[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spine-degeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spine-degeneration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,49,78,121,148,172,200,232,258],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100623395","pre-operative-risk-assessment-combined-with-targeted-intervention-in-the-chinese-elderly-with-spine-surgery-ii-100623395",false,"NCT07396077","Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II","Multimodal Physiological Reserve Optimizing Prehabilitation Program (PHYSIO-Prehab) in the Chinese Elderly With Spine Surgery","PRACTICE-2","Inclusion Criteria:\n\n1. Aged ≥75 years at the time of screening\n2. Voluntarily sign the informed consent form\n3. Clinically diagnosed with degenerative lumbar spinal disorders with duration of symptoms \\>6 months\n4. Requiring elective lumbar fusion surgery (single-level or multi-level, open or minimally invasive approach)\n5. No severe cognitive impairment (Mini-Mental State Examination score \\> 9)\n6. Scheduled to undergo surgery within 6-8 weeks after screening (allowing completion of the 6-week prehabilitation program)\n\nExclusion Criteria:\n\n1. Scheduled to undergo other emergency surgery or day surgery\n2. Urgent medical conditions requiring priority management before spinal surgery\n3. With spinal disorders other than degenerative diseases (spinal fracture, tumor, metastasis, infection, ankylosing spondylitis, scoliosis with Cobb angle \\>40°)\n4. With contraindications to prehabilitation exercise (New York Heart Association Class IV heart failure, unstable angina, uncontrolled hypertension \\[systolic BP ≥180 mmHg or diastolic BP ≥110 mmHg despite medication\\])\n5. With severe functional disability for other disorders or long-term bedridden status unable to perform basic physical activities\n6. With allergy or intolerance to nutritional supplements used in the prehabilitation program\n7. Participating in another clinical trial involving prehabilitation, perioperative intervention, or spinal surgery within 3 months before screening","ALL","75 Years",{"count":20,"type":21},248,"ESTIMATED","INTERVENTIONAL",[24],"NA","This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be randomized 1:1 into the intervention and usual care groups. The intervention group will receive a 6-week PHYSIO-Prehab multimodal prehabilitation program, including multicomponent exercise, nutritional intervention, comorbidity optimization, and cognitive prehabilitation with brain protection strategies. The control group will receive standard health education provided via a manual, and both groups will receive consistent perioperative Enhanced Recovery After Surgery care. The primary outcome will be the change in Barthel Index (a tool for assessing independence in activities of daily living) from baseline to 30 days postoperatively; secondary outcomes will include pain scores, disability, patient satisfaction, and the 30-day postoperative Comprehensive Complication Index. The trial will initiate recruitment in April 2026 and conclude in December 2027, aiming to evaluate the feasibility and efficacy of PHYSIO-Prehab and provide high-quality evidence for patient-centered perioperative care pathways in this population.",[27,28,29,30,31],"Spine Degeneration","Lumbar Degenerative Disease","Frail Elderly","Enhanced Recovery After Surgery (ERAS) Protocol","Prehabilitation",[31,33,34,35],"ERAS","lumbar fusion","ADL","RECRUITING","2026-04-26",{"date":39,"type":40},"2026-04-28","ACTUAL",{"date":42,"type":40},"2026-04-15",{"date":44,"type":21},"2027-12-30",{"name":46,"class":47},"Xuanwu Hospital, Beijing","OTHER",4,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100452385","clariance-erys-registry-100452385","NCT05170815","Clariance ErYs Registry","Clariance Registry of ERISMA® and Idys® Devices","ErYs","Inclusion Criteria:\n\n* Considered as adult in the respective geography (18 years old or older for France and 21 years old or older for United-States).\n* Indicated for treatment with one or more commercially available sponsor spine device included into the study.\n* For France only, affiliated with or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Subjects who are not able to comply with the study procedures based on the judgment of the investigator (e.g., inability to comprehend study related questions, inability to keep scheduled assessment times).