancer on stimulation site or metastatic cancer\n* have unstable health conditions\n* have unhealed wound, scar or pain which makes positioning of the electrodes impossible\n* participants with specific contraindications to TMS (epilepsy, non-union cranial fracture and increased intracranial pressure) will be able to participate in the study, but will not receive TMS","16 Years",{"count":86,"type":21},40,[53],"The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury (SCI). As secondary aims, the study will also investigate at how this combination approach affects the cortical changes in the somatosensory and motor areas of the brain, as well as in the spinal cord and whether it helps participants use their arms more in daily life.\n\nThe main questions relevant to this study are:\n\n1. Can the combination of ABT + tSCS improve motor and sensory functions of the arms and hands more than ABT alone during the sub-acute stage after SCI?\n2. Does ABT + tSCS induce neuroplasticity, that is, changes in the brain and spinal cord activity linked to motor and sensory functions?\n3. Do participants who receive ABT + tSCS report greater use of their arms in daily activities compared to those who receive ABT only?\n\nIn this study, participants will:\n\n* Receive either ABT + tSCS or ABT + sham stimulation (a low-intensity current that does not facilitate the movements)\n* Take part in 20 training sessions over 6-8 weeks (3 times per week, 45 min of active training each). During this, they will perform strengthening, task-based training, and mental imagery exercises with a therapist.\n* Complete clinical tests and neurophysiological assessments (transspinal electrical stimulation, electroencephalography and transcranial magnetic stimulation) at three time points-- at the start, after training, and one month later to measure recovery and brain activity changes.\n\nResearchers will compare the assessment outcomes across the three time points.",[28,90,91],"Spinal Cord Injury, Acute","Spinal Cord Injury (Quadraplegia)",[93,94,95,96,97,98,99,100,101,102,103,104,105,106],"Spinal cord injury","Sub-acute","Neuromodulation","transcutaneous Spinal Cord Stimulation","Activity-based therapy","Upper extremity motor score","Rehabilitation","Electroencephalography","EEG","Somatosensory evoked potential","Transcranial Magnetic Stimulation","Motor evoked potential","Clinical assessment","Neuroplasticity","NOT_YET_RECRUITING","2026-02-27",{"date":110,"type":33},"2026-03-02",{"date":112,"type":21},"2026-04-01",{"date":114,"type":21},"2028-08-09",{"name":116,"class":40},"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":41},"100563098","restoration-of-hand-function-in-cervical-sci-100563098","NCT06611748","Restoration of Hand Function in Cervical SCI","Evaluation of a Simple Neuroprosthesis for Restoration of Hand Function in Cervical Spinal Cord Injury","KeyGrip","Inclusion Criteria:\n\n* Male or female adults 18 years of age or older;\n* Cervical spinal cord injury as defined by: a) International Standard for Neurological Classification of Spinal Cord Injury motor level of C1 through C7; and b) American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C;\n* Six months or more post-injury (neurostability);\n* Neurologically stable following any nerve transfers affecting the upper extremity (typically, one-year post-surgery);\n* Musculoskeletally and neurologically stable following any tendon transfers affecting the upper extremity (typically 6 months post-surgery).\n* Peripheral nerve innervation to upper extremity muscles, including Grade 3\u002F5 or higher Stimulated Manual Muscle Testin at least two of the muscles in one arm:\n* Good proximal voluntary upper extremity strength as defined by biceps\u002F brachialis \u002F brachioradialis strength of 2\u002F5 or higher on Manual Muscle Testing the side intended for implantation;\n* Medically stable; and\n* Able to understand and provide informed consent;\n\nExclusion Criteria:\n\n* Other neurological conditions (Multiple Sclerosis, diabetes with peripheral nerve involvement);\n* Associated peripheral nerve \u002F brachial plexus injury;\n* Progressive Spinal Cord Injury;\n* Active implantable medical device (AIMD) such as a pacemaker or defibrillator;\n* Active untreated infection such as urinary tract infection or pneumonia;\n* Active pressure injury;\n* History of coagulopathy, HIV, cardiopulmonary disease, bradycardia, poorly controlled autonomic dysreflexia, or chronic obstructive pulmonary disease that would preclude safe participation in the trial as determined by the investigator;\n* Unhealed fractures that prevent functional use of arm;\n* Extensive upper extremity denervation (fewer than two excitable hand muscles);\n* Involvement in other ongoing clinical studies that exclude concurrent involvement in this study;\n* Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant based on self-report); Urine or serum testing will happen during the pre-surgery evaluation.\n* Presence of disease that might interfere with participant safety, compliance, or evaluation of the condition under study;\n* Other significant medical findings that, in the opinion of the investigator, preclude safe participation in the trial",{"count":126,"type":21},20,[53],"The purpose of this study is to evaluate a new method of restoring hand function to people with spinal cord injury. Current methods to restore hand function include tendon transfers and nerve transfers. This study will evaluate the grasp strength that can be achieved with a small, implantable stimulator.\n\nKeyGrip is an investigational device that works by activating paralyzed muscles with low levels of electrical current. The word \"investigational\" means the study device is still being tested in research studies and is not approved by the U.S. Food and Drug Administration (FDA) for the use being studied.\n\nHypothesis. The study is designed to explore the feasibility of this approach; no hypothesis is planned at this stage",[28],[131],"Cervical Spinal Cord Injury (SCI)","2026-02-20",{"date":134,"type":33},"2026-02-24",{"date":136,"type":33},"2025-01-01",{"date":138,"type":21},"2030-11",{"name":140,"class":40},"MetroHealth Medical Center",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":41},"100610284","development-of-optimal-sensory-feedback-strategies-to-maximize-function-after-tetraplegia-100610284","NCT07225582","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia: A Sub-study of the Reconnecting the Hand and Arm to the Brain (ReHAB) Clinical Trial","Inclusion Criteria:\n\n1. Enrolled in the ReHAB clinical trial and received ReHAB system components via implantation surgery.\n2. Willingness and availability to follow the study protocol.