[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spine-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spine-disease":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,73,115,136,159,180,203,228,252,274],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100551641","phase-1-ldgraft-in-single-level-anterior-lumbar-interbody-fusion-alif-100551641",false,"NCT06462729","LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)","A Randomized Study of LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)","RESTORE","Inclusion Criteria:\n\n1. Skeletally mature adults ≥22 and ≤80 years at the time of surgery\n2. Willing and able to give written informed consent and comply with study protocol and postoperative management program\n3. Degenerative disc disease of the lumbosacral spine in one level (L3 to S1) requiring fusion confirmed by patient history and radiographic imaging (CT\u002FMRI\u002FX-rays) with one or more of the following:\n\n   * instability (as defined by ≥3mm translation or ≥5° angulation);\n   * osteophyte formation of facet joints or vertebral endplates;\n   * decreased disc height, on average by \\>2mm, but dependent upon the spinal level;\n   * scarring\u002Fthickening of ligamentum flavum, annulus fibrosis, or facet joint capsule;\n   * herniated nucleus pulposus;\n   * facet joint degeneration\u002Fchanges; and\u002For\n   * vacuum phenomenon.\n4. Preoperative Oswestry Disability Index score ≥ 35\n5. Participant has not responded to conservative treatment (e.g. medications, injections, physical therapy, etc.) for a period of 6 months\n6. Participant is indicated for an ALIF approach to the lumbar spine\n\nExclusion Criteria:\n\n1. Previous lumbar spine instrumentation (i.e., anterior disc replacement, interspinous device) or a previous interbody fusion procedure in the lumbar spine\n2. More than one level lumbar spine level requiring fusion\n3. Three or more contiguous lumbar spine levels requiring decompression (Note: Up to two contiguous levels of decompression is acceptable)\n4. Known hypersensitivity or allergy to any components of the study treatments inclusive of hypersensitivity or allergy to any BMP-2 type recombinant proteins or peptides.\n5. Pregnant, planning to become pregnant during the follow-up time period, or breast-feeding women\n6. Presence of active malignancy\n7. Requires bone growth stimulation in the lumbar spine\n8. Active local or systemic infection\n9. Spondylolisthesis greater than Grade 1 (25% translation)\n10. Currently smoking or using nicotine products, including e-cigarette products (e.g., vaping) (Use within 30 days of screening date is considered 'current')\n11. Any degenerative muscular or neurological condition that would interfere with evaluation of outcomes, including but not limited to Parkinson's disease, amyotrophic lateral sclerosis (ALS), or multiple sclerosis\n12. Any medical condition requiring treatment with any drug known to potentially interfere with bone\u002Fsoft tissue healing (e.g. chronic systemic steroids) or receiving radiation therapy that is expected to continue for the duration of the study\n13. Body Mass Index \\> 35\n14. Insulin-dependent diabetes mellitus\n15. Osteopenia or osteoporosis of the spine, DEXA T score of ≤ -1.0\n16. Any secondary causes of osteoporosis (e.g. chronic liver or kidney disease, uncontrolled hyper- or hypothyroidism, type I or type II diabetes mellitus, gastrointestinal malabsorption syndromes) or other conditions known to adversely affect osteogenesis (e.g. Paget's disease, Ehlers-Danlos syndrome or osteogenesis imperfecta)\n17. Participation in another investigational study within 30 days prior to surgery for investigational devices, or within the last three months for investigational drugs;\n18. Current or recent history of chemical\u002Falcohol abuse or dependency using standard medical definition of DSM-5 (Diagnostic and Statistical Manual) code\n19. In the opinion of the investigator, the participant has a behavioral, cognitive, social or medical problem that may interfere with the assessment of the safety or effectiveness of the product\n20. Radiographically compromised vertebral bodies at the index level due to current or past trauma, e.g., by the radiographic appearance of the fracture callus, deformity, malunion or nonunion\n21. Currently a prisoner\n22. Involved in active litigation relating to his\u002Fher spinal condition or workers compensation claimants.","ALL","22 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","The objective of this study is to evaluate the safety and effectiveness of