[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-fusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-fusion":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,38,72,100,131,156,197,226,256,287,310,330,358,384,411,444,471,497,518],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100544389","durability-of-suppl-rod-constructs-supplementary-rod-technique-for-long-segment-posterior-instrumented-spinal-fusions-100544389",false,"NCT06368245","Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions","Durability of Supplementary Rod Constructs-SuppleMentAry Rod Technique (SMART)-for Long-segment Posterior Instrumented Spinal Fusion Procedures: A Multicenter Retrospective Comparative Study With Dual-rod Constructs","Inclusion Criteria:\n\n* Age 45 years and older.\n* Patients receiving long-segment posterior TL instrumented fusion using either supplementary rod constructs or dual-rod constructs (the index surgery).\n\n  * Long-segment is defined as the UIV at a thoracic level and the LIV at the sacrum\u002Filium.\n  * Supplementary rod constructs are defined as: in addition to the traditional two primary rods, at least one supplementary rod (eg, accessory rods or satellite rods) is used, and at least one supplementary rod and one primary rod (ie, at least two rods) together must span multiple (≥ 2) vertebral levels. The supplementary rod constructs do not include rods connected end-to-end or side-to-side that do not bridge multiple vertebral levels.\n  * The index surgery can be a primary surgery or a revision surgery.\n  * The index surgery, staged or non-staged, must use posterior spinal fusion but can be in combination with other approaches such as an anterior procedure.\n* If the index surgery is a revision surgery, the primary rods must be replaced in the revision surgery, with the exception of Harrington or Luque rods which can remain in place.\n\n  o If the Harrington or Luque rods remain in situ, they must already have the UIV at the thoracic level and the LIV at the sacrum\u002Filium, or an extension of the existing Harrington or Luque is performed such that the UIV is at the thoracic level and the LIV at the sacrum\u002Filium.\n* The index surgery was performed between January 1, 2014, and December 31, 2020, inclusive.\n* Minimum 3 months of FU after the index surgery.\n* Ability to provide informed consent according to the IRB\u002FEC defined and approved procedures if applicable for retrospective data analysis.\n\nExclusion Criteria:\n\n* Spinal fusion performed for acute trauma (ie, ≤ 1 year of trauma).\n* Spinal fusion performed for tumor.\n* Spinal fusion performed for infection.\n* Patients with Parkinson's Disease.\n* Patients with neuromuscular disorders.\n* Patients with spine malignancies requiring chemo- or radiation therapy.","ALL","45 Years",{"count":19,"type":20},1244,"ESTIMATED","OBSERVATIONAL","This is a multicenter retrospective comparative cohort study. The index surgery for this study is primary or revision long-segment posterior thoracolumbar (TL) instrumented fusion using either a supplementary rod construct or a dual-rod construct. Eligible patients who already had index surgery, will be identified for enrollment through a review of medical records of the participating surgeons at the study sites.",[24],"Spinal Fusion","RECRUITING","2026-06-29",{"date":28,"type":29},"2026-06-30","ACTUAL",{"date":31,"type":29},"2025-03-24",{"date":33,"type":20},"2029-07-31",{"name":35,"class":36},"AO Foundation, AO Spine","OTHER",17,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100519373","kids-with-iron-deficiency-and-scoliosis-100519373","NCT06042699","Kids With Iron Deficiency and Scoliosis","Kids With Iron Deficiency and Scoliosis (KIDS) Study","KIDS","Inclusion Criteria:\n\n1. 10-26 years old;\n2. diagnosis of scoliosis or kyphosis;\n3. self-reported ability to swallow a tablet;\n4. spinal fusion procedure planned approximately 6 to 24 weeks from an orthopedic surgical clinic visit at which patient agrees to phlebotomy for screening blood work;\n5. serum ferritin less than or equal to 25 µg\u002FL.\n\nExclusion Criteria:\n\n1. taking or planning to take iron-containing supplement on patient's own volition, and not willing to stop for duration of study;\n2. taking or planning to take iron-containing supplement as prescribed or recommended under the care of a physician;\n3. Hg \\\u003C10mg\u002FdL if post-menarchal, Hg \\\u003C 11 if premenarchal or male\n4. C-reactive protein \\> 10 mg\u002FL\n5. receiving nutritional support by report in the medical chart;\n6. self-reported history of hypersensitivity reaction to iron-containing supplements;\n7. self-reported history of or suspected non-iron deficient hematologic disorder;\n8. self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis;\n9. objection to receiving red blood cell transfusions;\n10. current pregnancy (by self-report);\n11. prisoners;\n12. patient or parent decides against study participation.",true,"10 Years","26 Years",{"count":50,"type":20},275,"INTERVENTIONAL",[53],"NA","This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in adolescents undergoing scoliosis surgery.