\n* Subjects who are considered as vulnerable: minor, pregnant woman or people under legal protection (guardianship or curatorship).\n* Contraindicated for spine surgery utilizing a commercially available sponsor spine device.","18 Years",{"count":59,"type":21},760,"OBSERVATIONAL","International, prospective, single arm, multicenter and observational Post-Market Clinical Follow-up (PMCF).\n\nThe overall objective of this study is to collect preoperative, intraoperative and postoperative (at 9 weeks, 6 months, 1 year and 2 years) data on the clinical complications and functional outcomes of the study devices to demonstrate safety and performance in a real-world setting.\n\nThe primary objective is to demonstrate that the use of the study devices is safe.\n\nThe secondary objective is to demonstrate that the use of the study devices decreases the pain, and improves the quality of life and the daily activities of the subjects.",[27,63,64,65,66],"Spine Spondylosis Thoracic","Spinal Deformity","Spinal Tumor","Spinal Fracture","2026-03-16",{"date":69,"type":40},"2026-03-17",{"date":71,"type":40},"2022-01-17",{"date":73,"type":21},"2028-12",{"name":75,"class":76},"Clariance","INDUSTRY",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":77},"100621170","occupational-exposure-to-whole-body-vibration-among-us-military-veterans-acute-and-chronic-contributions-to-musculoskeletal-disorders-and-spine-area-pain-100621170","NCT07367139","Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain","Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain, and the Role of Water","Inclusion Criteria:\n\n* English speaking; Male\u002FFemale Veterans age 20-45 years; BMI \\\u003C 30; ability to sit upright for 60 mins; ability to drive to Deerfield, IL; ambulatory\n\nExclusion Criteria:\n\n* Previous spinal surgery; conditions\u002Fdiseases associated with altered pain perception including neurological diseases (e.g., multiple sclerosis, trigeminal neuralgia, central sensitization), major psychiatric disorders, diabetes, neoplasm and cardiovascular disorders, chronic widespread pain diagnosis, pregnant women, MRI contraindications.",true,"20 Years","45 Years",{"count":89,"type":21},112,[24],"Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain. Military operational exposure to whole body vibration (WBV) is known to contribute to MSK disorders and pain. Our preliminary studies identified accelerated lumbar and cervical spine degenerative changes in military fighter pilots and helicopter aircrew compared to age- and sex-matched civilian controls. Those changes were likely associated with WBV that military aircrew experience during flight training, primarily affected intervertebral discs (IVDs) and endplates, were associated with neck and back pain symptoms and reduced functional capacity, and are likely to lead to lifelong spine-related issues. Therefore, these aircrew, and other military personnel that experience occupational WBV, are likely to enter the VA Healthcare system with pre-existing degenerative changes and spine-related pain symptoms that can progress over time. Similarly, many Veterans enter civilian occupations that involve WBV such as truck drivers and heavy equipment operators that may also have detrimental effects to the spine and lead to spine-related pain. Development of informed interventions and treatment protocols requires a mechanistic understanding of how the spine is acutely and chronically affected by occupational WBV from both structural and physiological perspectives. Innovation and Impact: Novel multi-parametric application of noninvasive magnetic resonance imaging (MRI) techniques such as arterial spin labeling (ASL), T2\\* decay from ultra short TE, and diffusion MRI can provide early objective indications of endplate degenerative state and IVD hydration and perfusion, and novel application of upright MR imaging allows for gravitational loading of the IVD while observing segmental and region IVD fluid distribution and transport patterns. Specific Aims: The goal of the proposed effort is to characterize the effects of previous military and current civilian occupational WBV on IVD and endplate health and degeneration (Aim 1), and segmental and regional IVD fluid distribution