LDGraft (investigational device) compared to 100% human tissue product allograft bone (control) when applied in an ALIF procedure in the treatment of patients with lumbar degenerative disc disease (DDD).",[29,30,31,32],"Degenerative Disc Disease","Lumbar Disc Disease","Spine Disease","Lumbar Spine Degeneration","RECRUITING","2026-05-22",{"date":36,"type":37},"2026-05-27","ACTUAL",{"date":39,"type":37},"2024-11-12",{"date":41,"type":22},"2027-12",{"name":43,"class":44},"Locate Bio Pty Ltd","INDUSTRY",3,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100637400","lumbar-paravertebral-block-vs-erector-spinae-plane-block-in-elderly-patients-undergoing-lumbar-spine-surgery-100637400","NCT07607509","Lumbar Paravertebral Block vs Erector Spinae Plane Block in Elderly Patients Undergoing Lumbar Spine Surgery","A Prospective, Randomized Controlled Trial Comparing the Analgesic Efficacy of Lumbar Paravertebral Block and Lumbar Erector Spinae Plane Block in Elderly Patients Undergoing Lumbar Spine Surgery","Inclusion Criteria:\n\n* ge ≥65 years\n* Scheduled for elective lumbar spine surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to assess pain using the Numeric Rating Scale (NRS)\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Chronic opioid therapy\n* Coagulation disorders\n* Use of anticoagulant therapy contraindicating regional anesthesia\n* Infection at the planned needle insertion site\n* Allergy to ropivacaine or other study-related medications\n* Severe hepatic failure\n* Severe renal failure\n* Cognitive impairment preventing reliable pain assessment\n* Inability to cooperate with study procedures\n* Extensive reoperation or surgery of unusually large extent that may interfere with outcome assessment\n* Contraindications to general anesthesia or regional anesthesia","65 Years","100 Years",{"count":56,"type":22},120,[58],"NA","This prospective, randomized controlled trial aims to compare the analgesic efficacy of lumbar paravertebral block (L-PVB) and lumbar erector spinae plane block (L-ESPB) in elderly patients undergoing lumbar spine surgery. Effective postoperative pain management in this population is essential due to increased susceptibility to opioid-related adverse effects.\n\nParticipants aged 65 years and older will be randomly assigned to receive either bilateral L-PVB or bilateral L-ESPB in addition to standardized general anesthesia. The primary objective is to evaluate differences in postoperative opioid consumption within the first 48 hours after surgery. Secondary outcomes include pain intensity, intraoperative opioid use, time to mobilization, length of hospital stay, and incidence of opioid-related adverse events.",[31],"NOT_YET_RECRUITING","2026-05-20",{"date":64,"type":37},"2026-05-26",{"date":66,"type":22},"2026-06-01",{"date":68,"type":22},"2027-08-31",{"name":70,"class":71},"Poznan University of Medical Sciences","OTHER",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":97,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":72},"100609711","trans-auricular-stimulation-for-postoperative-inflammation-in-spine-surgery-100609711","NCT07218133","Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery","TAPIS","Inclusion Criteria:\n\n* Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions)\n* Ability to undergo a reliable neurologic examination and pain assessments\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Shorter-segment spinal fusions than those described above\n* Undergoing current active cancer therapy\n* Undergoing treatment with immunosuppressive drugs\n* Additional spinal surgery within past 6 months\n* Sustained bradycardia or presence of pacemaker\n* History of substance abuse","18 Years",{"count":82,"type":22},50,[58],"This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.",[86,87,88,89,31,90,91,92,93,94,95,96],"Spinal Fusion","Hyperglycemia","Postoperative Pain Management","Postoperative Care","Neurologic Deficits","Neurological Disorder","Inflammation","Spine Condition","Spinal (Fusion) Surgery","Cytokine Levels","Spine Fusion",[98,99,100,101,102,103,104,105],"spinal fusion","postoperative pain","glycemic control","inflammation","vagal nerve stimulation","postoperative complications","cytokine","spine surgery","2026-02-17",{"date":108,"type":37},"2026-02-20",{"date":110,"type":37},"2025-10-08",{"date":112,"type":22},"2026-12",{"name":114,"class":71},"Alexander T. Yahanda",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":72},"100520671","active-informed-consent-a-new-solution-to-improve-and-objectively-test-the-patient-understanding-of-complex-surgical-procedures-proposals-100520671","NCT06059599","Active Informed Consent: a New Solution to Improve and Objectively Test the Patient Understanding of Complex Surgical Procedures Proposals","Inclusion Criteria:\n\n* Adults aged ≥ 18 years (with full legal capacity to consent).