\n\nResearch Question(s)\u002FHypothesis(es):\n\nPrimary\n\n* Iron supplementation will reduce the incidence of perioperative RBC transfusion in iron deficient scoliosis patients undergoing spinal fusion.\n\nSecondary\n\n* Iron supplementation will reduce postoperative neurocognitive functional declines in iron deficient scoliosis patients undergoing spinal fusion.\n* Iron supplementation will improve patient-reported physical functioning in iron deficient scoliosis patients undergoing spinal fusion.",[56,57,58,59,60,24,61],"Adolescent Idiopathic Scoliosis","Neuromuscular Scoliosis","Perioperative\u002FPostoperative Complications","Iron Deficiencies","Anemia","Postoperative Cognitive Dysfunction","2026-06-25",{"date":64,"type":29},"2026-06-26",{"date":66,"type":29},"2024-01-11",{"date":68,"type":20},"2028-02-01",{"name":70,"class":36},"Columbia University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":71},"100525269","endothelial-damage-in-major-spine-surgery-measured-by-circulating-syndecan-1-an-observational-studyglycortho-100525269","NCT06119542","Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)","Endothelial Glycocalyx Damage in Major Spine Surgery, as Measured by Circulating Syndecan-1 Levels: a Prospective Observational Pilot Study.(GlycOrtho)","GlycOrtho","Inclusion Criteria:\n\n* Undergoing Major Spine Surgery with estimated blood loss\\> 25% of total blood volume\n* American Society of Anesthesiology status 1-2-3\n* Able to comprehend and sign informed consent.\n* If age \\\u003C18 years: parent or legal representative able to comprehend and sign informed consent\n\nExclusion Criteria:\n\n* Surgery outside of laboratory opening hours\n* Patients undergoing spine surgery for genetic syndromes\u002Fneuromuscular scoliosis","12 Years","75 Years",{"count":83,"type":20},30,"The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1.\n\nThe main questions it aims to answer are:\n\n* What is the extent of endothelial glycocalyx shedding in major spine surgery?\n* Are there differences in different type of surgical populations? (adolescent idiopathic scoliosis, adult degenerative spine disease, oncologic surgery)\n\nTo do so, blood samples will be drawn from participants at the following timepoints:\n\n* basal\n* after surgery\n* if transfusion of Fresh Frozen Plasma: before and after transfusion\n* Post-Operative Day 1-2-4",[24],[87,88,89,90],"Endothelium","Syndecan-1","Surgery","Glycocalyx","2026-05-20",{"date":93,"type":29},"2026-05-22",{"date":95,"type":29},"2026-02-28",{"date":97,"type":20},"2026-09-30",{"name":99,"class":36},"Istituto Ortopedico Rizzoli",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":51,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":71},"100543543","phase-2-aprepitant-treatment-to-prevent-postoperative-nausea-and-vomiting-in-children-undergoing-scoliosis-surgery-100543543","NCT06357234","Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery","A Randomized Controlled Trial Comparing Aprepitant to Standard of Care for Postoperative Nausea and Vomiting Prophylaxis in Children and Adolescents Undergoing Scoliosis Surgery: The APRE-PONV Trial","Inclusion Criteria:\n\n* Posterior Spinal Instrumentation and Fusion (PSIF) for idiopathic scoliosis\n* The fusion must include at least 6 vertebral levels.\n* Children greater than or equal to 8 years old, and less than 19 years old on the day of surgery\n* Weight \\> 40kg - for ease of pharmacy preparation (PONV dose 1mg per kg to max 40mg)\n\nExclusion Criteria:\n\n* Patient\u002F Parent refusal\n* Hypersensitivity to Aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to Aprepitant)\n* Developmental delay as reported by parents\n* Pregnant - Pregnancy test done as standard of care pre-operative\n* Severe systemic disease ASA classification III or greater\n* Concurrent use of any medication with severe interaction with Aprepitant as outlined in product monograph.\n* Neuromuscular or congenital scoliosis\n* Inability to take PO medications","8 Years","19 Years",{"count":110,"type":20},100,[112],"PHASE2","This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).",[24,115,116],"Nausea and Vomiting, Postoperative","Anesthesia",[118,119,120,121],"pediatric","anesthetic","scoliosis","Aprepitant","2026-04-22",{"date":124,"type":29},"2026-04-27",{"date":126,"type":29},"2025-03-17",{"date":128,"type":20},"2027-09",{"name":130,"class":36},"IWK Health Centre",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":51,"phases":140,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":71},"100474683","early-phase-1-regional-nerve-blocks-to-improve-analgesia-and-recovery-in-older-adults-undergoing-spinal-fusion-100474683","NCT05461092","Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion","Inclusion Criteria:\n\n* Are 65 or older\n* Indicated for lumbar spinal fusion of less than or equal to 3 levels\n* Undergoing elective surgery\n* no contraindications to local anesthetic or procedures\n* no severe cardiac or respiratory disease\n* no preexisting cognitive dysfunction\u002Fdementia\n\nExclusion Criteria:\n\n* 64 years old and younger\n* emergency treatment\n* pathologic fractures\n* seeking revision surgery\n* major liver or kidney dysfunction\n* coexisting hematological disorder or irreversible