\n\nExclusion Criteria:\n\n1. Lack of function or operability of all implanted ReHAB system components\n2. Severe pain or other chronic medical condition that would prevent the participant from completing study-related activities",{"count":149,"type":21},3,[53],"The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the \"Reconnecting the Hand and Arm to the Brain (ReHAB)\" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also have received electrodes around the nerves in their arm. In this clinical trial, participants will receive two types of electrical stimulation:\n\n* Intracortical microstimulation (ICMS) which involves sending small electrical pulses to the part of the brain that processes sensation.\n* Peripheral nerve stimulation (PNS) which involves sending small electrical pulses to the nerves in the arm that transmit sensations from the hand.\n\nResearchers will try different patterns of stimulation for both ICMS and PNS and study how the participants perceive the sensations from the different stimulation patterns. The researchers will also study how combining ICMS and PNS affects the perceived sensations.",[28,153],"Spinal Cord Injuries (Complete and Incomplete)",[155,156,157,158],"spinal cord injury","tetraplegia","intracortical microstimulation","peripheral nerve stimulation","2026-02-17",{"date":161,"type":33},"2026-02-19",{"date":163,"type":33},"2026-01-13",{"date":165,"type":21},"2030-09-01",{"name":167,"class":40},"Case Western Reserve University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":177,"briefSummary":179,"conditions":180,"keywords":184,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":201},"100580781","phase-1-a-study-to-evaluate-the-safety-of-a-delivery-device-for-administering-lctopc1-in-participants-with-spinal-cord-injury-100580781","NCT06841770","A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury","Delivery of Oligodendrocyte Progenitor Cells for Spinal Cord Injury: Evaluation of a Novel Device (DOSED)","DOSED","Inclusion Criteria:\n\n1. Sensorimotor complete, traumatic SCI (ASIA Impairment Scale A) or sensory incomplete, traumatic SCI (ASIA Impairment Scale B)\n2. For subjects with subacute injury, International Standards for Neurological Classification of SCI (ISNCSCI) Neurological Level of Injury (NLI) from C-4 to T-10 occurring 21 to 42 days prior to LCTOPC1 injection\n3. For subjects with chronic injury, ISNCSCI NLI from C-4 to T-10 and more than 30 days without clinical improvement from last assessment, occurring 1 to 5 years prior to LCTOPC1 injection\n4. Individuals must have at least one upper extremity ISNCSCI key muscle with at least 1\u002F5 strength\n5. 18 through 65 years of age, inclusive, at time of consent\n6. Single injury with sufficient visualization of the spinal cord injury epicenter and lesion margins to enable post-injection safety monitoring\n7. Informed consent for this protocol must be provided and documented (i.e., signed ICF)\n8. Able to participate in an elective surgical procedure to inject LCTOPC1 21 days or later following SCI\n9. Female subjects of child-bearing potential must agree to the use of contraception for 1 year following LCTOPC1 injection; male subjects must agree to use contraception to prevent pregnancy in any female partners of child-bearing potential for 1 year following LCTOPC1 injection\n\nExclusion Criteria:\n\n1. SCI due to penetrating trauma\n2. Traumatic anatomical transection, laceration, or inadequate decompression of the spinal cord based on prior surgery or MRI\n3. Any concomitant injury that interferes with the performance, interpretation, or validity of neurological examinations, such as multiple spinal cord lesions, brachial\u002Flumbar plexus injury, cauda equina injury or traumatic brain injury\n4. Subjects with a cavity structure that would preclude successful transplantation, as identified on MRI, which may include septations or irregularities in tissue structure\n5. Persons with syringomyelia, defined as those with progressively enlarging cysts on T2-weighted images associated with neurological decline\n6. Inability to communicate effectively with neurological examiner such that the validity of patient data could be compromised\n7. Organ damage or systemic disease that would create an unacceptable risk for surgery or immunosuppression\n8. Need for mechanical support of ventilation (ventilator, continuous positive airway pressure \\[CPAP\\], bi-level positive airway pressure \\[BiPAP\\]), excluding supplemental oxygen, at baseline\n9. History of any malignancy (except non-melanoma skin cancers). For cancers in remission for more than five years, enrollment is allowed with concurred documented approval of principal investigator, oncologist, and Sponsor's medical monitor prior to enrollment\n10. Pregnant or nursing women\n11. Subjects with an implanted spinal cord stimulator (SCS), whether temporary or permanent.",{"count":20,"type":21},[178],"PHASE1","The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI). LCTOPC1 is designed to replace or support cells that are absent or dysfunctional due to traumatic injury, with a goal to help improve the quality of life and restore or augment functional activity in persons suffering from a traumatic cervical or thoracic injuries.",[28,181,90,182,183],"Spinal Cord Injury Thoracic","Spinal Cord Injury","Spinal Cord Injury, Chronic",[182,174,185,186,187,188,189,190,60,62,61],"Subacute spinal cord injury","Oligodendrocyte Progenitor Cell","Chronic spinal cord injury","Stem Cell Transplant","Cervical spinal cord injury","Thoracic spinal cord injury","2026-02-11",{"date":193,"type":33},"2026-02-12",{"date":195,"type":33},"2025-06-30",{"date":197,"type":21},"2037-06-30",{"name":199,"class":200},"Lineage Cell Therapeutics, Inc.","INDUSTRY",2,{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":41},"100603366","non-invasive-interventions-for-respiratory-recovery-in-chronic-spinal-cord-injury-100603366","NCT07135583","Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury","Non-Invasive Interventions and Biomarker Identification for Respiratory Recovery in Chronic Spinal Cord Injury","Combinatorial","Inclusion Criteria:\n\n1. adults 18 to 70 years of age (the latter to reduce likelihood of cardiovascular disease);\n2. chronic SCI for ≥ 1 year at or below C-3 to T-8\n3. incomplete SCI based on classification of incomplete-B, C or D\n4. medically stable with clearance from physician\n5. SCI due to non-progressive etiology\n6. \\>20% impairment in maximal inspiratory or expiratory pressure generation\n\nExclusion Criteria:\n\n* Individuals will be excluded due to (1) current diagnosis of an additional neurologic condition (eg. multiple sclerosis or stroke) (2) loss of diaphragm EMG activity on forced respiratory tests; (3) severe illness or infection (4) non-healing decubitus ulcers (5) untreated bladder or urinary infections (6) cardiovascular disease (7) lung disease (8) active heterotopic ossification (9) uncontrolled hypertension; (10) severe neuropathic pain; (11) pregnancy (5) severe recurrent and uncontrolled autonomic dysreflexia (6) history of seizure disorder.","70 Years",{"count":126,"type":21},[53],"Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing. As a result, people with SCI often face breathing problems, a higher risk of lung infections, and even early death. While breathing exercises can help strengthen these muscles, they often aren't intense enough to make a big difference, especially in people with long-term injuries.