and transport differences (Aim 2). The endplates contain vasculature that permits IVD fluid exchange and may be linked to IVD fluid dynamics. We propose looking for connections between segmental and regional IVD fluid dynamics, degenerative state of the associated endplates, and WBV exposure (acute-controlled and longitudinal-occupational). Finally, we propose evaluating the impact of body hydration state on IVD fluid distribution and transport following acute (30 min) controlled WBV (Aim 3). Cumulatively, these results inform population-specific preventative measures to preserve endplate health for Veterans in occupations that present with WBV and identify potential areas for further research and targeted treatment of MSK disorders and MSK pain. Methodology: This study will explore acute and chronic changes to the structure and physiology of the spine by enrolling Veterans with prior military or current civilian occupation that involves daily WBV. Advanced MRI sequences will identify endplate sclerosis and physiological changes including disc hydration and perfusion. Acute effects of WBV will be assessed using pre\u002Fpost MRI scans with experimental WBV. Path to translation\u002FImplementation: Our existing relationships with VA clinicians, including spine surgeons, physical medicine and rehabilitation, and pain medicine, will ensure VA patient applicability of these findings and will help to translate any outcomes from this research and future studies directly into patient care.",[93,94,27,95],"Spine Health","Spine Injuries and Disorders","Whole Body Vibration",[97,98,95,99,100,101,102,103,104,105,106,107,108,109],"Biomechanics","Magnetic Resonance Imaging (MRI)","Lumbar Spine","Degeneration","Intervertebral Disc","Hydration","Oswestry Disability Index","PainDETECT","Pain Catastrophizing","PROMIS","Brief Pain Inventory","Longitudinal","Endplate","NOT_YET_RECRUITING","2026-01-16",{"date":113,"type":40},"2026-01-26",{"date":115,"type":21},"2026-07-01",{"date":117,"type":21},"2030-06-30",{"name":119,"class":120},"Milwaukee VA Medical Center","FED",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":77},"100608247","rate-of-bone-union-after-surgery-with-stand-alone-fibergraft-100608247","NCT07199075","Rate of Bone Union After Surgery With Stand-alone Fibergraft","Fusion Rate of Anterior Lumbar Interbody Fusion and Extreme Lateral Interbody Fusion Using Titanium Cages Filled With Stand-alone Fibergraft in Lumbar Spinal Fusion","Fibergraft","Inclusion Criteria:\n\n* Adults ≥ 18 years old\n* Diagnosed with the following lumbar spine disorders: foraminal nerve root compression, isthmic spondylolisthesis, and short-segment (1-2 levels) deformity.\n* Undergone primary surgery of ALIF or XLIF using titanium cages filled with standalone Fibergraft and with the following criteria fulfilled (ie, the index surgery):\n\n  * ALIF (up to 2 levels) as either standalone (ie, no posterior procedure) or as an anterior first procedure with posterior procedure as a second procedure.\n  * XLIF (up to 2 levels) as an anterior first procedure with posterior procedure as a second procedure.\n* Consenting to have CT scans taken to allow assessment of fusion status at 12-24 months post index surgery\n\n  * This criterion is applicable to patients who have not undergone revision surgery.\n  * For patients who have undergone revision surgery due to any reason other than nonunion, which typically occurs within 1 year of the index surgery, this criterion is only applicable if it is possible to obtain the CT scan within 12-24 months of the index surgery. If no CT scan can be taken during this window, the patient does not need to undergo the CT scan; in such cases, the CT scan that has been taken as part of the standard of care before the revision surgery will be retrospectively retrieved to assess the fusion status at the time of the revision surgery.\n  * This criterion is not applicable to patients who underwent revision surgery due to nonunion, which typically occurs 1 year after the index surgery; these patients do not need to undergo the CT scan. In such cases, the CT scan that has been taken as part of the standard of care before the revision surgery will also be retrospectively retrieved to assess and grade the fusion status at the time of the revision surgery.