abnormal coagulation\n* patients with previous diagnosis of dementia or SLUMS score \\\u003C20\n* patient unable to communicate\u002Fcooperate\u002Flanguage barrier\n* BMI\\>40\n* allergy to study medications\n* opioid tolerant (oral opioid intake morphine equivalent =\\\u003C 60 mg\u002Fday)\n* other sources of chronic pain like fibromyalgia\n* patients with associated significant CNS or respiratory disease (home oxygen requirements)\n* incarcerated patients\n* psychiatric illnesses preoperative neurological deficits greater than one motor group, less than three out of five motor functions\n* pregnant or breast feeding","65 Years",{"count":139,"type":20},50,[141],"EARLY_PHASE1","This initial study is a feasibility study for implementing thoracolumbar interfascial plane, or TLIP, blocks in older adults undergoing spinal fusion. TLIP blocks are done by using anesthesia. In this case, it will be done to either side of the back where surgery will be performed. This has been shown to decrease pain the patients have post-operatively in previous research. In this study, the investigators will examine recruitment rates, completion of assessments, dropout rate, gather patient feedback, and identify barriers to performing TLIP. Further, this feasibility study will provide data to determine adequate sample size and refine methods and outcomes for a future randomized clinical trial. The ultimate goal is to perform a large, appropriately powered randomized control trial to determine the effect of TLIP blocks on pain, physical function and disability, opioid consumption, and delirium in older adult undergoing spinal fusion.",[144,145,24,146],"Delirium","Pain, Back","Thoracolumbar Interfascial Plane Block","2026-03-24",{"date":149,"type":29},"2026-03-27",{"date":151,"type":29},"2024-01-01",{"date":153,"type":20},"2026-12-31",{"name":155,"class":36},"University of Iowa",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":51,"phases":165,"briefSummary":166,"conditions":167,"keywords":179,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":71},"100609711","trans-auricular-stimulation-for-postoperative-inflammation-in-spine-surgery-100609711","NCT07218133","Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery","TAPIS","Inclusion Criteria:\n\n* Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions)\n* Ability to undergo a reliable neurologic examination and pain assessments\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Shorter-segment spinal fusions than those described above\n* Undergoing current active cancer therapy\n* Undergoing treatment with immunosuppressive drugs\n* Additional spinal surgery within past 6 months\n* Sustained bradycardia or presence of pacemaker\n* History of substance abuse","18 Years",{"count":139,"type":20},[53],"This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.",[24,168,169,170,171,172,173,174,175,176,177,178],"Hyperglycemia","Postoperative Pain Management","Postoperative Care","Spine Disease","Neurologic Deficits","Neurological Disorder","Inflammation","Spine Condition","Spinal (Fusion) Surgery","Cytokine Levels","Spine Fusion",[180,181,182,183,184,185,186,187],"spinal fusion","postoperative pain","glycemic control","inflammation","vagal nerve stimulation","postoperative complications","cytokine","spine surgery","2026-02-17",{"date":190,"type":29},"2026-02-20",{"date":192,"type":29},"2025-10-08",{"date":194,"type":20},"2026-12",{"name":196,"class":36},"Alexander T. Yahanda",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":81,"enrollmentInfo":204,"targetDuration":4,"studyType":51,"phases":206,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":225},"100537818","photobiomodulation-for-lower-back-pain-post-spinal-fusion-and-decompression-surgery-100537818","NCT06282770","Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery","Utilizing Photobiomodulation Via Laser Diode Belts To Treat Chronic Lower Back Pain in Patients Who Have Undergone Spinal Fusion and Decompression Surgery","Inclusion Criteria:\n\n* Subject will have undergone minimally invasive spinal fusion surgery or spinal decompression surgery in their lower back L1-S1.\n* Have low back pain of \\>3 months and a pain threshold of \\> 4 (as described by the the subject), age \\> 18 years, and English speaking to eliminate possible miscommunication and consequent human error regarding belt use.\n* Subject must have had surgery at minimum to 1 year prior to start of study and no more than 5 years prior to start to study\n\nExclusion Criteria:\n\n* Patients with tumors\n* Current infection\n* Drug misuse history\n* Skin conditions preclude the use of laser belt\n* Severe spondylolisthesis, spondylolysis, spinal stenosis, ankylosing spondylitis\n* Previous low back surgery exceeding 5 years to initial start date.",{"count":205,"type":20},80,[53],"After spinal fusion and decompression surgery there is a possible risk of developing chronic back pain. After surgery there is typically inflammation around the operation site and this inflammation can be painful and debilitating to patients.