\n* Scheduled for elective surgery in one of the two domains: spinal surgery or radical prostatectomy in the waiting list of our centers.\n* Ability to comprehend Italian language.\n* Basic computer or internet access skills. Patients (or their family members) should have the ability to access multimedia content.\n\nExclusion Criteria:\n\n* Patients under age: minors.\n* Inability to provide informed consent or self-determination (significant cognitive impairment, severe mental illness, or decisional incapacity that would prevent them from understanding the consent materials or participating in the decision-making).\n* Urgent or emergency surgery cases.",{"count":122,"type":22},300,[58],"This is an interventional, non-pharmacological, randomized controlled superiority study (RCT), multicenter, open label, parallel group.\n\nThe aim is to evaluate the effectiveness of a new preoperative information method, based on multimedia tools and on the objective control of understanding by the patient candidate for spinal or urological surgery.",[31,126],"Urologic Diseases","2026-01-29",{"date":129,"type":37},"2026-02-02",{"date":131,"type":37},"2024-06-19",{"date":133,"type":22},"2026-10",{"name":135,"class":71},"Istituto Ortopedico Rizzoli",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":72},"100518440","effect-of-an-interdisciplinary-spine-rehabilitation-program-100518440","NCT06030570","Effect of an Interdisciplinary Spine Rehabilitation Program","PROGRESS: The Effect of an Interdisciplinary Program for Rehabilitation for Spinal Disorders","PROGRESS","Inclusion criteria\n\n* Adults, age \\> 18 years\n* Spine problem for \\> 6 weeks, needing interdisciplinary care (risk factors, failure of first line treatment, etc)\n* Inclusion in Revita program\n* Informed consent to participate\n\nExclusion criteria\n\n* Patients without sufficient understanding of the Dutch language\n* Unable to participate in 2h rehabilitation sessions with exercises",{"count":145,"type":22},90,"OBSERVATIONAL","The goal of this research project is to evaluate the effectiveness of the current interdisciplinary rehabilitation program (Revita) and follow-up trajectory for chronic lumbar spine disorders in the University Hospitals Leuven.",[149,31],"Low Back Pain","2025-09-22",{"date":152,"type":37},"2025-09-23",{"date":154,"type":37},"2023-08-22",{"date":156,"type":22},"2025-12",{"name":158,"class":71},"KU Leuven",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":72},"100606852","phase-4-comparison-of-perineural-dexamethasone-versus-dexmedetomidine-as-adjuvants-to-erector-spinae-plane-block-in-lumbar-spine-surgery-a-randomized-double-blind-controlled-trial-100606852","NCT07180940","Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to N\u002FA (no limit)\n* Scheduled for elective lumbar spine surgery (e.g., decompression or fusion) via posterior approach\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body weight ≥ 50 kg\n* Ability to provide written informed consent\n* Expected postoperative hospitalization of at least 48 hours\n\nExclusion Criteria:\n\n* Known allergy or contraindication to ropivacaine, dexamethasone, or dexmedetomidine\n* Infection at or near the site of block placement\n* Coagulation disorders or current use of anticoagulant therapy (not discontinued per guidelines)\n* Chronic opioid use or opioid dependence\n* Neurological or psychiatric disorders interfering with pain assessment\n* Diabetes mellitus with poorly controlled glycemia (e.g., HbA1c \\> 8%)\n* Severe hepatic or renal dysfunction\n* Body mass index (BMI) \\> 40 kg\u002Fm²\n* Pregnancy or breastfeeding\n* Refusal or inability to cooperate with the study protocol",{"count":166,"type":22},150,[168],"PHASE4","This clinical study aims to determine which of two medications-dexamethasone or dexmedetomidine-works better and is safer when used together with a local anesthetic (ropivacaine) in a type of nerve block called the erector spinae plane block (ESPB). This block helps reduce pain after lumbar spine surgery.",[31,171],"Spinal Diseases","2025-09-12",{"date":174,"type":37},"2025-09-18",{"date":176,"type":37},"2025-09-01",{"date":178,"type":22},"2026-12-31",{"name":70,"class":71},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":72},"100594326","prevalence-of-diabetes-in-patients-who-are-candidates-for-spine-surgery-100594326","NCT07017985","Prevalence