[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-surgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,74,106,125,153,179,207,233],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100582011","effects-of-three-different-methods-applied-to-patients-after-spine-surgery-on-nausea-thirst-and-comfort-100582011",false,"NCT06857760","Effects of Three Different Methods Applied to Patients After Spine Surgery on Nausea, Thirst and Comfort","Inclusion Criteria:\n\n* Adult patients who underwent lumbar disc herniation (LDH) surgery\n* LDH surgery patients who recieve general anesthesia\n* The patients who were conscious\n* The duration of surgery is between 0-3 hours\n\nExclusion Criteria:\n\n* Patients who cannot understand and speak Turkish\n* Allergic patients to menthol\n* Patients who received spinal anesthesia\n* Patients with lesions on the oral mucosa and lips\n* Patients requiring intensive care after surgical intervention","ALL","18 Years",{"count":18,"type":19},128,"ESTIMATED","INTERVENTIONAL",[22],"NA","The aim of this study was to determine the effects of postoperative methods on nausea, thirst and comfort levels of patients undergoing spinal surgery.",[25],"Spinal Surgery",[27],"nausea, thirst, comfort","RECRUITING","2026-05-08",{"date":31,"type":32},"2026-05-13","ACTUAL",{"date":34,"type":32},"2025-02-28",{"date":36,"type":19},"2026-06-30",{"name":38,"class":39},"Ondokuz Mayıs University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100634903","comparison-of-5-vs-8-cmho-peep-on-respiratory-mechanics-in-prone-lumbar-surgery-100634903","NCT07545733","Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery","The Effect of Different PEEP Levels Accompanied by PCV-VG Mode on Respiratory Mechanics and Gas Exchange in Lumbar Surgeries Performed in the Prone Position Under TIVA","PROPEEP","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective lumbar spine surgery in the prone position\n* Planned general anesthesia with total intravenous anesthesia (TIVA)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* History of significant pulmonary disease (e.g., COPD, asthma)\n* Severe cardiovascular disease\n* Pregnancy\n* Known difficult airway\n* Requirement for intraoperative vasopressor infusion due to hemodynamic instability\n* Conversion to different surgical position or change in surgical plan\n* Incomplete data or protocol deviation","65 Years",{"count":51,"type":19},60,[22],"This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.",[55,25,56,57],"Lumbar Disc Herniation","Prone Position","General Anesthesia",[59,60,61,62,56,63],"PEEP","Driving Pressure","Mechanical Power","PCV-VG Ventilation","Lung Protective Ventilation","NOT_YET_RECRUITING","2026-04-28",{"date":67,"type":32},"2026-04-29",{"date":69,"type":19},"2026-05-01",{"date":71,"type":19},"2026-09-03",{"name":73,"class":39},"Harran University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":20,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":40},"100633385","phase-4-dexmedetomidine-esketamine-combination-and-chronic-postsurgical-pain-after-spinal-surgery-100633385","NCT07525999","Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Chronic Postsurgical Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years and \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic or lumbar spine surgery under general anesthesia, with an expected operative duration \\>= 2 hours;\n3. Requirement for patient-controlled intravenous analgesia (PCIA) postoperatively.\n\nExclusion Criteria:\n\n1. Severe uncontrolled hypertension preoperatively (baseline ward blood pressure: SBP \\> 180 mmHg or DBP \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, or a history of myocardial infarction within one year, severe heart failure (NYHA class \\>= III), or rapid ventricular arrhythmia;\n3. Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;\n4. Preoperative history of hyperthyroidism or pheochromocytoma;\n5. Inability to communicate preoperatively due to coma, severe dementia, or language impairment;\n6. Severe cardiac insufficiency (preoperative LVEF \\\u003C 30% or NYHA class IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or ASA physical status \\>= grade IV;\n7. Other conditions deemed inappropriate for study participation by the investigator or attending physician.","40 Years","80 Years",{"count":84,"type":19},274,[86],"PHASE4","Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may reduce CPSP in patients after spinal surgery.",[25,89,90,91,92],"Pain Intensity","Dexmedetomidine","Esketamine","Postoperative Analgesia",[94,95,90,91,96],"Spinal surgery","Pain intensity","Postoperative analgesia","2026-04-13",{"date":99,"type":32},"2026-04-16",{"date":101,"type":19},"2026-04",{"date":103,"type":19},"2027-12",{"name":105,"class":39},"Peking University First Hospital",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":82,"enrollmentInfo":113,"targetDuration":4,"studyType":20,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":124,"locationsCount":40},"100633179","phase-4-dexmedetomidine-esketamine-combination-and-moderate-to-severe-pain-after-spinal-surgery-100633179","NCT07523321","Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Moderate-to-severe Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years but \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic, or lumbar spine surgery with an expected duration \\>= 2 hours under general anesthesia;\n3. Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n1. Uncontrolled preoperative hypertension (ward systolic blood pressure \\> 180 mmHg or diastolic blood pressure \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, a history of myocardial infarction within one year, or presence of rapid ventricular arrhythmia;\n3. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or prresence of intracranial hypertension;\n4. Uncontrolled hyperthyroidism or pheochromocytoma;\n5. Inability to communicate due to coma, severe dementia, or language barrier;\n6. Severe cardiac insufficiency (preoperative left ventricular ejection fraction \\\u003C 30% or New York Heart Association Functional classification IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or American Society of Anesthesiologists physical status \\>= IV;\n7. Other conditions that are considered unsuitable for study participation.",{"count":84,"type":19},[86],"Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may improve analgesia and reduce moderate-to-severe pain in patients after spinal surgery.",[25,89,90,91,92],[94,95,90,91,96],"2026-04-09",{"date":120,"type":32},"2026-04-14",{"date":101,"type":19},{"date":123,"type":19},"2027-05",{"name":105,"class":39},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":15,"minAge":16,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":20,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100610014","phase-4-methadone-to-reduce-chronic-opioid-use-after-major-spine-surgery-the-mend-pilot-feasibility-study-100610014","NCT07222072","Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study","MEND","Inclusion Criteria:\n\n* Adult ≥ 18 years of age\n* Scheduled for multilevel lumbar and\u002For thoracic spine fusion (primary or revision)\n\nExclusion Criteria:\n\n* \\\u003C18 or \\>72 Years of age\n* Body Mass Index \\>40\n* Known allergy to methadone\n* Pregnant females\n* Non-English-speaking patients",true,"72 Years",{"count":135,"type":19},120,[86],"The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.",[139,25],"Post Operative Pain",[141,142,143],"Methadone","non-opioid","spinal surgery","2025-12-15",{"date":146,"type":32},"2025-12-17",{"date":148,"type":32},"2025-11-15",{"date":150,"type":19},"2028-10",{"name":152,"class":39},"The Cleveland Clinic",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":15,"minAge":161,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":20,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100597296","staircase-nutritional-intervention-for-elderly-patients-undergoing-spinal-fusion-surgery-100597296","NCT07056647","Staircase Nutritional Intervention for Elderly Patients Undergoing Spinal Fusion Surgery","A Prospective Multicenter Randomized Controlled Trial of a Staircase Nutritional Intervention Strategy Versus Conventional ERAS Diet Management for Elderly Patients Undergoing Spinal Fusion Surgery","SNIEPUSFS","Inclusion Criteria:\n\n* Age and Gender: Aged ≥ 75 years, regardless of gender. Surgery Type: Scheduled for elective spinal fusion surgery, including but not limited to lumbar, thoracic, and cervical spinal fusion surgeries. The surgeries are aimed at treating spinal degenerative diseases (such as lumbar disc herniation, lumbar spinal stenosis, etc.), spinal trauma, spinal deformities, etc.\n\nNutritional Status: Willing and able to cooperate with nutritional assessments (such as Mini - Nutritional Assessment, MNA), and patients with any level of nutritional risk are included.\n\nPhysical Condition: American Society of Anesthesiologists (ASA) physical status classification Ⅰ - Ⅲ, meaning the physical condition is relatively tolerable for surgery, without severe failure of important organs such as the heart, lungs, liver, and kidneys, and without uncontrolled severe hypertension, diabetic ketoacidosis, and other acute complications.\n\nCognitive and Communication Ability: Possessing basic cognitive and communication abilities, being able to understand the purpose, process, and relevant requirements of the study, and signing a written informed consent form.\n\nLife Expectancy: With a life expectancy of more than 1 year to facilitate long - term postoperative follow - up and assessment.\n\nExclusion Criteria:\n\n* Severe Underlying Diseases: Presence of severe heart failure (New York Heart Association functional class Ⅳ), end - stage liver disease (such as decompensated liver cirrhosis with severe ascites, hepatic encephalopathy, etc.), end - stage renal disease (requiring maintenance dialysis treatment), end - stage malignant tumors, and other serious underlying diseases that severely affect life and health and recovery.