\n\nMany possible treatment plans have been incorporated to assist the patient with recovery - notably medications, physical therapy, and braces. However, few studies have looked at laser diodes that utilize high-power laser lights that are aimed at decreasing pain and inflammation. Investigators aim to look compare patients using a back brace with laser diodes within versus those who wear a normal brace used as a placebo. Investigators will also assess the patient's surgical wound to monitor the progression of wound healing while using the brace.",[24,209],"Chronic Lower Back Pain",[211,212,174,24,213,214,215],"Photobiomodulation","Laser Diode","Spinal Decompression","Lumbar","Back Pain","2026-01-11",{"date":218,"type":29},"2026-01-13",{"date":220,"type":29},"2023-07-01",{"date":222,"type":20},"2026-07-01",{"name":224,"class":36},"University of California, Los Angeles",2,{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":233,"targetDuration":4,"studyType":51,"phases":235,"briefSummary":236,"conditions":237,"keywords":240,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":225},"100460304","necessity-of-fusion-following-decompression-surgery-in-patients-with-single-level-lumbar-stenosis-100460304","NCT05273879","Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis","Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis: Study Protocol for an Open-label Multicenter Non-inferiority Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* age of patients from 45 to 75 years;\n* stenosis C or D according to Shizas et al. according to MRI at the level of L2-L3, L3-L4, L4-L5 or L5-S1;\n* clinical manifestations of lumbar stenosis (neurogenic claudication syndrome and\u002For radiculopathy);\n* lack of effect from conservative therapy within 3 months;\n* Informed consent to take part in the study.\n\nExclusion Criteria:\n\n* spondylolisthesis more than 3 mm;\n* spinal instability according to functional radiography;\n* sagittal imbalance (type 4 according to C. Barrey);\n* bone density of the vertebrae at the level of the operation is less than 100 HU;\n* clinically significant spinal stenosis at 2 or more levels;\n* previously performed surgeries on the spine;\n* risk of anesthesia 4 or 5 according to ASA;\n* inability to take part in control examinations within 2 years after the operation;\n* participation in other clinical trials related to surgical or conservative treatment of diseases of the spine.",{"count":234,"type":20},86,[53],"Long-term clinical results of two methods of surgical treatment (spinal decompression with or without fusion) in patients with single-level lumbar stenosis will be compared. A clear framework for surgical treatment methods and standardized postoperative rehabilitation treatment will be set to obtain the maximum homogeneity of the patient groups.\n\nThis trial should provide the first level of evidence for the need for spinal fusion in patients with single-level lumbar stenosis, subject to the high homogeneous comparison groups. Additional results will allow comparing the economic aspects of different surgical treatments for 2 years after surgery.",[238,239,24],"Lumbar Spinal Stenosis","Spinal Stenosis",[241,242,243,244,245],"lumbar spine","lumbar fusion","laminotomy","decompression without fusion","lumbar stenosis","2025-12-11",{"date":248,"type":29},"2025-12-18",{"date":250,"type":29},"2022-04-01",{"date":252,"type":20},"2026-12-30",{"name":254,"class":255},"Sklifosovsky Institute of Emergency Care","OTHER_GOV",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":108,"enrollmentInfo":264,"targetDuration":4,"studyType":51,"phases":266,"briefSummary":268,"conditions":269,"keywords":276,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":284,"leadSponsor":286,"locationsCount":71},"100609691","phase-2-intravenous-iron-in-kids-with-iron-deficiency-and-scoliosis-study-100609691","NCT07217873","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis","IV-KIDS","Inclusion Criteria:\n\n* 10 -19 years old\n* diagnosis of scoliosis or kyphosis\n* scheduled for imminent spinal fusion procedure (\\\u003C6 weeks) at MS-CHONY\n* Iron deficiency or hypoferritinemia, defined as serum ferritin less than or equal to 50 μg\u002FL\n\nExclusion Criteria:\n\n* C-reactive protein \\> 10 mg\u002FL\n* receiving nutritional support by report in the medical chart\n* self-reported history of hypersensitivity reaction to iron-containing supplements\n* self-reported history of receiving intravenous iron supplements\n* self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis\n* objection to receiving red blood cell transfusions\n* current pregnancy (identified by self-report or documentation of preoperative screening test in the medical record)\n* prisoners\n* patient or parent decides against study participation",{"count":265,"type":20},120,[112,267],"PHASE3","Adolescents and young adults undergoing spinal fusion surgery for the correction of scoliosis and other spinal deformity are at high risk of perioperative iron deficiency and anemia, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative intravenous iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.",[270,271,272,273,24,274,275],"Scoliosis Correction","Iron Deficiency","Transfusion Blood","Surgery Complications","Scoliosis Idiopathic Adolescent","Scoliosis Neuromuscular",[120,277,278,180,279],"iron