[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-stimulation-scs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-stimulation-scs":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,72,99,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100606734","the-effect-of-spinal-cord-stimulators-on-restless-leg-syndrome-100606734",false,"NCT07179406","The Effect of Spinal Cord Stimulators on Restless Leg Syndrome","Inclusion Criteria:\n\n* Has Restless Leg Syndrome\n* No major changes in RLS medications in past 4 weeks\n* Willing and able to comply with study protocol\n* Healthy Controls - No RLS diagnosis\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Any mental or physical limitation that would prevent completing any of the studies\n* Currently using another device to treat RLS\n* Unable or unwilling to comply with study protocols\n* Other medical condition that would put the subject at risk as determined by the investigator\n* Pregnant, breastfeeding, or trying to become pregnant\n* Currently participating or planning to participate in any other investigational clinical evaluation during the study period that may, in the opinion of the investigator, affect RLS\n* One or more of the following diseases: spinal cord injury, severe peripheral neuropathy or radiculopathy, severe psychiatric or cognitive disorder that may interfere with participation of the study, history of drug or alcohol abuse within the past year, epilepsy or seizure disorder, current active or chronic infection other than the common cold, malignancy within the past 5 years (not including basal cell or squamous cell skin cancer), severe movement disorder (i.e. Parkinson's disease), deep vein thrombosis, or multiple sclerosis.",true,"ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and\u002For chronic pain. Participants will undergo standard clinical assessments including EEG, EMG, h-reflex, SSEP, ERP, and TMS under varying SCS conditions.The study involves 4 arms. Arm 1 are individuals diagnosed with RLS and Healthy Controls. Arm 2 are individuals diagnosed with RLS and have an existing SCS. Arm 3 are individuals diagnosed with RLS and scheduled to receive a SCS. Arm 4 are individuals with chronic pain and have a SCS, but no diagnosis of RLS.",[26,27],"Restless Leg Syndrome (RLS)","Spinal Cord Stimulation (SCS)",[29,30,31,32],"SCS","Spinal Cord Stimulation","RLS","Restless Leg Syndrome","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":37},"2025-08-04",{"date":41,"type":20},"2028-12-31",{"name":43,"class":44},"University of Alabama at Birmingham","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100623953","severe-chronic-neuropathic-pain-a-treatment-bundle-using-spinal-cord-stimulation-and-multidisciplinary-treatment-to-reduce-pain-and-improve-physical-function-100623953","NCT07403331","Severe Chronic Neuropathic Pain: A Treatment Bundle, Using Spinal Cord Stimulation and Multidisciplinary Treatment, to Reduce Pain and Improve Physical Function.","Optimizing Treatment for Chronic Neuropathic Pain: A Replicated Single Case Experimental Design Evaluating a Treatment Bundle Consisting of Multidisciplinary Rehabilitation and Spinal Cord Stimulation (SCS-R)","SCS-R","Inclusion criteria:\n\n* Peripheral neuropathic pain in one or both legs for \\>6 months due to:\n\n  * (1) Post Spinal Pain Syndrome (type 1 or 2).\n  * (2) Localized nerve damage.\n* The area of the neuropathic pain in the leg(s) must be the dominant pain component.\n* Age ranges from 18-60 years.\n* Previous standard conservative (or surgical) treatment attempted.\n* Opioid use within permissible limits at implantation time (daily opioid dose \\\u003C50 mg OMEQ).\n* Willingness to actively participate in the treatment bundle.\n* Living within reasonable travelling distance from Oslo.\n* Proficiency in understanding oral and written Norwegian, essential to benefit from the program that relies on mutual comprehension, nuanced conversation, and emotional expression, which are language-dependent.\n* Cognitive capacity to provide informed consent.\n* Ability to master the technical aspects of the SCS system (switching programs on the remote control).\n\nExclusion criteria:\n\n* Currently undergoing the claims process for health benefits (e.g., disability pensions from NAV (Norwegian Labour and Welfare Administration).\n* Presenting a psychological or psychiatric disorder that may impact treatment efficacy.\n* Chronic generalized pain conditions.\n* Other pain conditions in the affected area, such as osteoarthritis.\n* Pregnancy.","60 Years",{"count":56,"type":20},10,[23],"People with nerve damage can develop nerve pain. The pain can sometimes be severe and unpredictable, causing odd or alarming sensations - for example, lightning-like or electric shock feelings in the area served by the damaged nerve.\n\nThe investigators will examine a treatment for nerve pain in the legs caused by nerve damage, which can occur after a herniated disc or a bone fracture, with or without surgery.\n\nPrevious research suggests that spinal cord stimulation can relieve nerve pain in the legs after surgery or injury, but its effectiveness is still debated. Other studies show that multidisciplinary treatment helps people with long-term pain to improve their quality of life and to better cope in life. National and international guidelines recommend this kind of multidisciplinary care for long-term pain.