\n\nThis research project is exploring a new way to improve breathing in people with chronic SCI. The goal is to \"wake up\" the remaining nerve pathways that still connect the brain and spinal cord to the breathing muscles. By doing this, the investigators hope to make breathing exercises more effective and improve overall respiratory health.\n\nThe investigators are testing a combination of two non-invasive (non-surgical) techniques:\n\nTranscutaneous Spinal Cord Stimulation (tSCS): This uses small electrical pulses delivered through the skin to stimulate the spinal cord and help activate the muscles used for breathing.\n\nHypercapnic-Hypoxia Protocol (HiCO₂-AIH): This involves breathing air with lower oxygen and higher carbon dioxide for short periods. This naturally increases the brain's drive to breathe and may help strengthen the breathing muscles.\n\nThe investigators believe that using these two techniques together will \"prime\" the nervous system, making it more responsive to breathing exercises. This could lead to better outcomes for people with SCI.\n\nIn addition to testing this treatment, the investigators are also collecting saliva and blood samples to look for biomarkers-biological clues that might help predict who will benefit most from this therapy. These include genetic markers and signs of nerve damage in the blood.\n\nWho Can Participate\n\nThe investigators are looking for adults aged 18 to 70 who:\n\nHave had a spinal cord injury for at least one year. Have an injury between the neck and upper back (from C3 to T8). Have an incomplete injury (some nerve function remains). Are medically stable and cleared by a doctor. Have at least a 20% reduction in breathing strength. What Participants Will Do\n\nEach participant will complete four rounds of treatment. Each round includes four days in a row of therapy, followed by a three-week break before the next round.\n\nEach daily session lasts about two hours and includes:\n\nBreathing special air mixtures (low oxygen and high carbon dioxide) for short periods, followed by normal air.\n\nA short break. Then, spinal cord stimulation combined with breathing exercises that use resistance (like breathing through a straw).\n\nWhat the Investigators Will Measure\n\nThe investigators will track:\n\nBreathing ability using lung function tests and pressure measurements. Nerve activity using brain and spinal cord stimulation to see how well the diaphragm (the main breathing muscle) responds.\n\nSafety by monitoring oxygen levels, heart rate, blood pressure, and breathing responses during each session.\n\nBiological Samples\n\nParticipants will provide:\n\nA one-time saliva sample for genetic testing. A one-time blood sample to look for markers of nerve injury. Why This Matters\n\nThis study could lead to new, non-invasive treatments that improve breathing and quality of life for people living with spinal cord injuries. By identifying who is most likely to benefit from this therapy, the investigators can also move toward more personalized and effective care in the future.",[183,28,181,215],"Incomplete Spinal Cord Injury",[217,218,219,220,221],""Spinal Cord Stimulation" [MeSH]","acute intermittant hypoxia","respiratory resistance training","Genetic Biomarker","Blood biomarker","2026-02-02",{"date":224,"type":33},"2026-02-05",{"date":226,"type":33},"2025-09-18",{"date":228,"type":21},"2027-08-15",{"name":230,"class":40},"Thomas Jefferson University",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":41},"100505620","grasp-release-assessment-of-a-networked-neuroprosthesis-device-100505620","NCT05863754","Grasp-Release Assessment of a Networked Neuroprosthesis Device","GRANND","Inclusion Criteria:\n\n* Male or female, age \\> 16 years.\n* Cervical level spinal cord injury, as defined by:\n\n  1. International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor level of C1 through C7 and\n  2. American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, or C;\n* Six months or more post-injury (neurostability);\n* Neurologically stable following any nerve transfers affecting the upper extremity (typically, one year post surgery);\n* Musculoskeletally and neurologically stable following any tendon transfers affecting the upper extremity (typically, 6-months).\n* Peripheral nerve innervation to upper extremity muscles, including a grade 3\u002F5 or higher Stimulated Manual Muscle Test (SMMT) strength in at least two of the following muscles in one arm:\n\n  1. Adductor Pollicus, Abductor Pollicus Brevis (AbPB), Flexor Pollicus Longus (FPL), Extensor Pollicus Longus (EPL)\u002FExtensor Pollicus Brevis (EPB), Extensor Digitorum Communis (EDC), Flexor Digitorum Superficialis (FDS), Flexor Digitorum Profundus (FDP), Pronator Quadratus (PQ), Extensor Carpi Ulnaris (ECU), Extensor Carpi Radialis Brevis (ECRB), Extensor Carpi Radialis Longus (ECRL), Flexor Carpi Ulnaris (FCU), Flexor Carpi Radialis (FCR), First Dorsal Interosseous(1DI), triceps,\n  2. At least two of the grade 3\u002F5 or higher excitable muscles must also have grade 2\u002F5 or lower voluntary strength;\n* Good proximal upper extremity strength as defined by biceps\u002Fbrachialis\u002Fbrachioradialis strength of 2\u002F5 or higher on Manual Muscle Test on the side intended for implantation;\n* Medically stable;\n* Able to understand and provide informed consent.\n\nExclusion Criteria:\n\n* Other neurological conditions (MS(multiple Sclerosis), diabetes with peripheral nerve involvement); Associated peripheral nerve \u002F brachial plexus injury\n* Progressive SCI;\n* Co-existing cervical spine pathology (syrinx, unstable segment)\n* Active implantable medical device (AIMD) such as a pacemaker or defibrillator;\n* Active untreated infection such as pressure injury, urinary tract infection, pneumonia;\n* History of coagulopathy, HIV, cardiopulmonary disease, bradycardia, poorly controlled autonomic dysreflexia, or chronic obstructive pulmonary disease that would preclude safe participation in the trial as determined by the investigator;\n* Unhealed fractures that prevent functional use of arm;\n* Extensive upper extremity denervation (fewer than two excitable hand muscles);\n* Involvement in other ongoing clinical studies that exclude concurrent involvement in this study;\n* Disorder or condition that requires MRI monitoring;\n* Mechanical ventilator