\n\nPsychiatric and Neurological Diseases: Suffering from severe mental illnesses (such as schizophrenia, major depressive disorder in the acute phase and unable to cooperate with the study), Alzheimer's disease and unable to understand the content of the study, and serious neurological diseases (such as long - term bedridden patients with severe stroke and impaired consciousness).\n\nContraindications to Nutritional Supplements: Allergic to the components of the nutritional supplements involved in the study (such as enteral nutrition powder mixture, low - sugar whole - protein enteral nutrition powder, etc.) or having severe intolerance.\n\nRecent Special Situations: Having a history of severe trauma or major surgery (other than the planned spinal fusion surgery) in the past 3 months; having a history of severe gastrointestinal diseases such as gastrointestinal bleeding and intestinal obstruction in the past 1 month.\n\nOthers: Currently participating in other clinical trials that may affect the results of this study; having insurmountable compliance problems (such as failure to take nutritional supplements on time, refusal of follow - up, etc.).","75 Years",{"count":163,"type":19},88,[22],"The goal of this prospective multicenter randomized controlled clinical trial is to evaluate the efficacy of a staircase nutritional intervention in reducing postoperative complications and improving long-term functional recovery in elderly patients aged ≥75 years scheduled for spinal fusion surgery. The main questions it aims to answer are:\n\n1. Does the staircase nutritional intervention reduce the 30-day postoperative complication rate, as measured by the Comprehensive Complication Index (CCI), compared to conventional ERAS diet management?\n2. Does the staircase nutritional intervention improve 1-year functional recovery, as assessed by Oswestry\u002FNeck Disability Index (ODI\u002FNDI) and health-related quality of life (EQ-5D), compared to conventional ERAS diet management?\n\nResearchers will compare the intervention group receiving MNA - based staircase nutritional intervention (including 14-day preadmission oral nutritional supplementation, perioperative personalized nutritional support, and postdischarge continuous management) combined with surgery-specific prehabilitation training to the control group receiving conventional ERAS diet management to see if the former leads to better clinical outcomes and long-term functional recovery.\n\nParticipants will\n\nUndergo randomization: Be randomly assigned to either the intervention group or the control group.\n\nReceive assigned interventions:\n\nControl group: Receive conventional ERAS diet management, including preadmission nutritional education and early postoperative oral intake.\n\nIntervention group: Undergo MNA - based staircase nutritional intervention and surgery-specific prehabilitation training.\n\nParticipate in follow-up: Complete short-term (within 90 days postoperatively) and long-term (6 and 12 months postoperatively) follow-up assessments, including laboratory tests, functional evaluations, and satisfaction surveys.",[167,25,168,169],"Nutritional Intervention","Elderly","Enhanced Recovery After Surgery","2025-06-29",{"date":172,"type":32},"2025-07-09",{"date":174,"type":19},"2025-07-01",{"date":176,"type":19},"2028-01-31",{"name":178,"class":39},"Xuanwu Hospital, Beijing",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":186,"enrollmentInfo":187,"targetDuration":189,"studyType":190,"phases":4,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":40},"100551899","correlation-analysis-of-pod-and-pncd-in-elderly-spinal-surgery-patients-100551899","NCT06466083","Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients","Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Spinal Surgery Patients","Inclusion Criteria:\n\n* Patients ≥65 years of age who have undergone spinal surgery anesthesia; Sign informed consent\n\nExclusion Criteria:\n\n* Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases","100 Years",{"count":188,"type":19},165,"1 Year","OBSERVATIONAL","This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).",[193,194,25],"Postoperative Delirium","Postoperative Neurocognitive Disorder",[196,197,198,143],"postoperative delirium","postoperative neurocognitive disorder","serum indexes","2025-03-30",{"date":201,"type":32},"2025-04-03",{"date":203,"type":32},"2025-01-14",{"date":205,"type":19},"2026-07-01",{"name":178,"class":39},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":214,"targetDuration":4,"studyType":20,"phases":216,"briefSummary":217,"conditions":218,"keywords":221,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":40},"100580889","phase-4-perioperative-rectal-methadone-in-spine-surgery-100580889","NCT06843174","Perioperative Rectal Methadone in Spine Surgery","PROMISE","Inclusion Criteria:\n\n1. 18 to 65 years-old.\n2. Elective spinal surgery with fusion of one or more sacral, lumbar, thoracic, and\u002For cervical levels\n3. Capacity to provide informed consent\n4. For participants of childbearing potential, use of contraception.