\n\nThere has yet been published research on spinal cord stimulation combined with multidisciplinary treatment as a bundle intervention. The investigators therefore want to find out whether this combined approach can reduce nerve pain in the legs and improve physical functioning.",[60,61,62,63,27],"Neuropathic Pain","Multidisciplinary Approach","Rehabilitation Exercise","Acceptance & Commitment Therapy","2026-05-04",{"date":66,"type":37},"2026-05-06",{"date":64,"type":20},{"date":69,"type":20},"2027-07-01",{"name":71,"class":44},"Oslo University Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":45},"100604722","analysis-of-selected-biochemical-parameters-in-cerebrospinal-fluid-and-peripheral-blood-in-the-treatment-of-neuropathic-pain-using-spinal-cord-stimulation-scs-100604722","NCT07153211","Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)","Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS) Assessment of the Mechanism of Action of SCS and the Potential of Biochemical Studies in Therapy Planning and Monitoring","Inclusion Criteria:\n\n* Age 18-80\n* PSPS or CRPS\n* Neuropathic pain for at least 6 months\n\nExclusion Criteria:\n\n* Drug\u002Falcohol addiction\n* Malignant tumour\n* Psychiatric disorders\n* Active infection\n* Pregnancy","80 Years",{"count":81,"type":20},30,[23],"This project aims to identify key cells and molecules involved in the development and modulation of neuropathic pain treated with spinal cord stimulation (SCS). By measuring concentrations of selected inflammatory mediators and signaling molecules (e.g., IL-1β, IL-6, IL-17, IL-33, BDNF, VEGF, GABA) in the blood and cerebrospinal fluid (CSF) of patients undergoing SCS, the study seeks to better understand the mechanism of action of SCS. The findings may allow the development of predictive biomarkers, help tailor stimulation parameters, and support complementary pharmacotherapy. The project also explores differences in response to various stimulation types and the role of glial cells in SCS efficacy, with a view to improving patient outcomes through more personalized neuromodulation strategies.",[60,85,27],"Chronic Pain",[87,88,89],"spinal cord stimulation","neuropathic pain","immunomodulatory effects of scs","2025-08-29",{"date":92,"type":37},"2025-09-03",{"date":94,"type":37},"2022-11-01",{"date":96,"type":20},"2026-12-31",{"name":98,"class":44},"Pawel Sokal",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":110,"conditions":111,"keywords":117,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":129,"locationsCount":45},"100595836","investigating-the-impact-of-spinal-cord-electrical-stimulation-combined-with-individualized-physical-therapy-on-lower-extremity-function-in-patients-with-spinal-cord-injury-100595836","NCT07037628","Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury","Inclusion Criteria:\n\n* Aged between 20 and 70 years.\n* Diagnosed with spinal cord injury, classified as ASIA Grade A-D.\n* Neurological level of injury between T1 and L2.\n* Spinal cord injury has stabilized (for at least 3 months).\n* Currently receiving standard treatment at Hualien Tzu Chi Hospital and referred by a neurosurgeon or orthopedic surgeon to receive spinal cord stimulation (SCS) and\u002For individualized physical therapy.\n* Capable of participating in one-on-one physical therapy sessions 3 to 5 times per week, and assessed by the medical team as able to complete at least a 3 weeks course of treatment.\n* Fully conscious, able to understand the study information, and willing to sign the consent form and participate in the full assessment process.\n\nExclusion Criteria:\n\n* Individuals with severe brain injury, neurodegenerative diseases, or other major neurological disorders.\n* Those with severe fractures, joint contractures, or conditions preventing participation in lower limb training.\n* Individuals with a cardiac pacemaker or who are pregnant.\n* Those unable to comply with the treatment or assessment procedures.","20 Years","70 Years",{"count":108,"type":20},76,"OBSERVATIONAL","This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries:\n\n1. Spinal cord stimulation (SCS) combined with one-on-one physical therapy\n2. One-on-one physical therapy alone",[112,113,114,115,27,30,116],"Spinal Cord Injury","Spinal Cord Injury Thoracic","Spinal Cord Injury\u002FDamage","Spinal Cord Injury T1-L2","Epidural Electrical Stimulation",[118,119,120,121],"ASIA B","ASIA C","ASIA D","ASIA A","NOT_YET_RECRUITING","2025-06-24",{"date":125,"type":37},"2025-06-27",{"date":127,"type":20},"2025-08-01",{"date":41,"type":20},{"name":130,"class":44},"Lian-Cing Yan, MSPT",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":45},"100574593","psychological-assessment-in-patients-treated-with-spinal-cord-stimulation-100574593","NCT06761300","Psychological Assessment in Patients Treated with Spinal Cord Stimulation","Psychological Assessment in Patients Suffering from Chronic Pain Treated with Spinal Cord Stimulation","Inclusion Criteria:\n\n1. Patients suffering from chronic pain (VAS\\>4) from at least 6 months\n2. Patient eligible for SCS implantation\n3. Age \\>18 years old\n4. Willingness and ability to comply with scheduled visits and other trial procedures\n5. Understanding and speaking Italian language\n6. Written informed consent\n\nExclusion Criteria:\n\n1. Psychiatric disorders or conditions that might impair the ability to give informed consent\n2. Comorbidity that may impact on compliance to study procedures",{"count":19,"type":20},"This is a prospective observational study to investigate the impact of spinal cord stimulation (SCS) procedure in chronic pain perception and management. Patients' psychological status at different time points and its correlation with pain outcomes and satisfaction with the SCS intervention will be also evaluated.\n\nThe primary aim is to study the associations between psychological variables and intervention outcomes (pain reduction, satisfaction, removal of SCS). Our hypothesis is that people with higher scores in anxiety and depression symptoms would report lower satisfaction with SCS procedure and higher levels of perceived pain after the implantation of the device",[27,85],[30,142],"chronic pain","2024-12-31",{"date":145,"type":37},"2025-01-07",{"date":147,"type":37},"2024-04-09",{"date":149,"type":20},"2026-01-01",{"name":151,"class":44},"European Institute of Oncology"]