deficiency","blood transfusion","iron supplementation","2025-11-21",{"date":282,"type":29},"2025-11-26",{"date":280,"type":29},{"date":285,"type":20},"2027-10-31",{"name":70,"class":36},{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":294,"enrollmentInfo":295,"targetDuration":4,"studyType":51,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":71},"100552304","postoperative-pain-control-in-ais-using-liposomal-bupivacaine-vs-025-bupivacaine-with-epinephrine-100552304","NCT06471348","Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine","Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine","Inclusion Criteria:\n\n* ≥10 years old and ≤17 years old at assessment\n* Diagnosis of Adolescent Idiopathic Scoliosis\n* Planned surgical treatment of progressive spinal deformity with posterior spinal fusion\n\nExclusion Criteria:\n\n* Diagnosis of neuromuscular, syndromic, or congenital scoliosis\n* History of known allergy to local anesthesia\n* Chronic pre-operative opioid consumptions\n* Any other analgesic treatment for chronic pain before surgery\n* Psychiatric or neurological disorders\n* Cannot fluently read or speak English","17 Years",{"count":296,"type":20},128,[53],"A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption compared to an equal volume injection of 0.25% bupivacaine with epinephrine for patients aged 10 to 17, with 128 patients randomly assigned to one of two arms: liposomal bupivacaine or 0.25% bupivacaine with epinephrine.",[300,24],"Post Operative Pain","2025-10-21",{"date":303,"type":29},"2025-10-22",{"date":305,"type":29},"2025-08-15",{"date":307,"type":20},"2028-08-31",{"name":309,"class":36},"Boston Children's Hospital",{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":51,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":71},"100525322","pulse-width-modulation-100525322","NCT06120231","Pulse-Width Modulation","Pulse-width Modulation During Pedicle Screw Stimulation","Inclusion Criteria:\n\n* A patient will be eligible for study participation once they have been booked for a surgery involving pedicle screw placement and intraoperative neuromonitoring.\n\nExclusion Criteria:\n\n* The study excludes neonates, minors, pregnant women, prisoners and cognitively impaired patients.",{"count":139,"type":20},[53],"The overarching aim of this project is to modulate the pulse-width during stimulation of pedicle screws and record the response thresholds associated with each PWM setting. During this initial phase of the investigation, no further data will be collected.",[24,239],"2025-06-03",{"date":323,"type":29},"2025-06-05",{"date":325,"type":29},"2023-12-01",{"date":327,"type":20},"2027-06-01",{"name":329,"class":36},"Dartmouth-Hitchcock Medical Center",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":46,"sex":16,"minAge":338,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":51,"phases":341,"briefSummary":342,"conditions":343,"keywords":346,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":356,"locationsCount":71},"100440042","phase-3-a-clinical-trial-of-intravenous-lidocaine-after-spinal-surgery-to-prevent-delirium-and-reduce-pain-100440042","NCT05010148","A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain","Continuous Post-operative Lidocaine Infusion Following Major Reconstructive Spine Surgery in the Elderly to Minimize Delirium and Opiate Use: A Randomized Control Trial","LIMPP","Inclusion Criteria:\n\n* Elective spinal fusion surgery\n* Estimated length of stay ≥3 days\n* Fluent in English\n\nExclusion Criteria:\n\nSurgical:\n\n* Cervical spine surgery\n* Non-spine surgeries\n\nOther:\n\n* Allergy or intolerance of lidocaine\n* Significant heart disease (2nd or 3rd heart block without a pacemaker, Left ventricular ejection fraction (LVEF) \\\u003C30%, significant arrhythmia \\[Adams-strokes, Wolff-Parkinson-white syndrome\\], concurrent treatment with a class 1 antiarrhythmic or amiodarone)\n* Significant hepatic or renal dysfunction\n* History of uncontrolled seizures\n* Acute porphyria\n* Preoperative usage of long-acting opioids (methadone, buprenorphine, fentanyl patch, ms-contin, oxycontin) or preoperative opioid usage greater than or equal to the equivalent of 60 mg of oral morphine equivalents.\n* Severe cognitive impairment (reported by proxy or a score of \\>5 on the Short Portable Mental Status Questionnaire (SPMSQ))\n* Self-, or proxy-reported physical impairment preventing the subject from consenting or answering questions\n* Evidence of preoperative delirium\n* Participated in Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain (GIPP) or Postoperative Cognition in Older Adult Surgical Patients (PCD) study previously\n* Participating in any other clinical trial","60 Years",{"count":340,"type":20},278,[267],"Postoperative delirium is one of the most frequent adverse events following elective non-cardiac surgery and is associated with cognitive impairment at discharge, as well as in-hospital and long-term mortality, however, despite being a well-recognized problem there is a dearth of effective interventions for prevention and management. A modifiable risk factor associated with postoperative delirium is poor postoperative pain control, and by