dependency;\n* Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant);\n* Presence of disease that might interfere with participant safety, compliance, or evaluation of the condition under study;\n* Other significant medical findings that, in the opinion of the investigator, preclude safe participation in the trial.",{"count":239,"type":21},13,[53],"The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.",[243,56,28],"Spinal Cord Injury at C5-C7 Level","2025-12-17",{"date":246,"type":33},"2025-12-19",{"date":248,"type":33},"2022-01-23",{"date":250,"type":21},"2028-12-01",{"name":140,"class":40},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":259,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":262,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":41},"100234426","multi-functional-neuroprosthetic-system-for-restoration-of-motor-function-in-spinal-cord-injury-100234426","NCT02329652","Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury","NNP-UE+T","Inclusion Criteria:\n\n* Diagnosis of cervical level spinal cord injury, either complete or incomplete; International Standards for Neurological Classification of Spinal Cord Injury (INCSCI) motor level of C4 through C8; American Spinal Injury Impairment Scale (AIS) grade A, B, C, or D; six months or more post-injury\n* Biceps\u002Fbrachialis\u002Fbrachioradialis strength of 2\u002F5 or higher on Manual Muscle Test\n* Peripheral nerve innervation to upper extremity and trunk muscles, including a grade 3\u002F5 or higher stimulated strength (Manual Muscle Test) in at least two of the following muscles in one arm: adductor pollicis, abductor pollicis brevis, flexor pollicis longus, extensor pollicis longus, extensor digitorum communis, flexor digitorum superficialis, flexor digitorum profundus, pronator quadratus, extensor carpi ulnaris, extensor carpi radialis brevis, extensor radialis longus, flexor carpi ulnaris, flexor carpi radialis, first dorsal interosseous; and in at least two of the following muscles: left\u002Fright gluteus maximus, left\u002Fright erector spinae, left\u002Fright quadratus lumborum,\n* Age \\> 16 years\n* Medically stable - cleared for surgery\n* Able and willing to take part in study\n\nExclusion Criteria:\n\n* Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant)\n* Other neurological conditions (multiple sclerosis, diabetes with peripheral nerve involvement)\n* History of coagulopathy, HIV, severe cardiopulmonary disease, severe bradycardia, severe autonomic dysreflexia, or chronic obstructive pulmonary disease.\n* Active untreated infection such as decubitus ulcer, urinary tract infection, pneumonia\n* Presence of other active implantable medical devices with unknown or untested interaction with the NNP implant\n* Active implantable medical device (AIMD) such as a pacemaker or defibrillator, with the exception of the implanted stimulator-telemeter (IST) or implanted receiver stimulator (IRS) systems developed by the Cleveland Functional Electrical Stimulation Center\n* Unhealed fractures that prevent functional use of arm or trunk\n* Less than six months post-injury (neuroprosthesis implantation delayed until criteria met)\n* Extensive upper extremity denervation (fewer than two stimulatable hand muscles and two stimulatable trunk muscles)\n* Involvement in other ongoing clinical studies that exclude concurrent until criteria met)\n* Disorder or condition that require MRI monitoring\n* Mechanical ventilator dependency\n* Progressive SCI In subjects who are undergoing bilateral implantation, subjects should not have a history of autonomic dysreflexia, hypertension, diabetes or any condition which requires frequent blood pressure monitoring or frequent venipuncture.\n* Adverse interaction between system components and typical electromagnetic (EM) sources in subject's home and work environments, including wheelchair or other active implantable devices.","17 Years",{"count":261,"type":21},30,[53],"This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury.\n\nFunding Sources:\n\nFDA OOPD NIH NINDS",[56,243,28,265,266],"Spinal Cord Injury at C5-C7 Level With Complete Lesion","Spinal Cord Injury at C5-C7 Level With Incomplete Lesion",[268,269,270,271,272,273,274,275,276,277,278,279,280],"Neuroprosthesis","Functional Electrical Stimulation","Grasp","Posture","Standing","Function","Recovery","Device","Stimulation","Implant","Reach","Independence","Activities of Daily Living",{"date":246,"type":33},{"date":283,"type":33},"2014-12-01",{"date":285,"type":21},"2031-12-31",{"name":287,"class":40},"Anne Bryden",{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":296,"briefSummary":297,"conditions":298,"keywords":299,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":201},"100582784","spine-and-brain-stimulation-for-movement-recovery-after-cervical-spinal-cord-injury-100582784","NCT06867809","Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury","Pilot Study to Evaluate the Safety and Tolerability of Spinal Cord Stimulation (SCS) and Paired Spine And Brain Stimulation For Movement Recovery After Spinal Cord Injury (SCI)","Inclusion Criteria:\n\n* Patients aged ≥18 years with incomplete traumatic SCI (American Spinal Injury Association (ASIA) B-D, levels between C4 to T1) incurred \\> 1 year before the start of the study\n* At least 2\u002F5 motor power in at least one upper extremity muscle group\n* International Standards for Neurological Classification of Spinal Cord Injury Upper Extremity Motor Score (ISNCSCI-UEMS) ≤ 40\u002F50\n* Able to follow multistep commands\n* Ability and willingness to provide informed consent\n* English speaking\n\nExclusion Criteria:\n\n* Cervical or thoracic stenosis that would preclude safe lead placement\n* Any ongoing ventilator use (continuous or intermittent)\n* Urinary tract infection or pneumonia requiring treatment (within past 3 months)\n* Skin ulcers or other lesions\n* History of posterior cervical fusion\n* Autonomic dysreflexia requiring treatment (within past 3 months)\n* Implanted brain stimulators\n* Intracranial aneurysm clips\n* Ferromagnetic metallic implants in the head (except for within mouth)\n* Any active implanted device including intrathecal medication pumps or existing spinal cord stimulators (does not include non-active spinal instrumentation such as rods, screws, or interbody devices)\n* Cochlear implants\n* Cardiac pacemaker\u002Fdefibrillator\n* Any history of seizures\n* Family history of idiopathic epilepsy in a first degree relative\n* Bipolar disorder\n* Any history of suicide attempt\n* Active psychosis\n* Intracranial lesion or increased intracranial pressure\n* History of stroke or intracranial neurologic conditions with structural damage\n* Medications that lower seizure threshold\n* Substance use that lowers seizure threshold (heavy alcohol use)\n* Moderate to severe heart disease\n* Pregnancy or plans to become pregnant within the study