\n* Ability to provide informed consent according to the IRB\u002FEC defined and approved procedures\n\nExclusion Criteria:\n\n* Revision surgery\n* Standalone XLIF\n* Posterior lumbar interbody fusion\n* Diagnosis of fractures, malignancies, ankylosing spondylitis, or acute cauda equina syndrome\n* Diagnosis of Parkinson's disease\n* Body mass index \\> 35kg\u002Fm2",{"count":130,"type":21},80,"Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking. A common treatment is a type of back surgery called lumbar interbody fusion, which helps stabilize the spine.\n\nAt the St. Maartenskliniek in the Netherlands, doctors have been using a special material called Fibergraft Bioactive Glass Putty for such surgeries since 2023. This material helps bones grow and heal, and it's placed inside the spine without needing extra bone from another part of the body.\n\nThis study will look at how well this material works by evaluating how many patients' bones successfully healed after surgery using this material. It will also look at how patients feel and recover after the procedure",[27,133,134,135,136,137,138],"Spine Disorder","Spine Pain","Spine Fusion","Spine Fusion for Degenerative Spine Disease","Nerve Root Compress;Lumbosac","Spondylolisthesis","2025-09-22",{"date":141,"type":40},"2025-09-30",{"date":143,"type":21},"2025-10-31",{"date":145,"type":21},"2026-05-30",{"name":147,"class":47},"AO Innovation Translation Center",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":77},"100547396","evaluating-the-efficacy-of-a-mobile-application-in-postoperative-rehabilitation-100547396","NCT06407427","Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation","Using a Mobile Application for In-Bed Conditioning Exercises for Orthopedic Postoperative Patients","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* English reading\u002Fspeaking\n* Are status post low-energy hip fracture, total knee\u002Fhip arthroplasty, or single to multilevel spinal fusion without paralysis\n* Must be able bodied enough to participate in a mobile app tool for physical therapy\n* Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration\\]\n\nExclusion Criteria:\n\n* Severe cognitive impairment: Not alert and oriented to person, place, time, and reason for being the hospital; and unable to follow 2 step commands\n* Severe physical impairment:\n\n  * Neurologic paralysis\n  * Polytraumas with restrictions incompatible with anti-gravity exercises\n  * Knee immobilization, bed rest\n* Unstable medical conditions:\n\n  * On ventilatory support\n  * Utilizing high degrees of oxygen support (continuous BiPAP, high flow nasal cannula, nonrebreather mask, aerosol mask \\>3L\u002Fmin)\n  * Hemodynamic instability requiring pressor medication support (can include those on pressors for elevated mean arterial pressure goals (MAPs))\n  * Neurologically instable with strokes, hemorrhages, increased intracranial pressures\n* Open wounds or surgical incisions\n\n  * Tenuous closed wounds requiring immobilization or bending restrictions\n  * Open wounds that are either packed\u002Fdressed or dressed with a wound vacuum\n  * Surgical wounds that are draining fluid or purulence\n* Vulnerable populations\n\n  * Incarcerated individuals\n* Patients without access to a mobile phone with iOS capability",{"count":156,"type":21},100,[24],"This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.",[27,160,161,162],"Hip Arthritis","Knee Osteoarthritis","Hip Fractures","2025-08-29",{"date":165,"type":40},"2025-09-02",{"date":167,"type":40},"2025-07-21",{"date":169,"type":21},"2026-07",{"name":171,"class":47},"Yale University",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":77},"100594984","proteomic-and-histological-analysis-of-ligamentum-flavum-in-lumbar-stenosis-100594984","NCT07026552","Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis","Proteomic and Histological Analysis of Ligamentum Flavum Hypertrophy and Degeneration in Lumbar Spinal Stenosis: Clinical, Surgical, and Therapeutic Implications","APIDeLeG","Inclusion Criteria:\n\n* Radiological (CT and\u002For MRI) and clinical evidence of lumbar spinal stenosis (LSS).\n* Age range: 50-85 years.\n* Signed informed consent, medical records release form, and HIPAA authorization form (or equivalent according to local regulations), reviewed and signed by the patient or legally authorized representatives.