improving the pain regimen the investigators may be able to decrease the incidence and\u002For severity of postoperative delirium. In this study, the investigators seek to study whether a postoperative intravenous infusion of lidocaine, known to improve pain control in other contexts, can decrease the risk of postoperative delirium and other opioid-related side effects, following major reconstructive spinal surgery.",[344,345,24],"Postoperative Delirium","Postoperative Pain",[347,348,349],"lidocaine","spinal surgery","opioid sparing","2025-05-05",{"date":352,"type":29},"2025-05-07",{"date":354,"type":29},"2021-09-17",{"date":128,"type":20},{"name":357,"class":36},"University of California, San Francisco",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":366,"conditions":367,"keywords":370,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":71},"100462292","a-post-market-surveillance-on-infuse-bone-graft-100462292","NCT05299762","A Post Market Surveillance on INFUSE Bone Graft","Inclusion Criteria:\n\n* Has degenerative disc disease and is indicated for lumbar interbody spine fusion from L2-S1 with INFUSE™ Bone Graft via ALIF or OLIF technique\n* Agrees to participate in the study and is able to understand and sign the Informed Consent\n* The procedure planned for the patient complies with the labeling of the devices that may be used in the surgical procedure\n* Has at least six months of nonoperative treatment prior to the study treatment\n* Is at least 18 years old at the time of informed consent\n\nExclusion Criteria:\n\n* Has a known hypersensitivity to recombinant human Bone Morphogenetic Protein-2, bovine Type I collagen, or to other components of the formulation\n* Has any active malignancy or undergoes treatment for a malignancy, or operative site is in the vicinity of a resected or extant tumor\n* Is skeletally immature (\\\u003C18 years of age or no radiographic evidence of epiphyseal closure)\n* Is pregnant or lactating\n* Has an active infection at the operative site or with an allergy to titanium, titanium alloy, or polyetheretherketone\n* The use of the Infuse™ Bone Graft component implanted at locations other than the lower lumbar spine (e.g., cervical spine)\n* Repeat applications of the Infuse™ Bone Graft component\n* Has up to Grade 1 retrolisthesis\n* Has hepatic or renal impairment\n* Has metabolic bone disease\n* Has autoimmune disease\n* Has immunosuppressive disease or suppressed immune systems resulting from radiation therapy, chemotherapy, steroid therapy, or other treatments\n* Is illiterate or vulnerable (e.g., the participant is incapable of judgment or is under tutelage) as per the investigator's assessment\n* Concurrent participation in another clinical study that may confound study results\n* Has a considerable risk for surgery\n* Has a condition that could compromise study (e.g., mentally incompetent, alcohol or drug abuse) as per the investigator's assessment",{"count":365,"type":20},600,"This study aims to evaluate the safety and effectiveness of INFUSE™ Bone Graft in the real-world setting in Korea.",[368,24,369],"Intervertebral Disc Degeneration","Lumbar Disc Disease",[371,372,373,374],"INFUSE Bone Graft","Lumbar Interbody Fusion","Anterior Lumbar Interbody Fusion","Oblique Lumbar Interbody Fusion",{"date":376,"type":29},"2025-03-20",{"date":378,"type":29},"2022-08-10",{"date":380,"type":20},"2025-08-31",{"name":382,"class":383},"Medtronic Spinal and Biologics","INDUSTRY",{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":48,"enrollmentInfo":391,"targetDuration":4,"studyType":51,"phases":393,"briefSummary":395,"conditions":396,"keywords":397,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":71},"100573332","phase-4-safety-and-efficacy-of-subdermal-betadine-during-posterior-spinal-fusion-100573332","NCT06744907","Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion","Subdermal Betadine to Reduce Microbacterial Bioburden During Posterior Spinal Fusion","Inclusion Criteria\n\n* Males and females\n* Undergoing primary posterior spinal fusion of the thoracic and\u002For lumbar spine\n* English Speaking\n\nExclusion Criteria\n\n* Patients who have undergone prior spinal surgery\n* Undergoing procedures other than primary posterior spinal fusion of the thoracic and\u002For lumbar spine (cervical fusion, anterior surgery, growth-friendly instrumentation)\n* Any contraindication to povidone-iodine, including pregnancy, allergy, or prior treatment with radioiodine",{"count":392,"type":20},60,[394],"PHASE4","Bacterial in the subdermal layer of the skin, such as in hair follicles and sweat glands, may contaminate surgical wounds. The goal of this study is to learn about povidone-iodine and its ability to prevent infections specifically in patients with scoliosis receiving a spinal fusion.",[24],[24,398,399,400,401],"Lumbar Spine","Thoracic Spine","Subdermal Betadine","Microbacterial bioburden","2025-01-09",{"date":404,"type":29},"2025-01-13",{"date":406,"type":29},"2025-01-03",{"date":408,"type":20},"2026-11",{"name":410,"class":36},"Akron Children's Hospital",{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":51,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":71},"100562489","clinical-evaluation-and-cost-effectiveness-analysis-of-3d-digital-surgery-in-traumatology-100562489","NCT06603831","Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology","Randomized, Prospective and Multicenter Clinical Study for the Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology and Orthopedic Surgery","Inclusion Criteria:\n\n\\- Patients that requires one of the following surgical procedures \u002F interventions: Radius osteotomy due to non-articular metaphyseal malunion Complex acetabular arthroplasty Thoracic-lumbar spine arthrodesis.