period\n* Any other medical or psychological condition that precludes involvement in the study as determined by a study physician",{"count":126,"type":21},[53],"Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury. While some scientists have begun to study the effect of electrical stimulation on patient's ability to walk and move their legs after lower spinal cord injury, the use of stimulation of the upper (cervical) spine to restore arm and hand function after cervical spinal cord injury remains less well explored. The investigators are doing this research study to improve understanding of whether cervical spinal cord stimulation and brain stimulation can be used to improve arm and hand function. To do this, the investigators will combine spine stimulation (in the form of electrical stimulation from electrical stimulation wires temporarily implanted next to the cervical spinal cord) and brain stimulation (in the form of transcranial magnetic stimulation). The investigators will perform a series of experiments over 29 days to study whether these forms of stimulation can be applied and combined to provide improvement in arm and hand function.",[182,28],[182,66,300,301],"Neurorehabilitation","Neurological Recovery","2025-10-29",{"date":304,"type":33},"2025-10-30",{"date":306,"type":21},"2026-01-15",{"date":308,"type":21},"2027-03-31",{"name":310,"class":40},"Jason Carmel",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":210,"enrollmentInfo":318,"targetDuration":4,"studyType":22,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":201},"100554048","task-practice-and-spinal-cord-stimulation-100554048","NCT06494020","Task Practice and Spinal Cord Stimulation","Task Practice Combined With Transcutaneous Spinal Cord Stimulation to Reduce Muscle Co-contraction and Improve Motor Function in Chronic Spinal Cord Injury","Inclusion Criteria:\n\n* 22-70 years of age\n* Non-progressive cervical spinal cord injury\n* Minimum 12 months year post-injury.\n* American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification B, C, or D.\n* Able to take part in upper extremity therapy procedures.\n* GRASSP-Prehension score ≥10.\n* MAS Score ≥3 but \\\u003C6 in at least one arm.\n* Can commit to the time required for the study.\n* Stable medication profile for at least 4 weeks prior to enrollment.\n* Able to reduce Baclofen dose to 30 mg or less daily.\n* Capable of providing informed consent.\n\nExclusion Criteria:\n\n* Has any unstable or significant medical condition that is likely to interfere with study procedures like severe neuropathic pain, depression, mood disorders, or other cognitive disorders.\n* Has uncontrolled cardiopulmonary disease or cardiac symptoms.\n* Requires ventilator support.\n* Has been diagnosed with autonomic dysreflexia that is severe, unstable, and uncontrolled.\n* Has an autoimmune etiology of spinal cord dysfunction\u002Finjury\n* Previously diagnosed as having transverse myelitis\n* History of additional neurologic diseases such as stroke, multiple sclerosis, traumatic brain injury, epilepsy or history of seizures.\n* Peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.)\n* Uncontrolled spasms, which have been unstable over the past three months prior to enrollment and are not expected to change.\n* Received Botulinum toxin injections in their upper extremity, neck, or hand within six months prior to enrollment.\n* Has painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection at the time of enrollment.\n* Breakdown in skin area that will come into contact with electrodes.\n* Presence of syringomyelia as determined by an MRI.\n* Currently undergoing treatment for cancer or has been in remission for less than 2 years.\n* Received stem cell treatment within the past two years prior to enrollment.\n* Has any active implanted medical device.\n* Concurrent participation in another drug or device trial that may interfere with this study.\n* In the opinion of the investigators, the study is not safe or appropriate for the participant.\n* Persons who are unable to consent, pregnant women, and prisoners.",{"count":319,"type":21},6,[53],"The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity. Transcutaneous stimulation has been shown to improve motor function in some individuals with chronic spinal cord injury. The study intends to explore scientifically the association between higher stimulation frequencies and spasticity\u002Fhypertonicity.",[28,323],"Spastic",[325,326],"Transcutaneous","Transcutaneous Cervical Spinal Cord Stimulation","2025-08-13",{"date":329,"type":33},"2025-08-19",{"date":331,"type":33},"2024-09-01",{"date":333,"type":21},"2027-10-01",{"name":335,"class":40},"University of Miami",{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":16,"minAge":344,"maxAge":49,"enrollmentInfo":345,"targetDuration":4,"studyType":22,"phases":346,"briefSummary":347,"conditions":348,"keywords":354,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":41},"100588304","bci-assisted-scs-exs-for-gait-optimization-100588304","NCT06939660","BCI-Assisted SCS-EXS for Gait Optimization","Spatiotemporal Spinal Cord Stimulation Based on Implantable Brain-machine Interfaces and Exoskeletons for Spinal Cord Injury (BASEGO)","BASEGO","Inclusion Criteria:\n\n* Age 14-65 years, any gender.\n* Clinical diagnosis of spinal cord injury (SCI) due to trauma, inflammation, tumor, vascular disease, or iatrogenic factors, confirmed by medical history, physical examination, and ancillary tests, resulting in lower limb motor dysfunction.\n* SCI diagnosed ≥6 months prior, with ≥1 month of continuous conventional rehabilitation (e.g., physical therapy, acupuncture, hydrotherapy, ≥3 hours daily) without significant improvement in motor function in the past 2 months.\n* ASIA Impairment Scale (AIS) grade A, B, or C based on the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI).\n* Good general health with a life expectancy ≥12 months.\n* Mini-Mental State Examination (MMSE) score ≥22.\n* Educational attainment of secondary school or above.\n* Willingness to participate, provide informed consent, and comply with study follow-up.\n\nExclusion Criteria:\n\n* Presence of diseases other than spinal cord injury (SCI) that affect lower limb motor function, including brain diseases (e.g., brain tumor, stroke), lower limb vascular diseases (e.g., lower limb vascular occlusion), peripheral nerve diseases, or lower limb bone diseases (e.g., osteoarthritis, joint contracture).\n* Requires continuous medical interventions (e.g., tracheal intubation, nasogastric feeding) to maintain critical physiological functions (e.g., heartbeat, respiration, swallowing).\n* Congenital or acquired structural abnormalities of the lower limb bones or muscles.\n* Presence of surgical contraindications (e.g., anesthesia-related adverse reactions, coagulation risks, or surgeon's determination of unsuitability for surgery).