of Diabetes in Patients Who Are Candidates for Spine Surgery","PREDIR","Inclusion Criteria:\n\n* Adult patients,\n* Patients who have been informed of the research and have not indicated their opposition to the use of their medical data,\n* Patients who are candidates for their first lumbar spine surgery, whether instrumented or not\n\nExclusion Criteria:\n\n* Non-instrumented percutaneous surgery (cementoplasty)\n* Presence of spinal osteosynthesis equipment\n* Surgery performed for an infectious or tumoral spinal condition\n* Surgery via an anterior or lateral approach",{"count":188,"type":22},500,"The purpose of the study is to assess, through systematic screening, the prevalence of diabetes or prediabetes in patients who are candidates for lumbar spine surgery.",[31],[192,193],"Spine surgery","Diabetes","2025-06-11",{"date":196,"type":37},"2025-06-12",{"date":198,"type":37},"2024-03-28",{"date":200,"type":22},"2026-06-30",{"name":202,"class":71},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":210,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":211,"targetDuration":213,"studyType":146,"phases":4,"briefSummary":214,"conditions":215,"keywords":216,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":4},"100590999","wearable-flexible-sensors-for-spinal-motion-monitoring-100590999","NCT06974721","Wearable Flexible Sensors for Spinal Motion Monitoring","Wearable Flexible Sensors for Spinal Motion Monitoring in Spinal Diseases","Inclusion Criteria:\n\n1. Clinical diagnosis of Spinal Cord Injury\n2. Clinical diagnosis of cervical spondylotic myelopathy with Impaired Hand Function\n3. Clinical diagnosis of Kyphosis\n4. Clinical diagnosis of Spinal Imbalance\n5. Clinical diagnosis of Scoliosis Patients\n6. Clinical diagnosis of Lumbar Spondylolisthesis Patients\n\nExclusion Criteria:\n\n1. Obesity (BMI\\>30)\n2. Inability to complete functional assessments due to physical condition or other reasons;\n3. Comorbid neuromuscular disorders",true,{"count":212,"type":22},20,"1 Month","With the deepening of societal aging, degenerative spinal diseases have become increasingly prevalent in China and are one of the leading causes of disability among middle-aged and elderly populations. Current musculoskeletal assessment methods primarily focus on imaging rather than functional evaluation, and emphasize static over dynamic analysis, failing to capture the daily functional state of the musculoskeletal system. This limitation hinders a deeper understanding of functional patterns and their role in the progression of degenerative spinal diseases. Therefore, there is an urgent need to develop precise and dynamic functional assessment methods that overcome the constraints of time and space in measurement. This project adopts a dynamic perspective of the musculoskeletal system, developing a wearable monitoring approach based on flexible sensors to assess limb and spinal motion. The method will be validated against traditional imaging techniques such as X-ray and ultrasound, laying the foundation for investigating the pathogenesis of degenerative spinal diseases. This research aligns with China's strategic initiatives and practical needs in addressing the challenges of an aging population.",[31],[217,218],"flexible sensor","spine disease","2025-05-13",{"date":221,"type":37},"2025-05-16",{"date":223,"type":22},"2025-06-01",{"date":225,"type":22},"2027-12-01",{"name":227,"class":71},"Peking University Third Hospital",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":234,"targetDuration":4,"studyType":23,"phases":236,"briefSummary":237,"conditions":238,"keywords":240,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":72},"100475650","outcomes-post-treatment-impact-on-motor-impairment-of-sleep-efficiency-in-sci-optimise-sci-trial-100475650","NCT05473689","Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)","Inclusion Criteria:\n\n* English-speaking adults (18 years of age or older)\n* Acute (≤ 30 days after injury), cervical\u002Fthoracic (injury level at C2 to T12), complete or incomplete (AIS A to D) SCI\n* Not being treated for sleep apnea prior to the spinal cord impairment onset.