\n\n-Patients that can understand the clinical study and that are able to read, understand and sign the consent form\n\nExclusion Criteria:\n\n* Patients that are not able to read, understand or sign the consent form.\n* Patients that can't or have no support to complete the clinical trial.\n* Patients with complex deformities or complications that would require mandatory personalized digital surgery treatment","80 Years",{"count":420,"type":20},180,[53],"Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications. Nowadays, medical case planning and an optimal preparation before surgery are still a challenge for surgeons. This lack of preparation is translated into longer surgical procedures, potential complications, unnecessary sterilization of materials and a high number of fluoroscopies. 2D techniques such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and X-rays remain essential for medical planning, however, in many cases, a 3D visualization is needed to achieve better results, especially in complex cases.The use of personalized medical instruments such as surgical guides has proven to increase clinical accuracy, assuring a better correction of bone deformities, and allowing a more precise location of implants and screw positioning. Furthermore, the use of 3D-printed patient-specific prosthesis can lead to better clinical outcomes as they reduce the number of complications as well as they present a longer lifespan compared to conventional generic implants.Despite the potential of 3D technology in the medical field, there is still a lack of robust studies that compares clinical benefits between digital surgery and conventional 2D surgery, and its economic impact is still unknown. Thus, the investigators propose this randomized, prospective and multi-center clinical study to evaluate the use of 3D technology in traumatology. The aim of this project is to prove that digital surgery is a cost-effective methodology and therefore it should be adopted by the public health system as a gold standard procedure.",[424,425,426,427,428,429,430,431,432,24,433,434],"Radius; Deformity","Hip Osteoarthritis","Hip Arthritis","Hip Arthropathy","Spine Injury","Radius; Anomaly","Vertebra; Degeneration","Vertebral Fracture","Hip Prosthesis Infection","Spine Osteoarthritis","Spinal Deformity","2024-11-08",{"date":437,"type":29},"2024-11-12",{"date":439,"type":29},"2024-10-21",{"date":441,"type":20},"2027-12-31",{"name":443,"class":36},"Corporacion Parc Tauli",{"id":445,"slug":446,"hasResults":11,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":450,"eligibilityCriteria":451,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":452,"enrollmentInfo":453,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":455,"conditions":456,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":71},"100408660","personalized-spine-study-group-pssg-registry-100408660","NCT04601363","Personalized Spine Study Group (PSSG) Registry","Personalized Spine Study Group (PSSG) Registry of Patients With Personalized Spine Rod Implantation","PSSG","Inclusion Criteria:\n\n* Patient has been\u002F will be operated and instrumented with patient-specific rod or spine hardware (control cohort)\n* Patient able to consent or assent\n\nExclusion Criteria:\n\n* Patient unable to sign an informed consent form\n* Patient unable to complete a self-administered questionnaire\n* Patient is pregnant or planning on becoming pregnant during the duration of their study participation\n* Patient is older than 85\n* Patient is younger than 10","85 Years",{"count":454,"type":20},1000,"The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.",[457,458,24,459,460,239,461],"Scoliosis; Adolescence","Degenerative Disc Disease","Kyphoscoliosis","Pseudoarthrosis of Spine","Kyphoses, Scheuermann","2024-10-01",{"date":464,"type":29},"2024-10-03",{"date":466,"type":29},"2020-10-29",{"date":468,"type":20},"2030-04",{"name":470,"class":36},"University of Colorado, Denver",{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":4,"enrollmentInfo":479,"targetDuration":4,"studyType":51,"phases":481,"briefSummary":482,"conditions":483,"keywords":484,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":71},"100517659","pedicle-screw-malposition-in-spine-arthrodesis-surgeries-with-o-arm-guided-navigation-100517659","NCT06020417","Pedicle Screw Malposition in Spine Arthrodesis Surgeries With O-ARM-guided Navigation","Occurrence of Pedicle Screw Malposition in Spine Arthrodesis Surgeries Performed With O-ARM-guided Navigation at a University Hospital: a Randomized Controlled Trial","NoHARM","Inclusion Criteria:\n\n* spine deformities (spinal cord trauma, osteoarthritis, intervertebral disc degeneration, degenerative or isthmic spondylolisthesis, intervertebral disc degeneration, spinal stenosis and degenerative scoliosis).