\n* Presence of active implantable devices except for SCS or BCI devices (e.g., pacemakers, defibrillators, drug infusion pumps, cochlear implants, sacral nerve stimulators).\n* Unable to receive implantable devices due to other disease treatments or investigations, or requires magnetic resonance imaging (MRI) during the device implantation period.\n* MRI shows structural damage \\>50% in motor function areas (precentral and postcentral gyri, ventromedial sensorimotor areas, mid temporal lobe, Broca's area, Wernicke's area, Geschwind's area), or DTI shows damage \\>50% in the posterior limb of the internal capsule.\n* Severe cardiovascular disease: Above level II myocardial ischemia or myocardial infarction, uncontrolled arrhythmias (including QTc interval ≥450 ms in men, ≥470 ms in women), level III-IV heart failure (NYHA classification), or echocardiography showing LVEF \\\u003C50%.\n* Coagulation abnormalities (INR \\>1.5 ULN, PT \\>ULN +4 s, or APTT \\>1.5 ULN), hemorrhagic tendency, or undergoing thrombolytic or anticoagulant therapy.\n* Severe infections within 4 weeks before surgery (requiring IV antibiotics, antifungals, or antivirals) or lumbar soft tissue infections, or unexplained fever \\>38.5℃ during screening or before surgery.\n* HIV infection, acquired immunodeficiency syndrome (AIDS), active tuberculosis, active hepatitis B (HBV DNA ≥500 IU\u002Fml), hepatitis C (positive HCV antibody and detectable HCV-RNA), or co-infection of hepatitis B and C.\n\nSevere cerebrovascular events (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, or pulmonary embolism within 12 months before enrollment.\n\n* Metastatic malignancies or untreated malignant tumors.\n* Major surgery or severe traumatic injuries, fractures, or ulcers within 4 weeks before enrollment.\n* Addictive habits such as drug abuse or alcoholism.\n* History of psychotropic drug abuse that is not controllable or presence of mental disorders, including major psychiatric illnesses (e.g., depression \\[BDI score \\>20\\], anxiety, obsessive-compulsive disorder, schizophrenia, autism, chronic sleep disorders, consciousness disorders).\n* Pregnant, breastfeeding, planning to conceive, or women of childbearing potential without reliable contraception.\n* Participation in other clinical trials within the past month.\n* Cognitive impairments or poor compliance from subjects, family members, or caregivers, or inability to complete at least 12 months of follow-up and rehabilitation training.\n* Other conditions that increase the risk of study participation or device use, as determined by the investigator.","14 Years",{"count":149,"type":21},[53],"The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury (SCI). The primary aim is to determine whether the BCI-SCS-EXS system can safely and effectively improve lower limb motor function and quality of life in individuals with chronic SCI.\n\nParticipant Population:\n\nAdults aged 14-65 years (sex\u002Fgender not limited). Patients with chronic SCI (≥6 months post-injury) classified as ASIA A, B, or C.\n\nIndividuals with stable health status, MMSE ≥22, and secondary education or above.\n\nPrimary Questions:\n\n1. Is the BCI-SCS-EXS system safe and technically feasible for SCI rehabilitation?\n2. Does the system improve lower limb motor function and quality of life in SCI patients?\n\nInterventions:\n\nParticipants will undergo the following procedures:\n\nPhase I (Implantation):\n\nBCI implantation: ECoG electrodes placed over the motor cortex to decode lower limb movement intent.\n\nSCS electrode implantation: 5-6-5 paddle electrodes at T11-L2 for targeted spinal cord stimulation.\n\nPhase II (System Calibration):\n\nBCI-SCS synchronization: Calibration of decoded motor intent to trigger SCS parameters.\n\nSCS-EXO synchronization: Integration of SCS pulses with exoskeleton-assisted gait training.\n\nPhase III (Rehabilitation):\n\nDaily BCI-SCS-EXS training sessions (60 minutes, 5 times\u002Fweek for 1 year). Adaptive adjustments to stimulation parameters and exoskeleton support based on performance.\n\nRemote monitoring of device performance and emergency intervention for technical issues.\n\nOutcome Measures:\n\nPrimary: Safety (adverse events, device performance, synchronization metrics). Secondary: Efficacy (motor function, neurophysiological function, quality of life).\n\nEthics and Safety:\n\nInformed consent will be obtained from all participants. Adverse events will be monitored and reported according to CTCAE 5.0 guidelines.\n\nParticipant confidentiality will be strictly maintained. This study will provide foundational evidence for the safety and feasibility of the BCI-SCS-EXO system, paving the way for future randomized controlled trials in SCI rehabilitation.",[349,183,182,28,181,91,350,351,352,353],"Spinal Cord Injuries (SCI)","Motor Impairment","Motor Deficits","Gait Training","Gait Impairment",[355,356,357,99,93,358,359,360,361,362,363,364],"Brain-computer interface","Spianl cord stimulation","Exoskeleton","Motor dysfunction","BCI","Brain-spinal interface","BSI","Brain-machine interface","Gait training","Neural plasticity","2025-05-14",{"date":367,"type":33},"2025-05-20",{"date":369,"type":33},"2025-04-23",{"date":371,"type":21},"2027-04-30",{"name":373,"class":40},"Xuanwu Hospital, Beijing",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":380,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":381,"targetDuration":4,"studyType":22,"phases":383,"briefSummary":384,"conditions":385,"keywords":386,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":41},"100578769","neuromodulation-after-spinal-cord-injury-to-improve-limb-function-100578769","NCT06815601","Neuromodulation After Spinal Cord Injury to Improve Limb Function","Inclusion Criteria:\n\n* Healthy adults between the ages of 18-75 years old who are right-handed\n* Adults between the ages of 18-75 years old who have had a spinal cord injury (SCI)\n\nExclusion Criteria:\n\nFor both healthy individuals and those with SCI:\n\n* Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease\n* Any debilitating disease prior to the SCI that caused exercise intolerance\n* Ongoing major depression or altered cognitive status\n* Metal plate in skull\n* History of seizures\n* Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs\n* Pregnant females",true,{"count":382,"type":21},60,[53],"The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement. The goal of the study is to learn about how the brain, nerves, and muscles of the body are connected and perform everyday tasks. This may help us to develop ways to improve the hand functions of people with spinal cord injuries.",[182,28],[155,387,276,60,388,389],"SCI","rTMS","transcranial magnetic stimulation","2025-04-14",{"date":392,"type":33},"2025-04-15",{"date":394,"type":33},"2025-04-10",{"date":396,"type":21},"2028-01",{"name":398,"class":40},"State University of New York at Buffalo",{"id":400,"slug":401,"hasResults":11,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":406,"targetDuration":4,"studyType":22,"phases":407,"briefSummary":408,"conditions":409,"keywords":410,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":41},"100575515","combining-spinal-cord-transcutaneous-stimulation-and-activity-based-training-in-inpatient-rehabilitation-to-facilitate-upper-limb-function-of-individuals-with-acute-to-subacute-cervical-spinal-cord-injury-100575515","NCT06773286","Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury","Establishing the Feasibility, Safety, and Efficacy of Spinal Cord Transcutaneous Stimulation with Activity-based Training for Upper Extremity Function Recovery in Individuals with Acute to Subacute Tetraplegia","Inclusion Criteria:\n\n* must be at least 18 years of age.