\n\nExclusion Criteria:\n\n1. American Society of Anesthesiologists Physical Status \\> IV\n2. Hypersensitivity to the active substance (methadone hydrochloride) or other opioid analgesics or to any ingredient in the formulation\n3. Pregnant or nursing participants\n4. Known or suspected mechanical gastrointestinal obstruction\n5. Acute respiratory depression, elevated carbon dioxide levels in the blood, cor pulmonale, or pulmonary disease necessitating home oxygen therapy\n6. Acute alcohol intoxication, delirium tremens, and convulsive disorders secondary to alcohol intoxication\n7. Severe central nervous system depression, increased intracranial pressure, or head injury\n8. Use of monoamine oxidase (MAO) inhibitors, such as isocarboxazid, phenelzine, selegiline, and tranylcypromine, within 14 days of enrollment\n9. Diarrhea associated with pseudomembranous colitis caused by cephalosporins, lincomycins, or penicillins\n10. Preoperative renal insufficiency or failure\n11. Significant liver disease (cirrhosis or hepatic failure)\n12. History of opioid use disorder within the last 3 months\n13. Patients taking more than 90 mg of morphine equivalents daily\n14. Poor comprehension of the English language\n15. Patients who are likely to remain intubated postoperatively\n16. QT interval \\> 500ms on preoperative ECG",{"count":215,"type":19},40,[86],"Patients undergoing spinal surgery require pain control medication after their surgery. Investigators have successfully used intravenous Methadone to manage pain after surgery. However, doctors in Canada do not have the intravenous form of Methadone to prescribe to their patients. The investigators in Canada propose a pilot trial to investigate whether Methadone administered rectally could be used to manage pain after spinal surgery.\n\nThe main questions are:\n\n1. Are investigators able to recruit participants for this trial and learn from this study to plan a larger trial?\n2. Does Methadone administered rectally during surgery, reduce participants' pain intensity, use less pain medication, and have a better recovery after surgery? Investigators will compare Methadone to a placebo (a look-alike substance that contains no drug) to see if Methadone works to manage pain after surgery better than the usual pain management.\n\nParticipants will:\n\n* receive either Methadone or placebo during surgery.\n* be asked some questions about their pain during days 1 to 3 after surgery\n* be contacted by phone to ask about their recovery\n\nAt this time, the study aims to recruit 40 participants from St. Michael's Hospital, to learn whether it will be feasible to plan a larger study.",[25,219,220],"Post-operative Care","Post-operative Pain Management",[222,223,224],"Intraoperative Methadone","Rectal Methadone administration","spinal surgery post-operative pain management","2025-03-25",{"date":199,"type":32},{"date":228,"type":32},"2025-02-19",{"date":230,"type":19},"2026-08",{"name":232,"class":39},"Unity Health Toronto",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":49,"enrollmentInfo":240,"targetDuration":4,"studyType":20,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":40},"100550788","esketamine-on-postoperative-sleep-disturbance-of-patients-undergoing-spinal-surgery-100550788","NCT06451627","Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery","Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery：A Randomized Controlled Trial","Inclusion Criteria:\n\n* 18-65 years old,\n* American Society of Anesthesiologist (ASA) Physical Status classification I to III ;\n* Patients scheduled to undergo elective spinal surgery under general anesthesia;\n* Signed informed consent ;\n\nExclusion Criteria:\n\n* BMI \\> 35kg \u002F m2 ;\n* Severe lesions of important organs and systems ;\n* The estimated duration of surgery is more than 4 hours\n* Patients who were retained tracheal intubation or admitted to intensive care unit (ICU) postoperatively.\n* History of adverse reactions or contraindications to ketamine and esketamine ;\n* Cognitive dysfunction, communication disorders ;\n* Refused to participate in this study.",{"count":241,"type":19},156,[22],"The goal of this clinical trial is to learn about the effect of intraoperative esketamine infusion on postoperative sleep disturbance(PSD) of patients undergoing spinal surgery. The main aims to answer are:\n\n* To explore the effect of intraoperative infusion of esketamine on the incidence of postoperative sleep disturbance and sleep quality in patients undergoing spinal surgery.\n* To explore the effect of intraoperative infusion of esketamine on postoperative pain, anxiety and depression ; Participants will be patients undergoing spinal surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg\u002Fkg\u002Fh esketamine or saline will be infused during surgery . The incidence of sleep disturbance , sleep quality, pain scores, hospital anxiety and depression scores and perioperative adverse events after surgery will be investigated.",[91,245,25],"Sleep Disturbance","2025-01-22",{"date":248,"type":32},"2025-01-24",{"date":250,"type":32},"2024-06-10",{"date":252,"type":19},"2026-01-28",{"name":254,"class":39},"Beijing Tiantan Hospital"]