\n\nExclusion Criteria:\n\n* Non-traumatic spinal cord disease at risk for neurologic progression (e.g., demyelinating spine diseases such as neuromyelitis optica and multiple sclerosis, spinal cord malignancy)\n* Concomitant diseases of the central nervous system\n* Preinjury chronic pain\n* Other pre-existing diseases of the central nervous system\n* Significant psychiatric disorders with recent episode of exacerbation\n* Neuromuscular diseases\n* Current substance misuse\n* Known history of primary hypersomnia or secondary hypersomnia of any cause except for SRBDs (e.g., hypothyroidism, moderate or severe iron deficiency anemia, infections, depression, kidney failure, chronic fatigue syndrome, neurodegenerative diseases, and myotonic dystrophy)\n* Epilepsy\n* Vitamin B12 deficiency",{"count":235,"type":22},66,[58],"This randomized clinical trial will compare three groups of individuals with cervical\u002Fthoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe sleep-related breathing disorders (SRBDs) among adults at 6 weeks after SCI; (ii) delayed CPAP therapy in the management of moderate-to-severe SRBDs among adults at 22 weeks after SCI; and (iii) no treatment as they either have mild or no SRBD.",[239,31],"Spinal Cord Injuries",[241,242],"sleep apnea","sleep-related breathing disorders","2024-12-05",{"date":245,"type":37},"2024-12-11",{"date":247,"type":37},"2022-08-15",{"date":249,"type":22},"2025-07-31",{"name":251,"class":71},"University Health Network, Toronto",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":273},"100425864","phase-4-the-effect-of-intrawound-vancomycin-powder-in-spine-surgery-100425864","NCT04825522","The Effect of Intrawound Vancomycin Powder in Spine Surgery","The Effect of Intrawound Vancomycin Powder in Spine Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients requiring surgery due to any spine disease.\n\nExclusion Criteria:\n\n* A previous history of infections at the spine surgical site.\n* Biopsy procedure.\n* Patients with a postoperative follow-up time of less than 12 weeks.\n* Patients allergic to vancomycin.\n* Patient is less than 18 years old.",{"count":260,"type":22},1643,[168],"Problem: Postoperative wound infection following various spinal surgeries is a serious complication. The incidence of post-surgical wounds in spine surgery is high, and various researchers have reported different infection rates. In addition, increased healthcare costs, prolonged lengths of stay in hospital, and reduced quality of life as a result of surgical site infections (SSI) are also major concerns. Several methods for avoiding SSI, such as betadine irrigation, vacuum-assisted closure, and intra-wound vancomycin powder, have been used to reduce the rate of wound infection in spine surgery. Use of local vancomycin has been popular because of its protective effects and lower cost. According to some reports, prophylactic administration of intra-wound vancomycin powder before wound closure is an effective method for decreasing postoperative wound infection rates; however, other studies have revealed a non-significant effect of intra-wound vancomycin use for decreasing the postsurgical wound infection rate.\n\nSolution: Therefore, the investigators will prospectively randomize all various types of spinal surgeries to patients who will receive intrawound vancomycin powder and control group who will not receive the powder and to see it's effect in reducing the post-surgical infection.",[31],"2024-04-22",{"date":266,"type":37},"2024-04-23",{"date":268,"type":37},"2022-03-27",{"date":270,"type":22},"2028-12-01",{"name":272,"class":71},"Windsor-Essex Compassionate Care Community",2,{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":210,"sex":17,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":72},"100528632","mri-analysis-and-degenerative-spine-100528632","NCT06163300","MRI Analysis and Degenerative Spine","Inclusion Criteria:\n\n* Age between 50 and 85 years\n* Diagnosis of spinal disease by clinical and imagiological criteria\n* More than 3 months duration of disease\n* Ability to give consent\n* Fluent portuguese speaker\n\nExclusion Criteria:\n\n* Previous spine surgery\n* Spinal instability\n* Neurological disease that might interfere with walking\n* Known orthopedic conditions that causes significant gait impairment\n* Dementia or development disorder with cognitive impairment\n* Inability to give consent","50 Years","85 Years",{"count":283,"type":22},200,"Analysis of MRI advanced techniques in degenerative spinal disease.\n\nThe main questions it aims to answer are:\n\n* Can we assess microstructural integrity of compressed nerve roots in degenerative spinal disease\n* What are the image biomarkers affected by disease\n* How they evolve with disease progression and treatment",[31],"2024-01-26",{"date":288,"type":37},"2024-01-30",{"date":290,"type":37},"2024-01-01",{"date":292,"type":22},"2026-09",{"name":294,"class":71},"Universidade Nova de Lisboa"]