\n* must have had a spinal cord injury for less than or equal to 8 weeks.\n* must have a traumatic cervical SCI with lesions (AIS A or B, C5-C7).\n* must have some degree of motor dysfunction in the hand (bilateral UE motor score \\\u003C25).\n* must be medically stable enough to participate in activity-based recovery training.\n* must be able to tolerate spinal cord transcutaneous stimulation, as determined by study staff.\n* must have ability to understand and the willingness to sign an informed consent.\n\nExclusion Criteria:\n\n* have a history of seizures, head trauma and\u002For cognitive deficit\n* have surgically implanted foreign bodies such as a pacemaker, metal plate in the skull, and metal inside the skull\n* have a pressure sore or skin issues.\n* have severe spasticity.\n* in medically unstable condition.\n* have a history of illicit drug abuse.\n* have a history of medical disorders of my heart, lungs, bladder, kidneys or other parts of my body that are unrelated to my spinal cord injury.\n* unable or unwilling to wean from anti-spasticity medication (for an example: baclofen, Xeomin, and Lioresal).\n* unable to meet the attendance requirements.\n* currently enrolled in another interventional research study.\n* unable to follow instructions and maintain alertness during assessments and training.",{"count":261,"type":21},[53],"The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training (ABT) and spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hands, arms, and trunk in an inpatient rehabilitation program. The main questions it aims to answer are:\n\n* Is the combination of spinal cord transcutaneous stimulation and ABT is safe and practical when applied to individuals with acute to subacute cervical SCI during inpatient rehabilitation?\n* How the combined intervention can improve hand and arm function when applied to those individuals? The investigators will assess the safety, feasibility, and preliminary efficacy of the combined intervention and compare to a sham control (sham stimulation combined with ABT) and a ABT only group to see if the combined intervention can lead to greater function recovery.\n\nParticipants will:\n\n* Receive one type of the three intervention (scTS+ABT, sham scTS+ABT, or ABT only) for 10 sessions with 30 mins\u002Fsession over 2 weeks.\n* Receive assessment before, during, and immediately after the intervention, and at 1-month, 2-month, and 3-month follow-up visits.",[28],[182,411,412,413,414],"Inpatient Rehabilitation","Upper Extremity","Spinal Cord Transcutaneous Stimulation","Activity-based Training","2025-01-08",{"date":417,"type":33},"2025-01-14",{"date":419,"type":33},"2024-04-08",{"date":421,"type":21},"2025-12",{"name":423,"class":40},"Kessler Foundation",{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":16,"minAge":431,"maxAge":432,"enrollmentInfo":433,"targetDuration":435,"studyType":436,"phases":4,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":41},"100383709","combined-nerve-and-tendon-transfer-for-the-restoration-of-hand-function-in-individuals-with-tetraplegia-100383709","NCT04276181","Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia","[CNaTT]","Inclusion criteria:\n\n* Subjects must be between 15-55 years of age\n* Subjects must be diagnosed with a spinal cord injury AIS level C5 to C7\n* Time after injury ≤ 12 months\n* The strength of the muscle supplied by the donor nerve (supinator) must be graded ≥ 4 according to Medical Research Council (MRC)\n* The strength of musculus brachioradialis and wrist extensors must be graded ≥ 4 according to MRC (to be used in grip reconstruction)\n\nExclusion criteria:\n\n* Finger extensor strength ≤ MRC 1\n* Evidence of lower motor neuron injury in muscles supplied by the donor nerve\n* Subjects must not have any current serious or unstable illness that could interfere with the study\n* Medically unstable to undergo surgery as determined by physician\n* Spasticity in the forearm or hand graded \\> 1 according to Modified Ashworth Scale","15 Years","55 Years",{"count":434,"type":21},94,"1 Year","OBSERVATIONAL","Tetraplegia after a cervical spinal cord injury (C-SCI) radically alters an individual's ability to perform normal activities of daily life due to paralysis in all extremities, resulting in lifelong dependence.\\[1\\] Traditional tendon transfer surgery has proven successful in restoring grip functions which greatly improves autonomy, but with a restricted passive opening of the hand. The number of transferrable muscles in the arm is however limited, why nerve transfer surgery is a new attractive option to further improve hand function by enabling active opening of the hand. Significant advantages of distal nerve transfers include less extensive surgical dissection, greatly reduced hospital stay, rehabilitation and restrictions, and thereby less health care use and costs. In an effort to further improve hand function and independence in patients with tetraplegia, hand surgeons at Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital (SUH)\u002FMölndal have developed a strategy in which a nerve transfer procedure aiming to restore active opening of the hand is done prior to reconstruction of grip functions. To date, no study has compared the efficacy of this combined nerve and tendon transfer (CNaTT) procedure to traditional grip reconstruction by means of tendon transfer alone, thus constituting a major gap in the literature. The purpose of this study is therefore to fill that knowledge gap by comparing the clinical outcomes of a cohort of patients who undergo the CNaTT procedure to restore hand function, to those treated by means of tendon transfer alone.",[28,439,440,99,441],"Tendon Transfer","Nerve Transfer","Grip Function","2024-08-07",{"date":444,"type":33},"2024-08-09",{"date":446,"type":33},"2020-01-26",{"date":448,"type":21},"2026-12-31",{"name":450,"class":40},"Göteborg