\n\nExclusion Criteria:\n\n* Pediatric population and individuals under 50 years of age.\n* Concomitant genetic musculoskeletal disorders.\n* History of trauma.\n* Spinal infections (spondylodiscitis, osteomyelitis, abscess, etc.).\n* Presence of spinal tumors or other neoplasms.","50 Years","85 Years",{"count":156,"type":21},"Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration. Fibrotic processes involving elastin and collagen alterations contribute to LF thickening and spinal instability. Despite progress, the molecular mechanisms underlying LFH remain unclear, necessitating targeted diagnostic and therapeutic strategies.\n\nObjective This study aims to analyze the proteomic and histological changes in LFH associated with LSS, correlating molecular signatures with imaging and surgical findings to identify potential therapeutic targets.\n\nMethods LF samples from LSS patients undergoing surgery will be analyzed using mass spectrometry-based proteomics and histology to identify biomarkers and molecular pathways. Correlations between imaging, intraoperative findings, and molecular profiles will be assessed.\n\nExpected Results The study aims to identify specific biomarkers and molecular pathways involved in LFH, linking them to clinical and imaging findings. Statistical analyses will evaluate associations between molecular alterations and surgical outcomes to define therapeutic targets.\n\nSignificance By identifying molecular markers of LFH, this research aims to improve LSS diagnosis and treatment, potentially guiding targeted therapies to slow disease progression and enhance patient outcomes.\n\nStudy Design A multidisciplinary team from Fondazione Policlinico Universitario Agostino Gemelli and Università Cattolica del Sacro Cuore will conduct the study, ensuring robust data integration and statistical evaluation.\n\nConclusion This comprehensive study will provide valuable insights into the molecular and histological modifications associated with LFH in LSS, paving the way for new therapeutic approaches to improve patient outcomes and satisfaction.",[185,27],"Spinal Stenosis of Lumbar Region",[187,188,189,190],"Lumbar Spinal Stenosis","Ligamentum Flavum Hypertrophy","Proteomic Analysis","Molecular Biomarkers","2025-08-04",{"date":193,"type":40},"2025-08-07",{"date":195,"type":40},"2025-06-15",{"date":197,"type":21},"2028-03-01",{"name":199,"class":47},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":215,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":231},"100502091","strategic-use-of-big-data-in-spine-surgery---testing-digital-prediction-of-outcome-in-clinical-praxis-100502091","NCT05817747","Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis","Strategic Use of Big Data in Spine Surgery - Testing a Digital Prediction of Outcome Tool in Clinical Praxis","Inclusion Criteria:\n\n* Refered to a participating clinic regarding surgery for lumbar spinal stenosis or cervical radiculopathy\n* 18 years of age or older\n* Magnetic Resonance Imaging (MRT) examination within the last 12 months confirming the diagnosis, concurrent with symptoms described by the referring physician\n* Giving informed consent\n\nExclusion Criteria:\n\n* Another condition found to be the reason for the symptoms.\n* Not giving informed consent\n* Need for further investigation that prevents inclusion within one month of the doctor visit.",{"count":208,"type":21},900,[24],"The goal of this prospective, multicenter clinical trial is to determine if the use of the postoperative outcome prediction model the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction compared to current practice.\n\nThe main questions it aims to answer are:\n\n* Does its use alter patient-reported outcome measured by general assessment regarding leg pain and Satisfaction in lumbar spinal stenosis?\n* Does its use alter patient-reported outcome as measured by general assessment regarding arm pain and Satisfaction in cervical rhizopathy?\n* How does the Quality of Life in patients - who after assessment by spinal surgeon do not proceed to surgery - compare with patients with the same baseline profile who did undergo surgery?\n\nEligible participants will be presented with their predicted postoperative outcome generated by the Dialogue Support tool, as an adjunct to the ordinary assessment by a spine surgeon.