[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injury-sci-initial-encounter\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injury-sci-initial-encounter":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100629308","protocol-for-rapid-onset-of-mobilization-in-patients-with-traumatic-spinal-cord-injury-ii-prompt-sci-ii-trial-100629308",false,"NCT07472985","Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial","Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial: Initiating Early Acute Cycling Within the First Days After Spinal Cord Injury to Decrease Complications and Improve Neurofunctional Recovery","PROMPT-SCI II","Inclusion Criteria:\n\n* adults 18 years or older with non-penetrating traumatic SCI\n* SCI severity AIS grade A (complete injury with no motor or sensory function below lesion), B (sensory but no motor function preserved) or C (motor function preserved with most key muscles unable to move against gravity)\n* NLI between C0 and L2; and spine surgery performed within 48 hours of SCI\n\nExclusion Criteria:\n\n* intubated and mechanically ventilated\n* conditions interfering with patient safety or ability to undergo cycling\n* body mass index 40 kg\u002Fm2 or less (to prevent \"frog leg\" position during cycling)\n* moderate or severe traumatic brain injury\n* hemodynamic instability\n* pelvic or lower extremity\n* injury with weight-bearing or mobilization restrictions","ALL","18 Years",{"count":20,"type":21},102,"ESTIMATED","INTERVENTIONAL",[24],"NA","Spinal cord injuries (SCI) are among the most catastrophic survivable events experienced by human beings. Affected individuals remain with lifelong neurological impairment involving motor, sensory, bladder and bowel functions, which in turn impacts quality of life and independence. Currently, patients have no access to exercise therapy for weeks to months after the injury because clinicians remain fearful that early initiation of exercise therapy may be harmful to patients, and could lead to neurological deterioration. Patients are therefore mostly immobilized during the first weeks after the injury, and are at high risk of complications associated with immobility. In addition, there are compelling preclinical evidence showing that early exercise therapy is effective for promoting neurofunctional recovery. The PROMPT-SCI trial was the first to initiate early exercise therapy in the form of in-bed leg cycling within days after SCI. This trial has shown that it is safe and does not lead to neurological deterioration. However, in-bed leg cycling remains difficult to translate into the clinical environment of acute SCI, and its potential to decrease complications and improve neurofunctional recovery seems limited by the positioning in bed. The PROMPT-SCI II trial will therefore evaluate the potential of sitting leg cycling initiated within the first week of a SCI to decrease complications and improve neurofunctional recovery up to one year after the injury, in comparison to our prior data obtained with early in-bed cycling.",[27,28],"Spinal Cord Injuries","Spinal Cord Injury (SCI), Initial Encounter",[30,31,32,33,34,35,36,37],"spinal cord injury","exercise","activity-based therapy","rehabilitation","complications","acute care","critical care","neuroplasticity","RECRUITING","2026-03-17",{"date":41,"type":42},"2026-03-19","ACTUAL",{"date":44,"type":21},"2026-03-09",{"date":46,"type":21},"2031-12-31",{"name":48,"class":49},"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":5},"100557119","assessment-of-neural-signals-for-the-control-of-assistive-devices-100557119","NCT06533969","Assessment of Neural Signals for the Control of Assistive Devices","Inclusion Criteria:\n\n* Patients age 18 and older\n* Able to sign informed consent\n* Not participating in other studies that limit participation\n* Chronic (\\>6 month) traumatic Spinal Cord Injury (SCI) (C4-T1 neurological injury with American Spinal Injury Association Impairment Scale (AIS A-D) with some residual function.\n\nExclusion Criteria:\n\n* Patients that are pregnant\n* Patients under the age of 18\n* Patients unable to provide informed consent",{"count":58,"type":21},3,[24],"The study will investigate the use of motor intention-based cortical signals to trigger epidural spinal cord stimulation (ESCS) with individuals with SCI. Motor intention of UL tasks will be decoded using brain-computer interface (BCI) system based on cortical signals recorded using an Electroencephalographic (EEG) system or using their intracranially implanted devices Electrocorticographic (ECoG).",[28],[63,64],"Brain Computer Interface","Epidural Spinal Cord Stimulation","2025-09-08",{"date":67,"type":42},"2025-09-15",{"date":69,"type":42},"2024-09-06",{"date":71,"type":21},"2027-12-31",{"name":73,"class":49},"University of Miami"]