University",{"id":452,"slug":453,"hasResults":11,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":457,"eligibilityCriteria":458,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":459,"targetDuration":4,"studyType":22,"phases":461,"briefSummary":462,"conditions":463,"keywords":464,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":41},"100552430","activity-based-therapy-and-transcutaneous-spinal-cord-stimulation-after-spinal-cord-injury-abt-tcscs-100552430","NCT06472986","Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)","Feasibility and Efficacy of Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation for Neurorestoration of Upper Limbs After Cervical Spinal Cord Injury","ABT-TCSCS","Inclusion Criteria:\n\n* Individuals with chronic traumatic and non-traumatic cervical SCI (ASIA classification A-incomplete\\*\\*, B, C, D) between C1-C8\n* Adults more than 18 years old\n* At least 6 months post-spinal cord injury\n* A score of 2 - 15 on the upper extremity motor score of the ISNCSCI\n* A score between 5 - 40 on GRASSP Version 1 Strength on at least one side\n* Individuals who are medically stable\n\nExclusion Criteria:\n\n* Individuals with any other upper extremity deficit\n* Unable to provide informed consent\n* Unable to participate in an intensive rehabilitation outpatient program\n* Spasticity that limits the range of motion greater than 50% for the elbow or wrist",{"count":460,"type":21},24,[53],"The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.",[56,28],[465,466,467],"stroke","cerebrovascular accident","CVA","2024-07-07",{"date":470,"type":33},"2024-07-09",{"date":472,"type":33},"2022-10-07",{"date":474,"type":21},"2027-06-30",{"name":476,"class":40},"University Health Network, Toronto",{"id":478,"slug":479,"hasResults":11,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":4,"eligibilityCriteria":483,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":22,"phases":486,"briefSummary":488,"conditions":489,"keywords":490,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":201},"100537145","early-phase-1-neuromodulation-to-reduce-muscle-stiffness-following-spinal-cord-injury-100537145","NCT06274021","Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury","Shared and Distinct Antispastic Effects of Electrical and Pharmacological Neuromodulation","Inclusion criteria:\n\n* Age 18 years or older\n* History of spinal cord injury\n* Time since diagnosis longer than six months\n* Presence of spasticity in the lower limbs (≥ 3 on the Numerical Rating Scale of Spasticity Severity \\[range from 0 to 10\\])\n* If needed, agreement to reduce antispastic medication\n\nExclusion criteria:\n\n* Neurological level of spinal cord injury below T11\n* Ventilatory-dependent\n* Change in neurological status over the past 2 months\n* Rigidity, contraction, or passive range of motion of less than 40 deg in both knee joints\n* Botulinum toxin injections in lower extremities in the previous 3 months before enrollment\n* Systolic blood pressure at rest lower than 90 mm Hg\n* Implanted active devices (e.g., intrathecal baclofen pumps)\n* Passive implants (plates, screws) between T11 and L2 vertebras\n* Skin conditions precluding placement of electrodes\n* Pressure ulcers stage 2 or higher on the gluteal area or lower extremities\n* Receiving antibiotics for infections\n* Pregnancy\n* Difficulty following instructions\n* Participation in another study with investigational drugs or devices within the 30 days preceding and during the present study\n* Other medical risks\u002Fcontraindications as determined by the study physicians",{"count":485,"type":21},16,[487],"EARLY_PHASE1","People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly.\n\nThe investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of stimulation pulse rates. Also, transcutaneous spinal stimulation is compared to muscle relaxants such as baclofen and tizanidine, commonly given to people with spinal cord injuries, to reduce muscle stiffness and spasms. By doing this, the investigators hope to discover if transcutaneous spinal stimulation similarly reduces muscle spasms and stiffness or if combining both methods works best. This could help improve treatment options for people with spinal cord injuries in the future.",[56,182,28,181],[182,95,491,66,492,493,494,495,60,496],"Electrical Stimulation","Spasticity","Transcutaneous Spinal Stimulation","Lower extremity","Transcutaneous spinal cord stimulation","Spinal reflex","2024-06-28",{"date":499,"type":33},"2024-07-01",{"date":501,"type":33},"2024-03-01",{"date":503,"type":21},"2025-12-31",{"name":505,"class":40},"University of Mississippi Medical Center",{"id":507,"slug":508,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":513,"targetDuration":4,"studyType":22,"phases":514,"briefSummary":515,"conditions":516,"keywords":517,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":4},"100549708","epidural-stimulation-for-upper-extremity-function-100549708","NCT06437548","Epidural Stimulation for Upper Extremity Function","Spinal Cord Stimulation for Reanimation After Nervous System Injury","Inclusion Criteria:\n\n* Age ≥18 years and ≤65\n* Provides informed consent\n* History of upper extremity nerve transfer \\> 6 months prior to enrollment\n* Completion of standard post-nerve transfer occupational therapy\n* Baseline upper extremity strength of \\\u003C 5\u002F5 grade with the MRC\n* Scheduled to undergo a cervical spinal cord stimulation procedure for chronic pain refractory to first line therapy\n* Willing and able to adhere to the study protocol\n\nExclusion Criteria:\n\n* Central nervous system (CNS) malignancy\n* A contraindication to the SCS procedure\n* Diagnosis that precludes the patient from full participation in the protocol\n* A functional implanted device (pacemaker, vagus nerve device, baclofen pump)\n* Botulinum toxin injection in upper extremity muscles \\\u003C 6 months prior to enrollment\n* For female participants, current\u002Fplanned pregnancy (females of childbearing age will be asked to take a pregnancy test on the day of the intervention)\n* Other factors that prevent participation in the opinion of the surgeon-principal investigator",{"count":126,"type":21},[53],"Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life.\n\nAt present, there are limited options for hand or arm reanimation in this patient population. Nerve transfer is one such option that can partially restore the natural movement of hand or arm function in select patients.\n\nThe investigators are interested in understanding whether recovery of hand or arm motor function after nerve transfer can be augmented by cervical epidural spinal cord stimulation.",[28,61],[518,519,520,521,522,523,524],"spinal","cord","stimulation","percutaneous","peripheral","nerve","transfer","2024-05-30",{"date":527,"type":33},"2024-05-31",{"date":529,"type":21},"2024-09",{"date":531,"type":21},"2027-09",{"name":533,"class":40},"Brigham and Women's Hospital"]