\n\nResearchers will compare participants with a matched control group from the Swedish Spine Register (\"Swespine\") to see if the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction.",[212,27,213,214],"Constriction, Pathologic","Surgery","Radiculopathy",[216,217,218,213,219,220,221],"Spine","Cervical radiculopathy","Lumbar spinal stenosis","Neck","Prognostic model","External validation","2025-05-12",{"date":224,"type":40},"2025-05-13",{"date":226,"type":40},"2022-03-01",{"date":228,"type":21},"2029-03-01",{"name":230,"class":47},"Sahlgrenska University Hospital",10,{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":243,"conditions":244,"keywords":245,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":77},"100577392","risk-factors-of-paraspinal-muscles-in-degenerative-lumbar-spondylolisthesis-100577392","NCT06797700","Risk Factors of Paraspinal Muscles in Degenerative Lumbar Spondylolisthesis","Prediction of Risk Factors of Paraspinal Muscles in Degenerative Lumbar Spondylolisthesis Based on Spine MRI","RFPMDLS","Inclusion Criteria:\n\n* Patients who presented to our hospital with back pain(the diagnosis was spondylolisthesis or no spondylolisthesis);\n* Patients older than 50 years;\n* Patients with complete clinical data and magnetic resonance imaging (MRI) before surgery.\n\nExclusion Criteria:\n\n* The patient has previous spinal surgery;\n* Patients with lumbar tumor,lumbar infection and lumbar tuberculosis;\n* Patients with incomplete MRI sequence.","80 Years",{"count":242,"type":21},1000,"This is a retrospectively observational study. The goal of this observational study is to analyze the risk factors of paraspinal muscles associated with the occurrence of spondylolisthesis in patients with degenerative lumbar spondylolisthesis(DLS) and to construct a predictive model. The main question it aims to answer is: Which paraspinal muscle changes are risk factors for DLS? We will collect the information of patients who have undergone lumbar MRI in our hospital and have been diagnosed with back pain ( including spondylolisthesis or no spondylolisthesis) during the period from 2022 to 2024.The collected data included gender, age, body mass index (BMI), diabetes, hypertension, occupation and imaging parameters. We will then retrospectively analyze the risk factors associated with lumbar spondylolisthesis.",[27],[246,247,248],"degenerative lumbar spondylolisthesis","paraspinal muscles","MRI","2025-03-04",{"date":251,"type":40},"2025-03-05",{"date":253,"type":21},"2025-03-06",{"date":255,"type":21},"2025-08-31",{"name":257,"class":47},"The First People's Hospital of Yunnan",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":267,"conditions":268,"keywords":271,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":4},"100560686","spine-surgery-video-observation-study-the-creation-of-a-benchmark-video-rgb-depth-dataset-to-investigate-the-feasibility-of-developing-a-markerless-tracking-system-for-spine-surgery-100560686","NCT06580379","Spine Surgery Video Observation Study. The Creation of a Benchmark Video (RGB-Depth) Dataset to Investigate the Feasibility of Developing a Markerless Tracking System for Spine Surgery.","SPIVOS","Inclusion Criteria:\n\n* Candidate surgeries include all spine surgeries taking a posterior approach. This includes both 'open' and 'minimally invasive' surgeries, provided some portion of vertebrae bone is exposed.\n\nExclusion Criteria:\n\n* Candidate surgeries will be excluded if the patient is under the age of 18 or the clinical lead feels the patient lacks capacity to consent.",{"count":266,"type":21},25,"The primary study objective is to build a video dataset, consisting of both colour and depth information, of spine surgery that includes both 'open' and 'minimally invasive' (MIS) surgeries. Using accompanying preoperative CT scans of the patient's spine, we aim to develop a markerless tracking system for spine surgery, which the collected dataset will be used to both train, and then benchmark against.",[135,269,27,270],"Spine Injury","Navigation, Spatial",[272,273,274,275],"Imaging","Depth Imaging","Spine Surgery","Intraoperative Registration","2024-08-28",{"date":278,"type":40},"2024-08-30",{"date":280,"type":21},"2024-10",{"date":282,"type":21},"2027-10",{"name":284,"class":47},"Imperial College London"]