\n\nExclusion Criteria:\n\n* anatomical abnormalities that can not be used the neuronavigation.",{"count":480,"type":20},124,[53],"Background: Throughout the history of spinal deformity there have been continuous advances in the surgical treatment. Although many techniques have been successfully developed despite the anatomy complex, screw placement still remains difficult with a significant risk of misplaced implants. The O-ARM guided Navigation is a scanner that allows imaging of screws intraoperatively and could be a tool to facilitate screw revision and reduce the occurrence of misplaced implants. Methods: This is a prospective and randomized clinical study that will be carried out at the University Hospital of the Federal University of Piaui, which provides exclusive assistance to patients of the Unified Health System (UHS), in northeastern Brazil.",[24,434,428],[485,486,487],"neuronavigation","spinal deformity","Spine injury","2024-09-24",{"date":490,"type":29},"2024-09-25",{"date":492,"type":29},"2024-08-01",{"date":494,"type":20},"2025-12-31",{"name":496,"class":36},"Federal University of Piaui",{"id":498,"slug":499,"hasResults":11,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":506,"conditions":507,"keywords":4,"overallStatus":508,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":71},"100560550","perioperative-smoking-cessation-in-elderly-chinese-undergoing-spinal-fusion-100560550","NCT06578611","Perioperative Smoking Cessation in Elderly Chinese Undergoing Spinal Fusion","The Effects of Perioperative Smoking Cessation on Complications in Elderly Chinese Undergoing Spinal Fusion With Enhanced Recovery After Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients aged 65 years old or more;\n2. Patients who plan to undergo spinal fusion with ERAS program;\n3. Patients who agreed to participate in this study.\n\nExclusion Criteria:\n\n1. Patients who cannot understand the study content or have difficulty communicating;\n2. Patients with a history of spinal fusion surgery;\n3. Patients with spinal fractures, spinal tumor, or spinal infections;\n4. Patients with congenital spinal deformity;\n5. Patients who were unable to complete at least 6 months of follow-up;\n6. Patients with incomplete clinical information.",{"count":505,"type":20},2000,"As China's society ages faster, the number of elderly patients undergoing spinal fusion surgery will gradually increase. Since elderly patients are at higher risk of postoperative complications than younger patients, minimizing complications after spinal fusion becomes a priority in postoperative rehabilitation. The purpose of this prospective cohort study is to develop an enhanced recovery after surgery program including individualized perioperative smoking cessation strategies in Chinese elderly undergoing spinal fusion.",[24],"NOT_YET_RECRUITING","2024-08-28",{"date":511,"type":29},"2024-08-29",{"date":513,"type":20},"2024-09",{"date":515,"type":20},"2027-12",{"name":517,"class":36},"The Second Hospital of Shandong University",{"id":519,"slug":520,"hasResults":11,"nctId":521,"briefTitle":522,"officialTitle":522,"acronym":4,"eligibilityCriteria":523,"healthyVolunteers":11,"sex":16,"minAge":524,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":51,"phases":527,"briefSummary":528,"conditions":529,"keywords":531,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":542,"locationsCount":71},"100353525","vancomycin-powder-combined-with-autogenous-bone-graft-as-a-prevention-for-post-operative-infection-for-spine-surgery-100353525","NCT03883022","Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery","Inclusion Criteria:\n\n* Patients who have instrumented spine fusion surgery due to failed conservative treatment (bed rest, medication, rehabilitation programs) for 3 to 6 months\n* Patients who are willing to sign the surgical permit after the surgeon explains all surgical procedures along with the surgical risks\n* Patients who fully understand the surgical procedures as well as the surgical risks and are willing to sign the surgical permit and the inform consent\n* Patients who agree one more blood withdrawal after operation\n\nExclusion Criteria:\n\n* Patients who agree to accept the spine surgery but do not agree to sign the inform consent\n* Patients who have allergic reaction to vancomycin","20 Years",{"count":526,"type":20},400,[53],"Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome. This ambispective study was designed to examine the effect of vancomycin powder mixed with autogenous bone graft and bone substitute on preventing deep surgical site infection (DSSI) in degenerative lumbar fusion surgeries as well as any interference with bony fusion.",[24,239,530],"Spondylolisthesis",[532,533,534,535],"Deep surgical site infection","Vancomycin-impregnated bone graft","Spine surgery","Degenerative lumbar disorder","2019-03-18",{"date":538,"type":29},"2019-03-20",{"date":540,"type":29},"2018-09-03",{"date":441,"type":20},{"name":543,"class":255},"Taipei Veterans General Hospital, Taiwan"]